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Note 1 - Significant Accounting Policies - Summary of Revenues (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended		12 Months Ended
	Jun. 30, 2020	Jun. 30, 2019	Jun. 30, 2020	Jun. 30, 2019	Dec. 31, 2019
Revenues	$ 2,871	$ 1,448	$ 7,694	$ 7,335
Torii Pharmaceutical Co. [Member]
Revenues					$ 20,101
Product [Member]
Revenues	0	0	218	1,679
Royalty [Member]
Revenues	44	696	1,989	3,018
Collaborative and Other Research and Development [Member]
Revenues	2,827	752	5,487	2,638
Collaborative and Other Research and Development [Member] | US Department of Health and Human Services [Member]
Revenues	2,545	752	4,152	2,638
Collaborative and Other Research and Development [Member] | Torii Pharmaceutical Co. [Member]
Revenues	$ 282	$ 0	$ 1,335	$ 0

X

- Definition

Amount, including tax collected from customer, of revenue from satisfaction of performance obligation by transferring promised good or service to customer. Tax collected from customer is tax assessed by governmental authority that is both imposed on and concurrent with specific revenue-producing transaction, including, but not limited to, sales, use, value-added and excise.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
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Reference 2: http://www.xbrl.org/2003/role/disclosureRef
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Reference 3: http://www.xbrl.org/2003/role/disclosureRef
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