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Note 1 - Significant Accounting Policies (Tables) | 9 Months Ended
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Sep. 30, 2020
Notes Tables |
Debt Securities, Available-for-sale [Table Text Block] |
|  | September 30, 2020 |
|  |  |  |  |  |  |  |  |  | Gross |  |  | Gross |  |  |  |  |
|  | Amortized |  |  | Accrued |  |  | Unrealized |  |  | Unrealized |  |  | Estimated |
|  | Cost |  |  | Interest |  |  | Gains |  |  | Losses |  |  | Fair Value |
Obligations of U.S. Government and its agencies |  | $ | 45,722 |  |  | $ | 18 |  |  | $ | 6 |  |  | $ | - |  |  | $ | 45,746 |
Corporate debt securities |  |  | 590 |  |  |  | 4 |  |  |  | - |  |  |  | - |  |  |  | 594 |
Certificates of deposit |  |  | 3,477 |  |  |  | 9 |  |  |  | 3 |  |  |  | - |  |  |  | 3,489 |
Total investments |  | $ | 49,789 |  |  | $ | 31 |  |  | $ | 9 |  |  | $ | - |  |  | $ | 49,829 |
|  |  | December 31, 2019 |
|  |  |  |  |  |  |  |  |  | Gross |  |  | Gross |  |  |  |  |
|  | Amortized |  |  | Accrued |  |  | Unrealized |  |  | Unrealized |  |  | Estimated |
|  | Cost |  |  | Interest |  |  | Gains |  |  | Losses |  |  | Fair Value |
Obligations of U.S. Government and its agencies |  | $ | 10,488 |  |  |  | 50 |  |  | $ | 23 |  |  | $ | - |  |  | $ | 10,561 |
Corporate debt securities |  |  | 9,742 |  |  |  | 59 |  |  |  | 10 |  |  |  | (1 | ) |  |  | 9,810 |
Certificates of deposit |  |  | 1,669 |  |  |  | 7 |  |  |  | 7 |  |  |  | - |  |  |  | 1,683 |
Total investments |  | $ | 21,899 |  |  |  | 116 |  |  | $ | 40 |  |  | $ | (1 | ) |  | $ | 22,054 |
Available For Sale Securities Debt Maturities Fair Value [Table Text Block] |
|  | September 30, 2020 |  | December 31, 2019
Maturing in one year or less |  | $ | 46,827 |  |  | $ | 22,054 |
Maturing after one year through two years |  |  | 3,002 |  |  |  | - |
Total investments |  | $ | 49,829 |  |  | $ | 22,054 |
Schedule of Receivables from Collaborations [Table Text Block] |
|  |  | September 30, 2020 |
|  | Billed |  |  | Unbilled |  |  | Total |
U.S. Department of Health and Human Services |  | $ | - |  |  | $ | 3,547 |  |  | $ | 3,547 |
Shionogi & Co. Ltd. |  |  | 1,679 |  |  |  | 4 |  |  |  | 1,683 |
Green Cross Corporation |  |  | 142 |  |  |  | 8 |  |  |  | 150 |
Mundipharma International Holdings Limited |  |  | 42 |  |  |  | - |  |  |  | 42 |
Total receivables |  | $ | 1,863 |  |  | $ | 3,559 |  |  | $ | 5,422 |
|  |  | December 31, 2019 |
|  | Billed |  |  | Unbilled |  |  | Total |
U.S. Department of Health and Human Services |  | $ | 1,353 |  |  | $ | 15,023 |  |  | $ | 16,376 |
Shionogi & Co. Ltd. |  |  | 1,336 |  |  |  | 4 |  |  |  | 1,340 |
Green Cross Corporation |  |  | 2,924 |  |  |  | 8 |  |  |  | 2,932 |
Mundipharma International Holdings Limited |  |  | 56 |  |  |  | - |  |  |  | 56 |
Seqirus UK Limited |  |  | 1,091 |  |  |  | 351 |  |  |  | 1,442 |
Total receivables |  | $ | 6,760 |  |  | $ | 15,386 |  |  | $ | 22,146 |
Disaggregation of Revenue [Table Text Block] |
|  | Three Months |  |  | Nine Months |
|  | 2020 |  |  | 2019 |  |  | 2020 |  |  | 2019 |
Product sales |  | $ | 2,478 |  |  | $ | 335 |  |  | $ | 2,696 |  |  | $ | 2,014 |
Royalty revenue |  |  | 254 |  |  |  | 508 |  |  |  | 2,243 |  |  |  | 3,526 |
Collaborative and other research and development revenues: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
U.S. Department of Health and Human Services |  |  | 3,088 |  |  |  | 932 |  |  |  | 7,240 |  |  |  | 3,570 |
Torii Pharmaceutical Co., Ltd. |  |  | 282 |  |  |  | — |  |  |  | 1,617 |  |  |  | — |
Total collaborative and other research and development revenues |  |  | 3,370 |  |  |  | 932 |  |  |  | 8,857 |  |  |  | 3,570 |
Total revenues |  | $ | 6,102 |  |  | $ | 1,775 |  |  | $ | 13,796 |  |  | $ | 9,110 |

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