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Note 1 - Significant Accounting Policies (Tables)
9 Months Ended
Sep. 30, 2020
Notes Tables  
Debt Securities, Available-for-sale [Table Text Block]
  September 30, 2020 
          Gross  Gross     
  Amortized  Accrued  Unrealized  Unrealized  Estimated 
  Cost  Interest  Gains  Losses  Fair Value 

Obligations of U.S. Government and its agencies

 $45,722  $18  $6  $-  $45,746 

Corporate debt securities

  590   4   -   -   594 

Certificates of deposit

  3,477   9   3   -   3,489 

Total investments

 $49,789  $31  $9  $-  $49,829 
     December 31, 2019 
          

Gross

  

Gross

     
  

Amortized

  

Accrued

  

Unrealized

  

Unrealized

  

Estimated

 
  

Cost

  

Interest

  

Gains

  

Losses

  

Fair Value

 

Obligations of U.S. Government and its agencies

 $10,488   50  $23  $-  $10,561 

Corporate debt securities

  9,742   59   10   (1)  9,810 

Certificates of deposit

  1,669   7   7   -   1,683 

Total investments

 $21,899   116  $40  $(1) $22,054 
Available For Sale Securities Debt Maturities Fair Value [Table Text Block]
  

September 30, 2020

 

December 31, 2019

Maturing in one year or less

 $46,827  $22,054 

Maturing after one year through two years

  3,002   - 

Total investments

 $49,829  $22,054 
Schedule of Receivables from Collaborations [Table Text Block]
     September 30, 2020 
  

Billed

  

Unbilled

  

Total

 

U.S. Department of Health and Human Services

 $-  $3,547  $3,547 

Shionogi & Co. Ltd.

  1,679   4   1,683 

Green Cross Corporation

  142   8   150 

Mundipharma International Holdings Limited

  42   -   42 

Total receivables

 $1,863  $3,559  $5,422 
     December 31, 2019
 
  
 
  

Billed

  

Unbilled

  

Total

 

U.S. Department of Health and Human Services

 $1,353  $15,023  $16,376 

Shionogi & Co. Ltd.

  1,336   4   1,340 

Green Cross Corporation

  2,924   8   2,932 

Mundipharma International Holdings Limited

  56   -   56 

Seqirus UK Limited

  1,091   351   1,442 

Total receivables

 $6,760  $15,386  $22,146 
Disaggregation of Revenue [Table Text Block]
  

Three Months

  

Nine Months

 
  

2020

  

2019

  

2020

  

2019

 

Product sales

 $2,478  $335  $2,696  $2,014 

Royalty revenue

  254   508   2,243   3,526 

Collaborative and other research and development revenues:

                

U.S. Department of Health and Human Services

  3,088   932   7,240   3,570 

Torii Pharmaceutical Co., Ltd.

  282      1,617    

Total collaborative and other research and development revenues

  3,370   932   8,857   3,570 

Total revenues

 $6,102  $1,775  $13,796  $9,110