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Consolidated Statements of Comprehensive Loss (Unaudited) - USD ($)
shares in Thousands, $ in Thousands
 3 Months Ended 9 Months Ended
Sep. 30, 2020
Sep. 30, 2019
Sep. 30, 2020
Sep. 30, 2019
Revenues:        
Revenues $ 6,102 $ 1,775 $ 13,796 $ 9,110
Expenses        
Cost of product sales 1,517 0 1,517 1,399
Research and development 30,245 25,120 87,610 80,294
Selling, general and administrative 17,195 11,735 46,943 26,632
Royalty 9 18 78 131
Total operating expenses 48,966 36,873 136,148 108,456
Loss from operations (42,864) (35,098) (122,352) (99,346)
Interest and other income and expense (312) 402 8,892 1,545
Interest expense (2,927) (3,044) (8,892) (8,805)
(Loss) gain on foreign currency derivative (12) 148 31 331
Net loss (46,115) (37,592) (122,321) (106,275)
Unrealized gain (loss) on available for sale investments 6 19 (30) 357
Comprehensive loss $ (46,109) $ (37,573) $ (122,351) $ (105,918)
Basic and diluted net loss per common share (in dollars per share) $ (0.26) $ (0.34) $ (0.75) $ (0.96)
Weighted average shares outstanding (in shares) 176,521 110,416 164,127 110,308
Product [Member]        
Revenues:        
Revenues $ 2,478 $ 335 $ 2,696 $ 2,014
Royalty [Member]        
Revenues:        
Revenues 254 508 2,243 3,526
Collaborative and Other Research and Development [Member]        
Revenues:        
Revenues $ 3,370 $ 932 $ 8,857 $ 3,570