<SEC-DOCUMENT>0001140361-20-009639.txt : 20200424
<SEC-HEADER>0001140361-20-009639.hdr.sgml : 20200424
<ACCEPTANCE-DATETIME>20200424085535
ACCESSION NUMBER:		0001140361-20-009639
CONFORMED SUBMISSION TYPE:	S-3
PUBLIC DOCUMENT COUNT:		10
FILED AS OF DATE:		20200424
DATE AS OF CHANGE:		20200424

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			BIOCRYST PHARMACEUTICALS INC
		CENTRAL INDEX KEY:			0000882796
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				621413174
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		S-3
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-237820
		FILM NUMBER:		20812670

	BUSINESS ADDRESS:	
		STREET 1:		4505 EMPEROR BOULEVARD
		STREET 2:		SUITE 200
		CITY:			DURHAM
		STATE:			NC
		ZIP:			27703
		BUSINESS PHONE:		919-859-1302

	MAIL ADDRESS:	
		STREET 1:		4505 EMPEROR BOULEVARD
		STREET 2:		SUITE 200
		CITY:			DURHAM
		STATE:			NC
		ZIP:			27703
</SEC-HEADER>
<DOCUMENT>
<TYPE>S-3
<SEQUENCE>1
<FILENAME>nt10011234x1_s3.htm
<DESCRIPTION>S-3
<TEXT>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 540pt;"><a name="nt10011234x1_s3_100-regcov_pg1"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 540pt; margin-left: 0pt;"><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 12pt; text-align: center;">As filed with the Securities and Exchange Commission on April 24, 2020</div><div class="regno" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 7pt; font-weight: bold; margin-top: 2.75pt; text-align: right;">Registration No. 333-&#8195;&#8195;</div></div></div><div class="block-frill" style="width: 540pt; margin-left: 0pt;"><div><div class="rule-full" style="height: 0pt; width: 100%; border-bottom: 2pt solid #000000; margin-top: 1pt; margin-bottom: 1pt; margin-left: auto; margin-right: auto;"> </div><div class="rule-full" style="height: 0pt; width: 100%; border-bottom: 1pt solid #000000; margin-bottom: 1pt; margin-left: auto; margin-right: auto; margin-top: 4pt;"> </div></div></div><div class="block-main" style="width: 540pt; margin-left: 0pt;"><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 11pt; font-weight: bold; margin-top: 12pt; text-align: center;">UNITED STATES<br>SECURITIES AND EXCHANGE COMMISSION<br>Washington, D.C. 20549</div><div><div class="rule-partial" style="height: 0pt; width: 96pt; border-bottom: 1pt solid #000000; margin-bottom: 2pt; margin-left: auto; margin-right: auto; margin-top: 8.5pt;"> </div></div><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 12pt; font-weight: bold; margin-top: 9.25pt; text-align: center;">FORM S-3<br><font style="font-size: 10pt;">REGISTRATION STATEMENT</font><br><font style="font-size: 10pt;">UNDER THE SECURITIES ACT OF 1933</font></div><div><div class="rule-partial" style="height: 0pt; width: 96pt; border-bottom: 1pt solid #000000; margin-bottom: 2pt; margin-left: auto; margin-right: auto; margin-top: 8pt;"> </div></div><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 14pt; font-weight: bold; margin-top: 9.25pt; text-align: center;">BioCryst Pharmaceuticals, Inc.<br><font style="font-size: 7pt; font-style: italic; font-weight: normal;">(Exact name of registrant as specified in its charter)</font></div><div><div class="rule-partial" style="height: 0pt; width: 96pt; border-bottom: 1pt solid #000000; margin-bottom: 2pt; margin-left: auto; margin-right: auto; margin-top: 7pt;"> </div></div><table cellspacing="0" cellpadding="0" class="txttab" align="center" style="margin-top: 2.25pt; border-collapse: collapse; width: 540pt; margin-left: 0pt;"><tr><td style="width: 48.89%; text-align: center; vertical-align: top; padding-bottom: 1.5pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 7pt; font-weight: bold; margin-top: 0pt; text-align: center;">Delaware</div></td><td class="gutter" style="width: 1.11%; border-bottom: none; font-size: 2pt; padding-bottom: 1.5pt;">&#8203;</td><td class="gutter" style="width: 1.11%; border-bottom: none; font-size: 2pt; padding-bottom: 1.5pt;">&#8203;</td><td style="width: 48.89%; text-align: center; vertical-align: bottom; padding-bottom: 1.5pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 7pt; font-weight: bold; margin-top: 0pt; text-align: center;">62-1413174</div></td></tr><tr><td style="width: 48.89%; text-align: center; vertical-align: top; padding-top: 1.5pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 7pt; font-style: italic; margin-top: 0pt; text-align: center;">(State or other jurisdiction of incorporation or organization)</div></td><td class="gutter" style="width: 1.11%; border-bottom: none; font-size: 2pt; padding-top: 1.5pt;">&#8203;</td><td class="gutter" style="width: 1.11%; border-bottom: none; font-size: 2pt; padding-top: 1.5pt;">&#8203;</td><td style="width: 48.89%; text-align: center; vertical-align: bottom; padding-top: 1.5pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 7pt; font-style: italic; margin-top: 0pt; text-align: center;">(I.R.S. Employer Identification Number)</div></td></tr></table><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 7pt; font-weight: bold; margin-top: 0pt; text-align: center;">4505 Emperor Blvd., Suite 200<br>Durham, North Carolina 27703<br>(919) 859-1302<br><font style="font-style: italic; font-weight: normal;">(Address, including zip code, and telephone number, including area code, of registrant&#8217;s principal executive offices)</font></div><div><div class="rule-partial" style="height: 0pt; width: 96pt; border-bottom: 1pt solid #000000; margin-bottom: 2pt; margin-left: auto; margin-right: auto; margin-top: 7pt;"> </div></div><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 7pt; font-weight: bold; margin-top: 6.25pt; text-align: center;">Jon P. Stonehouse<br>President and Chief Executive Officer<br>4505 Emperor Blvd., Suite 200<br>Durham, North Carolina 27703<br>(919) 859-1302<br><font style="font-style: italic; font-weight: normal;">(Name, address, including zip code, and telephone number, including area code, of agent for service)</font></div><div><div class="rule-partial" style="height: 0pt; width: 96pt; border-bottom: 1pt solid #000000; margin-bottom: 2pt; margin-left: auto; margin-right: auto; margin-top: 7pt;"> </div></div><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 7pt; font-style: italic; margin-top: 5.25pt; text-align: center;">With a copy to:<br><font style="font-style: normal; font-weight: bold;">Brian Lane, Esq.</font><br><font style="font-style: normal; font-weight: bold;">Robyn Zolman, Esq.</font><br><font style="font-style: normal; font-weight: bold;">Gibson, Dunn &amp; Crutcher LLP</font><br><font style="font-style: normal; font-weight: bold;">1050 Connecticut Avenue, NW</font><br><font style="font-style: normal; font-weight: bold;">Washington, DC 20036</font><br><font style="font-style: normal; font-weight: bold;">(202) 955-8500</font></div><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 7pt; font-weight: bold; margin-top: 4.25pt; margin-left: 0pt; text-align: left;">Approximate date of commencement of proposed sale to the public:<font style="font-weight: normal;"> From time to time after the effective date of this Registration Statement, as determined by market conditions.</font></div><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 7pt; margin-top: 4.25pt; margin-left: 0pt; text-align: left;">If the only securities being registered on this Form are being offered pursuant to dividend or interest reinvestment plans, check the following box: <font style="font-size: 1pt;">&#8201;</font>&#x2610; </div><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 7pt; margin-top: 2pt; margin-left: 0pt; text-align: left;">If any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, other than securities offered only in connection with dividend or interest reinvestment plans, please check the following box: &#x2612; </div><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 7pt; margin-top: 2pt; margin-left: 0pt; text-align: left;">If this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, please check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. <font style="font-size: 1pt;">&#8201;</font>&#x2610; </div><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 7pt; margin-top: 2pt; margin-left: 0pt; text-align: left;">If this Form is a post-effective amendment filed pursuant to Rule 462(c) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering. <font style="font-size: 1pt;">&#8201;</font>&#x2610; </div><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 7pt; margin-top: 2pt; margin-left: 0pt; text-align: left;">If this Form is a registration statement pursuant to General Instruction I.D. or a post-effective amendment thereto that shall become effective upon filing with the Commission pursuant to Rule 462(e) under the Securities Act, check the following box. <font style="font-size: 1pt;">&#8201;</font>&#x2610; </div><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 7pt; margin-top: 2pt; margin-left: 0pt; text-align: left;">If this Form is a post-effective amendment to a registration statement filed pursuant to General Instruction I.D. filed to register additional securities or additional classes of securities pursuant to Rule 413(b) under the Securities Act, check the following box. <font style="font-size: 1pt;">&#8201;</font>&#x2610; </div><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 7pt; margin-top: 2pt; margin-left: 0pt; text-align: left;">Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of &#8220;large accelerated filer,&#8221; &#8220;accelerated filer,&#8221; &#8220;smaller reporting company&#8221; and &#8220;emerging growth company&#8221; in Rule 12b-2 of the Exchange Act.</div><table cellspacing="0" cellpadding="0" class="txttab" align="center" style="border-collapse: collapse; width: 540pt; margin-left: 0pt;"><tr><td style="width: 26.67%; text-align: left; vertical-align: top; padding-bottom: 2pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 7pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">Large accelerated filer</div></td><td class="gutter" style="width: 1.11%; border-bottom: none; font-size: 2pt; padding-bottom: 2pt;">&#8203;</td><td class="gutter" style="width: 1.11%; border-bottom: none; font-size: 2pt; padding-bottom: 2pt;">&#8203;</td><td style="width: 17.78%; text-align: left; vertical-align: bottom; padding-bottom: 2pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 1pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">&#8201;<font style="font-size: 7pt;">&#x2610;</font><font style="font-size: 7pt;"> </font></div></td><td class="gutter" style="width: 1.11%; border-bottom: none; font-size: 2pt; padding-bottom: 2pt;">&#8203;</td><td class="gutter" style="width: 1.11%; border-bottom: none; font-size: 2pt; padding-bottom: 2pt;">&#8203;</td><td style="width: 22.22%; text-align: left; vertical-align: bottom; padding-bottom: 2pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 7pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">Accelerated filer</div></td><td class="gutter" style="width: 1.11%; border-bottom: none; font-size: 2pt; padding-bottom: 2pt;">&#8203;</td><td class="gutter" style="width: 1.11%; border-bottom: none; font-size: 2pt; padding-bottom: 2pt;">&#8203;</td><td style="width: 26.67%; text-align: left; vertical-align: bottom; padding-bottom: 2pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 7pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">&#x2612; </div></td></tr><tr><td style="width: 26.67%; text-align: left; vertical-align: top; padding-top: 2pt; padding-bottom: 2pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 7pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">Non-accelerated filer</div></td><td class="gutter" style="width: 1.11%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt;">&#8203;</td><td class="gutter" style="width: 1.11%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt;">&#8203;</td><td style="width: 17.78%; text-align: left; vertical-align: bottom; padding-top: 2pt; padding-bottom: 2pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 1pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">&#8201;<font style="font-size: 7pt;">&#x2610;</font><font style="font-size: 7pt;"> </font></div></td><td class="gutter" style="width: 1.11%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt;">&#8203;</td><td class="gutter" style="width: 1.11%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt;">&#8203;</td><td style="width: 22.22%; text-align: left; vertical-align: bottom; padding-top: 2pt; padding-bottom: 2pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 7pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">Smaller reporting company</div></td><td class="gutter" style="width: 1.11%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt;">&#8203;</td><td class="gutter" style="width: 1.11%; border-bottom: none; font-size: 2pt; padding-top: 2pt; padding-bottom: 2pt;">&#8203;</td><td style="width: 26.67%; text-align: left; vertical-align: bottom; padding-top: 2pt; padding-bottom: 2pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 1pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">&#8201;<font style="font-size: 7pt;">&#x2610;</font><font style="font-size: 7pt;"> </font></div></td></tr><tr><td style="width: 26.67%; text-align: left; vertical-align: top; padding-top: 2pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 7pt;">&#160;</div></td><td class="gutter" style="width: 1.11%; border-bottom: none; font-size: 2pt; padding-top: 2pt;">&#8203;</td><td class="gutter" style="width: 1.11%; border-bottom: none; font-size: 2pt; padding-top: 2pt;">&#8203;</td><td style="width: 17.78%; text-align: left; vertical-align: bottom; padding-top: 2pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 7pt;">&#160;</div></td><td class="gutter" style="width: 1.11%; border-bottom: none; font-size: 2pt; padding-top: 2pt;">&#8203;</td><td class="gutter" style="width: 1.11%; border-bottom: none; font-size: 2pt; padding-top: 2pt;">&#8203;</td><td style="width: 22.22%; text-align: left; vertical-align: bottom; padding-top: 2pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 7pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">Emerging growth company</div></td><td class="gutter" style="width: 1.11%; border-bottom: none; font-size: 2pt; padding-top: 2pt;">&#8203;</td><td class="gutter" style="width: 1.11%; border-bottom: none; font-size: 2pt; padding-top: 2pt;">&#8203;</td><td style="width: 26.67%; text-align: left; vertical-align: bottom; padding-top: 2pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 1pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">&#8201;<font style="font-size: 7pt;">&#x2610;</font></div></td></tr></table><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 7pt; margin-top: 2pt; margin-left: 0pt; text-align: left;">If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of Securities Act. <font style="font-size: 1pt;">&#8201;</font>&#x2610; </div><div><div class="rule-partial" style="height: 0pt; width: 96pt; border-bottom: 1pt solid #000000; margin-bottom: 2pt; margin-left: auto; margin-right: auto; margin-top: 4pt;"> </div></div><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 9pt; font-weight: bold; margin-top: 11.25pt; text-align: center;">CALCULATION OF REGISTRATION FEE</div><div><div class="rule-full" style="height: 0pt; width: 100%; border-bottom: 1pt solid #000000; margin-bottom: 2pt; margin-left: auto; margin-right: auto; margin-top: 3pt;"> </div></div><table cellspacing="0" cellpadding="0" class="regtab" align="center" style="margin-top: 1.5pt; border-collapse: collapse; width: 540pt; margin-left: 0pt; border-top: 0.5pt solid #000000; border-bottom: 0.5pt solid #000000;"><tr class="header"><td style="width: 31.11%; text-align: center; vertical-align: bottom; border-bottom: 1pt solid #000000; padding-top: 2px; padding-bottom: 2.75pt;"><div class="calc" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 7pt; font-weight: bold; margin-top: 0pt; text-align: center;">Title of Each Class of Securities <br>to be Registered</div></td><td class="gutter" style="width: 0.56%; font-size: 2pt; border-right: 1pt solid #000000; border-bottom: 1pt solid #000000; padding-top: 2px; padding-bottom: 2.75pt;">&#8203;</td><td class="gutter" style="width: 0.56%; font-size: 2pt; border-bottom: 1pt solid #000000; padding-top: 2px; padding-bottom: 2.75pt;">&#8203;</td><td style="width: 16.11%; text-align: center; vertical-align: bottom; border-bottom: 1pt solid #000000; padding-top: 2px; padding-bottom: 2.75pt;"><div class="calc" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 7pt; font-weight: bold; margin-top: 0pt; text-align: center;">Amount to be <br>Registered<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(1)</sup></div></td><td class="gutter" style="width: 0.56%; font-size: 2pt; border-right: 1pt solid #000000; border-bottom: 1pt solid #000000; padding-top: 2px; padding-bottom: 2.75pt;">&#8203;</td><td class="gutter" style="width: 0.56%; font-size: 2pt; border-bottom: 1pt solid #000000; padding-top: 2px; padding-bottom: 2.75pt;">&#8203;</td><td style="width: 16.11%; text-align: center; vertical-align: bottom; border-bottom: 1pt solid #000000; padding-top: 2px; padding-bottom: 2.75pt;"><div class="calc" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 7pt; font-weight: bold; margin-top: 0pt; text-align: center;">Proposed Maximum <br>Offering Price Per Unit<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(2)</sup></div></td><td class="gutter" style="width: 0.56%; font-size: 2pt; border-right: 1pt solid #000000; border-bottom: 1pt solid #000000; padding-top: 2px; padding-bottom: 2.75pt;">&#8203;</td><td class="gutter" style="width: 0.56%; font-size: 2pt; border-bottom: 1pt solid #000000; padding-top: 2px; padding-bottom: 2.75pt;">&#8203;</td><td style="width: 16.11%; text-align: center; vertical-align: bottom; border-bottom: 1pt solid #000000; padding-top: 2px; padding-bottom: 2.75pt;"><div class="calc" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 7pt; font-weight: bold; margin-top: 0pt; text-align: center;">Proposed Maximum <br>Aggregate Offering Price</div></td><td class="gutter" style="width: 0.56%; font-size: 2pt; border-right: 1pt solid #000000; border-bottom: 1pt solid #000000; padding-top: 2px; padding-bottom: 2.75pt;">&#8203;</td><td class="gutter" style="width: 0.56%; font-size: 2pt; border-bottom: 1pt solid #000000; padding-top: 2px; padding-bottom: 2.75pt;">&#8203;</td><td style="width: 16.11%; text-align: center; vertical-align: bottom; border-bottom: 1pt solid #000000; padding-top: 2px; padding-bottom: 2.75pt;"><div class="calc" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 7pt; font-weight: bold; margin-top: 0pt; text-align: center;">Amount of <br>Registration Fee<sup style="vertical-align: text-top; 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font-size: 7pt;">&#160;</div></td><td class="gutter" style="width: 0.56%; border-bottom: none; font-size: 2pt; border-right: 1pt solid #000000; padding-top: 2.75pt; padding-bottom: 1.5pt;">&#8203;</td><td class="gutter" style="width: 0.56%; border-bottom: none; font-size: 2pt; padding-top: 2.75pt; padding-bottom: 1.5pt;">&#8203;</td><td style="width: 16.11%; text-align: center; vertical-align: bottom; white-space: nowrap; padding-top: 2.75pt; padding-bottom: 1.5pt;"><div class="calc" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 7pt;">&#160;</div></td><td class="gutter" style="width: 0.56%; border-bottom: none; font-size: 2pt; border-right: 1pt solid #000000; padding-top: 2.75pt; padding-bottom: 1.5pt;">&#8203;</td><td class="gutter" style="width: 0.56%; border-bottom: none; font-size: 2pt; padding-top: 2.75pt; padding-bottom: 1.5pt;">&#8203;</td><td style="width: 16.11%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 2.75pt; 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font-size: 7pt;">&#160;</div></td><td class="gutter" style="width: 0.56%; border-bottom: none; font-size: 2pt; border-right: 1pt solid #000000; padding-top: 1.5pt; padding-bottom: 1.5pt;">&#8203;</td><td class="gutter" style="width: 0.56%; border-bottom: none; font-size: 2pt; padding-top: 1.5pt; padding-bottom: 1.5pt;">&#8203;</td><td style="width: 16.11%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 1.5pt; padding-bottom: 1.5pt;"><div class="calc" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 7pt;">&#160;</div></td></tr><tr><td style="width: 31.11%; text-align: left; vertical-align: bottom; padding-top: 1.5pt; padding-bottom: 1.5pt;"><div class="calc" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 7pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">Units<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">(4)</sup><font style="padding-left: 4.68pt;"></font></div></td><td class="gutter" style="width: 0.56%; 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font-size: 7pt;">&#160;</div></td><td class="gutter" style="width: 0.56%; border-bottom: none; font-size: 2pt; border-right: 1pt solid #000000; padding-top: 1.5pt; padding-bottom: 1.5pt;">&#8203;</td><td class="gutter" style="width: 0.56%; border-bottom: none; font-size: 2pt; padding-top: 1.5pt; padding-bottom: 1.5pt;">&#8203;</td><td style="width: 16.11%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 1.5pt; padding-bottom: 1.5pt;"><div class="calc" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 7pt;">&#160;</div></td><td class="gutter" style="width: 0.56%; border-bottom: none; font-size: 2pt; border-right: 1pt solid #000000; padding-top: 1.5pt; padding-bottom: 1.5pt;">&#8203;</td><td class="gutter" style="width: 0.56%; border-bottom: none; font-size: 2pt; padding-top: 1.5pt; padding-bottom: 1.5pt;">&#8203;</td><td style="width: 16.11%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 1.5pt; padding-bottom: 1.5pt;"><div class="calc" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 7pt;">&#160;</div></td></tr><tr><td style="width: 31.11%; text-align: left; vertical-align: bottom; padding-top: 1.5pt;"><div class="calc" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 7pt; font-weight: bold; margin-top: 0pt; margin-left: 0pt; text-align: left;">Total<font style="font-weight: normal; padding-left: 0.95pt;"></font></div></td><td class="gutter" style="width: 0.56%; border-bottom: none; font-size: 2pt; border-right: 1pt solid #000000; padding-top: 1.5pt;">&#8203;</td><td class="gutter" style="width: 0.56%; border-bottom: none; font-size: 2pt; padding-top: 1.5pt;">&#8203;</td><td style="width: 16.11%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 1.5pt;"><div class="calc" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 7pt; margin-top: 0pt; margin-left: 24.25pt; text-align: left;">$500,000,000</div></td><td class="gutter" style="width: 0.56%; border-bottom: none; font-size: 2pt; border-right: 1pt solid #000000; padding-top: 1.5pt;">&#8203;</td><td class="gutter" style="width: 0.56%; border-bottom: none; font-size: 2pt; padding-top: 1.5pt;">&#8203;</td><td style="width: 16.11%; text-align: center; vertical-align: bottom; white-space: nowrap; padding-top: 1.5pt;"><div class="calc" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 7pt; margin-top: 0pt; margin-left: 37.47pt; text-align: left;">N/A</div></td><td class="gutter" style="width: 0.56%; border-bottom: none; font-size: 2pt; border-right: 1pt solid #000000; padding-top: 1.5pt;">&#8203;</td><td class="gutter" style="width: 0.56%; border-bottom: none; font-size: 2pt; padding-top: 1.5pt;">&#8203;</td><td style="width: 16.11%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 1.5pt;"><div class="calc" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 7pt; margin-top: 0pt; margin-left: 24.25pt; text-align: left;">$500,000,000</div></td><td class="gutter" style="width: 0.56%; border-bottom: none; font-size: 2pt; border-right: 1pt solid #000000; padding-top: 1.5pt;">&#8203;</td><td class="gutter" style="width: 0.56%; border-bottom: none; font-size: 2pt; padding-top: 1.5pt;">&#8203;</td><td style="width: 16.11%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 1.5pt;"><div class="calc" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 7pt; margin-top: 0pt; margin-left: 32.13pt; text-align: left;">$64,900</div></td></tr></table><div><div class="rule-full" style="height: 0pt; width: 100%; border-bottom: 1pt solid #000000; margin-bottom: 1pt; margin-left: auto; margin-right: auto; margin-top: 3pt;"> </div></div><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 3pt; margin-left: 0pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 7pt;">(1)<br></div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 7pt; text-align: left;">There are being registered under this registration statement such indeterminate number of securities of each identified class of the registrant, all at indeterminate prices, as shall have an aggregate initial offering price not to exceed $500,000,000 or the equivalent amount denominated in one or more foreign currencies. Any securities registered under this registration statement may be sold separately or as units with other securities registered hereunder. Separate consideration may or may not be received for securities that are issuable on exercise, conversion or exchange of other securities. </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 3pt; margin-left: 0pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 7pt;">(2)<br></div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 7pt; text-align: left;">The proposed maximum offering price per unit is not specified as to each class of securities to be registered, pursuant to General Instruction II.D of Form S-3 under the Securities Act. The proposed maximum offering price per unit will be determined from time to time by the registrant in connection with, and at the time of, the issuance of the securities registered hereunder.</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 3pt; margin-left: 0pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 7pt;">(3)<br></div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 7pt; text-align: left;">Calculated pursuant to Rule 457(o) under the Securities Act.</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 3pt; margin-left: 0pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 7pt;">(4)<br></div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 7pt; text-align: left;">Pursuant to Rule 457(i)&#160;under the Securities Act, the securities registered hereunder also include such indeterminate number of shares of common stock, preferred stock, depositary shares, purchase contracts, warrants, debt securities and units as may be issued upon exercise, settlement, exchange or conversion of any securities registered hereunder that provide for those issuances. In addition, pursuant to Rule 416 under the Securities Act, the securities registered hereunder include such indeterminate number of securities as may be issuable with respect to the securities being registered hereunder as a result of stock splits, stock dividends or similar transactions.</div></td></tr></table><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 7pt; font-weight: bold; margin-top: 2pt; margin-left: 0pt; text-align: left;">The registrant hereby amends this registration statement on such date or dates as may be necessary to delay its effective date until the registrant shall file a further amendment which specifically states that this registration statement shall thereafter become effective in accordance with Section 8(a) of the Securities Act of 1933 or until this registration statement shall become effective on such date as the Commission, acting pursuant to said Section 8(a) may determine.</div></div><div class="block-frill" style="width: 540pt; margin-top: 12pt; margin-left: 0pt;"><div><div class="rule-full" style="height: 0pt; width: 100%; border-bottom: 1pt solid #000000; margin-top: 1pt; margin-bottom: 1pt; margin-left: auto; margin-right: auto;"> </div><div class="rule-full" style="height: 0pt; width: 100%; border-bottom: 2pt solid #000000; margin-bottom: 1pt; margin-left: auto; margin-right: auto; margin-top: 4pt;"> </div></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 456pt;"><a name="nt10011234x1_s3_101-cov_pg1"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 456pt; margin-left: 0pt;"><div class="h1" style="color: #FC0014; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 12pt; text-align: center;"><div style="font-family: Arial, Helvetica, sans-serif; text-align: left; margin-bottom: 12pt;">The information in this prospectus is not complete and may be changed. We may not sell these securities until the registration statement filed with the Securities and Exchange Commission becomes effective. This prospectus is not an offer to sell these securities and it is not soliciting an offer to buy these securities in any state where the offer or sale is not permitted.</div>SUBJECT TO COMPLETION, DATED APRIL 24, 2020</div><div class="h2" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 22.75pt; margin-left: 0pt; text-align: left;">PROSPECTUS</div><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 17.5pt; text-align: center;"><img style="height: 114px; width: 282px;" src="logo_biocryst2a.jpg"><br>&#8201;</div><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 14pt; font-weight: bold; margin-top: 23.75pt; text-align: center;">$500,000,000<br>Common Stock<br>Preferred Stock<br>Depositary Shares<br>Purchase Contracts<br>Warrants<br>Debt Securities<br>Units</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">By this prospectus, we may from time to time offer securities to the public. We will provide specific terms of these securities in supplements to this prospectus. You should read this prospectus, the applicable prospectus supplement, and the information incorporated by reference in this prospectus and the applicable prospectus supplement carefully before you invest.</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Our common stock, par value $0.01 per share, trades on The Nasdaq Global Select Market under the symbol &#8220;BCRX.&#8221;</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">We have not authorized anyone to provide you with information different from that contained or incorporated by reference in this prospectus or any prospectus supplement. We take no responsibility for, and can provide no assurances as to the reliability of, any information other than the information contained in or incorporated by reference in this prospectus or any prospectus supplement. We are not making or soliciting an offer of any securities other than the securities described in this prospectus and any prospectus supplement. We are not making or soliciting an offer of these securities in any state or jurisdiction where the offer is not permitted or in any circumstances in which such offer or solicitation is unlawful. You should not assume that the information contained or incorporated by reference in this prospectus or any prospectus supplement is accurate as of any date other than the date on the front of those documents.</div><div><div class="rule-partial" style="height: 0pt; width: 96pt; border-bottom: 1pt solid #000000; margin-bottom: 2pt; margin-left: auto; margin-right: auto; margin-top: 18pt;"> </div></div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Investing in these securities involves a high degree of risk. See &#8220;Risk Factors&#8221; on page <a href="#tRF">2</a> of this prospectus, in the applicable prospectus supplement we will deliver with this prospectus and in the documents incorporated herein and therein by reference.</div><div><div class="rule-partial" style="height: 0pt; width: 96pt; border-bottom: 1pt solid #000000; margin-bottom: 2pt; margin-left: auto; margin-right: auto; margin-top: 18pt;"> </div></div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">The securities may be sold by us to or through underwriters or dealers, directly to purchasers or through agents designated from time to time, or through a combination of these methods. For additional information on the methods of sale, you should refer to the section entitled &#8220;Plan of Distribution&#8221; in this prospectus. If any underwriters are involved in the sale of any securities with respect to which this prospectus is being delivered, the names of such underwriters and any applicable discounts or commissions and over-allotment options will be set forth in a prospectus supplement. The price to the public of such securities and the net proceeds we expect to receive from such sale will also be set forth in a prospectus supplement. This prospectus may not be used to sell any securities unless accompanied by a prospectus supplement.</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities, or passed upon the adequacy or accuracy of this prospectus. Any representation to the contrary is a criminal offense.</div><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 23.25pt; text-align: center;">The date of this prospectus is &#8195;&#8195;&#8195;&#8195;, 2020. </div></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="nt10011234x1_s3_102-toc_pg1"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 12pt; text-align: center;">TABLE OF CONTENTS</div><a name="TOC"><!--Anchor--></a><table cellspacing="0" cellpadding="0" class="fintab" align="center" style="margin-top: 10.25pt; border-collapse: collapse; width: 468pt; margin-left: 0pt;"><tr class="header"><td style="width: 92.31%; text-align: left; vertical-align: bottom; padding-bottom: 4.25pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold;">&#160;</div></td><td class="gutter" style="width: 2.09%; border-bottom: none; font-size: 2pt; padding-bottom: 4.25pt;">&#8203;</td><td class="gutter" style="width: 2.09%; font-size: 2pt; padding-bottom: 4.25pt; border-bottom: 1px solid #ffffff;">&#8203;</td><td style="width: 3.51%; text-align: center; vertical-align: bottom; border-bottom: 1pt solid #000000; padding-bottom: 4.25pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">Page</div></td></tr><tr><td style="width: 92.31%; text-align: left; vertical-align: bottom; padding-top: 4.25pt; padding-bottom: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><a href="#tAT">ABOUT THIS PROSPECTUS<font style="padding-left: 4.33pt;"></font></a></div></td><td class="gutter" style="width: 2.09%; border-bottom: none; font-size: 2pt; padding-top: 4.25pt; padding-bottom: 3pt; background-color: #CCEEFF;">&#8203;</td><td class="gutter" style="width: 2.09%; border-bottom: none; font-size: 2pt; padding-top: 4.25pt; padding-bottom: 3pt; background-color: #CCEEFF;">&#8203;</td><td style="width: 3.51%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 4.25pt; padding-bottom: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 3.22pt; text-align: left;"><a href="#tAT"><font style="padding-left: 7.22pt;">i</font></a></div></td></tr><tr><td style="width: 92.31%; text-align: left; vertical-align: bottom; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><a href="#tPS">PROSPECTUS SUMMARY<font style="padding-left: 2.84pt;"></font></a></div></td><td class="gutter" style="width: 2.09%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td class="gutter" style="width: 2.09%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td style="width: 3.51%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 3.22pt; text-align: left;"><a href="#tPS"><font style="padding-left: 5pt;">1</font></a></div></td></tr><tr><td style="width: 92.31%; text-align: left; vertical-align: bottom; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><a href="#tRF">RISK FACTORS<font style="padding-left: 4.32pt;"></font></a></div></td><td class="gutter" style="width: 2.09%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">&#8203;</td><td class="gutter" style="width: 2.09%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">&#8203;</td><td style="width: 3.51%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 3.22pt; text-align: left;"><a href="#tRF"><font style="padding-left: 5pt;">2</font></a></div></td></tr><tr><td style="width: 92.31%; text-align: left; vertical-align: bottom; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><a href="#tIRF">INFORMATION REGARDING FORWARD-LOOKING STATEMENTS<font style="padding-left: 1.49pt;"></font></a></div></td><td class="gutter" style="width: 2.09%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td class="gutter" style="width: 2.09%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td style="width: 3.51%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 3.22pt; text-align: left;"><a href="#tIRF"><font style="padding-left: 5pt;">3</font></a></div></td></tr><tr><td style="width: 92.31%; text-align: left; vertical-align: bottom; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><a href="#tUOP">USE OF PROCEEDS<font style="padding-left: 0.07pt;"></font></a></div></td><td class="gutter" style="width: 2.09%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">&#8203;</td><td class="gutter" style="width: 2.09%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">&#8203;</td><td style="width: 3.51%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 3.22pt; text-align: left;"><a href="#tUOP"><font style="padding-left: 5pt;">5</font></a></div></td></tr><tr><td style="width: 92.31%; text-align: left; vertical-align: bottom; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><a href="#tDOC">DESCRIPTION OF COMMON STOCK, PREFERRED STOCK AND DEPOSITARY SHARES<font style="padding-left: 4.72pt;"></font></a></div></td><td class="gutter" style="width: 2.09%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td class="gutter" style="width: 2.09%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td style="width: 3.51%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 3.22pt; text-align: left;"><a href="#tDOC"><font style="padding-left: 5pt;">6</font></a></div></td></tr><tr><td style="width: 92.31%; text-align: left; vertical-align: bottom; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><a href="#tDOS">DESCRIPTION OF PURCHASE CONTRACTS<font style="padding-left: 0.1pt;"></font></a></div></td><td class="gutter" style="width: 2.09%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">&#8203;</td><td class="gutter" style="width: 2.09%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">&#8203;</td><td style="width: 3.51%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 3.22pt; text-align: left;"><a href="#tDOS">10</a></div></td></tr><tr><td style="width: 92.31%; text-align: left; vertical-align: bottom; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><a href="#tDOW">DESCRIPTION OF WARRANTS<font style="padding-left: 0.27pt;"></font></a></div></td><td class="gutter" style="width: 2.09%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td class="gutter" style="width: 2.09%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td style="width: 3.51%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 3.22pt; text-align: left;"><a href="#tDOW"><font style="padding-left: 0.37pt;">11</font></a></div></td></tr><tr><td style="width: 92.31%; text-align: left; vertical-align: bottom; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><a href="#tDOD">DESCRIPTION OF DEBT SECURITIES<font style="padding-left: 4.16pt;"></font></a></div></td><td class="gutter" style="width: 2.09%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">&#8203;</td><td class="gutter" style="width: 2.09%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">&#8203;</td><td style="width: 3.51%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 3.22pt; text-align: left;"><a href="#tDOD">12</a></div></td></tr><tr><td style="width: 92.31%; text-align: left; vertical-align: bottom; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><a href="#tDOU">DESCRIPTION OF UNITS<font style="padding-left: 0.64pt;"></font></a></div></td><td class="gutter" style="width: 2.09%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td class="gutter" style="width: 2.09%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td style="width: 3.51%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 3.22pt; text-align: left;"><a href="#tDOU">17</a></div></td></tr><tr><td style="width: 92.31%; text-align: left; vertical-align: bottom; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><a href="#tPOD">PLAN OF DISTRIBUTION<font style="padding-left: 3.98pt;"></font></a></div></td><td class="gutter" style="width: 2.09%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">&#8203;</td><td class="gutter" style="width: 2.09%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">&#8203;</td><td style="width: 3.51%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 3.22pt; text-align: left;"><a href="#tPOD">18</a></div></td></tr><tr><td style="width: 92.31%; text-align: left; vertical-align: bottom; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><a href="#tLM">LEGAL MATTERS<font style="padding-left: 3.22pt;"></font></a></div></td><td class="gutter" style="width: 2.09%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td class="gutter" style="width: 2.09%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td style="width: 3.51%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 3.22pt; text-align: left;"><a href="#tLM">21</a></div></td></tr><tr><td style="width: 92.31%; text-align: left; vertical-align: bottom; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><a href="#tE">EXPERTS<font style="padding-left: 1.77pt;"></font></a></div></td><td class="gutter" style="width: 2.09%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">&#8203;</td><td class="gutter" style="width: 2.09%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">&#8203;</td><td style="width: 3.51%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 3.22pt; text-align: left;"><a href="#tE">21</a></div></td></tr><tr><td style="width: 92.31%; text-align: left; vertical-align: bottom; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><a href="#tWY">WHERE YOU CAN FIND MORE INFORMATION<font style="padding-left: 3.84pt;"></font></a></div></td><td class="gutter" style="width: 2.09%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td class="gutter" style="width: 2.09%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td style="width: 3.51%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 3.22pt; text-align: left;"><a href="#tWY">22</a></div></td></tr><tr><td style="width: 92.31%; text-align: left; vertical-align: bottom; padding-top: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><a href="#tIOC">INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE<font style="padding-left: 4.67pt;"></font></a></div></td><td class="gutter" style="width: 2.09%; border-bottom: none; font-size: 2pt; padding-top: 3pt; background-color: #CCEEFF;">&#8203;</td><td class="gutter" style="width: 2.09%; border-bottom: none; font-size: 2pt; padding-top: 3pt; background-color: #CCEEFF;">&#8203;</td><td style="width: 3.51%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 3.22pt; text-align: left;"><a href="#tIOC">22</a></div></td></tr></table><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 18.5pt; text-align: center;"><a name="tAT"><!--Anchor--></a>ABOUT THIS PROSPECTUS</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">This prospectus is part of a registration statement on Form S-3 that we filed with the Securities and Exchange Commission, or the SEC, using a &#8220;shelf&#8221; registration or continuous offering process. Under this registration statement, we may sell any combination of the securities described in this prospectus from time to time, either separately or in units, in one or more offerings. Together, these offerings may total up to $500.0 million.</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">This prospectus provides you with a general description of the securities we may offer. Each time we sell securities, we will provide a prospectus supplement containing specific information about the terms of that offering. That prospectus supplement may add, update or change information contained in this prospectus and will also include the following information:</div><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the type and amount of securities that we propose to sell;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the public offering price of the securities;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the names of any underwriters, agents or dealers through or to which the securities will be sold;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">any compensation of those underwriters, agents or dealers;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">information about any securities exchanges or automated quotation systems on which the securities will be listed or traded;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">any risk factors applicable to the securities that we propose to sell; and</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">any other material information about the offering and sale of the securities.</div></td></tr></table><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">If there is any inconsistency between the information in this prospectus and any prospectus supplement, you should rely on the information in the prospectus supplement. You should read both this prospectus and any prospectus supplement together with the additional information described under the heading &#8220;Where You Can Find More Information.&#8221; The registration statement containing this prospectus, including the exhibits to the registration statement, provides additional information about us and the securities offered under this prospectus. The registration statement, including the exhibits, can be read at the SEC&#8217;s website referenced under the heading &#8220;Where You Can Find More Information.&#8221;</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">All references to &#8220;Company,&#8221; &#8220;BioCryst,&#8221; &#8220;we,&#8221; &#8220;our,&#8221; or &#8220;us&#8221; refer solely to BioCryst Pharmaceuticals, Inc. and not to the persons who manage us or sit on our Board of Directors. All trade names used in this prospectus are either our registered trademarks or trademarks of their respective holders.</div></div></div><div class="block-frill" style="width: 468pt; margin-top: 12pt; margin-left: 0pt;"><div class="unknown" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; text-align: center;">i<br></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 492pt;"><a name="nt10011234x1_s3_103-summary_pg1"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="border-box" style="border-top: 1pt solid #000000; border-left: 1pt solid #000000; border-right: 1pt solid #000000; border-bottom: 1pt solid #000000; margin-bottom: 12pt; padding-top: 12pt; padding-bottom: 12pt; width: 492pt; margin-left: 0pt;"><div class="block-main" style="width: 468pt; margin-left: 12pt;"><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 12pt; text-align: center;"><a name="tPS"><!--Anchor--></a>PROSPECTUS SUMMARY</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">This summary highlights information contained elsewhere or incorporated by reference into this prospectus. Because it is a summary, it does not contain all of the information that you should consider before investing in our securities. You should read this entire prospectus carefully, including the section entitled &#8220;Risk Factors&#8221; and the documents that we incorporate by reference into this prospectus, before making an investment decision.</div><div class="h2" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 23.75pt; margin-left: 0pt; text-align: left;">Business of BioCryst Pharmaceuticals, Inc.</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">We are a biotechnology company that discovers novel, oral, small-molecule medicines. We focus on oral treatments for rare diseases in which significant unmet medical needs exist and an enzyme plays the key role in the biological pathway of the disease. We integrate the disciplines of biology, crystallography, medicinal chemistry and computer modeling to discover and develop small molecule pharmaceuticals through the process known as structure-guided drug design. </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">We are a Delaware corporation originally founded in 1986. Our principal executive offices are located at 4505 Emperor Blvd. Suite 200, Durham, North Carolina 27703, and our telephone number is (919) 859-1302. For more information about us, please visit our website at http://www.biocryst.com. The information on our website is not incorporated by reference into this prospectus.</div></div></div></div><div class="block-frill" style="width: 468pt; margin-top: 12pt; margin-left: 12pt;"><div class="unknown" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; text-align: center;">1<br></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="nt10011234x1_s3_104-risk_pg1"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 12pt; text-align: center;"><a name="tRF"><!--Anchor--></a>RISK FACTORS</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Investing in our securities involves risks. Our business is influenced by many factors that are difficult to predict and beyond our control and that involve uncertainties that may materially affect our business, results of operations, financial condition or cash flows, or the value of these securities. These risks and uncertainties are described in the risk factors section of the documents that are incorporated by reference in this prospectus. Any subsequent prospectus supplement may contain a discussion of additional risks applicable to an investment in us and the particular type of securities we are offering under such prospectus supplement. You should carefully consider all of the information contained in or incorporated by reference in this prospectus and in the applicable prospectus supplement before you invest in our securities.</div></div></div><div class="block-frill" style="width: 468pt; margin-top: 12pt; margin-left: 0pt;"><div class="unknown" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; text-align: center;">2<br></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="nt10011234x1_s3_105-fls_pg1"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 12pt; text-align: center;"><a name="tIRF"><!--Anchor--></a>INFORMATION REGARDING FORWARD-LOOKING STATEMENTS</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">This prospectus and any subsequent prospectus supplement, including the information we incorporate by reference, contain forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended (the &#8220;Securities Act&#8221;) and Section 21E of the Securities Exchange Act of 1934, as amended (the &#8220;Exchange Act&#8221;), which are subject to the &#8220;safe harbor&#8221; created in Section 21E. All statements other than statements of historical facts contained in this prospectus, any subsequent prospectus supplement and the information we incorporate by reference are forward-looking statements. These forward-looking statements can generally be identified by the use of words such as &#8220;may,&#8221; &#8220;will,&#8221; &#8220;intends,&#8221; &#8220;plans,&#8221; &#8220;believes,&#8221; &#8220;anticipates,&#8221; &#8220;expects,&#8221; &#8220;estimates,&#8221; &#8220;predicts,&#8221; &#8220;potential,&#8221; the negative of these words or similar expressions. Statements that describe our future plans, strategies, intentions, expectations, objectives, goals or prospects are also forward-looking statements. These forward-looking statements include, but are not limited to, statements about:</div><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the effect of the novel coronavirus (COVID-19) outbreak on our business and operations or the business and operations of third parties, including our suppliers, vendors, development partners, and regulatory agencies and government bodies with which we work;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the preclinical development, clinical development, commercialization, or post-marketing studies of our product candidates and products, including our acute and prophylactic hereditary angioedema (&#8220;HAE&#8221;) programs, BCX9930, BCX9250, peramivir, galidesivir, and early stage discovery programs;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the potential funding from our contracts with the Biomedical Advanced Research and Development Authority (the &#8220;BARDA/HHS&#8221;) and the National Institute of Allergy and Infectious Diseases (&#8220;NIAID/HHS&#8221;) for the development of galidesivir;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the potential for government stockpiling orders of peramivir and galidesivir, additional regulatory approvals of peramivir, or milestones, royalties or profit from sales of peramivir by us or our partners;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the potential use of peramivir as a treatment for H1N1, H5N1, and H7N9 or other strains of influenza;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the implementation of our business model, strategic plans for our business, products, product candidates and technology;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">our ability to establish and maintain collaborations or out-license rights to our product candidates;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the outcome, cost and timing of any resolution of disputes and legal proceedings, including but not limited to the dispute with our partner Seqirus UK Limited (&#8220;SUL&#8221;);</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">plans, programs, progress and potential success of our collaborations, including SUL for peramivir, Mundipharma International Holdings Limited for mundesine, Torii Pharmaceutical, Ltd. for BCX7353 in Japan and Shionogi &amp; Co. Ltd. and Green Cross Corporation for peramivir in their territories;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">our ability, and the ability of our consolidated subsidiary, MDCP, LLC, to satisfy obligations under our secured loan facility with MidCap Financial, a Delaware statutory trust, pursuant to the terms and conditions of the Second Amended and Restated Credit and Security Agreement dated as of February&#160;5, 2019, as amended;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the ability of our wholly owned subsidiary, JPR Royalty Sub LLC (&#8220;Royalty Sub&#8221;) to service its payment obligations in respect of its PhaRMA Senior Secured 14.0% Notes due 2020 (the &#8220;PhaRMA Notes&#8221;);</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the foreign currency hedge agreement entered into by us in connection with the issuance by Royalty Sub of the PhaRMA Notes (the &#8220;Currency Hedge Agreement&#8221;);</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the scope of protection we are able to establish and maintain for intellectual property rights covering our product candidates and technology;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">our ability to operate our business without infringing the intellectual property rights of others;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">estimates of our expenses, revenues, capital requirements, annual cash utilization, and our needs for additional financing;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">our ability to continue as a going concern;</div></td></tr></table></div></div><div class="block-frill" style="width: 468pt; margin-top: 12pt; margin-left: 0pt;"><div class="unknown" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; text-align: center;">3<br></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="nt10011234x1_s3_105-fls_pg2"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the timing or likelihood of regulatory filings or regulatory agreements, deferrals, and approvals;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the timing or likelihood of entering into additional U.S. government stockpile orders and our ability to execute any such order;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">our ability to raise additional capital to fund our operations or repay our recourse debt obligations;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">our ability to comply with the covenants as set forth in the agreements governing our debt obligations;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">our financial performance;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the timing and success of our anticipated commercialization of BCX7353 in the U.S. and elsewhere; and</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">competitive companies, technologies and our industry.</div></td></tr></table><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">These statements relate to future events or to our future financial performance and involve known and unknown risks, uncertainties and other important factors that may cause our actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by these forward-looking statements. Factors that may cause actual results to differ materially from current expectations include, among other things, those listed under &#8220;Risk Factors&#8221; and elsewhere in this prospectus, any subsequent prospectus supplement and the documents incorporated by reference herein and therein. Any forward-looking statement reflects our current views with respect to future events and is subject to these and other risks, uncertainties and assumptions relating to our operations, results of operations, industry and future growth. Except as required by law, we assume no obligation to update or revise these forward-looking statements for any reason, even if new information becomes available in the future.</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Discussions containing these forward-looking statements are also included in &#8220;Management&#8217;s Discussion and Analysis of Financial Condition and Results of Operations,&#8221; incorporated by reference from our most recent Annual Report on Form 10-K, and in our Current Reports on Form 8-K filed subsequent to the Annual Report, as well as any amendments we make to those filings or any future filings we make with the SEC.</div></div></div><div class="block-frill" style="width: 468pt; margin-top: 12pt; margin-left: 0pt;"><div class="unknown" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; text-align: center;">4<br></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="nt10011234x1_s3_105-fls_pg3"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 12pt; text-align: center;"><a name="tUOP"><!--Anchor--></a>USE OF PROCEEDS</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Except as otherwise described in the applicable prospectus supplement, the net proceeds we expect to receive from the sale of any securities offered hereunder will be added to our general funds and used for general corporate purposes, which may include, but are not limited to:</div><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">funding commercialization, development, manufacturing and regulatory activities for BCX7353;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the advancement of development activities on other rare disease targets, including complement-mediated diseases and fibrodysplasia ossificans progressiva (FOP);</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">post-approval commitments for RAPIVAB&#8482;/ALPIVAB&#8482;;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">funding our research and development efforts; and </div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">capital expenditures and general working capital needs. </div></td></tr></table><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">We may also use a portion of the net proceeds to acquire or invest in businesses, assets, products and technologies that are complementary to our own, although we are not currently contemplating or negotiating any such acquisitions or investments.</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">The amount and timing of these expenditures will depend on a number of factors, including the progress of our research and development efforts and amounts received under our existing and any future government contracts and collaboration arrangements, as well as the amount of cash used in our operations. Accordingly, our management will have broad discretion in the application of these proceeds, and investors will be relying on the judgment of our management with regard to the use of these proceeds. Pending application of the net proceeds as described above, we intend to invest the net proceeds in investment grade interest bearing instruments.</div></div></div><div class="block-frill" style="width: 468pt; margin-top: 12pt; margin-left: 0pt;"><div class="unknown" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; text-align: center;">5<br></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="nt10011234x1_s3_106-description_pg1"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 12pt; text-align: center;"><a name="tDOC"><!--Anchor--></a>DESCRIPTION OF COMMON STOCK, PREFERRED STOCK AND DEPOSITARY SHARES</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">The following summary description of our capital stock summarizes general terms and provisions that apply to the capital stock. Because this is only a summary, it does not contain all of the information that may be important to you. This summary is subject to and qualified in its entirety by reference to our Third Restated Certificate of Incorporation, as amended (the &#8220;Certificate of Incorporation&#8221;) and our Amended and Restated Bylaws (the &#8220;Bylaws&#8221;), each of which are incorporated by reference into this prospectus. See &#8220;Where You Can Find More Information.&#8221;</div><div class="h2" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 23.75pt; margin-left: 0pt; text-align: left;">Common Stock</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Our Certificate of Incorporation authorizes us to issue 200,000,000 shares of common stock, par value $0.01&#160;per share, and 5,000,000 shares of preferred stock, par value $0.01 per share. On April 22, 2020, there were 154,257,247 shares of common stock outstanding and no shares of preferred stock outstanding. The number of authorized shares of common stock may be increased or decreased (but not below the number of shares thereof outstanding) by the affirmative vote of the holders of a majority of our common stock entitled to vote.</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">At the 2020 annual meeting of stockholders (the &#8220;2020 Annual Meeting&#8221;) we are asking stockholders to approve an amendment to our Certificate of Incorporation to increase the number of shares of Common Stock that we are authorized to issue from 200,000,000 to 450,000,000. Our board of directors (the &#8220;Board of Directors&#8221;) has approved the amendment, subject to the approval of our stockholders at the 2020 Annual Meeting. </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Common stockholders are entitled to one vote per share on all matters submitted to a vote of stockholders. There are no cumulative voting rights. Directors are elected by a plurality of the votes cast by the stockholders entitled to vote. Except as provided otherwise in our Certificate of Incorporation or Bylaws, the holders of a majority of the common stock present or represented and voting on a matter shall decide any matter to be voted upon by the stockholders at a meeting.</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Common stockholders have the right to receive dividends as and when declared by the Board of Directors from funds legally available therefor, subject to any preferential dividend rights of any preferred stock then outstanding. We have never paid cash dividends on our stock.</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Upon our dissolution or liquidation, whether voluntary or involuntary, common stockholders are entitled to receive all assets legally available for distribution to stockholders, subject to any preferential rights of any preferred stock then outstanding. Common stockholders have no preemptive rights and have no rights to convert their common stock into any other securities. There are no redemption or sinking fund provisions applicable to the common stock. All outstanding shares of common stock are validly issued, fully paid and nonassessable.</div><div class="h2" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 23.75pt; margin-left: 0pt; text-align: left;">Preferred Stock</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Preferred stock may be issued from time to time in one or more series, each such series to have such terms as determined by our Board of Directors. Our Board of Directors has the authority to determine and fix such voting powers, full or limited, or no voting powers, and such designations, preferences and relative participating, optional or other special rights, and qualifications, limitations or restrictions thereof, including without limitation dividend rights, conversion rights, redemption privileges and liquidation preferences, without further vote or action by our stockholders. We will distribute a prospectus supplement with regard to each particular series of preferred stock that will describe the terms and provisions of that series of preferred stock. The rights of the holders of any preferred stock that may be issued may adversely affect the rights of the holders of common stock. The issuance of preferred stock could make it more difficult for third parties to acquire a majority of our outstanding voting stock.</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Our Certificate of Incorporation currently authorizes us to issue 5,000,000 shares of preferred stock, of which 200,000 shares of preferred stock have been designated as Series B Junior Participating Preferred stock, $.001 par value. </div></div></div><div class="block-frill" style="width: 468pt; margin-top: 12pt; margin-left: 0pt;"><div class="unknown" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; text-align: center;">6<br></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="nt10011234x1_s3_106-description_pg2"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><div class="h2" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 12pt; margin-left: 0pt; text-align: left;">Anti-Takeover Provisions</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Some provisions of our Certificate of Incorporation, Bylaws and Delaware law may have the effect of delaying, discouraging or preventing a change in control of us or changes in our management. Pursuant to our Certificate of Incorporation and Bylaws:</div><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">our Board of Directors is authorized to issue &#8220;blank check&#8221; preferred stock without stockholder approval;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">our Board of Directors is classified, with members serving staggered three-year terms;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">stockholders may not cumulate votes in the election of directors;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">vacancies on the Board of Directors may be filled only by the board of directors;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">stockholders may remove directors only for cause and only by the affirmative vote of the holders of at least 75 percent of the total number of votes entitled to be cast by the holders of all of the shares of our capital stock then entitled to vote generally in the election of directors (a &#8220;supermajority vote&#8221;);</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">stockholders may take action only at a duly called meeting of the stockholders, and stockholders are not permitted to act by written consent;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">special meetings of stockholders may be called only by the Board of Directors; and</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">stockholders must satisfy advance notice procedures to submit proposals or nominate directors for consideration at a stockholders meeting.</div></td></tr></table><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">A supermajority vote is required to amend Article NINTH and Article TENTH of our Certificate of Incorporation, which pertain to the number, classification, and removal of our directors, the creation and filling of vacancies on our Board of Directors, the requirement that actions of stockholders be taken at a duly called meeting and not by written consent, and the requirement that special meetings only be called by the Board of Directors.</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">In addition, we are subject to the provisions of Section 203 of the Delaware General Corporation Law (&#8220;DGCL&#8221;). In general, the statute prohibits a publicly held Delaware corporation from engaging in a &#8220;business combination&#8221; with an &#8220;interested stockholder&#8221; for a period of three years after the date that the person became an interested stockholder unless, with some exceptions, the business combination or the transaction in which the person became an interested stockholder is approved in a prescribed manner. Generally, a &#8220;business combination&#8221; includes a merger, asset or stock sale or other transaction resulting in a financial benefit to the stockholder, and an &#8220;interested stockholder&#8221; is a person who, together with affiliates and associates, owns (or&#160;within three years prior, did own) 15% or more of the corporation&#8217;s outstanding voting stock. This provision may have the effect of delaying, deferring or preventing a change in control without further action by the stockholders.</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Our Bylaws also provide that unless we consent in writing to the selection of an alternative forum, the Court of Chancery of the State of Delaware will be the sole and exclusive forum for: (i)&#160;any derivative action or proceeding brought on our behalf; (ii)&#160;any action asserting a claim of breach of a fiduciary duty owed by any director, officer, stockholder, employee or agent of BioCryst or our stockholders; (iii)&#160;any action asserting a claim against us or any of our directors, officers, stockholders, employees or agents arising out of or relating to any provision of the DGCL, our Certificate of Incorporation or our Bylaws; or (iv)&#160;any action asserting a claim against us or any of our directors, officers, stockholders, employees or agents governed by the internal affairs doctrine. Our Bylaws provide that any person or entity purchasing or otherwise acquiring any interest in shares of our common stock will be deemed to have notice of and to have consented to this choice of forum provision.</div><div class="h2" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 23.75pt; margin-left: 0pt; text-align: left;">Depositary Shares</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">We may, at our option, elect to offer fractional shares of preferred stock, rather than full shares of preferred stock. If we exercise this option, we will issue to the public receipts for depositary shares, and each of these depositary shares will represent a fraction, to be set forth in the applicable prospectus supplement, of a share of a particular series of preferred stock.</div></div></div><div class="block-frill" style="width: 468pt; margin-top: 12pt; margin-left: 0pt;"><div class="unknown" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; text-align: center;">7<br></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="nt10011234x1_s3_106-description_pg3"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">The shares of any series of preferred stock underlying the depositary shares will be deposited under a deposit agreement between us and a bank or trust company selected by us. The depositary will have its principal office in the United States and a combined capital and surplus of at least $50,000,000. Subject to the terms of the deposit agreement, each owner of a depositary share will be entitled, in proportion to the applicable fraction of a share of preferred stock underlying the depositary share, to all the rights and preferences of the preferred stock underlying that depositary share. Those rights may include dividend, voting, redemption, conversion and liquidation rights.</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">The depositary shares will be evidenced by depositary receipts issued under a deposit agreement. Depositary receipts will be distributed to those persons purchasing the fractional shares of preferred stock underlying the depositary shares, in accordance with the terms of the offering. The following description of the material terms of the deposit agreement, the depositary shares and the depositary receipts is only a summary and you should refer to the forms of the deposit agreement and depositary receipts that will be filed with the SEC in connection with the offering of the specific depositary shares.</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Pending the preparation of definitive engraved depositary receipts, the depositary, upon our written order, may issue temporary depositary receipts substantially identical to the definitive depositary receipts but not in definitive form. These temporary depositary receipts would entitle their holders to all the rights of definitive depositary receipts. Temporary depositary receipts would be exchangeable for definitive depositary receipts at our expense.</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-style: italic; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Dividends and Other Distributions<font style="font-style: normal;">. The depositary will distribute all cash dividends or other cash </font><font style="font-style: normal;">distributions received with respect to the underlying stock to the record holders of depositary shares in proportion </font><font style="font-style: normal;">to the number of depositary shares owned by those holders.</font></div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">If there were a distribution other than in cash, the depositary would distribute property received by it to the record holders of depositary shares that are entitled to receive the distribution, unless the depositary determines that it is not feasible to make the distribution. If this occurs, the depositary, with our approval, would sell the property and distribute the net proceeds from the sale to the applicable holders.</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-style: italic; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Withdrawal of Underlying Preferred Stock<font style="font-style: normal;">. Unless we provide otherwise in a prospectus supplement, holders </font><font style="font-style: normal;">may surrender depositary receipts at the principal office of the depositary and, upon payment of any unpaid </font><font style="font-style: normal;">amount due to the depositary, would be entitled to receive the number of whole shares of underlying preferred </font><font style="font-style: normal;">stock and all money and other property represented by the related depositary shares. We will not issue any partial </font><font style="font-style: normal;">shares of preferred stock. If the holder delivers depositary receipts evidencing a number of depositary shares that </font><font style="font-style: normal;">represent more than a whole number of shares of preferred stock, the depositary will issue a new depositary </font><font style="font-style: normal;">receipt evidencing the excess number of depositary shares to that holder.</font></div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-style: italic; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Redemption of Depositary Shares<font style="font-style: normal;">. If a series of preferred stock represented by depositary shares were </font><font style="font-style: normal;">subject to redemption, the depositary shares would be redeemed from the proceeds received by the depositary </font><font style="font-style: normal;">resulting from the redemption, in whole or in part, of that series of underlying stock held by the depositary. The </font><font style="font-style: normal;">redemption price per depositary share would be equal to the applicable fraction of the redemption price per share </font><font style="font-style: normal;">payable with respect to that series of underlying stock. Whenever we redeem shares of underlying stock that are </font><font style="font-style: normal;">held by the depositary, the depositary will redeem, as of the same redemption date, the number of depositary </font><font style="font-style: normal;">shares representing the shares of underlying stock so redeemed. If fewer than all the depositary shares are to be </font><font style="font-style: normal;">redeemed, the depositary shares to be redeemed will be selected by lot or proportionately, as may be determined </font><font style="font-style: normal;">by the depositary.</font></div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-style: italic; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Voting<font style="font-style: normal;">. Upon receipt of notice of any meeting at which the holders of the underlying stock are entitled to </font><font style="font-style: normal;">vote, the depositary will mail the information contained in the notice to the record holders of the depositary </font><font style="font-style: normal;">shares underlying the preferred stock. Each record holder of the depositary shares on the record date, which will </font><font style="font-style: normal;">be the same date as the record date for the underlying stock, will be entitled to instruct the depositary as to the </font><font style="font-style: normal;">exercise of the voting rights pertaining to the amount of the underlying stock represented by that holder's </font><font style="font-style: normal;">depositary shares. The depositary will then try, as far as practicable, to vote the number of shares of preferred </font><font style="font-style: normal;">stock underlying those depositary shares in accordance with those instructions, and we will agree to take all </font><font style="font-style: normal;">actions which may be deemed necessary by the depositary to enable the depositary to do so. The depositary will </font><font style="font-style: normal;">not vote the underlying shares to the extent it does not receive specific instructions from the holders of </font><font style="font-style: normal;">depositary shares underlying the preferred stock.</font></div></div></div><div class="block-frill" style="width: 468pt; margin-top: 12pt; margin-left: 0pt;"><div class="unknown" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; text-align: center;">8<br></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="nt10011234x1_s3_106-description_pg4"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-style: italic; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Conversion of Preferred Stock<font style="font-style: normal;">. If the prospectus supplement relating to the depositary shares provides that </font><font style="font-style: normal;">the deposited preferred stock is convertible into or exchangeable for common stock or preferred stock of another </font><font style="font-style: normal;">series of BioCryst or securities of any third party, the following will apply. The depositary shares, as such, will </font><font style="font-style: normal;">not be convertible into or exchangeable for any securities of BioCryst or any third party. Rather, any holder of </font><font style="font-style: normal;">the depositary shares may surrender the related depositary receipts to the depositary with written instructions to </font><font style="font-style: normal;">instruct us to cause conversion or exchange of the preferred stock represented by the depositary shares into or for </font><font style="font-style: normal;">whole shares of common stock or shares of another series of preferred stock of BioCryst or securities of the </font><font style="font-style: normal;">relevant third party, as applicable. Upon receipt of those instructions and any amounts payable by the holder in </font><font style="font-style: normal;">connection with the conversion or exchange, we will cause the conversion or exchange using the same </font><font style="font-style: normal;">procedures as those provided for conversion or exchange of the deposited preferred stock. If only some of the </font><font style="font-style: normal;">depositary shares are to be converted or exchanged, a new depositary receipt or receipts will be issued for any </font><font style="font-style: normal;">depositary shares not to be converted or exchanged.</font></div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-style: italic; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Amendment and Termination of the Depositary Agreement<font style="font-style: normal;">. The form of depositary receipt evidencing the </font><font style="font-style: normal;">depositary shares and any provision of the deposit agreement may be amended at any time by agreement </font><font style="font-style: normal;">between us and the depositary. However, any amendment which materially and adversely alters the rights of the </font><font style="font-style: normal;">holders of depositary shares will not be effective unless the amendment has been approved by the holders of at </font><font style="font-style: normal;">least a majority of the depositary shares then outstanding. The deposit agreement may be terminated by us or by </font><font style="font-style: normal;">the depositary only if (a) all outstanding depositary shares have been redeemed or converted or exchanged for </font><font style="font-style: normal;">any other securities into which the underlying preferred stock is convertible or exchangeable or (b) there has </font><font style="font-style: normal;">been a final distribution of the underlying stock in connection with our liquidation, dissolution or winding up and </font><font style="font-style: normal;">the underlying stock has been distributed to the holders of depositary receipts.</font></div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-style: italic; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Charges of Depositary<font style="font-style: normal;">. We will pay all transfer and other taxes and governmental charges arising solely </font><font style="font-style: normal;">from the existence of the depositary arrangements. We will also pay charges of the depositary in connection with </font><font style="font-style: normal;">the initial deposit of the underlying stock and any redemption of the underlying stock. Holders of depositary </font><font style="font-style: normal;">receipts will pay other transfer and other taxes and governmental charges and those other charges, including a fee </font><font style="font-style: normal;">for any permitted withdrawal of shares of underlying stock upon surrender of depositary receipts, as are </font><font style="font-style: normal;">expressly provided in the deposit agreement to be for their accounts.</font></div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-style: italic; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Reports<font style="font-style: normal;">. The depositary will forward to holders of depositary receipts all reports and communications from </font><font style="font-style: normal;">us that we deliver to the depositary and that we are required to furnish to the holders of the underlying stock.</font></div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-style: italic; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Limitation on Liability<font style="font-style: normal;">. Neither we nor the depositary will be liable if either of us is prevented or delayed </font><font style="font-style: normal;">by law or any circumstance beyond our control in performing our respective obligations under the deposit </font><font style="font-style: normal;">agreement. Our obligations and those of the depositary will be limited to performance in good faith of our </font><font style="font-style: normal;">respective duties under the deposit agreement. Neither we nor the depositary will be obligated to prosecute or </font><font style="font-style: normal;">defend any legal proceeding in respect of any depositary shares or underlying stock unless satisfactory indemnity </font><font style="font-style: normal;">is furnished. We and the depositary may rely upon written advice of counsel or accountants, or upon information </font><font style="font-style: normal;">provided by persons presenting underlying stock for deposit, holders of depositary receipts or other persons </font><font style="font-style: normal;">believed to be competent and on documents believed to be genuine.</font></div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-style: italic; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Resignation and Removal of Depositary<font style="font-style: normal;">. The depositary may resign at any time by delivering notice to us of </font><font style="font-style: normal;">its election to resign. We may remove the depositary at any time. Any resignation or removal will take effect </font><font style="font-style: normal;">upon the appointment of a successor depositary and its acceptance of the appointment. The successor depositary </font><font style="font-style: normal;">must be appointed within 60 days after delivery of the notice of resignation or removal and must be a bank or </font><font style="font-style: normal;">trust company having its principal office in the United States and having a combined capital and surplus of at </font><font style="font-style: normal;">least $50,000,000.</font></div></div></div><div class="block-frill" style="width: 468pt; margin-top: 12pt; margin-left: 0pt;"><div class="unknown" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; text-align: center;">9<br></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="nt10011234x1_s3_106-description_pg5"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 12pt; text-align: center;"><a name="tDOS"><!--Anchor--></a>DESCRIPTION OF PURCHASE CONTRACTS</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">The following is a general description of the terms of the purchase contracts we may issue from time to time. Particular terms of any purchase contracts we offer will be described in the prospectus supplement relating to such purchase contracts. Material U.S. federal income tax considerations applicable to the purchase contracts will also be discussed in the applicable prospectus supplement. You should refer to the form of purchase contract and purchase certificate that we will file with the SEC in connection with the offering of the specific purchase contracts for more complete information.</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">We may issue purchase contracts, including contracts obligating holders to purchase from us, and obligating us to sell to holders, shares of common stock, preferred stock, depositary shares or debt securities at a future date. The consideration for such common stock, preferred stock, depositary shares or debt securities may be fixed at the time that the purchase contracts are issued or may be determined by reference to a specific formula set forth in the purchase contracts. Any purchase contract may include anti-dilution provisions to adjust the number of shares issuable pursuant to such purchase contract upon the occurrence of certain events.</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">The applicable prospectus supplement will describe the terms of any purchase contracts in respect of which this prospectus is being delivered, including, to the extent applicable, the following:</div><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">whether the purchase contracts obligate the holder or us to purchase or sell, or both purchase and sell, the securities subject to purchase under the purchase contract, and the nature and amount of each of those securities, or the method of determining those amounts;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">whether the purchase contracts are to be prepaid or not;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">whether the purchase contracts will be issued as part of a unit and, if so, the other securities comprising the unit;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">whether the purchase contracts are to be settled by delivery, or by reference or linkage to the value, performance, or level of the securities subject to purchase under the purchase contract;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">any acceleration, cancellation, termination, or other provisions relating to the settlement of the purchase contracts; and</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">whether the purchase contracts will be issued in full registered or global form.</div></td></tr></table></div></div><div class="block-frill" style="width: 468pt; margin-top: 12pt; margin-left: 0pt;"><div class="unknown" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; text-align: center;">10<br></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="nt10011234x1_s3_106-description_pg6"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 12pt; text-align: center;"><a name="tDOW"><!--Anchor--></a>DESCRIPTION OF WARRANTS</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">We may issue warrants to purchase our preferred stock, depositary shares, common stock or debt securities or any combination thereof. Warrants may be issued independently or together with any other securities in the form of units, and may be attached to, or separate from, such securities. The terms of any warrants to be issued and a description of the material provisions of the applicable warrant agreement will be set forth in the applicable prospectus supplement. Each series of warrants will be issued under a separate warrant agreement to be entered into between us and a bank or trust company, as warrant agent. You should refer to the form of warrant agreement and warrant that we file with the SEC in connection with the offering of the specific warrants for more complete information.</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 11.75pt; margin-left: 20pt; text-align: left;">The prospectus supplement will describe the terms of any warrants being offered, including:</div><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the title and the aggregate number of warrants;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the price or prices at which the warrants will be issued;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the currency or currencies in which the price of the warrants will be payable;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the securities or other rights, including rights to receive payment in cash or securities based on the value, rate or price of one or more specified commodities, currencies, securities or indices, or any combination of the foregoing, purchasable upon exercise of the warrants;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the price at which, and the currency or currencies in which, the securities or other rights purchasable upon exercise of such warrants may be purchased;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the periods during which, and places at which, the warrants are exercisable;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the date or dates on which the warrants shall commence and the date or dates on which the warrants will expire;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the terms of any mandatory or optional call provisions;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the price or prices, if any, at which the warrants may be redeemed at the option of the holder or will be redeemed upon expiration;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">whether the warrants will be sold separately or with other securities as part of a unit;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">if applicable, the designation and terms of the securities with which the warrants are issued and the number of warrants issued with each such security;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">if applicable, the date on and after which the warrants and the related securities will be separately transferable;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">any provisions for the adjustment of the number or amount of securities receivable upon exercise of warrants;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the identity of the warrant agent;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the exchanges, if any, on which the warrants may be listed;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the maximum or minimum number of warrants which may be exercised at any time;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">if applicable, a discussion of any material United States federal income tax considerations;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">whether the warrants shall be issued in book-entry form; and</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">any other terms of the warrants, including terms, procedures and limitations relating to the exchange and exercise of the warrants.</div></td></tr></table></div></div><div class="block-frill" style="width: 468pt; margin-top: 12pt; margin-left: 0pt;"><div class="unknown" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; text-align: center;">11<br></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="nt10011234x1_s3_106-description_pg7"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 12pt; text-align: center;"><a name="tDOD"><!--Anchor--></a>DESCRIPTION OF DEBT SECURITIES</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">We may issue debt securities from time to time, in one or more series, as either senior or subordinated debt or as senior or subordinated convertible debt. While the terms we have summarized below will apply generally to any debt securities that we may offer under this prospectus, we will describe the particular terms of any debt securities that we may offer in more detail in the applicable prospectus supplement. The terms of any debt securities offered under a prospectus supplement may differ from the terms described below. Unless the context requires otherwise, whenever we refer to the indenture, we also are referring to any supplemental indentures that specify the terms of a particular series of debt securities.</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">We will issue the debt securities under an indenture to be entered into between us and U.S. Bank National Association, or another trustee chosen by us that is qualified to act as such under the Trust Indenture Act of 1939, as amended (the &#8220;Trust Indenture Act&#8221;), and appointed under an indenture. The indenture will be qualified under the Trust Indenture Act. We have filed the form of indenture as an exhibit to the registration statement of which this prospectus is a part, and supplemental indentures and forms of debt securities containing the terms of the debt securities being offered will be filed as exhibits to the registration statement of which this prospectus is a part or will be incorporated by reference from reports that we file with the SEC.</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">The following summary of material provisions of the debt securities and the indenture is subject to, and qualified in its entirety by reference to, all of the provisions of the indenture. We urge you to read the applicable prospectus supplement and any related free writing prospectus related to the debt securities that we may offer under this prospectus, as well as the complete indenture that contains the terms of the debt securities.</div><div class="h2" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 23.75pt; margin-left: 0pt; text-align: left;">General</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">The indenture does not limit the amount of debt securities that we may issue. It provides that we may issue debt securities up to the principal amount that we may authorize and may be in any currency or currency unit that we may designate. Except for the limitations on consolidation, merger and sale of all or substantially all of our assets contained in the indenture, the terms of the indenture do not contain any covenants or other provisions designed to give holders of any debt securities protection against changes in our operations, financial condition or transactions involving us.</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">We may issue the debt securities issued under the indenture as &#8220;discount securities,&#8221; which means they may be sold at a discount below their stated principal amount. These debt securities, as well as other debt securities that are not issued at a discount, may be issued with &#8220;original issue discount,&#8221; or OID, for U.S. federal income tax purposes because of interest payment and other characteristics or terms of the debt securities. Material U.S. federal income tax considerations applicable to debt securities issued with OID will be described in more detail in any applicable prospectus supplement.</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">We will describe in the applicable prospectus supplement the terms of the series of debt securities being offered, including:</div><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the title of the series of debt securities;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">any limit upon the aggregate principal amount that may be issued;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the maturity date or dates;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the form of the debt securities of the series;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">whether or not the debt securities will be secured or unsecured, and the terms of any secured debt;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">whether the debt securities rank as senior debt, senior subordinated debt, subordinated debt or any combination thereof, and the terms of any subordination;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">if the price (expressed as a percentage of the aggregate principal amount thereof) at which such debt securities will be issued is a price other than the principal amount thereof, the portion of the principal amount thereof payable upon declaration of acceleration of the maturity thereof, or if applicable, the portion of the principal amount of such debt securities that is convertible into another security or the method by which any such portion shall be determined;</div></td></tr></table></div></div><div class="block-frill" style="width: 468pt; margin-top: 12pt; margin-left: 0pt;"><div class="unknown" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; text-align: center;">12<br></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="nt10011234x1_s3_106-description_pg8"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the interest rate or rates, which may be fixed or variable, or the method for determining the rate and the date interest will begin to accrue, the dates interest will be payable and the regular record dates for interest payment dates or the method for determining such dates;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">our right, if any, to defer payment of interest and the maximum length of any such deferral period;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">if applicable, the date or dates after which, or the period or periods during which, and the price or prices at which, we may, at our option, redeem the series of debt securities pursuant to any optional or provisional redemption provisions and the terms of those redemption provisions;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the date or dates, if any, on which, and the price or prices at which we are obligated, pursuant to any mandatory sinking fund or analogous fund provisions or otherwise, to redeem, or at the holder&#8217;s option to purchase, the series of debt securities and the currency or currency unit in which the debt securities are payable;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the denominations in which we will issue the series of debt securities, if other than denominations of $2,000 and multiples of $1,000 in excess thereof;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">any and all terms, if applicable, relating to any auction or remarketing of the debt securities of that series and any security for our obligations with respect to such debt securities and any other terms which may be advisable in connection with the marketing of debt securities of that series;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">whether the debt securities of the series shall be issued in whole or in part in the form of a global security or securities; the terms and conditions, if any, upon which such global security or securities may be exchanged in whole or in part for other individual securities; and the depositary for such global security or securities;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">if applicable, the provisions relating to conversion or exchange of any debt securities of the series and the terms and conditions upon which such debt securities will be so convertible or exchangeable, including the conversion or exchange price, as applicable, or how it will be calculated and may be adjusted, any mandatory or optional (at our option or the holders&#8217; option) conversion or exchange features, the applicable conversion or exchange period and the manner of settlement for any conversion or exchange;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">if other than the full principal amount thereof, the portion of the principal amount of debt securities of the series which shall be payable upon declaration of acceleration of the maturity thereof;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">additions to or changes in the covenants applicable to the particular debt securities being issued, including, among others, the consolidation, merger or sale covenant;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">additions to or changes in the events of default with respect to the securities and any change in the right of the trustee or the holders to declare the principal, premium, if any, and interest, if any, with respect to such securities to be due and payable;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">additions to or changes in or deletions of the provisions relating to covenant defeasance and legal defeasance;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">additions to or changes in the provisions relating to satisfaction and discharge of the indenture;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">additions to or changes in the provisions relating to the modification of the indenture both with and without the consent of holders of debt securities issued under the indenture;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the currency of payment of debt securities if other than U.S. dollars and the manner of determining the equivalent amount in U.S. dollars;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">whether interest will be payable in cash or additional debt securities at our or the holders&#8217; option and the terms and conditions upon which the election may be made;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the terms and conditions, if any, upon which we will pay amounts in addition to the stated interest, premium, if any and principal amounts of the debt securities of the series to any holder that is not a &#8220;United States person&#8221; for federal tax purposes;</div></td></tr></table></div></div><div class="block-frill" style="width: 468pt; margin-top: 12pt; margin-left: 0pt;"><div class="unknown" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; text-align: center;">13<br></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="nt10011234x1_s3_106-description_pg9"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">any restrictions on transfer, sale or assignment of the debt securities of the series; and</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">any other specific terms, preferences, rights or limitations of, or restrictions on, the debt securities, any other additions or changes in the provisions of the indenture, and any terms that may be required by us or advisable under applicable laws or regulations.</div></td></tr></table><div class="h2" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 17.75pt; margin-left: 0pt; text-align: left;">Events of Default and Remedies</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Unless otherwise described in the applicable prospectus supplement, an event of default with respect to any series of debt securities will be defined in the indenture or applicable supplemental indenture or authorizing resolution as being:</div><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">our failure to pay interest on any debt security of such series when the same becomes due and payable and the continuance of any such failure for a period of 30 days;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">our failure to pay the principal or premium of any debt security of such series when the same becomes due and payable at maturity, upon acceleration, redemption or otherwise;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">our failure or the failure of any restricted subsidiary to comply with any of its agreements or covenants in, or provisions of, the debt securities of such series or the indenture (as they relate thereto) and such failure continues for a period of 90 days after our receipt of notice of the default from the trustee or from the holders of at least 25% in aggregate principal amount of the then outstanding debt securities of that series (except in the case of a default with respect to the provisions of the indenture regarding the consolidation, merger, sale, lease, conveyance or other disposition of all or substantially all of our assets (or any other provision specified in the applicable supplemental indenture or authorizing resolution), which will constitute an event of default with notice but without passage of time); or</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">certain events of bankruptcy, insolvency or reorganization occur with respect to us.</div></td></tr></table><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">The indenture will provide that the trustee may withhold notice to the holders of any series of debt securities of any default, except a default in payment of principal or interest, if any, with respect to such series of debt securities, if the trustee considers it in the interest of the holders of such series of debt securities to do so.</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">The indenture will provide that if any event of default has occurred and is continuing with respect to any series of debt securities, the trustee or the holders of not less than 25% in principal amount of such series of debt securities then outstanding may declare the principal of all the debt securities of such series to be due and payable immediately. However, the holders of a majority in principal amount of the debt securities of such series then outstanding by notice to the trustee may waive any existing default and its consequences with respect to such series of debt securities, other than any event of default in payment of principal or interest. Holders of a majority in principal amount of the then outstanding debt securities of any series may rescind an acceleration with respect to such series and its consequences, except an acceleration due to nonpayment of principal or interest on such series, if the rescission would not conflict with any judgment or decree and if all existing events of default with respect to such series have been cured or waived.</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">The holders of a majority of the outstanding principal amount of the debt securities of any series will have the right to direct the time, method and place of conducting any proceedings for any remedy available to the trustee with respect to such series, subject to limitations specified in the indenture.</div><div class="h2" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 17.75pt; margin-left: 0pt; text-align: left;">Defeasance</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">The indenture will permit us to terminate all our respective obligations under the indenture as they relate to any particular series of debt securities, other than the obligation to pay interest, if any, on and the principal of the debt securities of such series and certain other obligations, at any time by:</div><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">depositing in trust with the trustee, under an irrevocable trust agreement, money or government obligations in an amount sufficient to pay principal of and interest, if any, on the debt securities of such series to their maturity or redemption; and</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">complying with other conditions, including delivery to the trustee of an opinion of counsel to the effect that holders will not recognize income, gain or loss for federal income tax purposes as a result of our exercise of such right and will be subject to federal income tax on the same amount and in the same manner and at the same times as would have been the case otherwise.</div></td></tr></table></div></div><div class="block-frill" style="width: 468pt; margin-top: 12pt; margin-left: 0pt;"><div class="unknown" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; text-align: center;">14<br></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="nt10011234x1_s3_106-description_pg10"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">The indenture will also permit us to terminate all of our respective obligations under the indenture as they relate to any particular series of debt securities, including the obligations to pay interest, if any, on and the principal of the debt securities of such series and certain other obligations, at any time by:</div><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">depositing in trust with the trustee, under an irrevocable trust agreement, money or government obligations in an amount sufficient to pay principal and interest, if any, on the debt securities of such series to their maturity or redemption; and</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">complying with other conditions, including delivery to the trustee of an opinion of counsel to the effect that (A) we have received from, or there has been published by, the Internal Revenue Service a ruling, or (B) since the date such series of debt securities were originally issued, there has been a change in the applicable federal income tax law, in either case to the effect that, and based thereon such opinion of counsel shall state that, holders will not recognize income, gain or loss for federal income tax purposes as a result of our exercise of such right and will be subject to federal income tax on the same amount and in the same manner and at the same times as would have been the case otherwise.</div></td></tr></table><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">In addition, the indenture will permit us to terminate substantially all our respective obligations under the indenture as they relate to a particular series of debt securities by depositing with the trustee money or government obligations sufficient to pay all principal and interest on such series at its maturity or redemption date if the debt securities of such series will become due and payable at maturity within one year or are to be called for redemption within one year of the deposit.</div><div class="h2" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 16.25pt; margin-left: 0pt; text-align: left;">Transfer and Exchange Rights</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">A holder will be able to transfer or exchange debt securities only in accordance with the indenture. The registrar may require a holder, among other things, to furnish appropriate endorsements and transfer documents, and to pay any taxes and fees required by law or permitted by the indenture.</div><div class="h2" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 16.25pt; margin-left: 0pt; text-align: left;">Consolidation, Merger or Sale</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Unless we provide otherwise in the prospectus supplement applicable to a particular series of debt securities, the indenture will not contain any covenant that restricts our ability to merge or consolidate, or sell, convey, lease, transfer or otherwise dispose of all of substantially all of our assets. However, any successor to or acquirer of such assets (other than a subsidiary of ours) must assume all of our obligations under the indenture or the debt securities, as appropriate.</div><div class="h2" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 15.75pt; margin-left: 0pt; text-align: left;">Amendment, Supplement and Waiver</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Without notice to or the consent of any holder, we and the trustee may amend or supplement the indenture or the debt securities of a series to:</div><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">cure any ambiguity, omission, defect or inconsistency;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">comply with the provisions of the indenture regarding the consolidation, merger, sale, lease, conveyance or other disposition of all or substantially all of our assets;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">provide that specific provisions of the indenture shall not apply to a series of debt securities not previously issued or to make a change to specific provisions of the indenture that only applies to any series of debt securities not previously issued or to additional debt securities of a series not previously issued;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">create a series and establish its terms;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">provide for uncertificated debt securities in addition to or in place of certificated debt securities;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">release a guarantor in respect of any series of debt securities which, in accordance with the terms of indenture applicable to the particular series, ceases to be liable in respect of its guarantee;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">add a guarantor subsidiary in respect of any series of debt securities;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">secure any series of debt securities;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">comply with requirements of the SEC in order to effect or maintain the qualification of the indenture under the Trust Indenture Act;</div></td></tr></table></div></div><div class="block-frill" style="width: 468pt; margin-top: 12pt; margin-left: 0pt;"><div class="unknown" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; text-align: center;">15<br></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="nt10011234x1_s3_106-description_pg11"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">make any change that does not adversely affect the rights of any holder; or</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">conform the provisions of the indenture to the final offering document in respect of any series of debt securities.</div></td></tr></table><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">With the exceptions discussed below, we and the trustee may amend or supplement the indenture or the debt securities of a particular series with the written consent of the holders of at least a majority in principal amount of the debt securities of such series then outstanding. In addition, the holders of a majority in principal amount of the debt securities of such series then outstanding may waive any existing default under, or compliance with, any provision of the debt securities of a particular series or of the indenture relating to a particular series of debt securities, other than any event of default in payment of interest or principal. These consents and waivers may be obtained in connection with a purchase of, or tender offer or exchange offer for, debt securities.</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 11.75pt; margin-left: 20pt; text-align: left;">Without the consent of each holder affected, we and the trustee may not:</div><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">reduce the amount of debt securities of such series whose holders must consent to an amendment, supplement or waiver;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">reduce the rate of or extend the time for payment of interest, including defaulted interest;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">reduce the principal of or extend the fixed maturity of any debt security or alter the provisions with respect to redemptions or mandatory offers to repurchase debt securities;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">make any change that adversely affects any right of a holder to convert or exchange any debt security into or for shares of our common shares or other securities, cash or other property in accordance with the terms of such security;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">modify the ranking or priority of the debt securities;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">make any change to any provision of the indenture relating to the waiver of existing defaults, the rights of holders to receive payment of principal and interest on the debt securities, or to the provisions regarding amending or supplementing the indenture or the debt securities of a particular series with the written consent of the holders of such series;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">waive a continuing default or event of default in the payment of principal of or interest on the debt securities; or</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">make any debt security payable at a place or in money other than that stated in the debt security, or impair the right of any holder of a debt security to bring suit as permitted by the indenture.</div></td></tr></table><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">The right of any holder to participate in any consent required or sought pursuant to any provision of the indenture, and our obligation to obtain any such consent otherwise required from such holder, may be subject to the requirement that such holder shall have been the holder of record of debt securities with respect to which such consent is required or sought as of a record date fixed by us in accordance with the indenture.</div><div class="h2" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 23.75pt; margin-left: 0pt; text-align: left;">Governing Law</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 10.75pt; margin-left: 20pt; text-align: left;">The laws of the State of New York will govern the indenture and the debt securities.</div></div></div><div class="block-frill" style="width: 468pt; margin-top: 12pt; margin-left: 0pt;"><div class="unknown" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; text-align: center;">16<br></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="nt10011234x1_s3_106-description_pg12"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 12pt; text-align: center;"><a name="tDOU"><!--Anchor--></a>DESCRIPTION OF UNITS</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">We may issue units consisting of one or more of the other securities described in this prospectus in any combination, as described in a prospectus supplement. We may issue units in one or more series, which will be described in a prospectus supplement. We will issue the units or hybrid securities under one or more unit agreements, each referred to as a unit agreement, to be entered into between us and a bank or trust company, as unit agent. You should refer to the form of unit agreement and unit certificate that we file with the SEC in connection with the offering of the specific units for more complete information.</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 11.75pt; margin-left: 20pt; text-align: left;">The applicable prospectus supplement will describe:</div><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the designation and the terms of the units and of the securities constituting the units, including whether and under what circumstances the securities comprising the units may be traded separately;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">any additional terms of the governing unit agreement;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">any additional provisions for the issuance, payment, settlement, transfer or exchange of the units or of the preferred stock, common stock, stock purchase contracts, depositary shares, warrants or debt securities constituting the units; and</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">any applicable United States federal income tax consequences.</div></td></tr></table></div></div><div class="block-frill" style="width: 468pt; margin-top: 12pt; margin-left: 0pt;"><div class="unknown" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; text-align: center;">17<br></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="nt10011234x1_s3_106-description_pg13"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 12pt; text-align: center;"><a name="tPOD"><!--Anchor--></a>PLAN OF DISTRIBUTION</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">We may sell the securities being offered hereby at prices and under terms then prevailing, at prices related to the then current market price or in negotiated transactions from time to time in one or more of the following ways:</div><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">directly to one or more purchasers;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">through one or more underwriters on a firm commitment or best-efforts basis;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">through broker-dealers, who may act as agents or principals, including a block trade in which a broker or dealer so engaged will attempt to sell as agent but may position and resell a portion of the block as principal to facilitate the transaction;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">through agents;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">through remarketing firms;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">in privately negotiated transactions; or</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">in any combination of these methods of sale.</div></td></tr></table><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 11.25pt; margin-left: 20pt; text-align: left;">We will set forth in a prospectus supplement the terms of the offering of securities, including:</div><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the name or names of any underwriters, dealers or agents;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">the number of securities and purchase price of the securities being offered and the proceeds we will receive from the sale;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">any underwriting discounts and commissions or agency fees and other items constituting underwriters&#8217; or agents&#8217; compensation;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">any over-allotment options under which underwriters may purchase additional securities from us;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">any delayed delivery arrangements;</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">any discounts or concessions allowed or re-allowed or paid to dealers; and</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">any securities exchange on which the securities may be listed.</div></td></tr></table><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">The distribution of the securities may be effected from time to time in one or more transactions at a fixed price or prices, which may be changed, at market prices prevailing at the time of sale, at prices related to the prevailing market prices or at negotiated prices.</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">We may designate agents who agree to use their reasonable efforts to solicit purchases for the period of their appointment or to sell securities on a continuing basis. Agents may receive compensation in the form of commissions, discounts or concessions from us. Agents may also receive compensation from the purchasers of the securities for whom they sell as principals. Each particular agent will receive compensation in amounts negotiated in connection with the sale, which might be in excess of customary commissions. Agents and any other participating broker-dealers may be deemed to be &#8220;underwriters&#8221; within the meaning of Section 2(11) of the Securities Act of 1933 (the &#8220;Securities Act&#8221;) in connection with sales of the securities. Accordingly, any commission, discount or concession received by them and any profit on the resale of the securities purchased by them may be deemed to be underwriting discounts or commissions under the Securities Act. We have not entered into any agreements, understandings or arrangements with any underwriters or broker-dealers regarding the sale of their securities. As of the date of this prospectus, there are no special selling arrangements between any broker-dealer or other person and us. No period of time has been fixed within which the securities will be offered or sold.</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">If required under applicable state securities laws, we will sell the securities only through registered or licensed brokers or dealers. In addition, in some states, we may not sell securities unless they have been registered or qualified for sale in the applicable state or an exemption from the registration or qualification requirement is available and complied with.</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">If we use underwriters for a sale of securities, the underwriters will acquire the securities for their own account. The underwriters may resell the securities in one or more transactions, including negotiated transactions, at a fixed public offering price or at varying prices determined at the time of sale. The obligations of the </div></div></div><div class="block-frill" style="width: 468pt; margin-top: 12pt; margin-left: 0pt;"><div class="unknown" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; text-align: center;">18<br></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="nt10011234x1_s3_106-description_pg14"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">underwriters to purchase the securities will be subject to the conditions set forth in the applicable underwriting agreement. We may change from time to time any initial public offering price and any discounts or concessions the underwriters allow or re-allow or pay to dealers. We may use underwriters with whom we have a material relationship. We will describe in the prospectus supplement naming the underwriter the nature of any such relationship.</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">We may use a remarketing firm to offer to sell the securities in connection with a remarketing arrangement upon their purchase. Remarketing firms will act as principals for their own account or as agents for us. These remarketing firms will offer or sell the securities pursuant to the terms of the securities. A prospectus supplement will identify any remarketing firm and the terms of its agreement, if any, with us and will describe the remarketing firm&#8217;s compensation. Remarketing firms may be deemed to be underwriters in connection with the securities they remarket.</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">If we offer and sell securities through a dealer, we or an underwriter will sell the securities to the dealer, as principal. The dealer may then resell the securities to the public at varying prices to be determined by the dealer at the time of resale. Any such dealer may be deemed to be an underwriter of the securities so offered and sold. The name of the dealer and the terms of the transactions will be set forth in the applicable prospectus supplement.</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">We may also sell securities directly to one or more purchasers without using underwriters or agents. Underwriters, dealers and agents that participate in the distribution of the securities may be underwriters as defined in the Securities Act and any discounts or commissions they receive from us and any profit on their resale of the securities may be treated as underwriting discounts and commissions under the Securities Act.</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">We will identify in the applicable prospectus supplement any underwriters, dealers or agents and will describe their compensation. We may have agreements with the underwriters, dealers and agents to indemnify them against specified civil liabilities, including liabilities under the Securities Act. Underwriters, dealers and agents may engage in transactions with or perform services for us in the ordinary course of their businesses.</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">We may authorize agents, dealers or underwriters to solicit offers to purchase securities at the public offering price under delayed delivery contracts. The terms of these delayed delivery contracts, including when payment for and delivery of the securities sold will be made under the contracts and any conditions to each party&#8217;s performance set forth in the contracts, will be described in the applicable prospectus supplement. The compensation received by underwriters, agents or dealers soliciting purchases of securities under delayed delivery contracts will be described in the applicable prospectus supplement.</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">We may enter into derivative or other hedging transactions with third parties, or sell securities not covered by this prospectus to third parties in privately negotiated transactions. If the applicable prospectus supplement indicates, in connection with those derivatives, the third parties may sell securities covered by this prospectus and the applicable prospectus supplement, including in short sale transactions. If so, the third party may use securities pledged by us or borrowed from us or others to settle those sales or to close out any related open borrowings of stock, and may use securities received from us in settlement of those derivatives to close out any related open borrowings of stock. We may also loan or pledge securities covered by this prospectus and the applicable prospectus supplement to third parties, who may sell the loaned securities or, in an event of default in the case of a pledge, sell the pledged securities pursuant to this prospectus and the applicable prospectus supplement.</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Unless otherwise specified in the related prospectus supplement, all securities we offer, other than common stock, will be new issues of securities with no established trading market. Any underwriters may make a market in these securities, but will not be obligated to do so and may discontinue any market making at any time without notice. We may apply to list any series of securities on an exchange, but we are not obligated to do so. Therefore, no assurance can be given as to the liquidity of, or the trading market for, any series of securities.</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Any underwriter may engage in overallotment, stabilizing transactions, short covering transactions and penalty bids in accordance with Regulation M under the Exchange Act. Overallotment involves sales in excess of the offering size, which create a short position. Stabilizing transactions permit bids to purchase the underlying security so long as the stabilizing bids do not exceed a specified maximum. Short covering transactions involve purchases of the securities in the open market after the distribution is completed to cover short positions. Penalty bids permit the underwriters to reclaim a selling concession from a dealer when the securities originally sold by </div></div></div><div class="block-frill" style="width: 468pt; margin-top: 12pt; margin-left: 0pt;"><div class="unknown" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; text-align: center;">19<br></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="nt10011234x1_s3_106-description_pg15"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">the dealer are purchased in a covering transaction to cover short positions. Those activities may cause the price of the securities to be higher than it would otherwise be. If commenced, the underwriters may discontinue any of the activities at any time. These transactions may be effected on The Nasdaq Global Select Market or otherwise.</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Any underwriters who are qualified market makers on The Nasdaq Global Select Market may engage in passive market making transactions in the common stock on The Nasdaq Global Select Market in accordance with Rule 103 of Regulation M, during the business day before the pricing of the offering, before the commencement of offers or sales of the common stock. Passive market makers must comply with applicable volume and price limitations and must be identified as passive market makers. In general, a passive market maker must display its bid at a price not in excess of the highest independent bid for such security; if all independent bids are lowered below the passive market maker&#8217;s bid, however, the passive market maker&#8217;s bid must then be lowered when certain purchase limits are exceeded.</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">We will bear all costs, expenses and fees in connection with the registration of the securities, as well as the expense of all commissions and discounts, if any, attributable to sales of the securities by us.</div></div></div><div class="block-frill" style="width: 468pt; margin-top: 12pt; margin-left: 0pt;"><div class="unknown" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; text-align: center;">20<br></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="nt10011234x1_s3_106-description_pg16"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 12pt; text-align: center;"><a name="tLM"><!--Anchor--></a>LEGAL MATTERS</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Gibson, Dunn &amp; Crutcher LLP has rendered an opinion with respect to the validity of the securities being offered by this prospectus. We have filed this opinion as an exhibit to the registration statement of which this prospectus is a part. If counsel for any underwriters passes on legal matters in connection with an offering made by this prospectus, we will name that counsel in the prospectus supplement relating to that offering.</div><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 23.75pt; text-align: center;"><a name="tE"><!--Anchor--></a>EXPERTS</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Ernst &amp; Young LLP, independent registered public accounting firm, has audited our consolidated financial statements included in our Annual Report on Form 10-K for the year ended December&#160;31, 2019, and the effectiveness of our internal control over financial reporting as of December&#160;31, 2019, as set forth in their reports, which are incorporated by reference in this prospectus and elsewhere in the registration statement. Our financial statements and our management&#8217;s assessment of the effectiveness of internal control over financial reporting as of December&#160;31, 2019 are incorporated by reference in reliance on Ernst &amp; Young LLP's reports, given on their authority as experts in accounting and auditing.</div></div></div><div class="block-frill" style="width: 468pt; margin-top: 12pt; margin-left: 0pt;"><div class="unknown" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; text-align: center;">21<br></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="nt10011234x1_s3_106-description_pg17"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 12pt; text-align: center;"><a name="tWY"><!--Anchor--></a>WHERE YOU CAN FIND MORE INFORMATION</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">We file electronically with the SEC our annual reports on Form 10-K, quarterly reports on Form 10-Q, current reports on Form 8-K, proxy statements and other information. We make available on or through our website, http://www.biocryst.com, free of charge, copies of these filings as soon as reasonably practicable after we electronically file them with or furnish them to the SEC. The information on our website is not incorporated by reference into this prospectus. You can also request copies of such documents by contacting our Investor Relations Department at 4505 Emperor Blvd., Suite 200, Durham, North Carolina 27703 or sending an email to investorrelations@biocryst.com. </div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">The SEC also maintains a website that contains reports, proxy and information statements, and other information about issuers, like BioCryst, that file electronically with the SEC. The address of that site is http://www.sec.gov. Unless specifically listed below under &#8220;Incorporation of Certain Documents by Reference&#8221; the information contained on the SEC website is not incorporated by reference into this prospectus.</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">We have filed with the SEC a registration statement on Form S-3 that registers the securities we are offering. The registration statement, including the attached exhibits and schedules, contains additional relevant information about us and our securities. The rules and regulations of the SEC allow us to omit certain information included in the registration statement from this prospectus.</div><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 23.75pt; text-align: center;"><a name="tIOC"><!--Anchor--></a>INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">The SEC allows us to &#8220;incorporate by reference&#8221; information into this prospectus. This means that we can disclose important information to you by referring you to another document filed separately with the SEC. The information incorporated by reference is considered to be part of this prospectus, except for any information that is superseded by information that is included directly in this document.</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">This prospectus includes by reference the documents listed below that we have previously filed with the SEC and that are not included in or delivered with this document. They contain important information about us and our financial condition.</div><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">Our Annual Report on Form 10-K for the year ended December&#160;31, 2019 filed with the SEC on <a href="https://www.sec.gov/Archives/edgar/data/882796/000117184320001710/f10k_031320p.htm">March&#160;13, 2020</a> (including the sections of our definitive proxy statement relating to our May&#160;12, 2020 annual meeting of stockholders that are incorporated by reference therein);</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">Our Current Reports on Form 8-K filed with the SEC on <a href="https://www.sec.gov/Archives/edgar/data/882796/000117184320000183/f8k_011320.htm">January&#160;13, 2020</a>, <a href="https://www.sec.gov/Archives/edgar/data/882796/000117184320000241/f8k_011520.htm">January&#160;15, 2020</a>, <a href="https://www.sec.gov/Archives/edgar/data/882796/000117184320000650/f8k_020320.htm">February&#160;3, 2020</a>, <a href="https://www.sec.gov/Archives/edgar/data/882796/000117184320001018/f8k_021820.htm">February&#160;18, 2020</a>, <a href="https://www.sec.gov/Archives/edgar/data/882796/000117184320001229/f8k_022520.htm">February&#160;25, 2020</a>, <a href="https://www.sec.gov/Archives/edgar/data/882796/000117184320001491/f8k_030520.htm">March&#160;5, 2020</a> (filing containing Items 8.01 and 9.01 only), <a href="https://www.sec.gov/Archives/edgar/data/882796/000117184320001589/f8k_031020.htm">March&#160;10, 2020</a>, <a href="https://www.sec.gov/Archives/edgar/data/882796/000117184320002124/f8k_033020.htm">March&#160;30, 2020</a>, <a href="https://www.sec.gov/Archives/edgar/data/882796/000117184320002295/f8k_040220.htm">April&#160;2, 2020</a> and <a href="https://www.sec.gov/Archives/edgar/data/882796/000117184320002530/f8k_040920.htm">April&#160;10, 2020</a>; and</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 6pt; margin-left: 20pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#8226;</div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left;">The description of our common stock which is contained in our Registration Statement on Form 8-A (File No. 000-23186) filed with the SEC on January&#160;7, 1994, together with the amendment thereto filed with the SEC on March&#160;14, 1994, including any other amendment or reports filed for the purpose of updating such description.</div></td></tr></table><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">All documents filed by us pursuant to Section 13(a), 13(c), 14 or 15(d) of the Exchange Act on or after the date of the registration statement of which this prospectus forms a part and prior to the effectiveness of such registration statement and on or after the date of this prospectus and prior to the termination of our offering of securities shall be deemed to be incorporated by reference herein and to be a part of this prospectus from the date of filing of such documents, excluding any information furnished under Item 2.02 or Item 7.01 of any Current Report on Form 8-K and exhibits filed on such form that are related to such items. Any statement contained in a document incorporated by reference herein shall be deemed to be modified or superseded for purposes of this prospectus to the extent that a statement contained herein or in any other subsequently filed document which also is or is deemed to be incorporated by reference herein modifies or supersedes such statement. Any statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this prospectus.</div></div></div><div class="block-frill" style="width: 468pt; margin-top: 12pt; margin-left: 0pt;"><div class="unknown" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; text-align: center;">22<br></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="nt10011234x1_s3_106-description_pg18"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">You can obtain any of the documents incorporated by reference in this prospectus from us without charge, excluding any exhibits to those documents unless the exhibit is specifically incorporated by reference as an exhibit to this prospectus. You can obtain documents incorporated by reference in this prospectus at no cost by requesting them in writing or by telephone from us at the following address:</div><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; text-align: center;">Investor Relations<br>BioCryst Pharmaceuticals, Inc.<br>4505 Emperor Blvd., Suite 200<br>Durham, North Carolina 27703<br>(919) 859-1302</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">We have not authorized anyone to provide you with information different from that contained or incorporated by reference in this prospectus or any prospectus supplement. We take no responsibility for, and can provide no assurances as to the reliability of, any information other than the information contained in or incorporated by reference in this prospectus or any prospectus supplement. If you are in a jurisdiction where offers to sell, or solicitations of offers to purchase, the securities offered by this document are unlawful, or if you are a person to whom it is unlawful to direct these types of activities, then the offer presented in this document does not extend to you.</div></div></div><div class="block-frill" style="width: 468pt; margin-top: 12pt; margin-left: 0pt;"><div class="unknown" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; text-align: center;">23<br></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 456pt;"><a name="nt10011234x1_s3_200-bcv_pg1"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="block-frill" style="width: 456pt; margin-left: 0pt;"><div><div class="rule-full" style="height: 0pt; width: 100%; border-bottom: 2pt solid #000000; margin-top: 1pt; margin-bottom: 1pt; margin-left: auto; margin-right: auto;"> </div><div class="rule-full" style="height: 0pt; width: 100%; border-bottom: 1pt solid #000000; margin-bottom: 1pt; margin-left: auto; margin-right: auto; margin-top: 4pt;"> </div></div></div><div class="page-content"><div class="block-main" style="width: 456pt; margin-left: 0pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; text-align: center;"><img style="height: 124px; width: 305px;" src="logo_biocryst2ax1.jpg"><br>&#8201;</div><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 20pt; font-weight: bold; margin-top: 23.75pt; text-align: center;">BioCryst Pharmaceuticals, Inc.</div><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 14pt; font-weight: bold; margin-top: 37pt; text-align: center;">$500,000,000</div><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 14pt; font-weight: bold; margin-top: 64pt; text-align: center;">Common Stock<br>Preferred Stock<br>Depositary Shares<br>Stock Purchase Contracts<br>Warrants<br>Debt Securities<br>Units</div><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 16pt; font-weight: bold; margin-top: 64pt; text-align: center;">PROSPECTUS </div><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 12pt; margin-top: 173.75pt; text-align: center;">&#8195;&#8195;&#8195;, 2020</div></div></div><div class="block-frill" style="width: 456pt; margin-top: 12pt; margin-left: 0pt;"><div><div class="rule-full" style="height: 0pt; width: 100%; border-bottom: 1pt solid #000000; margin-top: 1pt; margin-bottom: 1pt; margin-left: auto; margin-right: auto;"> </div><div class="rule-full" style="height: 0pt; width: 100%; border-bottom: 2pt solid #000000; margin-bottom: 1pt; margin-left: auto; margin-right: auto; margin-top: 4pt;"> </div></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="nt10011234x1_s3_201-part2_pg1"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 12pt; text-align: center;">PART II</div><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 16.25pt; text-align: center;">INFORMATION NOT REQUIRED IN PROSPECTUS</div><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 12pt; margin-left: 0pt;"><tr><td style="width: 50pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold;">ITEM 14.<br></div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; text-align: left;">OTHER EXPENSES OF ISSUANCE AND DISTRIBUTION.</div></td></tr></table><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">The following table sets forth all expenses payable by the registrant in connection with the issuance and distribution of the securities, other than underwriting discounts and commissions. The registrant will bear all of such expenses. All the amounts shown are estimates except the registration fee.</div><table cellspacing="0" cellpadding="0" class="fintab" align="center" style="margin-top: 11.25pt; border-collapse: collapse; width: 468pt; margin-left: 0pt;"><tr><td style="width: 87.18%; text-align: left; vertical-align: bottom; padding-bottom: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">Registration fee<font style="padding-left: 1.08pt;"></font></div></td><td class="gutter" style="width: 2.94%; border-bottom: none; font-size: 2pt; padding-bottom: 3pt; background-color: #CCEEFF;">&#8203;</td><td class="gutter" style="width: 2.94%; border-bottom: none; font-size: 2pt; padding-bottom: 3pt; background-color: #CCEEFF;">&#8203;</td><td style="width: 6.94%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-bottom: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><font style="padding-left: 5pt;">64,900</font></div></td></tr><tr><td style="width: 87.18%; text-align: left; vertical-align: bottom; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">Accounting fees and expenses<font style="padding-left: 2.22pt;"></font></div></td><td class="gutter" style="width: 2.94%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td class="gutter" style="width: 2.94%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td style="width: 6.94%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><font style="padding-left: 32.5pt;">*</font></div></td></tr><tr><td style="width: 87.18%; text-align: left; vertical-align: bottom; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">Legal fees and expenses<font style="padding-left: 1.11pt;"></font></div></td><td class="gutter" style="width: 2.94%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">&#8203;</td><td class="gutter" style="width: 2.94%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;">&#8203;</td><td style="width: 6.94%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><font style="padding-left: 32.5pt;">*</font></div></td></tr><tr><td style="width: 87.18%; text-align: left; vertical-align: bottom; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">Printing and engraving<font style="padding-left: 2.19pt;"></font></div></td><td class="gutter" style="width: 2.94%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td class="gutter" style="width: 2.94%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td style="width: 6.94%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><font style="padding-left: 32.5pt;">*</font></div></td></tr><tr><td style="width: 87.18%; text-align: left; vertical-align: bottom; padding-top: 3pt; padding-bottom: 4.25pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">Miscellaneous<font style="padding-left: 2.74pt;"></font></div></td><td class="gutter" style="width: 2.94%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 4.25pt; background-color: #CCEEFF;">&#8203;</td><td class="gutter" style="width: 2.94%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 4.25pt; background-color: #CCEEFF;">&#8203;</td><td style="width: 6.94%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 3pt; padding-bottom: 4.25pt; background-color: #CCEEFF;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><font style="padding-left: 32.5pt; border-bottom: 1pt solid #000000;"></font>*</div></td></tr><tr><td style="width: 87.18%; text-align: left; vertical-align: bottom; padding-top: 4.25pt; padding-bottom: 2.25pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 10pt; text-align: left;">Total<font style="padding-left: 0.09pt;"></font></div></td><td class="gutter" style="width: 2.94%; border-bottom: none; font-size: 2pt; padding-top: 4.25pt; padding-bottom: 2.25pt;">&#8203;</td><td class="gutter" style="width: 2.94%; border-bottom: none; font-size: 2pt; padding-top: 4.25pt; padding-bottom: 2.25pt;">&#8203;</td><td style="width: 6.94%; text-align: left; vertical-align: bottom; white-space: nowrap; padding-top: 4.25pt; padding-bottom: 2.25pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><font style="border-bottom: 3pt double #000000;">$</font><font style="padding-left: 27.5pt; border-bottom: 3pt double #000000;"></font>*</div></td></tr></table><div><div class="rule-partial" style="height: 0pt; width: 72pt; border-bottom: 1pt solid #000000; margin-bottom: 1pt; margin-right: auto; margin-left: 0pt; margin-top: 11.25pt;"> </div></div><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 3pt; margin-left: 0pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt;">*<br></div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; text-align: left;">These fees are calculated based on the securities offered and the number of issuances and accordingly cannot be estimated at this time.</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 12pt; margin-left: 0pt;"><tr><td style="width: 50pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold;">ITEM 15.<br></div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; text-align: left;">INDEMNIFICATION OF DIRECTORS AND OFFICERS.</div></td></tr></table><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Section 145 of the Delaware General Corporation Law (the &#8220;DGCL&#8221;) sets forth the circumstances in which a Delaware corporation is permitted and/or required to indemnify its directors and officers. The DGCL permits a corporation to indemnify its directors and officers in certain proceedings if the director or officer has complied with the standard of conduct set out in the DGCL. The standard of conduct requires that the director or officer must have acted in good faith, in a manner the person reasonably believed to be in or not opposed to the best interests of the corporation, and, with respect to matters in a criminal proceeding, the director or officer must have had no reason to believe that his or her conduct was unlawful. With respect to suits by or in the right of the corporation, the DGCL permits indemnification of directors and officers if the person meets the standard of conduct, except that it precludes indemnification of directors and officers who are adjudged liable to the corporation, unless the Court of Chancery or the court in which the corporation&#8217;s action or suit was brought determines that the director or officer is fairly and reasonably entitled to indemnity for expenses. To the extent that a present or former director or officer of the corporation is successful on the merits or otherwise in his or her defense of a proceeding, the corporation is required to indemnify the director or officer against reasonable expenses incurred in defending himself or herself. The rights provided in Section 145 of the DGCL are not exclusive, and the corporation may also provide for indemnification under bylaw, agreement, vote of stockholders or disinterested directors or otherwise.</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">The registrant&#8217;s Third Restated Certificate of Incorporation, as amended (the &#8220;Certificate of Incorporation&#8221;), provides for indemnification of any director or officer who was or is a party or is threatened to be made a party to any threatened, pending or completed action, suit or proceeding, whether civil, criminal, administrative or investigative, by reason of the fact that he is or was, or has agreed to become, a director or officer of the registrant, or is or was serving, or agreed to serve, at the request of the registrant, as a director, officer or trustee of, or in a similar capacity with, another corporation, partnership, joint venture, trust or other enterprise (including any employee benefit plan), or by reason of any action alleged to have been taken or omitted in such capacity, against all expenses (including attorneys&#8217; fees), judgments, fines and amounts paid in settlement actually and reasonably incurred by him or on his behalf in connection with such action, suit or proceeding and any appeal therefrom, in each case to the fullest extent permitted by the DGCL. The registrant shall not indemnify any person seeking indemnification in connection with a proceeding or part thereof initiated by such person unless the initiation was approved by the Board of Directors of the registrant. The Certificate of Incorporation further provides for permissible indemnification of employees and other agents to the maximum extent permitted by the DGCL and the Certificate of Incorporation with respect to directors and officers.</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Section 102(b)(7) of the DGCL provides that a corporation may relieve its directors from personal liability to the corporation or its stockholders for monetary damages for any breach of their fiduciary duty as directors except for (i)&#160;a breach of the duty of loyalty; (ii)&#160;acts or omissions not in good faith or that involve intentional misconduct or a knowing violation of law; (iii)&#160;willful or negligent violations of certain provisions in the DGCL </div></div></div><div class="block-frill" style="width: 468pt; margin-top: 12pt; margin-left: 0pt;"><div class="unknown" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; text-align: center;">II-1<br></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="nt10011234x1_s3_201-part2_pg2"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">imposing certain requirements with respect to stock repurchases, redemptions and dividends; or (iv)&#160;for any transactions from which the director derived an improper personal benefit. The registrant&#8217;s Certificate of Incorporation provides that no directors of the registrant shall be liable to the registrant or its stockholders for monetary damages for breach of fiduciary duty as a director to the fullest extent permitted by the DGCL.</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">In addition, the registrant currently maintains liability insurance for its directors and officers insuring them against certain liabilities asserted against them in their capacities as directors or officers or arising out of such status.</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">The indemnification provisions noted above may be sufficiently broad to permit indemnification of the registrant&#8217;s officers and directors for liabilities arising under the Securities Act.</div><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 12pt; margin-left: 0pt;"><tr><td style="width: 50pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold;">ITEM 16.<br></div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; text-align: left;">EXHIBITS.</div></td></tr></table><table cellspacing="0" cellpadding="0" class="txttab" align="center" style="margin-top: 10.25pt; border-collapse: collapse; width: 468pt; margin-left: 0pt;"><tr class="header"><td style="width: 10.26%; text-align: left; vertical-align: bottom; border-bottom: 1pt solid #000000; padding-bottom: 4.25pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; margin-left: 0pt; text-align: left;">Exhibit No.</div></td><td class="gutter" style="width: 1.28%; font-size: 2pt; padding-bottom: 4.25pt; border-bottom: 1px solid #ffffff;">&#8203;</td><td class="gutter" style="width: 1.28%; font-size: 2pt; padding-bottom: 4.25pt; border-bottom: 1px solid #ffffff;">&#8203;</td><td style="width: 87.18%; text-align: center; vertical-align: bottom; border-bottom: 1pt solid #000000; padding-bottom: 4.25pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">Description</div></td></tr><tr><td style="width: 10.26%; text-align: left; vertical-align: top; padding-top: 4.25pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">1.1*</div></td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 4.25pt; padding-bottom: 3pt;">&#8203;</td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 4.25pt; padding-bottom: 3pt;">&#8203;</td><td style="width: 87.18%; text-align: left; vertical-align: top; padding-top: 4.25pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">Form of Underwriting Agreement.</div></td></tr><tr><td style="width: 10.26%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><a href="https://www.sec.gov/Archives/edgar/data/882796/000103570406000836/d42297exv3w1.htm">4.1</a></div></td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td style="width: 87.18%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">Third Restated Certificate of Incorporation of the Company. Incorporated by reference to Exhibit 3.1 to the Company&#8217;s Form 8-K filed December&#160;22, 2006 (File No. 000-23186).</div></td></tr><tr><td style="width: 10.26%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><a href="https://www.sec.gov/Archives/edgar/data/882796/000136231007001386/c70813exv3w1.htm">4.2</a></div></td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td style="width: 87.18%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">Certificate of Amendment to the Third Restated Certificate of Incorporation of the Company. Incorporated by reference to Exhibit 3.1 to the Company&#8217;s Form 8-K filed July&#160;24, 2007 (File&#160;No.&#160;000-23186).</div></td></tr><tr><td style="width: 10.26%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><a href="https://www.sec.gov/Archives/edgar/data/882796/000119312514186707/d722313dex31.htm">4.3</a></div></td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td style="width: 87.18%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">Certificate of Amendment to the Third Restated Certificate of Incorporation of the Company. Incorporated by reference to Exhibit 3.1 to the Company&#8217;s Form 8-K filed May&#160;7, 2014 (File&#160;No.&#160;000-23186).</div></td></tr><tr><td style="width: 10.26%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><a href="https://www.sec.gov/Archives/edgar/data/882796/000136231008006580/c76716exv3w1.htm">4.4</a></div></td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td style="width: 87.18%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">Certificate of Increase of Authorized Number of Shares of Series B Junior Participating Preferred Stock. Incorporated by reference to Exhibit 3.1 to the Company&#8217;s Form 8-K filed November&#160;4, 2008 (File No. 000-23186).</div></td></tr><tr><td style="width: 10.26%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><a href="https://www.sec.gov/Archives/edgar/data/882796/000119312514186707/d722313dex32.htm">4.5</a></div></td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td style="width: 87.18%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">Certificate of Increase of Authorized Number of Shares of Series B Junior Participating Preferred Stock of the Company. Incorporated by reference to Exhibit 3.2 to the Company&#8217;s Form 8-K filed May&#160;7, 2014 (File No. 000-23186).</div></td></tr><tr><td style="width: 10.26%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><a href="https://www.sec.gov/Archives/edgar/data/882796/000136231008006580/c76716exv3w2.htm">4.6</a></div></td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td style="width: 87.18%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">Amended and Restated Bylaws of the Company effective October&#160;29, 2008. Incorporated by reference to Exhibit 3.2 to the Company&#8217;s Form 8-K filed November&#160;4, 2008 (File&#160;No.&#160;000-23186).</div></td></tr><tr><td style="width: 10.26%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><a href="https://www.sec.gov/Archives/edgar/data/882796/000110465918003194/a18-3548_1ex3d1.htm#Exhibit3_1_084143">4.7</a></div></td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td style="width: 87.18%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">Amendment to Amended and Restated Bylaws of the Company effective January&#160;21, 2018. Incorporated by reference to Exhibit 3.1 to the Company&#8217;s Form 8-K filed January&#160;22, 2018. (File&#160;No. 001-23186). </div></td></tr><tr><td style="width: 10.26%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><a href="https://www.sec.gov/Archives/edgar/data/882796/000095014408009035/g16835exv4w7.htm">4.8</a></div></td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td style="width: 87.18%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">Specimen Certificate for Registrant&#8217;s Common Stock. Incorporated by reference to Exhibit 4.7 to the Company&#8217;s Form S-3 filed November&#160;28, 2008 (File No. 333-155783).</div></td></tr><tr><td style="width: 10.26%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><a href="nt10011234x1_ex4-9.htm">(4.9)</a></div></td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td style="width: 87.18%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">Form of Indenture.</div></td></tr><tr><td style="width: 10.26%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">4.10*</div></td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td style="width: 87.18%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">Form of Supplemental Indenture or Officers&#8217; Certificate.</div></td></tr><tr><td style="width: 10.26%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">4.11*</div></td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td style="width: 87.18%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">Form of Global Debt Security.</div></td></tr><tr><td style="width: 10.26%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">4.12*</div></td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td style="width: 87.18%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">Certificate of Designation of Preferred Stock.</div></td></tr><tr><td style="width: 10.26%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">4.13*</div></td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td style="width: 87.18%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">Form of Warrant Agreement (including form of Warrant).</div></td></tr><tr><td style="width: 10.26%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">4.14*</div></td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td style="width: 87.18%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">Form of Deposit Agreement with respect to Depositary Shares (including form of Depositary Receipt).</div></td></tr><tr><td style="width: 10.26%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">4.15*</div></td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td style="width: 87.18%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">Form of Purchase Contract (including form of Purchase Certificate).</div></td></tr><tr><td style="width: 10.26%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">4.16*</div></td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td style="width: 87.18%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">Form of Unit Agreement (including form of Unit Certificate).</div></td></tr><tr><td style="width: 10.26%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><a href="nt10011234x1_ex5-1.htm">(5.1)</a></div></td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td style="width: 87.18%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">Opinion of Gibson, Dunn &amp; Crutcher LLP.</div></td></tr><tr><td style="width: 10.26%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><a href="nt10011234x1_ex23-1.htm">(23.1)</a></div></td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td style="width: 87.18%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">Consent of Ernst &amp; Young LLP, Independent Registered Public Accounting Firm.</div></td></tr><tr><td style="width: 10.26%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><a href="nt10011234x1_ex5-1.htm">(23.2)</a></div></td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td style="width: 87.18%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">Consent of Gibson, Dunn &amp; Crutcher LLP (included in Exhibit 5.1).</div></td></tr><tr><td style="width: 10.26%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><a href="#tPOA">(24.1)</a></div></td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td style="width: 87.18%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">Power of Attorney (included on the signature page of this Registration Statement).</div></td></tr><tr><td style="width: 10.26%; text-align: left; vertical-align: top; padding-top: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;"><a href="nt10011234x1_ex25-1.htm">(25.1)</a></div></td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt;">&#8203;</td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt;">&#8203;</td><td style="width: 87.18%; text-align: left; vertical-align: top; padding-top: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">Statement of eligibility of trustee for debt securities on Form T-1.</div></td></tr></table><div><div class="rule-partial" style="height: 0pt; width: 72pt; border-bottom: 1pt solid #000000; margin-bottom: 1pt; margin-right: auto; margin-left: 0pt; margin-top: 12.25pt;"> </div></div><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 3pt; margin-left: 0pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt;">*<br></div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; text-align: left;">To be filed by amendment hereto or pursuant to a Current Report on Form 8-K to be incorporated herein by reference.</div></td></tr></table><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 3pt; margin-left: 0pt;"><tr><td style="width: 20pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt;">(&#8201;&#8201;&#8201;)<br></div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; text-align: left;">Filed herewith. </div></td></tr></table></div></div><div class="block-frill" style="width: 468pt; margin-top: 12pt; margin-left: 0pt;"><div class="unknown" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; text-align: center;">II-2<br></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="nt10011234x1_s3_201-part2_pg3"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><table border="0" cellpadding="0" cellspacing="0" style="margin-top: 12pt; margin-left: 0pt;"><tr><td style="width: 70pt; text-align: left; vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold;">ITEM 17.<br></div></td><td style="vertical-align: top;"><div style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; text-align: left;">UNDERTAKINGS.</div></td></tr></table><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 10.25pt; margin-left: 20pt; text-align: left;">The undersigned registrant hereby undertakes:</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">(1)&#8195;To file, during any period in which offers or sales are being made, a post-effective amendment to this registration statement:</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 11.25pt; margin-left: 40pt; text-align: left;">(a)&#8195;To include any prospectus required by Section 10(a)(3) of the Securities Act;</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 20pt; text-indent: 20pt; text-align: left;">(b)&#8195;To reflect in the prospectus any facts or events arising after the effective date of the registration statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in the registration statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price represent no more than a 20 percent change in the maximum aggregate offering price set forth in the &#8220;Calculation of Registration Fee&#8221; table in the effective registration statement; and</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 20pt; text-indent: 20pt; text-align: left;">(c)&#8195;To include any material information with respect to the plan of distribution not previously disclosed in the registration statement or any material change to such information in the registration statement.</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-style: italic; margin-top: 6pt; margin-left: 20pt; text-indent: 20pt; text-align: left;">Provided, however,<font style="font-style: normal;"> that paragraphs (1)(a), (1)(b) and (1)(c) do not apply if the information required to </font><font style="font-style: normal;">be included in a post-effective amendment by those paragraphs is contained in reports filed with or </font><font style="font-style: normal;">furnished to the Commission by the registrant pursuant to Section 13 or 15(d) of the Exchange Act that are </font><font style="font-style: normal;">incorporated by reference in the registration statement, or is contained in a form of prospectus filed pursuant </font><font style="font-style: normal;">to Rule 424(b) that is part of the registration statement.</font></div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">(2)&#8195;That, for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial <font style="font-style: italic;">bona fide</font> offering thereof.</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">(3)&#8195;To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 11.25pt; margin-left: 20pt; text-align: left;">(4)&#8195;That, for the purpose of determining liability under the Securities Act to any purchaser:</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 20pt; text-indent: 20pt; text-align: left;">(a)&#8195;Each prospectus filed by the registrant pursuant to Rule 424(b)(3) shall be deemed to be part of the registration statement as of the date the filed prospectus was deemed part of and included in the registration statement; and</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 20pt; text-indent: 20pt; text-align: left;">(b)&#8195;Each prospectus required to be filed pursuant to Rule 424(b)(2), (b)(5), or (b)(7) as part of a registration statement in reliance on Rule 430B relating to an offering made pursuant to Rule 415(a)(1)(i), (vii), or (x)&#160;for the purpose of providing the information required by section 10(a) of the Securities Act shall be deemed to be part of and included in the registration statement as of the earlier of the date such form of prospectus is first used after effectiveness or the date of the first contract of sale of securities in the offering described in the prospectus. As provided in Rule 430B, for liability purposes of the issuer and any person that is at that date an underwriter, such date shall be deemed to be a new effective date of the registration statement relating to the securities in the registration statement to which that prospectus relates, and the offering of such securities at that time shall be deemed to be the initial <font style="font-style: italic;">bona fide</font> offering thereof. <font style="font-style: italic;">Provided, </font><font style="font-style: italic;">however</font>, that no statement made in a registration statement or prospectus that is part of the registration statement or made in a document incorporated or deemed incorporated by reference into the registration statement or prospectus that is part of the registration statement will, as to a purchaser with a time of contract of sale prior to such effective date, supersede or modify any statement that was made in the registration statement or prospectus that was part of the registration statement or made in any such document immediately prior to such effective date.</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">(5)&#8195;That, for the purpose of determining liability of the registrant under the Securities Act to any purchaser in the initial distribution of the securities, the undersigned registrant undertakes that in a primary offering of securities of the undersigned registrant pursuant to this registration statement, regardless of the underwriting method used to sell the securities to the purchaser, if the securities are offered or sold to such purchaser by </div></div></div><div class="block-frill" style="width: 468pt; margin-top: 12pt; margin-left: 0pt;"><div class="unknown" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; text-align: center;">II-3<br></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="nt10011234x1_s3_201-part2_pg4"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">means of any of the following communications, the undersigned registrant will be a seller to the purchaser and will be considered to offer or sell such securities to such purchaser:</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 20pt; text-indent: 20pt; text-align: left;">(a)&#8195;Any preliminary prospectus or prospectus of the undersigned registrant relating to the offering required to be filed pursuant to Rule 424;</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 20pt; text-indent: 20pt; text-align: left;">(b)&#8195;Any free writing prospectus relating to the offering prepared by or on behalf of the undersigned registrant or used or referred to by the undersigned registrant;</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 20pt; text-indent: 20pt; text-align: left;">(c)&#8195;The portion of any other free writing prospectus relating to the offering containing material information about the undersigned registrant or its securities provided by or on behalf of the undersigned registrant; and</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 20pt; text-indent: 20pt; text-align: left;">(d)&#8195;Any other communication that is an offer in the offering made by the undersigned registrant to the purchaser.</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">(6)&#8195;The undersigned registrant hereby undertakes that, for purposes of determining any liability under the Securities Act, each filing of the registrant&#8217;s annual report pursuant to Section 13(a) or Section 15(d) of the Exchange Act that is incorporated by reference in the registration statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial <font style="font-style: italic;">bona fide</font> offering thereof.</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">(7)&#8195;Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the registrant pursuant to the foregoing provisions described in Item 15, or otherwise, the registrant has been advised that in the opinion of the Commission such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the registrant of expenses incurred or paid by a director, officer or controlling person of the registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.</div></div></div><div class="block-frill" style="width: 468pt; margin-top: 12pt; margin-left: 0pt;"><div class="unknown" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; text-align: center;">II-4<br></div></div></div>
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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="nt10011234x1_s3_300-sig_pg1"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 12pt; text-align: center;">SIGNATURES</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Pursuant to the requirements of the Securities Act of 1933, as amended, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-3 and has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Durham, State of North Carolina, on April 24, 2020.</div><table cellspacing="0" cellpadding="0" class="txttab" align="center" style="margin-top: 11.25pt; border-collapse: collapse; width: 468pt; margin-left: 0pt;"><tr><td style="width: 41.03%; text-align: left; vertical-align: top; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#160;</div></td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-bottom: 3pt;">&#8203;</td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-bottom: 3pt;">&#8203;</td><td colspan="4" style="width: 56.41%; text-align: left; vertical-align: bottom; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">BioCryst Pharmaceuticals, Inc.</div></td></tr><tr><td style="width: 41.03%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#160;</div></td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td style="width: 2.56%; text-align: left; vertical-align: bottom; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#160;</div></td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td style="width: 51.28%; text-align: left; vertical-align: bottom; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#160;</div></td></tr><tr><td style="width: 41.03%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 4.25pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#160;</div></td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 4.25pt;">&#8203;</td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 4.25pt;">&#8203;</td><td style="width: 2.56%; text-align: left; vertical-align: bottom; padding-top: 3pt; padding-bottom: 4.25pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">By: </div></td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 4.25pt;">&#8203;</td><td class="gutter" style="width: 1.28%; font-size: 2pt; padding-top: 3pt; padding-bottom: 4.25pt; border-bottom: 1px solid #ffffff;">&#8203;</td><td style="width: 51.28%; text-align: left; vertical-align: bottom; border-bottom: 1pt solid #000000; padding-top: 3pt; padding-bottom: 4.25pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">/s/ Jon P. Stonehouse </div></td></tr><tr><td style="width: 41.03%; text-align: left; vertical-align: top; padding-top: 4.25pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#160;</div></td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 4.25pt; padding-bottom: 3pt;">&#8203;</td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 4.25pt; padding-bottom: 3pt;">&#8203;</td><td style="width: 2.56%; text-align: left; vertical-align: bottom; padding-top: 4.25pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#160;</div></td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 4.25pt; padding-bottom: 3pt;">&#8203;</td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 4.25pt; padding-bottom: 3pt;">&#8203;</td><td style="width: 51.28%; text-align: left; vertical-align: bottom; padding-top: 4.25pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">Jon P. Stonehouse</div></td></tr><tr><td style="width: 41.03%; text-align: left; vertical-align: top; padding-top: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#160;</div></td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt;">&#8203;</td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt;">&#8203;</td><td style="width: 2.56%; text-align: left; vertical-align: bottom; padding-top: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#160;</div></td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt;">&#8203;</td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt;">&#8203;</td><td style="width: 51.28%; text-align: left; vertical-align: bottom; padding-top: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">President and Chief Executive Officer</div></td></tr></table><div class="h1" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; font-weight: bold; margin-top: 18.5pt; text-align: center;"><a name="tPOA"><!--Anchor--></a>POWER OF ATTORNEY</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Each of the undersigned officers and directors of BioCryst Pharmaceuticals, Inc. hereby severally constitutes and appoints Jon P. Stonehouse, Anthony Doyle, and Alane Barnes, and each of them singly, his or her true and lawful attorneys-in-fact and agent, with full power to them and each of them singly, with full and several power of substitution and resubstitution, to sign for him or her in his or her name in the capacities indicated below, any and all amendments (including post-effective amendments or any abbreviated Registration Statement, and any amendments thereto, filed pursuant to Rule 462(b) under the Securities Act of 1933, as amended), and to file the same, with all exhibits thereto, and other documents in connection therewith, with the Securities and Exchange Commission; granting unto said attorneys-in-fact and agents, and each of them, full power and authority to perform any other act on behalf of the undersigned required to be done in the premises, hereby ratifying and confirming all that said attorneys-in-fact and agents, or any of them or their substitutes or resubstitutes, lawfully do or cause to be done by virtue hereof.</div><div class="para" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 6pt; margin-left: 0pt; text-indent: 20pt; text-align: left;">Pursuant to the requirements of the Securities Act of 1933, this registration statement has been signed by the following persons in the capacities indicated on April 24, 2020.</div><table cellspacing="0" cellpadding="0" class="txttab" align="center" style="margin-top: 11.25pt; border-collapse: collapse; width: 468pt; margin-left: 0pt;"><tr class="header"><td style="width: 41.03%; text-align: center; vertical-align: bottom; border-bottom: 1pt solid #000000; padding-bottom: 4.25pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">Name</div></td><td class="gutter" style="width: 1.28%; font-size: 2pt; padding-bottom: 4.25pt; border-bottom: 1px solid #ffffff;">&#8203;</td><td class="gutter" style="width: 1.28%; font-size: 2pt; padding-bottom: 4.25pt; border-bottom: 1px solid #ffffff;">&#8203;</td><td style="width: 56.41%; text-align: center; vertical-align: bottom; border-bottom: 1pt solid #000000; padding-bottom: 4.25pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">Title</div></td></tr><tr><td style="width: 41.03%; text-align: left; vertical-align: top; border-bottom: 1pt solid #000000; padding-top: 4.25pt; padding-bottom: 4.25pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">/s/ Jon P. 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<div class="page" style="text-align: left; margin: auto; position: relative; width: 468pt;"><a name="nt10011234x1_s3_300-sig_pg2"><!--Anchor--></a><p style="text-align: left; font-family: 'Times New Roman', Times, Serif; font-size: 8pt; font-variant: normal; font-weight: bold"><a href="#TOC">TABLE OF CONTENTS</a></p><div class="page-content"><div class="block-main" style="width: 468pt; margin-left: 0pt;"><table cellspacing="0" cellpadding="0" class="txttab" align="center" style="margin-top: 4pt; border-collapse: collapse; width: 468pt; margin-left: 0pt;"><tr class="header"><td style="width: 41.03%; text-align: center; vertical-align: bottom; border-bottom: 1pt solid #000000; padding-bottom: 4.25pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">Name</div></td><td class="gutter" style="width: 1.28%; font-size: 2pt; padding-bottom: 4.25pt; border-bottom: 1px solid #ffffff;">&#8203;</td><td class="gutter" style="width: 1.28%; font-size: 2pt; padding-bottom: 4.25pt; border-bottom: 1px solid #ffffff;">&#8203;</td><td style="width: 56.41%; text-align: center; vertical-align: bottom; border-bottom: 1pt solid #000000; padding-bottom: 4.25pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 8pt; font-weight: bold; margin-top: 0pt; text-align: center;">Title</div></td></tr><tr><td style="width: 41.03%; text-align: left; vertical-align: top; border-bottom: 1pt solid #000000; padding-top: 4.25pt; padding-bottom: 4.25pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">/s/ Robert A. Ingram </div></td><td class="gutter" style="width: 1.28%; font-size: 2pt; padding-top: 4.25pt; padding-bottom: 4.25pt; border-bottom: 1px solid #ffffff;">&#8203;</td><td class="gutter" rowspan="2" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 4.25pt; padding-bottom: 4.25pt;">&#8203;</td><td rowspan="2" style="width: 56.41%; text-align: center; vertical-align: top; padding-top: 4.25pt; padding-bottom: 4.25pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; text-align: center;">Director</div></td></tr><tr><td style="width: 41.03%; text-align: left; vertical-align: top; padding-top: 4.25pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">Robert A. 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Lee, Jr.</div></td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 4.25pt; padding-bottom: 3pt;">&#8203;</td></tr><tr><td style="width: 41.03%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#160;</div></td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td style="width: 56.41%; text-align: center; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#160;</div></td></tr><tr><td style="width: 41.03%; text-align: left; vertical-align: top; border-bottom: 1pt solid #000000; padding-top: 3pt; padding-bottom: 4.25pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">/s/ Alan G. Levin </div></td><td class="gutter" style="width: 1.28%; font-size: 2pt; padding-top: 3pt; padding-bottom: 4.25pt; border-bottom: 1px solid #ffffff;">&#8203;</td><td class="gutter" rowspan="2" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 4.25pt;">&#8203;</td><td rowspan="2" style="width: 56.41%; text-align: center; vertical-align: top; padding-top: 3pt; padding-bottom: 4.25pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; text-align: center;">Director</div></td></tr><tr><td style="width: 41.03%; text-align: left; vertical-align: top; padding-top: 4.25pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">Alan G. Levin</div></td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 4.25pt; padding-bottom: 3pt;">&#8203;</td></tr><tr><td style="width: 41.03%; text-align: left; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#160;</div></td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 3pt;">&#8203;</td><td style="width: 56.41%; text-align: center; vertical-align: top; padding-top: 3pt; padding-bottom: 3pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt;">&#160;</div></td></tr><tr><td style="width: 41.03%; text-align: left; vertical-align: top; border-bottom: 1pt solid #000000; padding-top: 3pt; padding-bottom: 4.25pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">/s/ Helen Thackray, M.D. </div></td><td class="gutter" style="width: 1.28%; font-size: 2pt; padding-top: 3pt; padding-bottom: 4.25pt; border-bottom: 1px solid #ffffff;">&#8203;</td><td class="gutter" rowspan="2" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 3pt; padding-bottom: 4.25pt;">&#8203;</td><td rowspan="2" style="width: 56.41%; text-align: center; vertical-align: top; padding-top: 3pt; padding-bottom: 4.25pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; text-align: center;">Director</div></td></tr><tr><td style="width: 41.03%; text-align: left; vertical-align: top; padding-top: 4.25pt;"><div class="fpara" style="color: #000000; font-family: 'Times New Roman', Times, serif; font-size: 10pt; margin-top: 0pt; margin-left: 0pt; text-align: left;">Helen Thackray, M.D.</div></td><td class="gutter" style="width: 1.28%; border-bottom: none; font-size: 2pt; padding-top: 4.25pt;">&#8203;</td></tr></table></div></div></div>
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<DOCUMENT>
<TYPE>EX-4.9
<SEQUENCE>2
<FILENAME>nt10011234x1_ex4-9.htm
<DESCRIPTION>EXHIBIT 4.9
<TEXT>
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      <div>
        <div style="text-align: right; font-weight: bold;">Exhibit 4.9</div>
        <div>&#160;</div>
        <div style="text-align: right; font-weight: bold;">EXECUTION VERSION</div>
        <div>&#160;</div>
        <div style="text-align: center; font-weight: bold;">BIOCRYST PHARMACEUTICALS, INC.</div>
        <div>&#160;</div>
        <div style="text-align: center; font-weight: bold;">Debt Securities</div>
        <div>&#160;</div>
        <div style="text-align: center; font-weight: bold;"><u>Indenture</u></div>
        <div>&#160;</div>
        <div style="text-align: center; font-size: 12pt;"><font style="font-size: 10pt; font-weight: bold;">Dated as of </font><font style="font-size: 10pt;">[___]</font></div>
        <div>&#160;</div>
        <div style="text-align: center; font-weight: bold;"><a name="z_9kMHG5YVtAB567F"></a>U.S. BANK NATIONAL ASSOCIATION.,</div>
        <div>&#160;</div>
        <div style="text-align: center; font-weight: bold;">as Trustee</div>
        <div>&#160;</div>
        <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
          <div style="page-break-after:always;" id="DSPFPageBreak">
            <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
        </div>
        <div style="text-align: center; font-weight: bold;">CROSS-REFERENCE TABLE</div>
        <div>&#160;</div>
        <div style="text-align: center;"><u>This Cross-Reference Table is not a part of the Indenture</u></div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" border="0" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 49.99%; vertical-align: top;">
                <div style="font-weight: bold;">TIA Section</div>
              </td>
              <td style="width: 50.01%; vertical-align: bottom;">
                <div style="text-align: right; font-weight: bold;">Indenture Section</div>
              </td>
            </tr>
            <tr>
              <td style="width: 49.99%; vertical-align: top;">
                <div>310(a)(1)</div>
              </td>
              <td style="width: 50.01%; vertical-align: bottom;">
                <div style="text-align: right;">7.10</div>
              </td>
            </tr>
            <tr>
              <td style="width: 49.99%; vertical-align: top;">
                <div>(a)(2)</div>
              </td>
              <td style="width: 50.01%; vertical-align: bottom;">
                <div style="text-align: right;">7.10</div>
              </td>
            </tr>
            <tr>
              <td style="width: 49.99%; vertical-align: top;">
                <div>(a)(3)</div>
              </td>
              <td style="width: 50.01%; vertical-align: bottom;">
                <div style="text-align: right;">N.A.</div>
              </td>
            </tr>
            <tr>
              <td style="width: 49.99%; vertical-align: top;">
                <div>(a)(4)</div>
              </td>
              <td style="width: 50.01%; vertical-align: bottom;">
                <div style="text-align: right;">N.A.</div>
              </td>
            </tr>
            <tr>
              <td style="width: 49.99%; vertical-align: top;">
                <div><a name="z_9kR3WTr8E8458k"></a>(b)</div>
              </td>
              <td style="width: 50.01%; vertical-align: bottom;">
                <div style="text-align: right;">7.08; 7.10; 12.02</div>
              </td>
            </tr>
            <tr>
              <td style="width: 49.99%; vertical-align: top;">
                <div>311(a)</div>
              </td>
              <td style="width: 50.01%; vertical-align: bottom;">
                <div style="text-align: right;">7.11</div>
              </td>
            </tr>
            <tr>
              <td style="width: 49.99%; vertical-align: top;">
                <div><a name="z_9kR3WTr8F9459l"></a>(b)</div>
              </td>
              <td style="width: 50.01%; vertical-align: bottom;">
                <div style="text-align: right;">7.11</div>
              </td>
            </tr>
            <tr>
              <td style="width: 49.99%; vertical-align: top;">
                <div>(c)</div>
              </td>
              <td style="width: 50.01%; vertical-align: bottom;">
                <div style="text-align: right;">N.A.</div>
              </td>
            </tr>
            <tr>
              <td style="width: 49.99%; vertical-align: top;">
                <div>312(a)</div>
              </td>
              <td style="width: 50.01%; vertical-align: bottom;">
                <div style="text-align: right;">2.05</div>
              </td>
            </tr>
            <tr>
              <td style="width: 49.99%; vertical-align: top;">
                <div><a name="z_9kMHG5YVtAGA67Am"></a>(b)</div>
              </td>
              <td style="width: 50.01%; vertical-align: bottom;">
                <div style="text-align: right;">12.03</div>
              </td>
            </tr>
            <tr>
              <td style="width: 49.99%; vertical-align: top;">
                <div>(c)</div>
              </td>
              <td style="width: 50.01%; vertical-align: bottom;">
                <div style="text-align: right;">12.03</div>
              </td>
            </tr>
            <tr>
              <td style="width: 49.99%; vertical-align: top;">
                <div>313(a)</div>
              </td>
              <td style="width: 50.01%; vertical-align: bottom;">
                <div style="text-align: right;">7.06</div>
              </td>
            </tr>
            <tr>
              <td style="width: 49.99%; vertical-align: top;">
                <div>(b)(1)</div>
              </td>
              <td style="width: 50.01%; vertical-align: bottom;">
                <div style="text-align: right;">N.A.</div>
              </td>
            </tr>
            <tr>
              <td style="width: 49.99%; vertical-align: top;">
                <div>(b)(2)</div>
              </td>
              <td style="width: 50.01%; vertical-align: bottom;">
                <div style="text-align: right;">7.06</div>
              </td>
            </tr>
            <tr>
              <td style="width: 49.99%; vertical-align: top;">
                <div><a name="z_9kR3WTr8F945An"></a>(c)</div>
              </td>
              <td style="width: 50.01%; vertical-align: bottom;">
                <div style="text-align: right;">12.02</div>
              </td>
            </tr>
            <tr>
              <td style="width: 49.99%; vertical-align: top;">
                <div>(d)</div>
              </td>
              <td style="width: 50.01%; vertical-align: bottom;">
                <div style="text-align: right;">7.06</div>
              </td>
            </tr>
            <tr>
              <td style="width: 49.99%; vertical-align: top;">
                <div>314(a)</div>
              </td>
              <td style="width: 50.01%; vertical-align: bottom;">
                <div style="text-align: right;">4.03; 12.02</div>
              </td>
            </tr>
            <tr>
              <td style="width: 49.99%; vertical-align: top;">
                <div><a name="z_9kMIH5YVtAGA67Am"></a>(b)</div>
              </td>
              <td style="width: 50.01%; vertical-align: bottom;">
                <div style="text-align: right;">N.A.</div>
              </td>
            </tr>
            <tr>
              <td style="width: 49.99%; vertical-align: top;">
                <div>(c)(1)</div>
              </td>
              <td style="width: 50.01%; vertical-align: bottom;">
                <div style="text-align: right;">12.04</div>
              </td>
            </tr>
            <tr>
              <td style="width: 49.99%; vertical-align: top;">
                <div>(c)(2)</div>
              </td>
              <td style="width: 50.01%; vertical-align: bottom;">
                <div style="text-align: right;">12.04</div>
              </td>
            </tr>
            <tr>
              <td style="width: 49.99%; vertical-align: top;">
                <div>(c)(3)</div>
              </td>
              <td style="width: 50.01%; vertical-align: bottom;">
                <div style="text-align: right;">N.A.</div>
              </td>
            </tr>
            <tr>
              <td style="width: 49.99%; vertical-align: top;">
                <div><a name="z_9kR3WTr8E845Bp"></a>(d)</div>
              </td>
              <td style="width: 50.01%; vertical-align: bottom;">
                <div style="text-align: right;">N.A.</div>
              </td>
            </tr>
            <tr>
              <td style="width: 49.99%; vertical-align: top;">
                <div>(e)</div>
              </td>
              <td style="width: 50.01%; vertical-align: bottom;">
                <div style="text-align: right;">12.05</div>
              </td>
            </tr>
            <tr>
              <td style="width: 49.99%; vertical-align: top;">
                <div>315(a)</div>
              </td>
              <td style="width: 50.01%; vertical-align: bottom;">
                <div style="text-align: right;">7.01(b)</div>
              </td>
            </tr>
            <tr>
              <td style="width: 49.99%; vertical-align: top;">
                <div><a name="z_9kMJI5YVtAGA67Am"></a>(b)</div>
              </td>
              <td style="width: 50.01%; vertical-align: bottom;">
                <div style="text-align: right;">7.05; 12.02</div>
              </td>
            </tr>
            <tr>
              <td style="width: 49.99%; vertical-align: top;">
                <div>(c)</div>
              </td>
              <td style="width: 50.01%; vertical-align: bottom;">
                <div style="text-align: right;">7.01(a)</div>
              </td>
            </tr>
            <tr>
              <td style="width: 49.99%; vertical-align: top;">
                <div>(d)</div>
              </td>
              <td style="width: 50.01%; vertical-align: bottom;">
                <div style="text-align: right;">7.01(c)</div>
              </td>
            </tr>
            <tr>
              <td style="width: 49.99%; vertical-align: top;">
                <div>(e)</div>
              </td>
              <td style="width: 50.01%; vertical-align: bottom;">
                <div style="text-align: right;">6.11</div>
              </td>
            </tr>
            <tr>
              <td style="width: 49.99%; vertical-align: top;">
                <div>316(a)(last sentence)</div>
              </td>
              <td style="width: 50.01%; vertical-align: bottom;">
                <div style="text-align: right;">12.06</div>
              </td>
            </tr>
            <tr>
              <td style="width: 49.99%; vertical-align: top;">
                <div>(a)(1)(A)</div>
              </td>
              <td style="width: 50.01%; vertical-align: bottom;">
                <div style="text-align: right;">6.05</div>
              </td>
            </tr>
            <tr>
              <td style="width: 49.99%; vertical-align: top;">
                <div>(a)(1)(B)</div>
              </td>
              <td style="width: 50.01%; vertical-align: bottom;">
                <div style="text-align: right;">6.04</div>
              </td>
            </tr>
            <tr>
              <td style="width: 49.99%; vertical-align: top;">
                <div>(a)(2)</div>
              </td>
              <td style="width: 50.01%; vertical-align: bottom;">
                <div style="text-align: right;">N.A.</div>
              </td>
            </tr>
            <tr>
              <td style="width: 49.99%; vertical-align: top;">
                <div><a name="z_9kMKJ5YVtAGA67Am"></a>(b)</div>
              </td>
              <td style="width: 50.01%; vertical-align: bottom;">
                <div style="text-align: right;">6.07</div>
              </td>
            </tr>
            <tr>
              <td style="width: 49.99%; vertical-align: top;">
                <div>317(a)(1)</div>
              </td>
              <td style="width: 50.01%; vertical-align: bottom;">
                <div style="text-align: right;">6.08</div>
              </td>
            </tr>
            <tr>
              <td style="width: 49.99%; vertical-align: top;">
                <div>(a)(2)</div>
              </td>
              <td style="width: 50.01%; vertical-align: bottom;">
                <div style="text-align: right;">6.09</div>
              </td>
            </tr>
            <tr>
              <td style="width: 49.99%; vertical-align: top;">
                <div>(b)d</div>
              </td>
              <td style="width: 50.01%; vertical-align: bottom;">
                <div style="text-align: right;">2.04</div>
              </td>
            </tr>
            <tr>
              <td style="width: 49.99%; vertical-align: top;">
                <div>318(a)</div>
              </td>
              <td style="width: 50.01%; vertical-align: bottom;">
                <div style="text-align: right;">12.01</div>
              </td>
            </tr>

        </table>
        <div><br>
        </div>
        <div>N.A. means Not Applicable.</div>
        <div><br>
        </div>
        <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
          <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">i</font></div>
          <div style="page-break-after:always;" id="DSPFPageBreak">
            <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
        </div>
        <div style="text-align: center; font-weight: bold;">TABLE OF CONTENTS</div>
        <div>&#160;</div>
        <div style="text-align: center;"><u>This Table of Contents is not a part of the Indenture</u></div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" border="0" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 13%; vertical-align: top;">&#160;</td>
              <td style="width: 82%; vertical-align: top;">&#160;</td>
              <td style="width: 5%; vertical-align: top;">
                <div style="text-align: right;"><u>Page</u></div>
              </td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top;">&#160;</td>
              <td style="width: 82%; vertical-align: top;">&#160;</td>
              <td style="width: 5%; vertical-align: top;">&#160;</td>
            </tr>
            <tr>
              <td colspan="3" style="vertical-align: top;">
                <div style="text-align: center; font-weight: bold;">ARTICLE ONE</div>
              </td>
            </tr>
            <tr>
              <td colspan="3" style="vertical-align: top;">
                <div style="text-align: center; font-weight: bold;">DEFINITIONS AND INCORPORATION BY REFERENCE</div>
              </td>
            </tr>
            <tr>
              <td colspan="3" style="vertical-align: top;">&#160;</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Section 1.01</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Definitions.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div style="text-align: right;">1</div>
              </td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Section 1.02</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Other Definitions.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(255, 255, 255); text-align: right;">4</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Section 1.03</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Incorporation by Reference of Trust Indenture Act.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: right;">5</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Section 1.04</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Rules of Construction.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(255, 255, 255); text-align: right;">5</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: right;">&#160;</td>
            </tr>
            <tr>
              <td colspan="3" style="vertical-align: top; background-color: rgb(255, 255, 255);">
                <div style="text-align: center; font-weight: bold;">ARTICLE TWO</div>
              </td>
            </tr>
            <tr>
              <td colspan="3" style="vertical-align: top; background-color: rgb(204, 238, 255);">
                <div style="text-align: center; font-weight: bold;">THE SECURITIES</div>
              </td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(255, 255, 255); text-align: right;">&#160;</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Section 2.01</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Form and Dating.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: right;">6</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Section 2.02</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Execution and Authentication.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(255, 255, 255); text-align: right;">8</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Section 2.03</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Registrar and Paying Agent.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: right;">9</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Section 2.04</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Paying Agent to Hold Money in Trust.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(255, 255, 255); text-align: right;">9</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Section 2.05</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Securityholder Lists.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: right;">9</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Section 2.06</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Transfer and Exchange.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div style="text-align: right;">10</div>
              </td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Section 2.07</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Replacement Securities.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: right;">10</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Section 2.08</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Outstanding Securities.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(255, 255, 255); text-align: right;">10</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Section 2.09</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Temporary Securities.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: right;">11</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Section 2.10</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Cancellation.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(255, 255, 255); text-align: right;">11</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Section 2.11</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Defaulted Interest.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: right;">11</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Section 2.12</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Treasury Securities.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(255, 255, 255); text-align: right;">11</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Section 2.13</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>CUSIP/ISIN Numbers.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: right;">12</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Section 2.14</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Deposit of Moneys.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(255, 255, 255); text-align: right;">12</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Section 2.15</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Book-Entry Provisions for Global Security.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: right;">12</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Section 2.16</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>No Duty to Monitor.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(255, 255, 255); text-align: right;">14</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: right;">&#160;</td>
            </tr>
            <tr>
              <td colspan="3" style="vertical-align: top; background-color: rgb(255, 255, 255);">
                <div style="text-align: center; font-weight: bold;">ARTICLE THREE</div>
              </td>
            </tr>
            <tr>
              <td colspan="3" style="vertical-align: top; background-color: rgb(204, 238, 255);">
                <div style="text-align: center; font-weight: bold;">REDEMPTION</div>
              </td>
            </tr>
            <tr>
              <td colspan="3" style="vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Section 3.01</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Notices to Trustee.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: right;">14</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Section 3.02</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Selection of Securities to be Redeemed.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(255, 255, 255); text-align: right;">15</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Section 3.03</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Notice of Redemption.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: right;">15</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Section 3.04</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Effect of Notice of Redemption.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(255, 255, 255); text-align: right;">16</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Section 3.05</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Deposit of Redemption Price.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: right;">16</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Section 3.06</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Securities Redeemed in Part.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(255, 255, 255); text-align: right;">16</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: right;">&#160;</td>
            </tr>
            <tr>
              <td colspan="3" style="vertical-align: top; background-color: rgb(255, 255, 255);">
                <div style="text-align: center; font-weight: bold;">ARTICLE FOUR</div>
              </td>
            </tr>
            <tr>
              <td colspan="3" style="vertical-align: top; background-color: rgb(204, 238, 255);">
                <div style="text-align: center; font-weight: bold;">COVENANTS</div>
              </td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(255, 255, 255); text-align: right;">&#160;</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Section 4.01</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Payment of Securities.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: right;">17</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Section 4.02</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Maintenance of Office or Agency.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(255, 255, 255); text-align: right;">17</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Section 4.03</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Compliance Certificate.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: right;">17</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Section 4.04</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Waiver of Stay, Extension or Usury Laws.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(255, 255, 255); text-align: right;">17</td>
            </tr>

        </table>
        <div><br>
        </div>
        <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
          <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">ii</font></div>
          <div id="DSPFPageBreak" style="page-break-after: always;">
            <hr style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;" noshade="noshade"></div>
        </div>
        <div>
          <div style="text-align: center; font-size: 12pt; font-weight: bold;"><a name="TOCHeadingContinued_1"></a><font style="font-size: 10pt;">TABLE OF CONTENTS<br>
              (<font style="font-style: italic;">continued</font>)</font></div>
          <div>&#160;</div>
        </div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" border="0" cellpadding="0" cellspacing="0">

            <tr>
              <td rowspan="1" colspan="2" style="vertical-align: top;">&#160;</td>
              <td rowspan="1" style="vertical-align: top;">
                <div style="text-align: right;"><u>Page</u></div>
              </td>
            </tr>
            <tr>
              <td rowspan="1" colspan="3" style="vertical-align: top;">&#160;</td>
            </tr>
            <tr>
              <td colspan="3" style="vertical-align: top;">
                <div style="text-align: center; font-weight: bold;">ARTICLE FIVE</div>
              </td>
            </tr>
            <tr>
              <td colspan="3" style="vertical-align: top; background-color: rgb(255, 255, 255);">
                <div style="text-align: center; font-weight: bold;">SUCCESSOR CORPORATION</div>
              </td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top;">&#160;</td>
              <td style="width: 82%; vertical-align: top;">&#160;</td>
              <td style="width: 5%; vertical-align: top;">&#160;</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Section 5.01</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Company May Merge, etc.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: right;">18</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(255, 255, 255); text-align: right;">&#160;</td>
            </tr>
            <tr>
              <td colspan="3" style="vertical-align: top; background-color: rgb(204, 238, 255);">
                <div style="text-align: center; font-weight: bold;">ARTICLE SIX</div>
              </td>
            </tr>
            <tr>
              <td colspan="3" style="vertical-align: top; background-color: rgb(255, 255, 255);">
                <div style="text-align: center; font-weight: bold;">DEFAULTS AND REMEDIES</div>
              </td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: right;">&#160;</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Section 6.01</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Events of Default.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(255, 255, 255); text-align: right;">18</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Section 6.02</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Acceleration.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div style="text-align: right;">19</div>
              </td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Section 6.03</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Other Remedies.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(255, 255, 255); text-align: right;">20</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Section 6.04</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Waiver of Existing Defaults.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: right;">20</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Section 6.05</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Control by Majority.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(255, 255, 255); text-align: right;">20</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Section 6.06</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Limitation on Suits.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: right;">21</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Section 6.07</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Rights of Holders to Receive Payment.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(255, 255, 255); text-align: right;">21</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Section 6.08</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Collection Suit by Trustee.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: right;">21</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Section 6.09</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Trustee May File Proofs of Claim.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(255, 255, 255); text-align: right;">22</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Section 6.10</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Priorities.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: right;">22</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Section 6.11</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Undertaking for Costs.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(255, 255, 255); text-align: right;">22</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: right;">&#160;</td>
            </tr>
            <tr>
              <td colspan="3" style="vertical-align: top; background-color: rgb(255, 255, 255);">
                <div style="text-align: center; font-weight: bold;">ARTICLE SEVEN</div>
              </td>
            </tr>
            <tr>
              <td colspan="3" style="vertical-align: top; background-color: rgb(204, 238, 255);">
                <div style="text-align: center; font-weight: bold;">TRUSTEE</div>
              </td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(255, 255, 255); text-align: right;">&#160;</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Section 7.01</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Duties of Trustee.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: right;">22</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Section 7.02</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Rights of Trustee.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(255, 255, 255); text-align: right;">24</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Section 7.03</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Individual Rights of Trustee.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: right;">25</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Section 7.04</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Trustee&#8217;s Disclaimer.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(255, 255, 255); text-align: right;">25</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Section 7.05</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Notice of Defaults.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: right;">26</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Section 7.06</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Reports by Trustee to Holders.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(255, 255, 255); text-align: right;">26</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Section 7.07</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Compensation and Indemnity.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: right;">26</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Section 7.08</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Replacement of Trustee.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(255, 255, 255); text-align: right;">27</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Section 7.09</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Successor Trustee by Merger, etc.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: right;">27</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Section 7.10</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Eligibility; Disqualification.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(255, 255, 255); text-align: right;">28</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Section 7.11</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Preferential Collection of Claims Against Company.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: right;">28</td>
            </tr>

        </table>
        <div><br>
        </div>
        <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
          <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">iii</font></div>
          <div id="DSPFPageBreak" style="page-break-after: always;">
            <hr style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;" noshade="noshade"></div>
        </div>
        <div>
          <div style="text-align: center; font-size: 12pt; font-weight: bold;"><font style="font-size: 10pt;">TABLE OF CONTENTS<br>
              (<font style="font-style: italic;">continued</font>)</font></div>
          <div>&#160;</div>
        </div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" border="0" cellpadding="0" cellspacing="0">

            <tr>
              <td rowspan="1" colspan="2" style="vertical-align: top;">&#160;</td>
              <td rowspan="1" style="vertical-align: top;">
                <div style="text-align: right;"><u>Page</u></div>
              </td>
            </tr>
            <tr>
              <td rowspan="1" colspan="3" style="vertical-align: top;">&#160;</td>
            </tr>
            <tr>
              <td colspan="3" style="vertical-align: top;">
                <div style="text-align: center; font-weight: bold;">ARTICLE EIGHT</div>
              </td>
            </tr>
            <tr>
              <td colspan="3" style="vertical-align: top; background-color: rgb(255, 255, 255);">
                <div style="text-align: center; font-weight: bold;">DISCHARGE OF INDENTURE</div>
              </td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top;">&#160;</td>
              <td style="width: 82%; vertical-align: top;">&#160;</td>
              <td style="width: 5%; vertical-align: top;">&#160;</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Section 8.01</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Defeasance upon Deposit of Moneys or Government Obligations.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: right;">28</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Section 8.02</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Survival of the Company&#8217;s Obligations.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(255, 255, 255); text-align: right;">31</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Section 8.03</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Application of Trust Money.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: right;">31</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Section 8.04</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Repayment to the Company.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(255, 255, 255); text-align: right;">31</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Section 8.05</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Reinstatement.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: right;">31</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(255, 255, 255); text-align: right;">&#160;</td>
            </tr>
            <tr>
              <td colspan="3" style="vertical-align: top; background-color: rgb(204, 238, 255);">
                <div style="text-align: center; font-weight: bold;">ARTICLE NINE</div>
              </td>
            </tr>
            <tr>
              <td colspan="3" style="vertical-align: top; background-color: rgb(255, 255, 255);">
                <div style="text-align: center; font-weight: bold;">RESERVED</div>
              </td>
            </tr>
            <tr>
              <td colspan="3" style="vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
            </tr>
            <tr>
              <td colspan="3" style="vertical-align: top; background-color: rgb(255, 255, 255);">
                <div style="text-align: center; font-weight: bold;">ARTICLE TEN</div>
              </td>
            </tr>
            <tr>
              <td colspan="3" style="vertical-align: top; background-color: rgb(204, 238, 255);">
                <div style="text-align: center; font-weight: bold;">AMENDMENTS, SUPPLEMENTS AND WAIVERS</div>
              </td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(255, 255, 255); text-align: right;">&#160;</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Section 10.01</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Without Consent of Holders.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: right;">32</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Section 10.02</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>With Consent of Holders.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(255, 255, 255); text-align: right;">33</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Section 10.03</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Compliance with Trust Indenture Act.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: right;">34</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Section 10.04</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Revocation and Effect of Consents.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(255, 255, 255); text-align: right;">34</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Section 10.05</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Notation on or Exchange of Securities.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: right;">35</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Section 10.06</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Trustee to Sign Amendments, etc.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(255, 255, 255); text-align: right;">35</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: right;">&#160;</td>
            </tr>
            <tr>
              <td colspan="3" style="vertical-align: top; background-color: rgb(255, 255, 255);">
                <div style="text-align: center; font-weight: bold;">ARTICLE ELEVEN</div>
              </td>
            </tr>
            <tr>
              <td colspan="3" style="vertical-align: top; background-color: rgb(204, 238, 255);">
                <div style="text-align: center; font-weight: bold;">SECURITIES IN FOREIGN CURRENCIES</div>
              </td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(255, 255, 255); text-align: right;">&#160;</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Section 11.01</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Applicability of Article.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: right;">35</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(255, 255, 255); text-align: right;">&#160;</td>
            </tr>
            <tr>
              <td colspan="3" style="vertical-align: top; background-color: rgb(204, 238, 255);">
                <div style="text-align: center; font-weight: bold;">ARTICLE TWELVE</div>
              </td>
            </tr>
            <tr>
              <td colspan="3" style="vertical-align: top; background-color: rgb(255, 255, 255);">
                <div style="text-align: center; font-weight: bold;">MISCELLANEOUS</div>
              </td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: right;">&#160;</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Section 12.01</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Trust Indenture Act Controls.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(255, 255, 255); text-align: right;">35</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Section 12.02</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Notices.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: right;">36</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Section 12.03</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Communications by Holders with Other Holders.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(255, 255, 255); text-align: right;">37</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Section 12.04</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Certificate and Opinion as to Conditions Precedent.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: right;">37</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Section 12.05</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Statements Required in Certificate or Opinion.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(255, 255, 255); text-align: right;">37</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Section 12.06</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Rules by Trustee and Agents.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div style="text-align: right;">38</div>
              </td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Section 12.07</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Legal Holidays.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(255, 255, 255); text-align: right;">38</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Section 12.08</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Governing Law.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: right;">38</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Section 12.09</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>No Adverse Interpretation of Other Agreements.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(255, 255, 255); text-align: right;">38</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Section 12.10</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>No Recourse Against Others.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: right;">38</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Section 12.11</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Successors and Assigns.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(255, 255, 255); text-align: right;">38</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Section 12.12</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Duplicate Originals.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: right;">38</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Section 12.13</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(255, 255, 255);">
                <div>Severability.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(255, 255, 255); text-align: right;">39</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Section 12.14</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>Waiver of Jury Trial.</div>
              </td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: right;">39</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(255, 255, 255);">&#160;</td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(255, 255, 255); text-align: right;">&#160;</td>
            </tr>
            <tr>
              <td style="width: 13%; vertical-align: top; background-color: rgb(204, 238, 255);">
                <div>SIGNATURES</div>
              </td>
              <td style="width: 82%; vertical-align: top; background-color: rgb(204, 238, 255);">&#160;</td>
              <td style="width: 5%; vertical-align: top; background-color: rgb(204, 238, 255); text-align: right;">&#160;</td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
          <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">iv</font></div>
          <div style="page-break-after:always;" id="DSPFPageBreak">
            <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
        </div>
        <div style="text-indent: 36pt;">INDENTURE dated as of <a name="z_9kR3WTr6GC45E"></a>[___], (the &#8220;<font style="font-weight: bold;">Base Indenture</font>&#8221;), by and among BIOCRYST PHARMACEUTICALS, INC., a Delaware corporation (together with its
          successors and assigns, the &#8220;<font style="font-weight: bold;">Company</font>&#8221;), and <a name="z_9kMIH5YVtAB567F"></a>U.S. Bank National Association, a national banking association, as trustee (the &#8220;<font style="font-weight: bold;">Trustee</font>&#8221;).</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">Each party agrees as follows for the benefit of the other party and for the equal and ratable benefit of the Holders of the Company&#8217;s debt securities issued under this Base Indenture:</div>
        <div>&#160;</div>
        <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;"><a name="z_Toc37987180"></a>ARTICLE ONE</div>
        <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;"><a name="z_Toc37968765"></a>DEFINITIONS AND INCORPORATION BY REFERENCE</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968766"></a><a name="z_Toc37987181"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 1.01</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Definitions.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">&#8220;<font style="font-weight: bold;">Affiliate</font>&#8221; means, when used with reference to a specified person, any Person directly or indirectly controlling or controlled by or under direct or indirect common control
          with the Person specified.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">&#8220;<font style="font-weight: bold;">Agent</font>&#8221; means any Registrar, Paying Agent or co-Registrar or agent for service of notices and demands.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">&#8220;<font style="font-weight: bold;">Authorizing Resolution</font>&#8221; means a resolution adopted by the Board of Directors or by an Officer or committee of Officers pursuant to delegation by the Board of Directors
          authorizing a Series of Securities which shall be delivered to the Trustee.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">&#8220;<font style="font-weight: bold;">Bankruptcy Law</font>&#8221; means Title 11 of the United States Code, as amended, or any similar federal or state law for the relief of debtors.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">&#8220;<font style="font-weight: bold;">Board of Directors</font>&#8221; means the Board of Directors of the Company or any duly authorized committee thereof.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">&#8220;<font style="font-weight: bold;">Capital Stock</font>&#8221; means, with respect to any Person, any and all shares, interests, participations or other equivalents (however designated) of or in such Person&#8217;s capital stock
          or other equity interests.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">&#8220;<font style="font-weight: bold;">control</font>&#8221; means, when used with respect to any Person, the power to direct the management and policies of such Person, directly or indirectly, whether through the ownership of
          voting securities, by contract or otherwise; and the terms &#8220;<u>controlling</u>&#8221; and &#8220;<u>controlled</u>&#8221; have meanings correlative to the foregoing.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">&#8220;<font style="font-weight: bold;">Default</font>&#8221; means any event, act or condition that is, or after notice or the passage of time or both would be, an Event of Default.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">&#8220;<font style="font-weight: bold;">Definitive Security</font>&#8221; means a certificated Security registered in the name of the Securityholder thereof.</div>
        <div>&#160;</div>
        <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
          <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">1</font></div>
          <div style="page-break-after:always;" id="DSPFPageBreak">
            <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
        </div>
        <div style="text-indent: 36pt;">&#8220;<font style="font-weight: bold;">Depositary</font>&#8221; means, with respect to Securities of any Series which the Company shall determine will be issued in whole or in part as a Global Security, DTC, another clearing
          agency, or any successor registered as a clearing agency under the Exchange Act, and any other applicable U.S. or foreign statute or regulation, which, in each case, shall be designated by the Company pursuant to <u>Section&#160;2.01</u>.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">&#8220;<font style="font-weight: bold;">Dollars</font>&#8221; and &#8220;<font style="font-weight: bold;">$</font>&#8221; mean United States Dollars.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">&#8220;<font style="font-weight: bold;">DTC</font>&#8221; means The Depository Trust Company, a New York corporation.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">&#8220;<font style="font-weight: bold;">Exchange Act</font>&#8221; means the Securities Exchange Act of 1934, as amended.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">&#8220;<font style="font-weight: bold;">Foreign Currency</font>&#8221; means any currency, currency unit or composite currency, including, without limitation, the euro, issued by the government of one or more countries other
          than the United States of America or by any recognized confederation or association of such governments and reasonably acceptable to the Trustee.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">&#8220;<font style="font-weight: bold;">GAAP</font>&#8221; means generally accepted accounting principles set forth in the accounting standards codification of the Financial Accounting Standards Board or in such other statements
          by such or any other entity as may be approved by a significant segment of the accounting profession of the United States, as in effect on the date of this Base Indenture.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">&#8220;<font style="font-weight: bold;">Global Security</font>&#8221; means, with respect to any Series of Securities, a Security executed by the Company and delivered by the Trustee to the Depositary or pursuant to the
          Depositary&#8217;s instruction, all in accordance with the Indenture, which shall be registered in the name of the Depositary or its nominee.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">&#8220;<font style="font-weight: bold;">Government Obligations</font>&#8221; means securities which are (i) direct obligations of the United States or the other government or governments in the confederation which issued the
          Foreign Currency in which the principal of or any interest on the Security of the applicable Series shall be payable, in each case for the payment of which its full faith and credit is pledged or (ii) obligations of a Person controlled or
          supervised by and acting as an agency or instrumentality of the United States or such other government or governments, in each case the payment of which is unconditionally guaranteed as a full faith and credit obligation by the United States or
          such other government or governments, which, in either case are not callable or redeemable at the option of the issuer or issuers thereof, and shall also include a depositary receipt issued by a bank or trust company as custodian with respect to
          any such Government Obligations or a specific payment of interest on or principal of any such Government Obligation held by such custodian for the account of the holder of a depositary receipt; <font style="font-style: italic;">provided</font>
          that (except as required by law) such custodian is not authorized to make any deduction from the amount payable to the holder of such depositary receipt from any amount received by the custodian in respect of the Government Obligation or the
          specific payment of interest on or principal of the Government Obligation evidenced by such depositary receipt.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">&#8220;<font style="font-weight: bold;">Holder</font>&#8221; or &#8220;<font style="font-weight: bold;">Securityholder</font>&#8221; means the Person in whose name a Security is registered on the Registrar&#8217;s books.</div>
        <div>&#160;</div>
        <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
          <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">2</font></div>
          <div style="page-break-after:always;" id="DSPFPageBreak">
            <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
        </div>
        <div style="text-indent: 36pt;">&#8220;<font style="font-weight: bold;">Indenture</font>&#8221; means this Base Indenture as amended or supplemented from time to time, including pursuant to any Authorizing Resolution or supplemental indenture pertaining to any
          Series, and including, for all purposes of this instrument and any such Authorizing Resolution or supplemental indenture, the provisions of the TIA that are deemed to be a part of and govern this Base Indenture and any such Authorizing Resolution
          or supplemental indenture, respectively.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">&#8220;<font style="font-weight: bold;">Issue Date</font>&#8221; means, with respect to any Series of Securities, the date on which the Securities of such Series are originally issued under this Indenture.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">&#8220;<font style="font-weight: bold;">NYUCC</font>&#8221; means the New York Uniform Commercial Code, as in effect from time to time.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">&#8220;<font style="font-weight: bold;">Officer</font>&#8221; means the Chairman of the Board, the President, any Vice President, the Treasurer, the Controller or the Secretary of the Company.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">&#8220;<font style="font-weight: bold;">Officers&#8217; Certificate</font>&#8221; means a certificate signed by two Officers or by an Officer and an Assistant Treasurer or an Assistant Secretary of the Company.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">&#8220;<font style="font-weight: bold;">Opinion of Counsel</font>&#8221; means a written opinion, in form and substance reasonably satisfactory to the Trustee, from legal counsel.&#160; The counsel may be an employee of or counsel to
          the Company.&#160; Each such opinion shall include the statements provided for in <u>Section&#160;12.05</u> if and to the extent required by the provisions of such Section.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">&#8220;<font style="font-weight: bold;">Person</font>&#8221; means any individual, corporation, partnership, limited liability company, joint venture, incorporated or unincorporated association, joint stock company, trust,
          unincorporated organization or government or any agency or political subdivision thereof.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">&#8220;<font style="font-weight: bold;">principal</font>&#8221; of a debt security means the principal of the security plus, when appropriate, the premium, if any, on the security.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">&#8220;<font style="font-weight: bold;">Property</font>&#8221; of any Person means all types of real, personal, tangible, intangible or mixed property owned by such Person, whether or not included in the most recent consolidated
          balance sheet of such Person and its Subsidiaries under GAAP.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">&#8220;<font style="font-weight: bold;">Restricted Subsidiary</font>&#8221; means any Subsidiary of the Company which is not an Unrestricted Subsidiary.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">&#8220;<font style="font-weight: bold;">SEC</font>&#8221; means the Securities and Exchange Commission or any successor agency performing the duties now assigned to it under the TIA.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">&#8220;<font style="font-weight: bold;">Securities</font>&#8221; means any Securities that are issued under this Base Indenture.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">&#8220;<font style="font-weight: bold;">Securities Act</font>&#8221; means the Securities Act of 1933, as amended.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">&#8220;<font style="font-weight: bold;">Series</font>&#8221; means a series of Securities established under this Base Indenture.</div>
        <div>&#160;</div>
        <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
          <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">3</font></div>
          <div style="page-break-after:always;" id="DSPFPageBreak">
            <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
        </div>
        <div style="text-indent: 36pt;">&#8220;<font style="font-weight: bold;">Significant Subsidiary</font>&#8221; means any Subsidiary of the Company which would constitute a &#8220;significant subsidiary&#8221; as defined in Rule 1.02 of Regulation S-X under the Securities
          Act and the Exchange Act.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">&#8220;<font style="font-weight: bold;">Subsidiary</font>&#8221; of any Person means any corporation or other entity of which a majority of the Capital Stock having ordinary voting power to elect a majority of the board of
          directors of such entity or other persons performing similar functions is at the time directly or indirectly owned or controlled by such Person.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">&#8220;<font style="font-weight: bold;">TIA</font>&#8221; means the Trust Indenture Act of 1939, as in effect from time to time, except as otherwise provided herein.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">&#8220;<font style="font-weight: bold;">Trustee</font>&#8221; means the party named as such in this Base Indenture until a successor replaces it pursuant to this Base Indenture and thereafter means the successor serving
          hereunder; provided, however, that if at any time there is more than one such Person, &#8220;Trustee&#8221; as used with respect to the Securities of any Series shall mean only the Trustee with respect to Securities of that Series.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">&#8220;<font style="font-weight: bold;">Trust Officer</font>&#8221; means, when used with respect to the Trustee, any officer within the corporate trust department of the Trustee, including any vice president, assistant vice
          president, assistant secretary, senior associate, associate, trust officer or any other officer of the Trustee who customarily performs functions similar to those performed by the Persons who at the time shall be such officers, respectively, or
          to whom any corporate trust matter is referred because of such person&#8217;s knowledge of and familiarity with the particular subject and who shall have direct responsibility for the administration of this Indenture.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">&#8220;<font style="font-weight: bold;">United States</font>&#8221; means the United States of America.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">&#8220;<font style="font-weight: bold;">Unrestricted Subsidiary</font>&#8221; means, with respect to any Series, any Subsidiary of the Company (1) so designated by a resolution adopted by the Board of Directors of the Company as
          provided below and (2) any Subsidiary of an Unrestricted Subsidiary, subject, in each case, to such conditions as may be stated in the supplemental indenture or specified in the Authorizing Resolution with respect to such Series.</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968767"></a><a name="z_Toc37987182"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 1.02</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Other Definitions.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" border="0" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 50%; vertical-align: top;">
                <div style="font-weight: bold;">Term</div>
              </td>
              <td style="width: 50%; vertical-align: top; font-weight: bold;">
                <div style="text-align: right;">Defined in Section</div>
              </td>
            </tr>
            <tr>
              <td style="width: 50%; vertical-align: top;">&#160;</td>
              <td style="width: 50%; vertical-align: top;">&#160;</td>
            </tr>
            <tr>
              <td style="width: 50%; vertical-align: top;">
                <div>Agent Members</div>
              </td>
              <td style="width: 50%; vertical-align: top;">
                <div style="text-align: right;">2.15</div>
              </td>
            </tr>
            <tr>
              <td style="width: 50%; vertical-align: top;">
                <div>Base Indenture</div>
              </td>
              <td style="width: 50%; vertical-align: top;">
                <div style="text-align: right;">Preamble</div>
              </td>
            </tr>
            <tr>
              <td style="width: 50%; vertical-align: top;">
                <div>Business Day</div>
              </td>
              <td style="width: 50%; vertical-align: top;">
                <div style="text-align: right;">12.07</div>
              </td>
            </tr>
            <tr>
              <td style="width: 50%; vertical-align: top;">
                <div>Company</div>
              </td>
              <td style="width: 50%; vertical-align: top;">
                <div style="text-align: right;">Preamble</div>
              </td>
            </tr>
            <tr>
              <td style="width: 50%; vertical-align: top;">
                <div>Covenant Defeasance</div>
              </td>
              <td style="width: 50%; vertical-align: top;">
                <div style="text-align: right;">8.01(c)</div>
              </td>
            </tr>
            <tr>
              <td style="width: 50%; vertical-align: top;">
                <div>Custodian</div>
              </td>
              <td style="width: 50%; vertical-align: top;">
                <div style="text-align: right;">6.01</div>
              </td>
            </tr>
            <tr>
              <td style="width: 50%; vertical-align: top;">
                <div>Event of Default</div>
              </td>
              <td style="width: 50%; vertical-align: top;">
                <div style="text-align: right;">6.01</div>
              </td>
            </tr>
            <tr>
              <td style="width: 50%; vertical-align: top;">
                <div>Legal Defeasance</div>
              </td>
              <td style="width: 50%; vertical-align: top;">
                <div style="text-align: right;">8.01(b)</div>
              </td>
            </tr>
            <tr>
              <td style="width: 50%; vertical-align: top;">
                <div>Legal Holiday</div>
              </td>
              <td style="width: 50%; vertical-align: top;">
                <div style="text-align: right;">12.07</div>
              </td>
            </tr>
            <tr>
              <td style="width: 50%; vertical-align: top;">
                <div>Paying Agent</div>
              </td>
              <td style="width: 50%; vertical-align: top;">
                <div style="text-align: right;">2.03</div>
              </td>
            </tr>
            <tr>
              <td style="width: 50%; vertical-align: top;">
                <div>Registrar</div>
              </td>
              <td style="width: 50%; vertical-align: top;">
                <div style="text-align: right;">2.03</div>
              </td>
            </tr>
            <tr>
              <td style="width: 50%; vertical-align: top;">
                <div>Security Register</div>
              </td>
              <td style="width: 50%; vertical-align: top;">
                <div style="text-align: right;">2.03</div>
              </td>
            </tr>
            <tr>
              <td style="width: 50%; vertical-align: top;">
                <div>Successor</div>
              </td>
              <td style="width: 50%; vertical-align: top;">
                <div style="text-align: right;">5.01</div>
              </td>
            </tr>
            <tr>
              <td style="width: 50%; vertical-align: top;">
                <div>Trustee</div>
              </td>
              <td style="width: 50%; vertical-align: top;">
                <div style="text-align: right;">Preamble</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
          <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">4</font></div>
          <div style="page-break-after:always;" id="DSPFPageBreak">
            <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
        </div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968768"></a><a name="z_Toc37987183"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 1.03</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Incorporation by Reference of Trust Indenture Act.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">Whenever this Indenture refers to a provision of the TIA, the provision is incorporated by reference in and made a part of this Indenture.&#160; The following TIA terms used in this Indenture have the following meanings:</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">&#8220;Commission&#8221; means the SEC.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">&#8220;indenture securities&#8221; means the Securities of a particular Series.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">&#8220;indenture security holder&#8221; means a Securityholder.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">&#8220;indenture to be qualified&#8221; means this Indenture.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">&#8220;indenture trustee&#8221; or &#8220;institutional trustee&#8221; means the Trustee.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">&#8220;obligor&#8221; on the indenture securities means the Company or any other obligor on the Securities of a Series.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">All other TIA terms used in this Indenture that are defined by the TIA, defined by TIA reference to another statute or defined by SEC rule have the meanings so assigned to them.</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968769"></a><a name="z_Toc37987184"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 1.04</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Rules of Construction.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">Unless the context otherwise requires:</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(1)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">a term has the meaning assigned to it herein;</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(2)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">an accounting term not otherwise defined has the meaning assigned to it in accordance with GAAP and all accounting determinations shall be made in accordance with GAAP;</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(3)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">&#8220;or&#8221; is not exclusive and &#8220;including&#8221; means &#8220;including without limitation&#8221;;</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(4)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">words in the singular include the plural, and in the plural include the singular;</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(5)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">&#8220;herein,&#8221; &#8220;hereof&#8221; and &#8220;hereunder,&#8221; and other words of similar import, refer to this Indenture as a whole (including any Authorizing Resolution or supplemental indenture relating to the relevant Series) and
                  not to any particular Article, Section or other subdivision;</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
          <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">5</font></div>
          <div style="page-break-after:always;" id="DSPFPageBreak">
            <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
        </div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(6)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">all exhibits are incorporated by reference herein and expressly made a part of this Indenture; and</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(7)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">any transaction or event shall be considered &#8220;permitted by&#8221; or made &#8220;in accordance with&#8221; or &#8220;in compliance with&#8221; this Indenture or any particular provision thereof if such transaction or event is not
                  expressly prohibited by this Indenture or such provision, as the case may be.</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;"><a name="z_Toc37987185"></a>ARTICLE TWO</div>
        <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;"><a name="z_Toc37968770"></a>THE SECURITIES</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968771"></a><a name="z_Toc37987186"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 2.01</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Form and Dating.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">The aggregate principal amount of Securities that may be issued under this Base Indenture is unlimited.&#160; The Securities may be issued from time to time in one or more Series.&#160; Each Series shall be created by an
          Authorizing Resolution or a supplemental indenture that establishes the terms of the Series, which may include the following:</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(1)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">the title of the Series;</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(2)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">the aggregate principal amount (or any limit on the aggregate principal amount) of the Series and, if any Securities of a Series are to be issued at a discount from their face amount, the method of
                  computing the accretion of such discount;</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(3)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">the interest rate or method of calculation of the interest rate;</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(4)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">the date from which interest will accrue;</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(5)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">the record dates for interest payable on Securities of the Series;</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(6)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">the dates when, places where and manner in which principal and interest are payable;</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(7)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">the Registrar and Paying Agent;</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(8)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">the terms of any mandatory (including any sinking fund requirements) or optional redemption by the Company;</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(9)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">the terms of any redemption at the option of Holders;</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(10)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">the permissible denominations in which Securities of such Series are issuable, if different from $2,000 and multiples of $1,000 in excess thereof;</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(11)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">whether Securities of such Series will be issued in registered or bearer form and the terms of any such forms of Securities;</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(12)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">whether the Securities of the Series shall be issued in whole or in part in the form of a Global Security or Securities, the terms and conditions, if different from those contained in this Base Indenture,
                  upon which such Global Security or Securities may be exchanged in whole or in part for Definitive Securities; the Depositary for such Global Security or Securities; the form of any legend or legends, if any, to be borne by any such Global
                  Security or Securities in addition to or in lieu of the legends referred to in <u>Section&#160;2.15</u>;</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
          <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">6</font></div>
          <div style="page-break-after:always;" id="DSPFPageBreak">
            <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
        </div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(13)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">the currency or currencies (including any composite currency) in which principal or interest or both may be paid;</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(14)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">if payments of principal or interest may be made in a currency other than that in which Securities of such Series are denominated, the manner for determining such payments, including the time and manner of
                  determining the exchange rate between the currency in which such Securities are denominated and the currency in which such Securities or any of them may be paid, and any deletions from or modifications of or additions to the terms of this
                  Indenture to provide for or to facilitate the issuance of Securities denominated or payable, at the election of the Company or a Holder thereof or otherwise, in a Foreign Currency;</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(15)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">provisions for electronic issuance of Securities or issuance of Securities of such Series in uncertificated form;</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(16)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">any Events of Default, covenants and/or defined terms in addition to or in lieu of those set forth in this Base Indenture;</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(17)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">whether and upon what terms Securities of such Series may be defeased or discharged if different from the provisions set forth in this Base Indenture;</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(18)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">the form of the Securities of such Series;</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(19)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">any terms that may be required by or advisable under applicable law;</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(20)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">the percentage of the principal amount of the Securities of such Series which is payable if the maturity of the Securities of such Series is accelerated in the case of Securities issued at a discount from
                  their face amount;</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(21)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">whether Securities of such Series will or will not have the benefit of guarantees and the Company&#8217;s Subsidiaries that will be the initial guarantors of such Series and, if applicable, the terms and
                  conditions upon which such guarantees may be subordinated to other indebtedness of the respective guarantors;</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(22)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">whether the Securities of such Series are senior or subordinated debt securities, and if subordinated debt securities, the terms of such subordination;</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(23)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">whether the Securities of the Series will be convertible into or exchangeable for other Securities, common shares or other securities of any kind of the Company or another obligor, and, if so, the terms and
                  conditions upon which such Securities will be so convertible or exchangeable, including the initial conversion or exchange price or rate or the method of calculation, how and when the conversion price or exchange ratio may be adjusted,
                  whether conversion or exchange is mandatory, at the option of the holder or at the Company&#8217;s option, the conversion or exchange period, and any other provision in relation thereto; and</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
          <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">7</font></div>
          <div style="page-break-after:always;" id="DSPFPageBreak">
            <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
        </div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(24)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">any other terms in addition to or different from those contained in this Base Indenture applicable to such Series.</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">All Securities of one Series need not be issued at the same time and, unless otherwise provided, a Series may be reopened for issuances of additional Securities of such Series pursuant to an Authorizing Resolution,
          an Officers&#8217; Certificate or in any indenture supplemental hereto.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">The creation and issuance of a Series and the authentication and delivery thereof are not subject to any conditions precedent.</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968772"></a><a name="z_Toc37987187"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 2.02</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Execution and Authentication.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">One Officer shall sign the Securities for the Company by manual or facsimile signature.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">If an Officer whose signature is on a Security no longer holds that office at the time the Trustee authenticates the Security, the Security shall nevertheless be valid.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">A Security shall not be valid until the Trustee manually signs the certificate of authentication on the Security.&#160; The signature shall be conclusive evidence that the Security has been authenticated under this Base
          Indenture.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">At any time and from time to time after the execution and delivery of this Indenture, the Company may deliver Securities of any series executed by the Company to the Trustee for authentication.&#160; Each Security shall
          be dated the date of its authentication.&#160; The Trustee shall authenticate Securities for original issue upon receipt of, and shall be fully protected in relying upon:</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(a)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="color: rgb(0, 0, 0);">An order to the Trustee signed by an officer of the Company directing the Trustee to authenticate the Securities;</font></div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(b)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="color: rgb(0, 0, 0);">a copy of the resolution or resolutions of the Board of Directors in or pursuant to which the terms and form of the Securities
            were established, certified by the Secretary or an Assistant Secretary of the Company to have been duly adopted by the Board of Directors and to be in full force and effect as of the date of such certificate, and if the terms and form of such
            Securities are established by an Officers&#8217; Certificate pursuant to general authorization of the Board of Directors, such Officers&#8217; Certificate;</font></div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(c)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="color: rgb(0, 0, 0);">an Officers&#8217; Certificate of the Company delivered in accordance with <u>Section&#160;12.04</u>; and</font></div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(d)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="color: rgb(0, 0, 0);">an Opinion of Counsel delivered in accordance with <u>Section&#160;12.04</u>, and that states that such Securities, when
            authenticated and delivered by Trustee and issued by the Company in the manner and subject to any conditions specified in such Opinion of Counsel, will constitute valid and legally binding obligations of the Company, enforceable in accordance
            with their terms, subject to bankruptcy, insolvency, reorganization and other laws of general applicability relating to or affecting the enforcement of creditors&#8217; rights and to general equity principles.</font></div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">The Trustee shall have the right to decline to authenticate and deliver any Securities under this Section if the Trustee, being advised by counsel, determines that such action may not lawfully be taken or if the
          Trustee in good faith shall determine that such action would expose the Trustee to personal liability to existing Holders.</div>
        <div>&#160;</div>
        <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
          <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">8</font></div>
          <div style="page-break-after:always;" id="DSPFPageBreak">
            <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
        </div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968773"></a><a name="z_Toc37987188"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 2.03</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Registrar and Paying Agent.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">The Company shall maintain an office or agency where Securities may be presented for registration of transfer or where Securities of a Series that are convertible or exchangeable may be surrendered for conversion or
          exchange (&#8220;<font style="font-weight: bold;">Registrar</font>&#8221;), an office or agency where Securities may be presented for payment (&#8220;<font style="font-weight: bold;">Paying Agent</font>&#8221;) and an office or agency where notices and demands to or
          upon the Company in respect of the Securities and this Indenture may be served.&#160; The Registrar shall keep a register of the Securities and of their transfer and exchange (the &#8220;<font style="font-weight: bold;">Security Register</font>&#8221;).&#160; The
          Company may have one or more co-Registrars and one or more additional paying agents.&#160; The term &#8220;Paying Agent&#8221; includes any additional paying agent.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">The Company shall enter into an appropriate agency agreement with any Agent not a party to this Base Indenture.&#160; The agreement shall implement the provisions of this Indenture that relate to such Agent.&#160; The Company
          shall promptly notify the Trustee in writing of the name and address of any such Agent and the Trustee shall have the right to inspect the Securities Register at all reasonable times to obtain copies thereof, and the Trustee shall have the right
          to rely upon such register as to the names and addresses of the Holders and the principal amounts and certificate numbers thereof.&#160; If the Company fails to maintain a Registrar or Paying Agent or fails to give the foregoing notice, the Trustee
          shall act as such.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">The Company initially appoints the Trustee as Registrar and Paying Agent.</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968774"></a><a name="z_Toc37987189"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 2.04</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Paying Agent to Hold Money in Trust.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">Each Paying Agent shall hold in trust for the benefit of Securityholders and the Trustee all money held by the Paying Agent for the payment of principal of or interest on the Securities, and shall notify the Trustee
          of any default by the Company in making any such payment.&#160; If the Company or a Subsidiary acts as Paying Agent, it shall segregate the money and hold it as a separate trust fund.&#160; The Company at any time may require a Paying Agent to pay all
          money held by it to the Trustee.&#160; Upon doing so the Paying Agent shall have no further liability for the money.</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968775"></a><a name="z_Toc37987190"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 2.05</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Securityholder Lists.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">The Trustee shall preserve in as current a form as is reasonably practicable the most recent list available to it of the names and addresses of Securityholders.&#160; If the Trustee is not the Registrar, the Company shall
          furnish to the Trustee at least five (5) Business Days before each semiannual interest payment date and at such other times as the Trustee may request in writing a list in such form and as of such date as the Trustee may reasonably require of the
          names and addresses of Securityholders.</div>
        <div>&#160;</div>
        <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
          <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">9</font></div>
          <div style="page-break-after:always;" id="DSPFPageBreak">
            <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
        </div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968776"></a><a name="z_Toc37987191"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 2.06</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Transfer and Exchange.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">Where a Security is presented to the Registrar or a co-Registrar with a request to register a transfer, the Registrar shall register the transfer as requested if the other provisions of this <u>Section&#160;2.06</u> are
          satisfied.&#160; Where Securities are presented to the Registrar or a co-Registrar with a request to exchange them for an equal principal amount of Securities of other denominations, the Registrar shall make the exchange as requested if the same
          requirements are met.&#160; To permit transfers and exchanges, the Trustee shall authenticate Securities at the Registrar&#8217;s request.&#160; The Registrar need not transfer or exchange any Security selected for redemption or repurchase, except the unredeemed
          or repurchased part thereof if the Security is redeemed or repurchased in part, or transfer or exchange any Securities for a period of 15 days before a selection of Securities to be redeemed or repurchased.&#160; Any exchange or transfer shall be
          without charge, except that the Company may require payment of a sum sufficient to cover any tax or other governmental charge that may be imposed in relation thereto except in the case of exchanges pursuant to 2.09, 3.06, or 10.05 not involving
          any transfer.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">Any Holder of a Global Security shall, by acceptance of such Global Security, agree that transfers of beneficial interests in such Global Security may be effected only through a book entry system maintained by the
          Holder of such Global Security (or its agent), and that ownership of a beneficial interest in the Security shall be required to be reflected in a book entry.</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968777"></a><a name="z_Toc37987192"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 2.07</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Replacement Securities.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">If the Holder of a Security claims that the Security has been lost, destroyed, mutilated or wrongfully taken, the Company shall issue and execute a replacement security and, upon written request of any Officer of the
          Company, the Trustee shall authenticate such replacement Security.&#160; If any such lost, destroyed, mutilated or wrongfully taken Security shall have matured or shall be about to mature, the Company may, instead of issuing a substitute Security
          therefor, pay such Security without requiring (except in the case of a mutilated Security) the surrender thereof.&#160; An indemnity bond must be sufficient in the judgment of the Company and the Trustee to protect the Company, the Trustee and any
          Agent from any loss which any of them may suffer if a Security is replaced, including the acquisition of such Security by a bona fide purchaser.&#160; The Company and the Trustee may charge for its expenses in replacing a Security.</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968778"></a><a name="z_Toc37987193"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 2.08</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Outstanding Securities.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">Securities outstanding at any time are all Securities authenticated by the Trustee except for those cancelled by it and those described in this Section.&#160; A Security does not cease to be outstanding because the
          Company or one of its Affiliates holds the Security.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">If a Security is replaced pursuant to <u>Section&#160;2.07</u>, it ceases to be outstanding unless the Trustee receives proof satisfactory to the Company that the replaced Security is held by a &#8220;protected purchaser&#8221; (as
          such term is defined in the NYUCC).</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">If the Paying Agent holds on a redemption date, purchase date or maturity date money sufficient to pay Securities payable on that date, then on and after that date such Securities shall cease to be outstanding and
          interest on them shall cease to accrue.</div>
        <div>&#160;</div>
        <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
          <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">10</font></div>
          <div style="page-break-after:always;" id="DSPFPageBreak">
            <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
        </div>
        <div style="text-indent: 36pt;">Subject to the foregoing provisions of this Section, each Security delivered under this Indenture upon registration of transfer of or in exchange for or in lieu of any other Security shall carry the rights to
          interest accrued and unpaid, and to accrue, which were carried by such other Security.</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968779"></a><a name="z_Toc37987194"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 2.09</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Temporary Securities.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">Until definitive Securities are ready for delivery, the Company may prepare and the Trustee shall authenticate temporary Securities.&#160; Temporary Securities shall be substantially in the form of definitive Securities
          but may have variations that the Company considers appropriate for temporary Securities.&#160; Without unreasonable delay, the Company shall prepare and, upon surrender for cancellation of the temporary Security, the Company shall execute and the
          Trustee shall authenticate definitive Securities in exchange for temporary Securities.&#160; Until so exchanged, the temporary Securities shall in all respects be entitled to the same benefits under this Indenture as definitive Securities
          authenticated and delivered hereunder.</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968780"></a><a name="z_Toc37987195"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 2.10</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Cancellation.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">The Company at any time may deliver Securities to the Trustee for cancellation.&#160; The Registrar and Paying Agent shall forward to the Trustee any Securities surrendered to them for registration of transfer, exchange,
          redemption, purchase or payment.&#160; The Trustee and no one else shall cancel and dispose of such cancelled or tendered securities, or retain in accordance with its standard retention policy, all Securities surrendered for registration of transfer,
          exchange, redemption, purchase, payment or cancellation.&#160; Unless the Authorizing Resolution or supplemental indenture so provides, the Company may not issue new Securities to replace Securities that it has previously paid or delivered to the
          Trustee for cancellation.</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968781"></a><a name="z_Toc37987196"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 2.11</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Defaulted Interest.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">If the Company defaults in a payment of interest on the Securities of any Series, it shall pay the defaulted interest plus any interest payable on the defaulted interest to the persons who are Securityholders of such
          Series on a subsequent special record date.&#160; The Company shall fix such special record date and a payment date which shall be reasonably satisfactory to the Trustee.&#160; At least 15 days before such special record date, the Company shall send to
          each Securityholder of the relevant Series a notice that states the record date, the payment date and the amount of defaulted interest to be paid.&#160; On or before the date such notice is sent, the Company shall deposit with the Paying Agent money
          sufficient to pay the amount of defaulted interest to be so paid.&#160; The Company may pay defaulted interest in any other lawful manner if, after written notice given by the Company to the Trustee of the proposed payment, such manner of payment
          shall be deemed practicable by the Trustee.</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968782"></a><a name="z_Toc37987197"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 2.12</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Treasury Securities.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">In determining whether the Holders of the required principal amount of Securities of a Series have concurred in any direction, waiver, consent or notice, Securities owned by the Company or any of its Affiliates shall
          be considered as though they are not outstanding, except that for the purposes of determining whether the Trustee shall be protected in relying on any such direction, waiver or consent, only Securities which a Trust Officer of the Trustee
          actually knows are so owned shall be so considered.</div>
        <div>&#160;</div>
        <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
          <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">11</font></div>
          <div style="page-break-after:always;" id="DSPFPageBreak">
            <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
        </div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968783"></a><a name="z_Toc37987198"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 2.13</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>CUSIP/ISIN Numbers.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">The Company in issuing the Securities of any Series may use a &#8220;CUSIP&#8221; and/or &#8220;ISIN&#8221; or other similar number, and if so, the Trustee shall use the CUSIP and/or ISIN or other similar number in notices of redemption or
          exchange as a convenience to Holders of such Securities; provided that no representation is hereby deemed to be made by the Trustee as to the correctness or accuracy of any such CUSIP and/or ISIN or other similar number printed in the notice or
          on such Securities, and that reliance may be placed only on the other identification numbers printed on such Securities.&#160; The Company shall promptly notify the Trustee in writing of any change in any CUSIP and/or ISIN or other similar number.</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968784"></a><a name="z_Toc37987199"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 2.14</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Deposit of Moneys.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">Prior to 11:00 a.m. New York City time on each interest payment date and maturity date with respect to each Series of Securities, the Company shall have deposited with the Paying Agent in immediately available funds
          money in the applicable currency sufficient to make cash payments due on such interest payment date or maturity date, as the case may be, in a timely manner which permits the Paying Agent to remit payment to the Holders of such Series on such
          interest payment date or maturity date, as the case may be.</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968785"></a><a name="z_Toc37987200"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 2.15</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Book-Entry Provisions for Global Security.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(a)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="color: rgb(0, 0, 0);">Any Global Security of a Series initially shall (i) be registered in the name of the Depositary or the nominee of such
            Depositary, (ii) be delivered to the Trustee as custodian for such Depositary and (iii) bear any required legends.</font></div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">Members of, or participants in, the Depositary (&#8220;<font style="font-weight: bold;">Agent Members</font>&#8221;) shall have no rights under this Indenture with respect to any Global Security held on their behalf by the
          Depositary, or the Trustee as its custodian, or under the Global Security, and the Depositary may be treated by the Company, the Trustee and any agent of the Company or the Trustee as the absolute owner of the Global Security for all purposes
          whatsoever.&#160; Notwithstanding the foregoing, nothing herein shall prevent the Company, the Trustee or any agent of the Company or the Trustee from giving effect to any written certification, proxy or other authorization furnished by the Depositary
          or impair, as between the Depositary and its Agent Members, the operation of customary practices governing the exercise of the rights of a Holder of any Security.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(b)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="color: rgb(0, 0, 0);">Transfers of any Global Security shall be limited to transfers in whole, but not in part, to the Depositary, its successors or
            their respective nominees.&#160; Interests of beneficial owners in the Global Security may be transferred or exchanged for Definitive Securities in accordance with the rules and procedures of the Depositary.&#160; In addition, Definitive Securities shall
            be transferred to all beneficial owners in exchange for their beneficial interests in a Global Security if (i) the Depositary notifies the Company that it is unwilling or unable to continue as Depositary for the Global Security and a successor
            depository is not appointed by the Company within 90 days of such notice or (ii) an Event of Default has occurred and is continuing and the Registrar has received a request from the Depositary to issue Definitive Securities.</font></div>
        <div>&#160;</div>
        <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
          <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">12</font></div>
          <div style="page-break-after:always;" id="DSPFPageBreak">
            <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
        </div>
        <div style="text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(c)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="color: rgb(0, 0, 0);">In connection with any transfer or exchange of a portion of the beneficial interest in any Global Security to beneficial
            owners pursuant to <u>paragraph (b)</u>, the Registrar shall (if one or more Definitive Securities are to be issued) reflect on its books and records the date and a decrease in the principal amount of the Global Security in an amount equal to
            the principal amount of the beneficial interest in the Global Security to be transferred, and the Company shall execute, and the Trustee shall authenticate and deliver, one or more Definitive Securities of like Series and amount.</font></div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(d)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="color: rgb(0, 0, 0);">In connection with the transfer of an entire Global Security to beneficial owners pursuant to <u>paragraph (b)</u>, the
            Global Security shall be deemed to be surrendered to the Trustee for cancellation, and the Company shall execute, and the Trustee shall authenticate and deliver, to each beneficial owner identified by the Depositary in exchange for its
            beneficial interest in the Global Security, an equal aggregate principal amount of Definitive Securities of the same Series in authorized denominations.</font></div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(e)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="color: rgb(0, 0, 0);">The Holder of any Global Security may grant proxies and otherwise authorize any person, including Agent Members and persons
            that may hold interests through Agent Members, to take any action which a Holder is entitled to take under this Indenture or the Securities of such Series.</font></div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(f)</font>&#160;&#160;&#160;&#160;&#160; &#160; &#160;&#160; <font style="color: rgb(0, 0, 0);">Unless otherwise provided in the Authorizing Resolution or supplemental indenture for a particular Series of Securities,
            each Global Security of such Series shall bear legends in substantially the following forms:</font></div>
        <div>&#160;</div>
        <div style="text-indent: 36pt; margin-right: 36pt; margin-left: 36pt;">&#8220;THIS GLOBAL SECURITY IS HELD BY THE DEPOSITARY (AS DEFINED IN THE INDENTURE GOVERNING THIS SECURITY) OR ITS NOMINEE IN CUSTODY FOR THE BENEFIT OF THE HOLDERS OF BENEFICIAL
          INTERESTS HEREIN, AND IS NOT TRANSFERABLE TO ANY PERSON UNDER ANY CIRCUMSTANCES EXCEPT THAT (I) THE TRUSTEE MAY MAKE ANY SUCH NOTATIONS HEREON AS MAY BE REQUIRED PURSUANT TO THE INDENTURE, (II) THIS GLOBAL SECURITY MAY BE EXCHANGED IN WHOLE BUT
          NOT IN PART PURSUANT TO SECTION 2.06 OF THE INDENTURE, (III) THIS GLOBAL SECURITY MAY BE DELIVERED TO THE TRUSTEE FOR CANCELLATION PURSUANT TO THE INDENTURE AND (IV) THIS GLOBAL SECURITY MAY BE TRANSFERRED TO A SUCCESSOR DEPOSITARY WITH THE PRIOR
          WRITTEN CONSENT OF THE COMPANY.&#8221;</div>
        <div>&#160;</div>
        <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
          <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">13</font></div>
          <div style="page-break-after:always;" id="DSPFPageBreak">
            <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
        </div>
        <div style="text-indent: 36pt; margin-right: 36pt; margin-left: 36pt;">&#8220;UNLESS AND UNTIL IT IS EXCHANGED IN WHOLE OR IN PART FOR SECURITIES IN DEFINITIVE FORM, THIS SECURITY MAY NOT BE TRANSFERRED EXCEPT AS A WHOLE BY THE DEPOSITARY TO A NOMINEE OF
          THE DEPOSITARY OR BY A NOMINEE OF THE DEPOSITARY TO THE DEPOSITARY OR TO ANOTHER NOMINEE OF THE DEPOSITARY OR BY THE DEPOSITARY OR ANY SUCH NOMINEE TO A SUCCESSOR DEPOSITARY OR A NOMINEE OF SUCH SUCCESSOR DEPOSITARY.&#160; UNLESS THIS CERTIFICATE IS
          PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY, A NEW YORK CORPORATION (&#8220;DTC&#8221;), TO ISSUER OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE, OR PAYMENT, ANY CERTIFICATE ISSUED IS REGISTERED IN THE NAME OF CEDE &amp;
          CO<a name="z_9kR3WTr5DA457"></a>. OR IN SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC (AND ANY PAYMENT IS MADE TO CEDE &amp; CO<a name="z_9kMHG5YVt7FC679"></a>. OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED
          REPRESENTATIVE OF DTC), ANY TRANSFER, PLEDGE, OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL INASMUCH AS THE REGISTERED OWNER HEREOF, CEDE &amp; CO., HAS AN INTEREST HEREIN.&#8221;</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968786"></a><a name="z_Toc37987201"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 2.16</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>No Duty to Monitor.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">The Trustee shall have no obligation or duty to monitor, determine or inquire as to compliance with any restrictions on transfer imposed under this Indenture or under applicable law with respect to any transfer of
          any interest in any Security (including any transfers between or among Agent Members or beneficial owners of interests in any Global Security) other than to require delivery of such certificates and other documentation or evidence as are
          expressly required by, and to do so if and when expressly required by the terms of, this Indenture, and to examine the same to determine substantial compliance as to form with the express requirements hereof.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">Neither the Trustee nor any Agent shall have any responsibility for any actions taken or not taken by the Depositary.</div>
        <div>&#160;</div>
        <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;"><a name="z_Toc37987202"></a>ARTICLE THREE</div>
        <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;"><a name="z_Toc37968787"></a>REDEMPTION</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968788"></a><a name="z_Toc37987203"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 3.01</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Notices to Trustee.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">Securities of a Series that are redeemable prior to maturity shall be redeemable in accordance with their terms and, unless the Authorizing Resolution or supplemental indenture provides otherwise, in accordance with
          this <u>Article&#160;Three</u>.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">If the Company wants to redeem Securities pursuant to <u>Paragraph 4</u> of the Securities, it shall notify the Trustee in writing of the redemption date and the principal amount of Securities to be redeemed.&#160; Any
          such notice may be cancelled at any time prior to notice of such redemption being sent to Holders.&#160; Any such cancelled notice shall be void and of no effect.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">If the Company wants to credit any Securities previously redeemed, retired or acquired against any redemption pursuant to <u>Paragraph 5</u> of the Securities, it shall notify the Trustee of the amount of the credit
          and it shall deliver any Securities not previously delivered to the Trustee for cancellation with such notice.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">The Company shall give each notice provided for in this <u>Section&#160;3.01</u> at least 15 days before the notice of any such redemption is to be delivered to Holders (unless a shorter notice shall be satisfactory to
          the Trustee).</div>
        <div>&#160;</div>
        <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
          <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">14</font></div>
          <div style="page-break-after:always;" id="DSPFPageBreak">
            <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
        </div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968789"></a><a name="z_Toc37987204"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 3.02</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Selection of Securities to be Redeemed.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">If fewer than all of the Securities of a Series are to be redeemed, the Securities to be redeemed shall be selected pro rata, by lot, or such other method the Trustee (or depository, as applicable) considers fair and
          appropriate and, in the case of Global Securities, in a manner that complies with applicable requirements of the Depositary.&#160; The Trustee (or depository, as applicable) shall make the selection from Securities outstanding not previously called
          for redemption and shall promptly notify the Company of the serial numbers or other identifying attributes of the Securities so selected.&#160; The Trustee (or depository, as applicable) may select for redemption portions of the principal of
          Securities that have denominations larger than the minimum denomination for the Series.&#160; Securities and portions of them it selects shall be in amounts equal to a permissible denomination for the Series.&#160; Provisions of this Indenture that apply
          to Securities called for redemption also apply to portions of Securities called for redemption.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">Unless otherwise provided in the Authorizing Resolution or supplemental indenture relating to a Series, if any Security selected for partial redemption is converted into or exchanged for shares of the Company&#8217;s
          common stock or other securities, cash or other property in part before termination of the conversion or exchange right with respect to the portion of the Security so selected, the converted portion of such Security shall be deemed (so far as may
          be) to be the portion selected for redemption.&#160; Securities which have been converted or exchanged during a selection of Securities to be redeemed shall be treated by the Trustee as outstanding for the purpose of such selection.</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968790"></a><a name="z_Toc37987205"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 3.03</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Notice of Redemption.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">At least 30 days but not more than 60 days before a redemption date, the Company shall mail a notice of redemption by first-class mail, postage prepaid (or in the case of Global Securities, deliver electronically in
          accordance with the applicable procedures of the Depositary), to each Holder of Securities to be redeemed.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">The notice shall identify the Securities to be redeemed and shall state:</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(1)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">the redemption date;</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(2)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">the redemption price or the formula pursuant to which such price will be calculated;</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(3)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">if any Security is being redeemed in part, the portion of the principal amount of such Security to be redeemed and that, after the redemption date, upon surrender of such Security, a new Security or
                  Securities in principal amount equal to the unredeemed portion shall be issued upon cancellation of the original Security;</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(4)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">in the case of Securities of a Series that are convertible or exchangeable into shares of the Company&#8217;s common stock or other securities, cash or other property, the conversion or exchange price or rate,
                  the date or dates on which the right to convert or exchange the principal of the Securities of such Series to be redeemed will commence or terminate and the place or places where such Securities may be surrendered for conversion or
                  exchange;</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
          <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">15</font></div>
          <div style="page-break-after:always;" id="DSPFPageBreak">
            <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
        </div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(5)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">the name and address of the Paying Agent;</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(6)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">that Securities called for redemption must be surrendered to the Paying Agent to collect the redemption price;</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(7)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">that interest on Securities called for redemption ceases to accrue on and after the redemption date;</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(8)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">that the Securities are being redeemed pursuant to the mandatory redemption or the optional redemption provisions, as applicable; and</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(9)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">the CUSIP number and that no representation is hereby deemed to be made be made by the Trustee as to the correctness or accuracy of any such CUSIP and/or ISIN or other similar number printed in the notice
                  or on such Securities, and that reliance may be placed only on the other identification numbers printed on such Securities.</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">At the Company&#8217;s request, the Trustee shall give the notice of redemption in the Company&#8217;s name and at its expense; provided, however, that the Company shall deliver to the Trustee at least 15 days prior to the date
          on which notice of redemption is to be sent or such shorter period as may be satisfactory to the Trustee, an Officers&#8217; Certificate requesting that the Trustee give such notice and setting forth the information to be stated in such notice as
          provided in the preceding paragraph.</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968791"></a><a name="z_Toc37987206"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 3.04</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Effect of Notice of Redemption.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">Once notice of redemption is sent, Securities called for redemption become due and payable on the redemption date and at the redemption price as set forth in the notice of redemption.&#160; Upon surrender to the Paying
          Agent, such Securities shall be paid at the redemption price, plus accrued and unpaid interest to the redemption date.&#160; Notices of redemption may be subject to one or more conditions.&#160; In the event that any such conditions are not satisfied the
          Company may amend or revoke such notice of redemption by sending notice to Securityholders (with a copy to the Trustee) in accordance with the applicable procedures of the depository.</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37987207"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 3.05</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Deposit of Redemption Price.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">On or before the redemption date, the Company shall deposit with the Paying Agent immediately available funds in the applicable currency sufficient to pay the redemption price of and accrued interest on all
          Securities to be redeemed on that date.</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968792"></a><a name="z_Toc37987208"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 3.06</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Securities Redeemed in Part.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">Upon surrender of a Security that is redeemed in part, the Company shall execute and the Trustee shall authenticate for each Holder a new Security of the same Series equal in principal amount to the unredeemed
          portion of the Security surrendered.</div>
        <div>&#160;</div>
        <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
          <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">16</font></div>
          <div style="page-break-after:always;" id="DSPFPageBreak">
            <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
        </div>
        <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;"><a name="z_Toc37987209"></a>ARTICLE FOUR</div>
        <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;"><a name="z_Toc37968793"></a>COVENANTS</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968794"></a><a name="z_Toc37987210"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 4.01</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Payment of Securities.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">The Company shall pay the principal of and interest on a Series on the dates, in the currency and in the manner provided in the Securities of the Series.&#160; An installment of principal or interest shall be considered
          paid on the date it is due if the Paying Agent holds on that date money in the applicable currency designated for and sufficient to pay the installment.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">The Company shall pay interest on overdue principal at the rate borne by the Series; it shall pay interest on overdue installments of interest at the same rate.</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968795"></a><a name="z_Toc37987211"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 4.02</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Maintenance of Office or Agency.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">The Company shall maintain the office or agency required under <u>Section&#160;2.03</u>.&#160; The Company shall give prior written notice to the Trustee of the location, and any change in the location, of such office or
          agency.&#160; If at any time the Company shall fail to maintain any such required office or agency or shall fail to furnish the Trustee with the address thereof, such presentations, surrenders, notices and demands may be made or served at the address
          of the Trustee.</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968796"></a><a name="z_Toc37987212"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 4.03</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Compliance Certificate.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">The Company shall deliver to the Trustee within 120 days after the end of each fiscal year of the Company an Officers&#8217; Certificate stating whether or not the signers know of any continuing Default by the Company in
          performing any of its obligations under this Indenture.&#160; If they do know of such a Default, the certificate shall describe the Default.&#160; In addition, the Company will notify the Trustee within 5 business days upon the Company&#8217;s knowledge of a
          Default.</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968797"></a><a name="z_Toc37987213"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 4.04</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Waiver of Stay, Extension or Usury Laws.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">The Company covenants (to the extent that it may lawfully do so) that it will not at any time insist upon, plead, or in any manner whatsoever claim or take the benefit or advantage of, any stay or extension law or
          any usury law or other law that would prohibit or forgive the Company from paying all or any portion of the principal of or interest on the Securities of any Series as contemplated herein, wherever enacted, now or at any time hereafter in force,
          or which may affect the covenants or the performance of this Indenture; and (to the extent that it may lawfully do so) the Company expressly waives all benefit or advantage of any such law, and covenants that it will not hinder, delay or impede
          the execution of any power herein granted to the Trustee, but will suffer and permit the execution of every such power as though no such law had been enacted.</div>
        <div>&#160;</div>
        <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
          <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">17</font></div>
          <div style="page-break-after:always;" id="DSPFPageBreak">
            <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
        </div>
        <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;"><a name="z_Toc37987214"></a>ARTICLE FIVE</div>
        <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;"><a name="z_Toc37968798"></a>SUCCESSOR CORPORATION</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968799"></a><a name="z_Toc37987215"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 5.01</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Company May Merge, etc.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">Nothing contained in this Indenture shall prevent any consolidation or merger of the Company with or into any other Person (whether or not affiliated with the Company) or successive consolidations or mergers in which
          the Company or its successor or successors may be a party or parties, or shall prevent any sale, conveyance, transfer, lease or other disposition of all or substantially all of the assets of the Company to any other Person (whether or not
          affiliated with the Company or its successor or successors); provided, however, the Company hereby covenants and agrees that, upon any such consolidation or merger (in each case, if the Company is not the survivor of such transaction) or any such
          sale, conveyance, transfer, lease or other disposition (other than a sale, conveyance, transfer, lease or other disposition to a Subsidiary of the Company), the due and punctual payment of the principal of (premium, if any) and interest on all of
          the Securities of all series in accordance with the terms of each series, according to their tenor, and the due and punctual performance and observance of all the covenants and conditions of this Indenture with respect to each series or
          established with respect to such series pursuant to <u>Section&#160;2.01</u> to be kept or performed by the Company shall be expressly assumed, by supplemental indenture (which shall conform to the provisions of the Trust Indenture Act, as then in
          effect) reasonably satisfactory in form to the Trustee executed and delivered to the Trustee by the Person formed by such consolidation, or into which the Company shall have been merged, or by the Person to which such sale, conveyance, transfer,
          lease or other disposition has been made (the &#8220;<font style="font-weight: bold;">Successor</font>&#8221;).</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">Upon any such consolidation, merger, sale, lease, conveyance or other disposition, the Successor will be substituted for the Company under the Indenture.&#160; The Successor may then exercise every power and right of the
          Company under this Indenture, and the Company will be released from all of its liabilities and obligations in respect of the Securities and the Indenture.</div>
        <div>&#160;</div>
        <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;"><a name="z_Toc37987216"></a>ARTICLE SIX</div>
        <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;"><a name="z_Toc37968800"></a>DEFAULTS AND REMEDIES</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968801"></a><a name="z_Toc37987217"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 6.01</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Events of Default.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">An &#8220;<font style="font-weight: bold;">Event of Default</font>&#8221; on a Series occurs if, voluntarily or involuntarily, whether by operation of law or otherwise, any of the following occurs:</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(1)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">the failure by the Company to pay interest on any Security of such Series when the same becomes due and payable and the continuance of any such failure for a period of 30 days;</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(2)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">the failure by the Company to pay the principal of any Security of such Series when the same becomes due and payable at maturity, upon acceleration, redemption or otherwise;</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
          <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">18</font></div>
          <div style="page-break-after:always;" id="DSPFPageBreak">
            <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
        </div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(3)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">the failure by the Company or any Restricted Subsidiary to comply with any of its agreements or covenants in, or provisions of, the Securities of such Series or this Indenture (as they relate thereto) and
                  such failure continues for the period and after the notice specified below (except in the case of a default with respect to <u>Article&#160;Five</u> (or any other provision specified in the applicable supplemental indenture or Authorizing
                  Resolution), which will constitute Events of Default with notice but without passage of time);</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(4)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">the Company pursuant to or within the meaning of any Bankruptcy Law:</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(A)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">commences a voluntary case,</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(B)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">consents to the entry of an order for relief against it in an involuntary case,</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(C)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">consents to the appointment of a Custodian of it or for all or substantially all of its Property, or</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(D)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">makes a general assignment for the benefit of its creditors;</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(5)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">a court of competent jurisdiction enters an order or decree under any Bankruptcy Law that:</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(A)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">is for relief against the Company as debtor in an involuntary case,</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(B)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">appoints a Custodian of the Company or a Custodian for all or substantially all of the Property of the Company, or</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(C)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">orders the liquidation of the, and the order or decree remains unstayed and in effect for 60 days.</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">A Default as described in <u>subclause&#160;(3) </u>above will not be deemed an Event of Default until the Trustee notifies the Company, or the Holders of at least 25 percent in principal amount of the then outstanding
          Securities of the applicable Series notify the Company and the Trustee, of the Default and (except in the case of a default with respect to <u>Article&#160;Five</u> (or any other provision specified in the applicable supplemental indenture or
          Authorizing Resolution)) and the Company does not cure the Default within 90 days after receipt of the notice.&#160; The notice must specify the Default, demand that it be remedied and state that the notice is a &#8220;Notice of Default.&#8221;&#160; If such a Default
          is cured within such time period, it ceases to exist, without any action by the Trustee or any other Person.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">The term &#8220;<font style="font-weight: bold;">Custodian</font>&#8221; means any receiver, trustee, assignee, liquidator, custodian or similar official under any Bankruptcy Law.</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968802"></a><a name="z_Toc37987218"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 6.02</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Acceleration.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">If an Event of Default (other than an Event of Default with respect to the Company resulting from <u>subclause&#160;(4)</u> or <u>(5)</u> above), shall have occurred and be continuing under the Indenture, the Trustee by
          notice to the Company, or the Holders of at least 25 percent in principal amount of the Securities of the applicable Series then outstanding by notice to the Company and the Trustee, may declare all Securities of such Series to be due and payable
          immediately.&#160; Upon such declaration of acceleration, the amounts due and payable on the Securities of such Series will be due and payable immediately.&#160; If an Event of Default with respect to the Company specified in <u>subclauses&#160;(4)</u> or <u>(5)</u>
          above occurs, all amounts due and payable on the Securities of such Series will ipso facto become and be immediately due and payable without any declaration, notice or other act on the part of the Trustee and the Company or any Holder.</div>
        <div>&#160;</div>
        <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
          <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">19</font></div>
          <div style="page-break-after:always;" id="DSPFPageBreak">
            <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
        </div>
        <div style="text-indent: 36pt;">Holders of a majority in principal amount of the then outstanding Securities of such Series may rescind an acceleration with respect to such Series and its consequence (except an acceleration due to nonpayment of
          principal or interest) if the rescission would not conflict with any judgment or decree and if all existing Events of Default (other than the non-payment of accelerated principal) have been cured or waived.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">No such rescission shall extend to or shall affect any subsequent Event of Default, or shall impair any right or power consequent thereon.</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968803"></a><a name="z_Toc37987219"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 6.03</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Other Remedies.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">If an Event of Default on a Series occurs and is continuing, the Trustee may pursue any available remedy by proceeding at law or in equity to collect the payment of principal of or interest on the Series or to
          enforce the performance of any provision in the Securities or this Indenture applicable to the Series.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">The Trustee may maintain a proceeding even if it does not possess any of the Securities or does not produce any of them in the proceeding.&#160; A delay or omission by the Trustee or any Securityholder in exercising any
          right or remedy accruing upon an Event of Default shall not impair the right or remedy or constitute a waiver of or acquiescence in the Event of Default.&#160; No remedy is exclusive of any other remedy.&#160; All available remedies are cumulative.</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968804"></a><a name="z_Toc37987220"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 6.04</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Waiver of Existing Defaults.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">Subject to <u>Section&#160;10.02</u>, the Holders of a majority in principal amount of the outstanding Securities of a Series on behalf of all the Holders of the Series by written notice to the Trustee may waive an
          existing Default on such Series and its consequences.&#160; When a Default is waived, it is cured and stops continuing, and any Event of Default arising therefrom shall be deemed to have been cured; but no such waiver shall extend to any subsequent or
          other Default or impair any right consequent thereon.</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968805"></a><a name="z_Toc37987221"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 6.05</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Control by Majority.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">The Holders of a majority in principal amount of the outstanding Securities of a Series may direct the time, method and place of conducting any proceeding for any remedy available to the Trustee or exercising any
          trust or power conferred on it with respect to such Series.&#160; The Trustee, however, may refuse to follow any direction (i) that conflicts with law or this Indenture, (ii) that, subject to <u>Section&#160;7.01</u>, the Trustee determines is unduly
          prejudicial to the rights of other Securityholders, (iii) that would involve the Trustee in personal liability, or (iv) if the Trustee shall not have been provided with indemnity satisfactory to it.</div>
        <div>&#160;</div>
        <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
          <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">20</font></div>
          <div style="page-break-after:always;" id="DSPFPageBreak">
            <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
        </div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968806"></a><a name="z_Toc37987222"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 6.06</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Limitation on Suits.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">A Securityholder of a Series may not pursue any remedy with respect to this Indenture or the Series unless:</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(1)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">the Holder gives to the Trustee written notice of a continuing Event of Default on the Series;</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(2)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">the Holders of at least a majority in principal amount of the outstanding Securities of the Series make a written request to the Trustee to pursue the remedy;</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(3)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">such Holder or Holders offer to the Trustee indemnity satisfactory to the Trustee against any loss, liability or expense;</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(4)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">the Trustee does not comply with the request within 60 days after receipt of the request and the offer of indemnity; and</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(5)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">no written request inconsistent with such written request shall have been given to the Trustee pursuant to this <u>Section&#160;6.06</u>.</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">A Securityholder may not use this Indenture to prejudice the rights of another Holder of Securities of the same Series or to obtain a preference or priority over another Holder of Securities of the same Series (it
          being understood that the Trustee does not have an affirmative duty to ascertain whether or not such actions or forbearances by such Holder are unduly prejudicial to another Holder).</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968807"></a><a name="z_Toc37987223"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 6.07</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Rights of Holders to Receive Payment.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">Notwithstanding any other provision of this Indenture, the right of any Holder to receive payment of principal of and interest on any Security, on or after the respective due dates expressed in the Security, or to
          bring suit for the enforcement of any such payment on or after such respective dates, is absolute and unconditional and shall not be impaired or affected without the consent of the Holder.</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968808"></a><a name="z_Toc37987224"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 6.08</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Collection Suit by Trustee.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">If an Event of Default in payment of interest or principal specified in <u>Section&#160;6.01(1)</u> or <u>(2)</u> occurs and is continuing, the Trustee may recover judgment in its own name and as trustee of an express
          trust against the Company for the whole amount of principal and interest remaining unpaid.</div>
        <div>&#160;</div>
        <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
          <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">21</font></div>
          <div style="page-break-after:always;" id="DSPFPageBreak">
            <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
        </div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968809"></a><a name="z_Toc37987225"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 6.09</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Trustee May File Proofs of Claim.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">The Trustee may file such proofs of claim and other papers or documents as may be necessary or advisable in order to have the claims of the Trustee (including any claim for the reasonable compensation, expenses,
          disbursements, and advances of the Trustee, its agents and counsel) and the Securityholders allowed in any judicial proceedings relative to the Company or its creditors or Property, and unless prohibited by applicable law or regulation, may vote
          on behalf of the Holders in any election of a Custodian, and shall be entitled and empowered to collect and receive any moneys or other Property payable or deliverable on any such claims and to distribute the same and any Custodian in any such
          judicial proceeding is hereby authorized by each Securityholder to make such payments to the Trustee.&#160; Nothing herein shall be deemed to authorize the Trustee to authorize or consent to or vote for or accept or adopt on behalf of any
          Securityholder any plan of reorganization, arrangement, adjustment or composition affecting the Securities or the rights of any Holder or to authorize the Trustee to vote in respect of the claim of any Securityholder except as aforesaid for the
          election of the Custodian.</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968810"></a><a name="z_Toc37987226"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 6.10</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Priorities.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">If the Trustee collects any money pursuant to this Article with respect to Securities of any Series, it shall pay out the money in the following order:</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;">&#160;</td>
              <td style="width: 63pt; vertical-align: top;"><font style="font-style: italic;">First</font>:</td>
              <td style="width: auto; vertical-align: top;">
                <div>to the Trustee for amounts due under <u>Section&#160;7.07</u>;</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 63pt; vertical-align: top;"><font style="font-style: italic;">Second</font>:</td>
              <td style="width: auto; vertical-align: top;">
                <div>to Securityholders of the Series for amounts due and unpaid on the Series for principal and interest, ratably, without preference or priority of any kind, according to the amounts due and payable on the Series for principal and
                  interest, respectively; and</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 63pt; vertical-align: top;"><font style="font-style: italic;">Third</font>:</td>
              <td style="width: auto; vertical-align: top;">
                <div>to the Company or as a court of competent jurisdiction shall direct.</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">The Trustee may fix a record date and payment date for any payment to Securityholders pursuant to this <u>Section&#160;6.10</u>.</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968811"></a><a name="z_Toc37987227"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 6.11</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Undertaking for Costs.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">In any suit for the enforcement of any right or remedy under this Indenture or in any suit against the Trustee for any action taken or omitted by it as Trustee, a court in its discretion may require the filing by any
          party litigant in the suit of an undertaking to pay the costs of the suit, and the court in its discretion may assess reasonable costs, including reasonable attorneys&#8217; fees and expenses, against any party litigant in the suit, having the due
          regard to the merits and good faith of the claims or defenses made by the party litigant.&#160; This Section does not apply to a suit by the Trustee, a suit by a Holder pursuant to <u>Section&#160;6.07</u> or a suit by Holders of more than 10% in
          principal amount of the Series.</div>
        <div>&#160;</div>
        <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;"><a name="z_Toc37987228"></a>ARTICLE SEVEN</div>
        <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;"><a name="z_Toc37968812"></a>TRUSTEE</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968813"></a><a name="z_Toc37987229"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 7.01</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Duties of Trustee.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(a)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="color: rgb(0, 0, 0);">If an Event of Default has occurred and is continuing with respect to Securities of any Series, the Trustee shall exercise its
            rights and powers and use the same degree of care and skill in their exercise as a prudent man would exercise or use under the circumstances in the conduct of his own affairs.</font></div>
        <div>&#160;</div>
        <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
          <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">22</font></div>
          <div style="page-break-after:always;" id="DSPFPageBreak">
            <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
        </div>
        <div style="text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(b)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="color: rgb(0, 0, 0);">Except during the continuance of an Event of Default:</font></div>
        <div>&#160;</div>
        <div style="text-indent: 72pt;"><font style="color: rgb(0, 0, 0);">(1)</font>&#160;&#160;&#160;&#160;&#160;&#160; &#160;&#160; <font style="color: rgb(0, 0, 0);">The Trustee need perform only those duties that are specifically set forth in this Indenture and no others and no implied
            covenants or obligations shall be read into this Indenture against the Trustee.</font></div>
        <div>&#160;</div>
        <div style="text-indent: 72pt;"><font style="color: rgb(0, 0, 0);">(2)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160; &#160; <font style="color: rgb(0, 0, 0);">In the absence of bad faith on its part, the Trustee may conclusively rely, as to the truth of the statements and the
            correctness of the opinions expressed therein, upon certificates or opinions furnished to the Trustee and conforming to the requirements of this Indenture.&#160; The Trustee, however, in the case of certificates or opinions specifically required by
            any provision hereof to be furnished to it, shall examine the certificates and opinions to determine whether or not they conform to the requirements of this Indenture but need not confirm or investigate the accuracy of mathematical calculations
            or other facts or matters stated therein.</font></div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(c)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="color: rgb(0, 0, 0);">The Trustee may not be relieved from liability for its own negligent action, its own negligent failure to act or its own
            willful misconduct, except that:</font></div>
        <div>&#160;</div>
        <div style="text-indent: 72pt;"><font style="color: rgb(0, 0, 0);">(1)</font>&#160;&#160;&#160;&#160;&#160;&#160; &#160;&#160; <font style="color: rgb(0, 0, 0);">This paragraph does not limit the effect of <u>paragraph (b)</u> of this Section.</font></div>
        <div>&#160;</div>
        <div style="text-indent: 72pt;"><font style="color: rgb(0, 0, 0);">(2)</font>&#160;&#160;&#160;&#160;&#160; &#160; &#160; <font style="color: rgb(0, 0, 0);">The Trustee shall not be liable for any error of judgment made in good faith by a Trust Officer, unless it is proved that the
            Trustee was negligent in ascertaining the pertinent facts.</font></div>
        <div>&#160;</div>
        <div style="text-indent: 72pt;"><font style="color: rgb(0, 0, 0);">(3)</font>&#160;&#160;&#160;&#160;&#160; &#160; &#160; <font style="color: rgb(0, 0, 0);">The Trustee shall not be liable with respect to any action it takes or omits to take in good faith in accordance with a
            direction received by it pursuant to <u>Section&#160;6.05</u> or any other direction of the Holders permitted hereunder.</font></div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(d)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="color: rgb(0, 0, 0);">Every provision of this Indenture that in any way relates to the Trustee is subject to <u>paragraphs (a)</u>, <u>(b)</u> and
            <u>(c)</u> of this Section.</font></div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(e)</font>&#160;&#160;&#160; &#160; &#160;&#160;&#160;&#160; <font style="color: rgb(0, 0, 0);">The Trustee may refuse to perform any duty or exercise any right or power unless it receives indemnity satisfactory to it
            against any loss, liability or expense.</font></div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(f)</font>&#160;&#160;&#160;&#160;&#160; &#160; &#160;&#160; <font style="color: rgb(0, 0, 0);">The Trustee shall not be liable for interest on any money received by it except as the Trustee may agree with the Company.&#160;
            Money held in trust by the Trustee need not be segregated from other funds except to the extent required by law.</font></div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(g)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="color: rgb(0, 0, 0);">None of the provisions contained in this Indenture shall require the Trustee to expend or risk its own funds or otherwise
            incur financial liability in the performance of any of its duties or in the exercise of any of its rights or powers, if there shall be reasonable grounds for believing that the repayment of such funds or adequate indemnity against such
            liability is not reasonably assured to it.</font></div>
        <div>&#160;</div>
        <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
          <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">23</font></div>
          <div style="page-break-after:always;" id="DSPFPageBreak">
            <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
        </div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968814"></a><a name="z_Toc37987230"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 7.02</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Rights of Trustee.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">Subject to <u>Section&#160;7.01</u>:</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(a)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="color: rgb(0, 0, 0);">The Trustee may conclusively rely and shall be fully protected in acting or refraining from acting on any document,
            resolution, certificate, instrument, report, or direction believed by it to be genuine and to have been signed or presented by the proper person.&#160; The Trustee need not investigate any fact or matter stated in the document, resolution,
            certificate, instrument, report, or direction.</font></div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(b)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="color: rgb(0, 0, 0);">Before the Trustee acts or refrains from acting, it may require an Officers&#8217; Certificate or an Opinion of Counsel or both,
            which shall conform to <u>Sections 12.04</u> and <u>12.05</u> hereof and containing such other statements as the Trustee reasonably deems necessary to perform its duties hereunder.&#160; The Trustee shall not be liable for any action it takes or
            omits to take in good faith in reliance on the Officers&#8217; Certificate, Opinion of Counsel or any other direction of the Company permitted hereunder.</font></div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(c)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="color: rgb(0, 0, 0);">The Trustee may act through agents and shall not be responsible for the misconduct or negligence of any agent appointed with
            due care.</font></div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(d)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="color: rgb(0, 0, 0);">The Trustee shall not be liable for any action taken, suffered or omitted by it in good faith and believed by it to be
            authorized or within the discretion or rights or powers conferred upon it by this Indenture.</font></div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(e)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="color: rgb(0, 0, 0);">The Trustee may consult with counsel of its selection, and the advice of such counsel or any Opinion of Counsel as to matters
            of law shall be full and complete authorization and protection in respect of any action taken, omitted or suffered by it hereunder in good faith and in accordance with the advice or opinion of such counsel.</font></div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(f)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160; &#160;&#160; <font style="color: rgb(0, 0, 0);">Unless otherwise specifically provided in the Indenture, any demand, request, direction or notice from the Company shall be
            sufficient if signed by an Officer of the Company.</font></div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(g)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="color: rgb(0, 0, 0);">For all purposes under this Indenture, the Trustee shall not be deemed to have notice or knowledge of any Event of Default
            unless written notice of any Event of Default is received by the Trustee at its address specified in <u>Section&#160;12.02</u> hereof and such notice references the Securities generally, the Company and this Indenture.</font></div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(h)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="color: rgb(0, 0, 0);">The Trustee shall be under no obligation to exercise any of the rights or powers vested in it by this Indenture at the request
            or direction of any of the Holders pursuant to this Indenture, unless such Holders shall have offered to the Trustee security or indemnity reasonably satisfactory to the Trustee against the costs, expenses and liabilities which might be
            incurred by it in compliance with such request or direction.</font></div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(i)</font>&#160;&#160;&#160;&#160;&#160; &#160; &#160;&#160; <font style="color: rgb(0, 0, 0);">The Trustee shall not be bound to make any investigation into the facts or matters stated in any resolution, certificate,
            statement, instrument, opinion, report, notice, request, direction, consent, order, bond, debenture, note, other evidence of indebtedness or other paper or document, but the Trustee, in its discretion, may make such further inquiry or
            investigation into such facts or matters as it may see fit, and, if the Trustee shall determine to make such further inquiry or investigation, it shall be entitled to examine the books, records and premises of the Company, personally or by
            agent or attorney at the sole cost of the Company and shall incur no liability or additional liability of any kind by reason of such inquiry or investigation.</font></div>
        <div>&#160;</div>
        <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
          <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">24</font></div>
          <div style="page-break-after:always;" id="DSPFPageBreak">
            <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
        </div>
        <div style="text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(j)</font>&#160;&#160;&#160;&#160;&#160; &#160; &#160;&#160; <font style="color: rgb(0, 0, 0);">In no event shall the Trustee be responsible or liable for special, indirect, punitive or consequential loss or damage of
            any kind whatsoever (including, but not limited to, loss of profit) irrespective of whether the Trustee has been advised of the likelihood of such loss or damage and regardless of the form of action.</font></div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(k)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="color: rgb(0, 0, 0);">The rights, privileges, protections, immunities and benefits given to the Trustee, including, without limitation, its right to
            be indemnified, are extended to, and shall be enforceable by, the Trustee in each of its capacities hereunder, and each agent, custodian and other Person employed to act hereunder.</font></div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(l)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160; &#160;&#160; <font style="color: rgb(0, 0, 0);">The Trustee may request that the Company deliver a certificate setting forth the names of individuals and/or titles of
            officers authorized at such time to take specified actions pursuant to this Indenture.</font></div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(m)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; <font style="color: rgb(0, 0, 0);">In no event shall the Trustee be responsible or liable for any failure or delay in the performance of its obligations
            hereunder arising out of or caused by, directly or indirectly, forces beyond its control, including, without limitation, strikes, work stoppages, accidents, acts of war or terrorism, civil or military disturbances, nuclear or natural
            catastrophes or acts of God, and interruptions, loss or malfunctions of utilities, communications or computer (software and hardware) services; it being understood that the Trustee shall use reasonable efforts which are consistent with accepted
            practices in the banking industry to resume performance as soon as practicable under the circumstances.</font></div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968815"></a><a name="z_Toc37987231"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 7.03</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Individual Rights of Trustee.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">The Trustee in its individual or any other capacity may become the owner or pledgee of Securities and may otherwise deal with the Company or its affiliates with the same rights it would have if it were not Trustee.&#160;
          Any Agent may do the same with like rights.&#160; The Trustee, however, must comply with <u>Sections 7.10</u> and <u>7.11</u>.</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968816"></a><a name="z_Toc37987232"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 7.04</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Trustee&#8217;s Disclaimer.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">The Trustee makes no representation as to the validity or adequacy of this Indenture, the Securities or of any prospectus used to sell the Securities of any Series; it shall not be accountable for the Company&#8217;s use
          of the proceeds from the Securities; it shall not be accountable for any money paid to the Company, or upon the Company&#8217;s direction, if made under and in accordance with any provision of this Indenture; it shall not be responsible for the use or
          application of any money received by any Paying Agent other than the Trustee; and it shall not be responsible for any statement of the Company in this Indenture or in the Securities other than its certificate of authentication.</div>
        <div>&#160;</div>
        <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
          <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">25</font></div>
          <div style="page-break-after:always;" id="DSPFPageBreak">
            <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
        </div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968817"></a><a name="z_Toc37987233"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 7.05</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Notice of Defaults.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">If a Default on a Series occurs and is continuing and if a responsible officer of the Trustee has actual knowledge of such Default, the Trustee shall deliver to each Securityholder of the Series notice of the Default
          (which shall specify any uncured Default known to it) within 90 days after the Trustee obtains such knowledge.&#160; Except in the case of a default in payment of principal of or interest on a Series, the Trustee may withhold the notice if and so long
          as the board of directors of the Trustee, the executive or any trust committee of such directors and/or responsible officers of the Trustee in good faith determine(s) that withholding the notice is in the interests of Holders of the Series.</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968818"></a><a name="z_Toc37987234"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 7.06</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Reports by Trustee to Holders.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">Within 60 days after each May 15 beginning with the May 15 following the date of this Base Indenture, the Trustee shall mail to each Securityholder a brief report dated as of such May 15 that complies with TIA &#167;
          313(a) (but if no event described in TIA &#167; 313(1) through (8) has occurred within the twelve months preceding the reporting date no report in relation thereto need be transmitted).&#160; The Trustee also shall comply with TIA &#167; 313(b).</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">A copy of each report at the time of its mailing to Securityholders shall be delivered to the Company and filed by the Trustee with the SEC and each national securities exchange on which the Securities are listed.&#160;
          The Company agrees to notify the Trustee of each national securities exchange on which the Securities are listed.</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968819"></a><a name="z_Toc37987235"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 7.07</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Compensation and Indemnity.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">The Company shall pay to the Trustee from time to time reasonable compensation for its services subject to any written agreement between the Trustee and the Company (which compensation shall not be limited by any
          provision of law in regard to the compensation of a trustee of an express trust).&#160; The Company shall reimburse the Trustee upon request for all reasonable out-of-pocket expenses incurred by it.&#160; Such expenses shall include the reasonable
          compensation and expenses of the Trustee&#8217;s agents and counsel.&#160; The Company shall indemnify the Trustee, its officers, directors, employees and agents and hold it harmless against any loss, liability, claim, damage or expense incurred or made by
          or on behalf of it in connection with the administration of this Indenture or the trust hereunder and its duties hereunder including the costs and expenses of defending itself against or investigating any claim in the premises.&#160; The Trustee shall
          notify the Company promptly of any claim of which it has received written notice and for which it may seek indemnity.&#160; The Company need not reimburse any expense or indemnify against any loss or liability incurred by the Trustee through the
          Trustee&#8217;s, or its officers&#8217;, directors&#8217;, or employees&#8217; negligence or willful misconduct.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">Unless otherwise provided in any supplemental indenture or Authorizing Resolution relating to any Series, to ensure the Company&#8217;s payment obligations in this Section, the Trustee shall have a lien prior to the
          Securities of all Series on all money or Property held or collected by the Trustee, except that held in trust to pay principal of or interest on particular Securities.&#160; When the Trustee incurs expenses or renders services in connection with an
          Event of Default specified in <u>Section&#160;6.01</u> or in connection with <u>Article&#160;Six</u> hereof, the expenses (including the reasonable fees and expenses of its counsel) and the compensation for services in connection therewith are to
          constitute expenses of administration under any Bankruptcy Law.&#160; <u>Section&#160;7.07</u> shall survive the discharge of the Indenture or resignation or removal of Trustee.</div>
        <div>&#160;</div>
        <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
          <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">26</font></div>
          <div style="page-break-after:always;" id="DSPFPageBreak">
            <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
        </div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968820"></a><a name="z_Toc37987236"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 7.08</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Replacement of Trustee.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">The Trustee may resign with respect to Securities of any or all Series by so notifying the Company.&#160; The Holders of a majority in principal amount of the outstanding Securities (or of the relevant Series) may remove
          the Trustee by so notifying the removed Trustee in writing (at any time when the Trustee holds funds on behalf of the Company, upon 30 days&#8217; prior written notice) and may appoint a successor trustee with the Company&#8217;s consent.&#160; Such resignation
          or removal shall not take effect until the appointment by the Securityholders of the relevant Series or the Company as hereinafter provided of a successor trustee and the acceptance of such appointment by such successor trustee.&#160; The Company (at
          any time when the Trustee holds funds on behalf of the Company, upon 30 days&#8217; prior written notice) may remove the Trustee and any Securityholder may petition any court of competent jurisdiction for the removal of the Trustee and the appointment
          of a successor trustee for any or no reason, including if:</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(1)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">the Trustee fails to comply with <u>Section&#160;7.10</u> after written request by the Company or any bona fide Securityholder who has been a Securityholder for at least six months;</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(2)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">the Trustee is adjudged a bankrupt or an insolvent;</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(3)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">a receiver or other public officer takes charge of the Trustee or its Property; or</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(4)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">the Trustee becomes incapable of acting.</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">If the Trustee resigns or is removed or if a vacancy exists in the office of Trustee for any reason, the Company shall promptly appoint a successor trustee with respect to the Securities of the relevant Series.&#160; If a
          successor trustee does not take office within 30 days after the retiring Trustee resigns or is removed, the retiring Trustee at the expense of the Company, the Company or any Holder may petition any court of competent jurisdiction for the
          appointment of a successor trustee.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">A successor trustee shall deliver a written acceptance of its appointment to the retiring Trustee and to the Company.&#160; Immediately after that, the retiring Trustee shall, upon payment of its fees and expenses
          (including, without limitation, reasonable fees and expenses of counsel) hereunder, transfer all Property held by it as Trustee to the successor trustee, the resignation or removal of the retiring Trustee shall become effective, and the successor
          trustee shall have all the rights, powers and duties of the Trustee under this Indenture.&#160; A successor trustee shall mail notice of its succession to each Securityholder.</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968821"></a><a name="z_Toc37987237"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 7.09</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Successor Trustee by Merger, etc.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">If the Trustee consolidates with, merges with or into or converts into, or transfers all or substantially all of its corporate trust business to, another corporation, the successor corporation without any further act
          shall be the successor trustee.</div>
        <div>&#160;</div>
        <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
          <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">27</font></div>
          <div style="page-break-after:always;" id="DSPFPageBreak">
            <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
        </div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968822"></a><a name="z_Toc37987238"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 7.10</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Eligibility; Disqualification.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">This Indenture shall always have a Trustee who satisfies the requirements of TIA &#167; 310(a)(1).&#160; The Trustee shall have a combined capital and surplus of at least $10,000,000 as set forth in its most recent published
          annual report of condition.&#160; The Trustee shall comply with TIA &#167; 310(b).</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968823"></a><a name="z_Toc37987239"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 7.11</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Preferential Collection of Claims Against Company.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">The Trustee shall comply with TIA &#167; 311(a), excluding any creditor relationship listed in TIA &#167; 311(b).&#160; A Trustee who has resigned or been removed shall be subject to TIA &#167; 311(a) to the extent indicated therein.</div>
        <div>&#160;</div>
        <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;"><a name="z_Toc37987240"></a>ARTICLE EIGHT</div>
        <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;"><a name="z_Toc37968824"></a>DISCHARGE OF INDENTURE</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968825"></a><a name="z_Toc37987241"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 8.01</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Defeasance upon Deposit of Moneys or Government Obligations.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(a)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="color: rgb(0, 0, 0);">The Company may, at its option and at any time, elect to have either <u>paragraph (b)</u> or <u>paragraph (c)</u> below be
            applied to the outstanding Securities of any Series upon compliance with the applicable conditions set forth in <u>paragraph (d)</u>.</font></div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(b)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="color: rgb(0, 0, 0);">Upon the Company&#8217;s exercise under <u>paragraph (a)</u> of the option applicable to this <u>paragraph (b)</u> with respect to
            any Series, the Company shall be deemed to have been released and discharged from its obligations with respect to the outstanding Securities of the Series on the date the applicable conditions set forth below are satisfied (hereinafter, &#8220;<font style="font-weight: bold;">Legal Defeasance</font>&#8221;).&#160; For this purpose, such Legal Defeasance means that the Company shall be deemed to have paid and discharged the entire indebtedness represented by the outstanding Securities of a Series,
            which shall thereafter be deemed to be &#8220;outstanding&#8221; only for the purposes of the Sections and matters under this Indenture referred to in (i) and (ii) below, and the Company shall be deemed to have satisfied all its other obligations under
            such Securities and this Indenture insofar as such Securities are concerned, except for the following which shall survive until otherwise terminated or discharged hereunder: (i) the rights of Holders of outstanding Securities of a Series to
            receive solely from the trust fund described in <u>paragraph (d)</u> below and as more fully set forth in such paragraph, payments in respect of the principal of and interest on such Securities when such payments are due and (ii) obligations
            listed in <u>Section&#160;8.02</u>, subject to compliance with this <u>Section&#160;8.01</u>.&#160; The Company may exercise its option under this <u>paragraph (b)</u> with respect to a Series notwithstanding the prior exercise of its option under <u>paragraph


              (c)</u> below with respect to the Securities of the Series.</font></div>
        <div>&#160;</div>
        <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
          <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">28</font></div>
          <div style="page-break-after:always;" id="DSPFPageBreak">
            <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
        </div>
        <div style="text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(c)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="color: rgb(0, 0, 0);">Upon the Company&#8217;s exercise under <u>paragraph (a)</u> of the option applicable to this <u>paragraph (c)</u> with respect to
            a Series, the Company shall be released and discharged from the obligations under any covenant contained in <u>Articles Four</u> and <u>Five</u> and any other covenant contained in or referenced in the Authorizing Resolution or supplemental
            indenture relating to such Series (to the extent such release and discharge shall not be prohibited thereby), on and after the date the conditions set forth below are satisfied (hereinafter, &#8220;<font style="font-weight: bold;">Covenant Defeasance</font>&#8221;),


            and the Securities of such Series shall thereafter be deemed to be not &#8220;outstanding&#8221; for the purpose of any direction, waiver, consent or declaration or act of Holders (and the consequences of any thereof) in connection with such covenants, but
            shall continue to be deemed &#8220;outstanding&#8221; for all other purposes hereunder.&#160; For this purpose, such Covenant Defeasance means that, with respect to the outstanding Securities of a Series, the Company may omit to comply with and shall have no
            liability in respect of any term, condition or limitation set forth in any such covenant, whether directly or indirectly, by reason of any reference elsewhere herein to any such covenant or by reason of any reference in any such covenant to any
            other provision herein or in any other document and such omission to comply shall not constitute a Default or an Event of Default under <u>Section&#160;6.01(3)</u> or otherwise, but, except as specified above, the remainder of this Indenture and
            such Securities shall be unaffected thereby.</font></div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(d)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="color: rgb(0, 0, 0);">The following shall be the conditions to application of either <u>paragraph (b)</u> or <u>paragraph (c)</u> above to the
            outstanding Securities of the applicable Series:</font></div>
        <div>&#160;</div>
        <div style="text-indent: 72pt;"><font style="color: rgb(0, 0, 0);">(1)</font>&#160;&#160;&#160;&#160;&#160;&#160; &#160;&#160; <font style="color: rgb(0, 0, 0);">The Company shall have irrevocably deposited in trust with the Trustee (or another qualifying trustee), money in the currency
            in which the Securities of such Series are payable or Government Obligations or a combination thereof in such amounts and at such times as are sufficient, in the opinion of a nationally recognized firm of independent public accountants, to pay
            the principal of and interest on the outstanding Securities of such Series to maturity or redemption; provided, however, that the Trustee (or other qualifying trustee) shall have received an irrevocable written order from the Company
            instructing the Trustee (or other qualifying trustee) to apply such money or the proceeds of such Government Obligations to said payments with respect to the Securities of such Series to maturity or redemption;</font></div>
        <div>&#160;</div>
        <div style="text-indent: 72pt;"><font style="color: rgb(0, 0, 0);">(2)</font>&#160;&#160;&#160;&#160; &#160; &#160;&#160; <font style="color: rgb(0, 0, 0);">No Default or Event of Default (other than a Default or Event of Default resulting from non-compliance with any covenant from
            which the Company is released upon effectiveness of such Legal Defeasance or Covenant Defeasance pursuant to <u>paragraph (b)</u> or <u>(c)</u> hereof, as applicable) shall have occurred and be continuing on the date of such deposit or result
            therefrom;</font></div>
        <div>&#160;</div>
        <div style="text-indent: 72pt;"><font style="color: rgb(0, 0, 0);">(3)</font>&#160;&#160;&#160;&#160; &#160; &#160;&#160; <font style="color: rgb(0, 0, 0);">Such deposit will not result in a breach or violation of, or constitute a default under, any other material instrument or
            agreement to which the Company or any of any of its Restricted Subsidiaries is a party or by which it or any of their Property is bound;</font></div>
        <div>&#160;</div>
        <div style="text-indent: 72pt;"><font style="color: rgb(0, 0, 0);">(4)</font>&#160; &#160; &#160;&#160;&#160;&#160;&#160; <font style="color: rgb(0, 0, 0);">(i) In the event the Company elects <u>paragraph (b)</u> hereof, the Company shall deliver to the Trustee an Opinion of
            Counsel in the United States, in form and substance reasonably satisfactory to the Trustee, to the effect that (A) the Company has received from, or there has been published by, the Internal Revenue Service a ruling or (B) since the Issue Date
            pertaining to such Series, there has been a change in the applicable federal income tax law, in either case to the effect that, and based thereon such Opinion of Counsel shall state that, or (ii) in the event the Company elects <u>paragraph
              (c)</u> hereof, the Company shall deliver to the Trustee an Opinion of Counsel in the United States, in form and substance reasonably satisfactory to the Trustee, to the effect that, in the case of <u>clauses&#160;(i)</u> and <u>(ii)</u>, and
            subject to customary assumptions and exclusions, Holders of the Securities of such Series will not recognize income, gain or loss for federal income tax purposes as a result of such deposit and the defeasance contemplated hereby and will be
            subject to federal income tax in the same amounts and in the same manner and at the same times as would have been the case if such deposit and defeasance had not occurred;</font></div>
        <div>&#160;</div>
        <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
          <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">29</font></div>
          <div style="page-break-after:always;" id="DSPFPageBreak">
            <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
        </div>
        <div style="text-indent: 72pt;"><font style="color: rgb(0, 0, 0);">(5)</font>&#160;&#160;&#160;&#160;&#160;&#160; &#160;&#160; <font style="color: rgb(0, 0, 0);">The Company shall have delivered to the Trustee an Officers&#8217; Certificate, stating that the deposit under <u>clause&#160;(1)</u>
            was not made by the Company with the intent of preferring the Holders of the Securities of such Series over any other creditors of the Company or with the intent of defeating, hindering, delaying or defrauding any other creditors of the Company
            or others; and</font></div>
        <div>&#160;</div>
        <div style="text-indent: 72pt;"><font style="color: rgb(0, 0, 0);">(6)</font>&#160;&#160;&#160;&#160;&#160;&#160; &#160;&#160; <font style="color: rgb(0, 0, 0);">The Company has delivered to the Trustee an Officers&#8217; Certificate and an Opinion of Counsel, each stating that all conditions
            precedent specified herein relating to the defeasance contemplated by this <u>Section&#160;8.01</u> have been complied with.</font></div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">In the event all or any portion of the Securities of a Series are to be redeemed through such irrevocable trust, the Company must make arrangements satisfactory to the Trustee, at the time of such deposit, for the
          giving of the notice of such redemption or redemptions by the Trustee in the name and at the expense of the Company.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;"><font style="color: rgb(0, 0, 0);">(e)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="color: rgb(0, 0, 0);">In addition to the Company&#8217;s rights above under this <u>Section&#160;8.01</u>, the Company may terminate all of its obligations
            under this Indenture with respect to a Series, when:</font></div>
        <div>&#160;</div>
        <div style="text-indent: 72pt;"><font style="color: rgb(0, 0, 0);">(1)</font>&#160;&#160;&#160;&#160;&#160; &#160;&#160;&#160; <font style="color: rgb(0, 0, 0);">All Securities of such Series theretofore authenticated and delivered (other than Securities which have been destroyed, lost
            or stolen and which have been replaced or paid as provided in <u>Section&#160;2.07</u> and Securities for whose payment money has theretofore been deposited in trust or segregated and held in trust by the Company and thereafter repaid to the
            Company or discharged from such trust) have been delivered to the Trustee for cancellation or all such Securities not theretofore delivered to the Trustee for cancellation (A) have become due and payable, (B) will become due and payable at
            maturity within one year or (C) are to be called for redemption within one year under arrangements satisfactory to the Trustee for the giving of notice of redemption by the Trustee in the name, and at the expense, of the Company, and in each
            such case, the Company has irrevocably deposited or caused to be deposited with the Trustee (or another qualifying trustee) as trust funds in trust solely for that purpose an amount of money in the currency in which the Securities of such
            Series are payable or Government Obligations or a combination thereof sufficient, in the opinion of a nationally recognized firm of independent public accountants, to pay and discharge the entire Indebtedness on the Securities of such Series
            not theretofore delivered to the Trustee for cancellation, for principal of and interest on the Securities of such Series, on the date of such deposit or to the maturity or redemption date, as the case may be;</font></div>
        <div>&#160;</div>
        <div style="text-indent: 72pt;"><font style="color: rgb(0, 0, 0);">(2)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160; &#160; <font style="color: rgb(0, 0, 0);">The Company has paid or caused to be paid all other sums payable hereunder by the Company;</font></div>
        <div>&#160;</div>
        <div style="text-indent: 72pt;"><font style="color: rgb(0, 0, 0);">(3)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160; &#160; <font style="color: rgb(0, 0, 0);">The Company has delivered irrevocable instructions to the Trustee (or such other qualifying trustee), to apply the deposited
            money toward the payment of the Securities of such Series at maturity or redemption, as the case may be; and</font></div>
        <div>&#160;</div>
        <div style="text-indent: 72pt;"><font style="color: rgb(0, 0, 0);">(4)</font>&#160;&#160;&#160;&#160;&#160;&#160; &#160;&#160; <font style="color: rgb(0, 0, 0);">The Company has delivered to the Trustee an Officers&#8217; Certificate and an Opinion of Counsel, stating that all conditions
            precedent specified in this <u>Section&#160;8.01(e)</u> relating to the satisfaction and discharge of this Indenture have been complied with.</font></div>
        <div>&#160;</div>
        <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
          <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">30</font></div>
          <div style="page-break-after:always;" id="DSPFPageBreak">
            <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
        </div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968826"></a><a name="z_Toc37987242"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 8.02</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Survival of the Company&#8217;s Obligations.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">Notwithstanding the satisfaction and discharge of this Indenture under <u>Section&#160;8.01</u>, the Company&#8217;s obligations in <u>Sections 2.03</u> through <u>2.07</u>, <u>4.01</u>, <u>7.07</u>, <u>7.08</u>, <u>8.04
            and 8.05,</u> however, shall survive until the Securities of an applicable Series are no longer outstanding.&#160; Thereafter, the Company&#8217;s obligations in <u>Sections 7.02</u>, <u>7.07</u>, <u>8.04</u> and <u>8.05</u> shall survive (as they
          relate to such Series) such satisfaction and discharge.</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968827"></a><a name="z_Toc37987243"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 8.03</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Application of Trust Money.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">The Trustee shall hold in trust money or Government Obligations deposited with it pursuant to <u>Section&#160;8.01</u>.&#160; It shall apply the deposited money and the money from Government Obligations in accordance with
          this Indenture to the payment of principal of and interest on the Securities of the defeased Series.</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968828"></a><a name="z_Toc37987244"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 8.04</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Repayment to the Company.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">The Trustee and the Paying Agent shall promptly pay to the Company upon request any excess money or securities held by them at any time.&#160; The Trustee and the Paying Agent shall pay to the Company upon request any
          money held by them for the payment of principal or interest that remains unclaimed for two years, provided, however, that the Trustee or such Paying Agent, before being required to make any such repayment, may at the expense of the Company cause
          to be published once in a newspaper of general circulation in the City of New York or send to each such Holder notice that such money remains unclaimed and that, after a date specified therein, which shall not be less than 30 days from the date
          of such publication or mailing, any unclaimed balance of such money then remaining will be repaid to the Company.&#160; After payment to the Company, Securityholders entitled to the money must look to the Company for payment as general creditors
          unless applicable abandoned property law designates another person and all liability of the Trustee or such Paying Agent with respect to such money shall cease.</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968829"></a><a name="z_Toc37987245"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 8.05</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Reinstatement.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">If the Trustee is unable to apply any money or Government Obligations in accordance with <u>Section&#160;8.01</u> by reason of any legal proceeding or by reason of any order or judgment of any court or governmental
          authority enjoining, restraining or otherwise prohibiting such application, the Company&#8217;s obligations under this Indenture and the Securities relating to the Series shall be revived and reinstated as though no deposit had occurred pursuant to <u>Section&#160;8.01</u>
          until such time as the Trustee is permitted to apply all such money or Government Obligations in accordance with <u>Section&#160;8.01</u>; provided, however, that (a) if the Company has made any payment of interest on or principal of any Securities
          of the Series because of the reinstatement of its obligations hereunder, the Company shall be subrogated to the rights of the Holders of such Securities to receive such payment from the money or Government Obligations held by the Trustee and (b)
          unless otherwise required by any legal proceeding or any order or judgment of any court or governmental authority, the Trustee shall return all such money or Government Obligations to the Company promptly after receiving a written request
          therefor at any time, if such reinstatement of the Company&#8217;s obligations has occurred and continues to be in effect.</div>
        <div>&#160;</div>
        <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
          <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">31</font></div>
          <div style="page-break-after:always;" id="DSPFPageBreak">
            <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
        </div>
        <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;"><a name="z_Toc37987246"></a>ARTICLE NINE</div>
        <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;"><a name="z_Toc37968830"></a>RESERVED</div>
        <div>&#160;</div>
        <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;"><a name="z_Toc37987247"></a>ARTICLE TEN</div>
        <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;"><a name="z_Toc37968831"></a>AMENDMENTS, SUPPLEMENTS AND WAIVERS</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968832"></a><a name="z_Toc37987248"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 10.01</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Without Consent of Holders.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">The Company and the Trustee may amend or supplement this Indenture or the Securities of a Series without notice to or consent of any Securityholder of such Series:</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(1)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">to cure any ambiguity, omission, defect or inconsistency;</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(2)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">to comply with <u>Article&#160;Five</u>;</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(3)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">to provide that specific provisions of this Indenture shall not apply to a Series not previously issued or to make a change to specific provisions of this Indenture that only applies to any Series not
                  previously issued or to additional Securities of a Series not previously issued;</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(4)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">to create a Series and establish its terms;</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(5)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">to provide for uncertificated Securities in addition to or in place of certificated Securities;</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(6)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">to release a guarantor in respect of any Series which, in accordance with the terms of this Indenture applicable to the particular Series, ceases to be liable in respect of its guarantee;</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(7)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">to add a guarantor in respect of any Series;</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(8)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">to secure any Series;</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(9)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">to comply with requirements of the SEC in order to effect or maintain the qualification of this Indenture under the TIA;</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(10)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">to make any other change that does not adversely affect the rights of Securityholders; and</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(11)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">to conform the provisions of the Indenture to the final offering memorandum in respect of any Series.</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">After an amendment under this <u>Section&#160;10.01</u> becomes effective, the Company shall deliver notice of such amendment to the Securityholders.</div>
        <div>&#160;</div>
        <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
          <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">32</font></div>
          <div style="page-break-after:always;" id="DSPFPageBreak">
            <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
        </div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968833"></a><a name="z_Toc37987249"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 10.02</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>With Consent of Holders.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">The Company and the Trustee may amend or supplement this Indenture or the Securities of a Series without notice to any Securityholder of such Series but with the written consent of the Holders of at least a majority
          in principal amount of the outstanding Securities of each Series affected by the amendment (including consents obtained in connection with a purchase of, or tender offer or exchange offer for, Securities of such Series).&#160; Each such Series shall
          vote as a separate class.&#160; The Holders of a majority in principal amount of the outstanding Securities of any Series may waive compliance by the Company with any provision of the Securities of such Series or of this Indenture relating to such
          Series without notice to any Securityholder (including any waiver granted in connection with a purchase of, or tender offer or exchange offer for, Securities of such Series).&#160; Without the consent of each Holder of a Security affected thereby,
          however, an amendment, supplement or waiver, including a waiver pursuant to <u>Section&#160;6.04</u>, may not:</div>
        <div>&#160;</div>
        <div style="text-indent: 72pt;"><font style="color: rgb(0, 0, 0);">(1)</font>&#160;&#160;&#160;&#160;&#160;&#160; &#160;&#160; <font style="color: rgb(0, 0, 0);">reduce the amount of Securities of the relevant Series whose Holders must consent to an amendment, supplement or waiver;</font></div>
        <div>&#160;</div>
        <div style="text-indent: 72pt;"><font style="color: rgb(0, 0, 0);">(2)</font>&#160;&#160;&#160;&#160;&#160; &#160; &#160; <font style="color: rgb(0, 0, 0);">reduce the rate of or extend the time for payment of interest, including defaulted interest, on any Security;</font></div>
        <div>&#160;</div>
        <div style="text-indent: 72pt;"><font style="color: rgb(0, 0, 0);">(3)</font>&#160;&#160;&#160;&#160;&#160; &#160; &#160; <font style="color: rgb(0, 0, 0);">reduce the principal of or extend the fixed maturity of any Security or alter the provisions (including related definitions)
            with respect to redemption of any Security pursuant to <u>Article&#160;Three</u> hereof or with respect to any obligations on the part of the Company to offer to purchase or to redeem Securities of a Series pursuant to the Authorizing Resolution or
            supplemental indenture pertaining to such Series (it being understood that only the consent of the Holders of a majority of the principal amount of the applicable Series of Securities will be required in connection with the waiver or
            modification of any obligation by the Company to make an offer to purchase the Securities of such Series as a result of a change of control prior to the occurrence of a change of control);</font></div>
        <div>&#160;</div>
        <div style="text-indent: 72pt;"><font style="color: rgb(0, 0, 0);">(4)</font>&#160;&#160;&#160;&#160;&#160; &#160;&#160;&#160; <font style="color: rgb(0, 0, 0);">make any change that adversely affects any right of a Holder to convert or exchange any Security into or for shares of the
            Company&#8217;s common stock or other securities, cash or other property in accordance with the terms of such Security;</font></div>
        <div>&#160;</div>
        <div style="text-indent: 72pt;"><font style="color: rgb(0, 0, 0);">(5)</font>&#160;&#160;&#160;&#160; &#160; &#160;&#160; <font style="color: rgb(0, 0, 0);">modify the ranking or priority of the Securities of the relevant Series or any guarantee thereof;</font></div>
        <div>&#160;</div>
        <div style="text-indent: 72pt;"><font style="color: rgb(0, 0, 0);">(6)</font>&#160;&#160;&#160;&#160;&#160; &#160; &#160; <font style="color: rgb(0, 0, 0);">release any guarantor of any Series from any of its obligations under its guarantee or this Indenture otherwise than in
            accordance with the terms of this Indenture;</font></div>
        <div>&#160;</div>
        <div style="text-indent: 72pt;"><font style="color: rgb(0, 0, 0);">(7)</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160; &#160; <font style="color: rgb(0, 0, 0);">make any change in <u>Sections 6.04</u>, <u>6.07</u> or this <u>Section&#160;10.02</u>;</font></div>
        <div>&#160;</div>
        <div style="text-indent: 72pt;"><font style="color: rgb(0, 0, 0);">(8)</font>&#160;&#160;&#160;&#160;&#160;&#160; &#160;&#160; <font style="color: rgb(0, 0, 0);">waive a continuing Default or Event of Default in the payment of the principal of or interest on any Security; or</font></div>
        <div>&#160;</div>
        <div style="text-indent: 72pt;"><font style="color: rgb(0, 0, 0);">(9)</font>&#160;&#160;&#160;&#160;&#160; &#160; &#160; <font style="color: rgb(0, 0, 0);">make any Security payable at a place or in money other than that stated in the Security, or impair the right of any
            Securityholder to bring suit as permitted by <u>Section&#160;6.07</u>.</font></div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">An amendment of a provision included solely for the benefit of one or more Series does not affect the interests of Securityholders of any other Series.</div>
        <div>&#160;</div>
        <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
          <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">33</font></div>
          <div style="page-break-after:always;" id="DSPFPageBreak">
            <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
        </div>
        <div style="text-indent: 36pt;">It shall not be necessary for the consent of the Holders under this Section to approve the particular form of any proposed supplement, but it shall be sufficient if such consent approves the substance thereof.</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968834"></a><a name="z_Toc37987250"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 10.03</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Compliance with Trust Indenture Act.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">Every amendment to or supplement of this Indenture or any Securities shall comply with the TIA as then in effect.</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968835"></a><a name="z_Toc37987251"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 10.04</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Revocation and Effect of Consents.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">A consent to an amendment, supplement or waiver by a Holder shall bind the Holder and every subsequent Holder of a Security or portion of a Security that evidences the same debt as the consenting Holder&#8217;s Security,
          even if notation of the consent is not made on any Security.&#160; Unless otherwise provided in the consent or the consent solicitation statement or other document describing the terms of the consent, any Holder or subsequent Holder may revoke the
          consent as to its Security or portion of a Security.&#160; Any revocation of a consent by the Holder of a Security or any such subsequent Holder shall be effective only if the Trustee receives the notice of revocation before the date on which the
          Trustee receives an Officers&#8217; Certificate from the Company certifying that the requisite number of consents have been received.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">The Company may, but shall not be obligated to, fix a record date for the purpose of determining the Holders of Securities of any Series entitled to consent to any amendment, supplement or waiver, which record date
          shall be at least 10 days prior to the first solicitation of such consent.&#160; If a record date is fixed, and if Holders otherwise have a right to revoke their consent under the consent or the consent solicitation statement or other document
          describing the terms of the consent, then notwithstanding the second to last sentence of the immediately preceding paragraph, those Persons who were Holders at such record date (or their duly designated proxies), and only those Persons, shall be
          entitled to revoke any consent previously given, whether or not such Persons continue to be Holders after such record date.&#160; No such consent shall be valid or effective for more than 90 days after such record date.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">An amendment, supplement or waiver with respect to a Series becomes effective upon the (i) receipt by the Company or the Trustee of the requisite consents, (ii) satisfaction of any conditions to effectiveness as set
          forth in this Indenture or any indenture supplemental hereto containing such amendment, supplement or waiver and (iii) execution of such amendment, supplement or waiver (or the related supplemental indenture) by the Company and the Trustee.&#160;
          After an amendment, supplement or waiver with respect to a Series becomes effective, it shall bind every Holder of such Series, unless it makes a change described in any of <u>clauses&#160;(1)</u> through <u>(9)</u> of <u>Section&#160;10.02</u>, in
          which case, the amendment, supplement or waiver shall bind a Holder of a Security who is affected thereby only if it has consented to such amendment, supplement or waiver and every subsequent Holder of a Security or portion of a Security that
          evidences the same debt as the consenting Holder&#8217;s Security; provided that no such waiver shall impair or affect the right of any Holder to receive payment of principal of and interest on a Security, on or after the respective due dates expressed
          in such Security, or to bring suit for the enforcement of any such payment on or after such respective dates without the consent of such Holder.</div>
        <div>&#160;</div>
        <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
          <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">34</font></div>
          <div style="page-break-after:always;" id="DSPFPageBreak">
            <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
        </div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968836"></a><a name="z_Toc37987252"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 10.05</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Notation on or Exchange of Securities.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">If an amendment, supplement or waiver changes the terms of a Security, the Company may require the Holder of the Security to deliver it to the Trustee, at which time the Trustee shall place an appropriate notation on
          the Security about the changed terms and return it to the Holder.&#160; Alternatively, if the Company or the Trustee so determines, the Company in exchange for the Security shall issue and the Trustee shall authenticate a new Security that reflects
          the changed terms.</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968837"></a><a name="z_Toc37987253"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 10.06</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Trustee to Sign Amendments, etc.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">Subject to <u>Section&#160;7.02(b)</u>, the Trustee shall sign any amendment, supplement or waiver authorized pursuant to this Article if the amendment, supplement or waiver does not adversely affect the rights, duties,
          liabilities or immunities of the Trustee.&#160; If it does, the Trustee may but need not sign it.&#160; In signing or refusing to sign such amendment or supplemental indenture, the Trustee shall be provided with and shall be fully protected in relying
          upon, an Officers&#8217; Certificate and an Opinion of Counsel as conclusive evidence that such amendment, supplement or waiver is authorized or permitted by this Indenture, and (solely with respect to such Opinion of Counsel) that it will be valid and
          binding upon the Company and enforceable in accordance with its terms.</div>
        <div>&#160;</div>
        <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;"><a name="z_Toc37987254"></a>ARTICLE ELEVEN</div>
        <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;"><a name="z_Toc37968838"></a>SECURITIES IN FOREIGN CURRENCIES</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968839"></a><a name="z_Toc37987255"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 11.01</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Applicability of Article.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">Whenever this Indenture provides for (i) any action by, or the determination of any of the rights of, Holders of Securities of any Series in which not all of such Securities are denominated in the same currency, or
          (ii) any distribution to Holders of Securities, in the absence of any provision to the contrary pursuant to this Indenture or the Securities of any particular Series, any amount in respect of any Security denominated in a Foreign Currency shall
          be treated for any such action or distribution as that amount of Dollars that could be obtained for such amount on such reasonable basis of exchange and as of the record date with respect to Securities of such Series (if any) for such action,
          determination of rights or distribution (or, if there shall be no applicable record date, such other date reasonably proximate to the date of such action, determination of rights or distribution) as the Company may specify in a written notice to
          the Trustee or, in the absence of such written notice, as the Trustee may determine.</div>
        <div>&#160;</div>
        <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;"><a name="z_Toc37987256"></a>ARTICLE TWELVE</div>
        <div style="text-align: center; color: rgb(0, 0, 0); font-weight: bold;"><a name="z_Toc37968840"></a>MISCELLANEOUS</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968841"></a><a name="z_Toc37987257"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 12.01</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Trust Indenture Act Controls.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">If any provision of this Indenture limits, qualifies or conflicts with another provision which is required to be included in this Indenture by the TIA, the required provision shall control.</div>
        <div>&#160;</div>
        <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
          <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">35</font></div>
          <div style="page-break-after:always;" id="DSPFPageBreak">
            <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
        </div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968842"></a><a name="z_Toc37987258"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 12.02</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Notices.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">Any order, consent, notice or communication shall be sufficiently given if in writing and delivered in person or mailed by first class mail, postage prepaid, or delivered by commercial courier service, addressed as
          follows:</div>
        <div>&#160;</div>
        <div style="margin-left: 72pt;">if to the Company:</div>
        <div>&#160;</div>
        <div style="margin-left: 108pt;">BioCryst Pharmaceuticals, Inc.</div>
        <div style="margin-left: 108pt;">4505 Emperor Blvd., Suite 200</div>
        <div style="margin-left: 108pt;">Durham, North Carolina 27703</div>
        <div style="margin-left: 108pt;">(919) 859-1302</div>
        <div style="margin-left: 108pt;">Attention: [_____________]</div>
        <div>&#160;</div>
        <div style="margin-left: 72pt;">if to the Trustee:</div>
        <div>&#160;</div>
        <div style="margin-left: 108pt;"><a name="z_9kMJI5YVtAB567F"></a>U.S. Bank National Association</div>
        <div style="margin-left: 108pt;">214 North Tyron Street, 27th Floor</div>
        <div style="margin-left: 108pt;">Charlotte, North Carolina 28202<br>
        </div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">The Company or the Trustee by notice to the other may designate additional or different addresses for subsequent notices or communications.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">Any notice or communication mailed to a Securityholder shall be mailed to him by first class mail, or delivered by commercial courier service, at his address as it appears on the registration books of the Registrar,
          or, in the case of Global Securities sent electronically in accordance with the procedures of the Depositary, and shall be sufficiently given to him if so sent within the time prescribed.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">Failure to send a notice or communication to a Securityholder or any defect in it shall not affect its sufficiency with respect to other Securityholders.&#160; If a notice or communication is sent in the manner provided
          above, it is duly given, whether or not the addressee receives it except that notice to the Trustee shall only be effective upon receipt thereof by the Trustee.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">If the Company sends notice or communications to the Securityholders, it shall send a copy to the Trustee at the same time.</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">In addition to the foregoing, the Trustee agrees to accept and act upon notice, instructions or directions pursuant to this Indenture sent by unsecured e-mail, facsimile transmission or other similar unsecured
          electronic methods.&#160; If the party elects to give the Trustee e-mail or facsimile instructions (or instructions by a similar electronic method) and the Trustee in its discretion elects to act upon such instructions, the Trustee&#8217;s understanding of
          such instructions shall be deemed controlling.&#160; The Trustee shall not be liable for any losses, costs or expenses arising directly or indirectly from the Trustee&#8217;s reliance upon and compliance with such instructions notwithstanding such
          instructions conflict or are inconsistent with a subsequent written instruction.&#160; The party providing electronic instructions agrees to assume all risks arising out of the use of such electronic methods to submit instructions and directions to
          the Trustee, including without limitation the risk of the Trustee acting on unauthorized instructions, and the risk of interception and misuse by third parties.</div>
        <div>&#160;</div>
        <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
          <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">36</font></div>
          <div style="page-break-after:always;" id="DSPFPageBreak">
            <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
        </div>
        <div style="text-indent: 36pt;">Notwithstanding any other provision of this Indenture or any Security, where this Indenture or any Security provides for notice of any event to a Holder of a Global Security (whether by mail or otherwise), such
          notice shall be sufficiently given if given to the Depositary (or its designee) pursuant to the standing instructions from the Depositary or its designee.</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968843"></a><a name="z_Toc37987259"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 12.03</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Communications by Holders with Other Holders.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">Securityholders may communicate pursuant to TIA &#167; 312(b) with other Securityholders with respect to their rights under this Indenture or the Securities.&#160; The Company, the Trustee, the Registrar and anyone else shall
          have the protection of TIA &#167; 312(c).</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968844"></a><a name="z_Toc37987260"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 12.04</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Certificate and Opinion as to Conditions Precedent.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">Upon any request or application by the Company to the Trustee to take any action under this Indenture, the Company shall furnish to the Trustee:</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(1)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">an Officers&#8217; Certificate (which shall include the statements set forth in <u>Section&#160;12.05</u>) stating that, in the opinion of the signers (who may rely upon an Opinion of Counsel with respect to matters
                  of law), all conditions precedent, if any, provided for in this Indenture relating to the proposed action have been complied with; and</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(2)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">an Opinion of Counsel (which shall include the statements set forth in <u>Section&#160;12.05</u>) stating that, in the opinion of such counsel (who may rely upon an Officers&#8217; Certificate or certificates of
                  public officials as to matters of fact), all such conditions precedent and covenants, compliance with which constitutes a condition precedent, if any, provided for in this Indenture relating to the proposed action or inaction, have been
                  complied with.</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968845"></a><a name="z_Toc37987261"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 12.05</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Statements Required in Certificate or Opinion.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">Each certificate or opinion with respect to compliance with a condition or covenant provided for in this Indenture shall include:</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(1)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">a statement that the person making such certificate or opinion has read such covenant or condition;</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(2)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">a brief statement as to the nature and scope of the examination or investigation upon which the statements or opinions contained in such certificate or opinion are based;</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(3)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">a statement that, in the opinion of such person, he has made such examination or investigation as is necessary to enable him to express an informed opinion as to whether or not such covenant or condition
                  has been complied with; and</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
          <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">37</font></div>
          <div style="page-break-after:always;" id="DSPFPageBreak">
            <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
        </div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 36pt;"><br>
              </td>
              <td style="width: 36pt; vertical-align: top; color: rgb(0, 0, 0);">(4)</td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0);">a statement as to whether or not, in the opinion of such person, such condition or covenant has been complied with.</div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968846"></a><a name="z_Toc37987262"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 12.06</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Rules by Trustee and Agents.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">The Trustee may make reasonable rules for action by or a meeting of Securityholders.&#160; The Registrar or Paying Agent may make reasonable rules for its functions.</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968847"></a><a name="z_Toc37987263"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 12.07</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Legal Holidays.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">A &#8220;<font style="font-weight: bold;">Legal Holiday</font>&#8221; is a Saturday, a Sunday, a legal holiday or a day on which banking institutions in New York, New York or in the place of payment are not required to be open.&#160;
          If a payment date is a Legal Holiday, payment may be made on the next succeeding day that is not a Legal Holiday, and no interest shall accrue for the intervening period.&#160; If this Indenture provides for a time period that ends or requires
          performance of any non-payment obligation by a day that is not a Business Day, then such time period shall instead be deemed to end on, and such obligation shall instead be performed by, the next succeeding Business Day.&#160; A &#8220;<font style="font-weight: bold;">Business Day</font>&#8221; is any day other than a Legal Holiday.</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968848"></a><a name="z_Toc37987264"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 12.08</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Governing Law.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">The laws of the State of New York shall govern this Indenture and the Securities of each Series.</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968849"></a><a name="z_Toc37987265"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 12.09</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>No Adverse Interpretation of Other Agreements.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">This Indenture may not be used to interpret another indenture, loan or debt agreement of the Company or a Subsidiary.&#160; Any such indenture, loan or debt agreement may not be used to interpret this Indenture.</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968850"></a><a name="z_Toc37987266"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 12.10</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>No Recourse Against Others.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">All liability described in <u>Paragraph 12</u> of the Securities of any director, officer, employee or stockholder, as such, of the Company is, to the fullest extent permitted by applicable law, waived and released.</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968851"></a><a name="z_Toc37987267"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 12.11</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Successors and Assigns.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">All covenants and agreements of the Company in this Indenture and the Securities shall bind its successors and assigns.&#160; All agreements of the Trustee in this Indenture shall bind its successors and assigns.</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968852"></a><a name="z_Toc37987268"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 12.12</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Duplicate Originals.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">The parties may sign any number of copies of this Indenture.&#160; Each signed copy shall be an original, but all of them together represent the same agreement.&#160; Signatures of the parties hereto transmitted by facsimile
          or other electronic transmission shall be deemed to be their original signatures for all purposes.</div>
        <div>&#160;</div>
        <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
          <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">38</font></div>
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            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968853"></a><a name="z_Toc37987269"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 12.13</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Severability.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">In case any one or more of the provisions contained in this Indenture or in the Securities of a Series shall for any reason be held to be invalid, illegal or unenforceable in any respect, such invalidity, illegality
          or unenforceability shall not affect any other provisions of this Indenture or of such Securities.</div>
        <div>&#160;</div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt; vertical-align: top;"><a name="z_Toc37968854"></a><a name="z_Toc37987270"></a><font style="font-weight: bold; color: rgb(0, 0, 0);">Section 12.14</font></td>
              <td style="width: auto; vertical-align: top;">
                <div style="color: rgb(0, 0, 0); font-weight: bold;"><u>Waiver of Jury Trial.</u></div>
              </td>
            </tr>

        </table>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">EACH OF THE COMPANY AND THE TRUSTEE (AND EACH HOLDER BY ITS ACCEPTANCE OF ANY NOTE) HEREBY IRREVOCABLY WAIVES, TO THE FULLEST EXTENT PERMITTED BY APPLICABLE LAW, ANY AND ALL RIGHT TO TRIAL BY JURY IN ANY LEGAL
          PROCEEDING ARISING OUT OF OR RELATING TO THIS INDENTURE, THE SECURITIES OR THE TRANSACTION CONTEMPLATED HEREBY.</div>
        <div><br>
        </div>
        <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
          <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">39</font></div>
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            <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
        </div>
        <div style="text-align: center; font-weight: bold;">SIGNATURES</div>
        <div>&#160;</div>
        <div style="text-indent: 36pt;">IN WITNESS WHEREOF, the parties have caused this Indenture to be duly executed, all as of the date first above written.</div>
        <div><br>
        </div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;" border="0" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 50%; vertical-align: top;">&#160;</td>
              <td colspan="2" style="vertical-align: top;">
                <div style="font-weight: bold;">BIOCRYST PHARMACEUTICALS, INC.</div>
              </td>
            </tr>
            <tr>
              <td style="width: 50%; vertical-align: top;">&#160;</td>
              <td colspan="2" rowspan="1" style="width: 5%; vertical-align: top;">&#160;</td>
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                <div>By:</div>
              </td>
              <td style="width: 45%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
            </tr>
            <tr>
              <td style="width: 50%; vertical-align: top;">&#160;</td>
              <td style="width: 5%; vertical-align: top;">
                <div>Name:</div>
              </td>
              <td style="width: 45%; vertical-align: top;">&#160;</td>
            </tr>
            <tr>
              <td style="width: 50%; vertical-align: top;">&#160;</td>
              <td style="width: 5%; vertical-align: top;">
                <div>Title:</div>
              </td>
              <td style="width: 45%; vertical-align: top;">&#160;</td>
            </tr>
            <tr>
              <td style="width: 50%; vertical-align: top;">&#160;</td>
              <td style="width: 5%; vertical-align: top;">&#160;</td>
              <td style="width: 45%; vertical-align: top;">&#160;</td>
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              <td style="width: 50%; vertical-align: top;">&#160;</td>
              <td colspan="2" style="vertical-align: top;">
                <div style="font-weight: bold;"><a name="z_9kR3WTr89345F"></a>U.S. BANK NATIONAL ASSOCIATION</div>
              </td>
            </tr>
            <tr>
              <td style="width: 50%; vertical-align: top;">&#160;</td>
              <td colspan="2" rowspan="1" style="width: 5%; vertical-align: top;">&#160;</td>
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              <td style="width: 50%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
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                <div>By:</div>
              </td>
              <td style="width: 45%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">&#160;</td>
            </tr>
            <tr>
              <td style="width: 50%; vertical-align: top;">&#160;</td>
              <td style="width: 5%; vertical-align: top;">
                <div>Name:</div>
              </td>
              <td style="width: 45%; vertical-align: top;">&#160;</td>
            </tr>
            <tr>
              <td style="width: 50%; vertical-align: top;">&#160;</td>
              <td style="width: 5%; vertical-align: top;">
                <div>Title:</div>
              </td>
              <td style="width: 45%; vertical-align: top;">&#160;</td>
            </tr>

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<DOCUMENT>
<TYPE>EX-5.1
<SEQUENCE>3
<FILENAME>nt10011234x1_ex5-1.htm
<DESCRIPTION>EXHIBIT 5.1
<TEXT>
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    <div style="text-align: right;"><font style="font-weight: bold;">Exhibit 5.1</font><font style="font-weight: bold;"><br>
      </font></div>
    <div><font style="font-weight: bold;"> </font><br>
    </div>
    <div style="text-align: center;"><font style="font-weight: bold;"> </font> [Letterhead of Gibson, Dunn &amp; Crucher LLP] </div>
    <div>
      <div><br>
      </div>
      <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">April 24, 2020</div>
      <div><br>
      </div>
      <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">BioCryst Pharmaceuticals, Inc.<br>
        4505 Emperor Blvd., Suite 200<br>
        Durham, North Carolina 27703</div>
      <div><br>
      </div>
      <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z1beae6d63398490989386952b3fbef55" cellpadding="0" cellspacing="0">

          <tr>
            <td style="width: 36pt; vertical-align: top; align: right; font-family: 'Times New Roman', Times, serif; font-size: 12pt;">Re:</td>
            <td style="width: auto; vertical-align: top;">
              <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">BioCryst Pharmaceuticals, Inc.<br>
                Registration Statement on Form S-3</div>
            </td>
          </tr>

      </table>
      <div><br>
      </div>
      <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">Ladies and Gentlemen:</div>
      <div><br>
      </div>
      <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">We have acted as counsel to BioCryst Pharmaceuticals, Inc., a Delaware corporation (the &#8220;<u>Company</u>&#8221;), in connection with the preparation and filing with the Securities
        and Exchange Commission (the &#8220;<u>Commission</u>&#8221;) of a Registration Statement on Form S-3 (the &#8220;<u>Registration Statement</u>&#8221;) under the Securities Act of 1933, as amended (the &#8220;<u>Securities Act</u>&#8221;), relating to the registration under the
        Securities Act and the proposed issuance and sale from time to time pursuant to Rule 415 under the Securities Act, together or separately and in one or more series (if applicable) of:</div>
      <div>
        <div><br>
        </div>
        <div style="text-indent: 72pt; font-family: 'Times New Roman', Times, serif;">(i)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;the Company&#8217;s unsecured debt securities (the &#8220;<u>Debt Securities</u>&#8221;);</div>
        <div><br>
        </div>
        <div style="text-indent: 72pt; font-family: 'Times New Roman', Times, serif;">(ii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; shares of the Company&#8217;s common stock, par value $0.01 per share (the &#8220;<u>Common Stock</u>&#8221;);</div>
        <div><br>
        </div>
        <div style="text-indent: 72pt; font-family: 'Times New Roman', Times, serif;">(iii)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; shares of the Company&#8217;s preferred stock, par value $0.01 per share (the &#8220;<u>Preferred Stock</u>&#8221;);</div>
        <div><br>
        </div>
        <div style="text-indent: 72pt; font-family: 'Times New Roman', Times, serif;">(iv)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; depositary shares each representing a fraction of a share of a particular series of Preferred Stock (the &#8220;<u>Depositary Shares</u>&#8221;);</div>
        <div><br>
        </div>
        <div style="text-indent: 72pt; font-family: 'Times New Roman', Times, serif;">(v)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; contracts for the purchase or sale of Debt Securities, Common Stock, Preferred Stock or Depositary Shares (the &#8220;<u>Purchase Contracts</u>&#8221;);</div>
        <div><br>
        </div>
        <div style="text-indent: 72pt; font-family: 'Times New Roman', Times, serif;">(vi)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; warrants for the purchase of Common Stock, Preferred Stock, Depositary Shares, Debt Securities or any combination thereof (the &#8220;<u>Warrants</u>&#8221;); and</div>
        <div><br>
        </div>
        <div style="text-align: center;"><img src="nc10011234x1_ex5-1image1.jpg" height="51" border="0" width="503"></div>
        <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
          <div id="DSPFPageBreak" style="page-break-after: always;">
            <hr style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;" noshade="noshade"></div>
        </div>
        <div style="text-indent: 72pt; font-family: 'Times New Roman', Times, serif;"><br>
          <div style="text-indent: 0px;">BioCryst Pharmaceuticals, Inc.</div>
          <div style="text-indent: 0px;">April 24, 2020</div>
          <div style="text-indent: 0px;">Page 2</div>
          <div style="font-size: 12pt; text-indent: 0px;"><font id="DSPFPageNumber"> <br>
            </font></div>
          <font id="DSPFPageNumber"> </font></div>
        <div style="text-indent: 72pt; font-family: 'Times New Roman', Times, serif;">(vii)&#160;&#160;&#160;&#160;&#160;&#160;&#160; units of the Company comprised of any combination of Common Stock, Preferred Stock, Depositary Shares, Purchase Contracts, Debt Securities or Warrants (the &#8220;<u>Units</u>&#8221;).</div>
        <div><br>
        </div>
        <div style="font-family: 'Times New Roman', Times, serif;">The Debt Securities, Common Stock, Preferred Stock, Depositary Shares, Purchase Contracts, Warrants and Units are collectively referred to herein as the &#8220;<u>Securities</u>.&#8221; The Debt
          Securities are to be issued under an indenture to be entered into<font style="font-weight: bold;">&#160;</font>between the Company and U.S. Bank National Association, as indenture trustee (the &#8220;<u>Base Indenture</u>&#8221;).</div>
        <div><br>
        </div>
        <div style="font-family: 'Times New Roman', Times, serif;">In arriving at the opinions expressed below, we have examined originals, or copies certified or otherwise identified to our satisfaction as being true and complete copies of the originals,
          of the form of Base Indenture, the specimen Common Stock certificate and such other documents, corporate records, certificates of officers of the Company and of public officials and other instruments as we have deemed necessary or advisable to
          enable us to render these opinions.&#160; In our examination, we have assumed the genuineness of all signatures, the legal capacity and competency of all natural persons, the authenticity of all documents submitted to us as originals and the
          conformity to original documents of all documents submitted to us as copies.&#160; As to any facts material to these opinions, we have relied to the extent we deemed appropriate and without independent investigation upon statements and representations
          of officers and other representatives of the Company and others.</div>
        <div><br>
        </div>
        <div style="font-family: 'Times New Roman', Times, serif;">We have assumed without independent investigation that:</div>
        <div><br>
        </div>
        <div style="text-indent: 72pt; font-family: 'Times New Roman', Times, serif;">(i)&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; at the time any Securities are sold pursuant to the Registration Statement (the &#8220;<u>Relevant Time</u>&#8221;), the Registration Statement and any supplements and
          amendments thereto (including post-effective amendments) will be effective and will comply with all applicable laws;</div>
        <div><br>
        </div>
        <div style="text-indent: 72pt; font-family: 'Times New Roman', Times, serif;">(ii)&#160;&#160;&#160;&#160;&#160;&#160;&#160; at the Relevant Time, a prospectus supplement will have been prepared and filed with the Commission describing the Securities offered thereby and all related
          documentation and will comply with all applicable laws;</div>
        <div><br>
        </div>
        <div style="text-indent: 72pt; font-family: 'Times New Roman', Times, serif;">(iii)&#160;&#160;&#160;&#160;&#160;&#160; all Securities will be issued and sold in the manner stated in the Registration Statement and the applicable prospectus supplement;</div>
        <div><br>
        </div>
        <div style="text-indent: 72pt; font-family: 'Times New Roman', Times, serif;">(iv)&#160;&#160;&#160;&#160;&#160;&#160; at the Relevant Time, all corporate or other action required to be taken by the Company to duly authorize each proposed issuance of Securities and any related
          documentation (including (a) the due reservation of any shares of Common Stock or Preferred Stock for issuance upon exercise, conversion or exchange of any Securities for Common Stock or Preferred Stock (a &#8220;<u>Convertible Security</u>&#8221;), and (b)
          the execution (in the case of certificated Securities), delivery and performance of the Securities and any related documentation referred to in paragraphs 1 through 6 below) shall have been duly completed and shall remain in full force and
          effect;</div>
        <div><br>
        </div>
        <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
          <div id="DSPFPageBreak" style="page-break-after: always;">
            <hr style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;" noshade="noshade"></div>
        </div>
        <div style="font-family: 'Times New Roman', Times, serif; text-indent: 0px;">
          <div style="font-size: 12pt; text-indent: 0px;"> <br>
          </div>
          <div style="text-indent: 0px;">BioCryst Pharmaceuticals, Inc.</div>
          <div style="text-indent: 0px;">April 24, 2020</div>
          <div style="font-size: 12pt; text-indent: 0px;"><font style="font-size: 10pt;">Page 3</font><br>
          </div>
          <div style="font-size: 12pt; text-indent: 0px;"><font id="DSPFPageNumber"> <br>
            </font></div>
          <font id="DSPFPageNumber"></font></div>
        <div style="text-indent: 72pt; font-family: 'Times New Roman', Times, serif;">(v)&#160;&#160;&#160;&#160;&#160;&#160; upon issuance of any Common Stock or Preferred Stock, including upon exercise, conversion or exchange of any Convertible Security, the total number of shares of
          Common Stock or Preferred Stock issued and outstanding will not exceed the total number of shares of Common Stock or Preferred Stock, as applicable, that the Company is then authorized to issue under its certificate of incorporation and other
          relevant documents;</div>
        <div><br>
        </div>
        <div style="text-indent: 72pt; font-family: 'Times New Roman', Times, serif;">(vi)&#160;&#160;&#160;&#160;&#160; in the case of Debt Securities, at the Relevant Time, the Base Indenture shall have been duly executed and delivered by the Company and all other parties
          thereto and duly qualified under the TIA;</div>
        <div><br>
        </div>
        <div style="text-indent: 72pt; font-family: 'Times New Roman', Times, serif;">(vii)&#160;&#160;&#160;&#160; at the Relevant Time, a definitive purchase, underwriting or similar agreement and any other necessary agreement with respect to any Securities offered or
          issued will have been duly authorized by all necessary corporate or other action of the Company and duly executed and delivered by the Company and the other parties thereto.</div>
        <div><br>
        </div>
        <div style="font-family: 'Times New Roman', Times, serif;">Based on the foregoing and in reliance thereon, and subject to the assumptions, exceptions, qualifications and limitations set forth herein, we are of the opinion that:</div>
        <div><br>
        </div>
        <div style="text-indent: 72pt;"><font style="font-family: 'Times New Roman', Times, serif;">1.</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-family: 'Times New Roman', Times, serif;">With respect to any Debt Securities, when:</font></div>
        <div><br>
        </div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z971de406895b4224bb54017d44a3d4b0" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt;"><br>
              </td>
              <td style="width: 18pt; vertical-align: top; font-family: 'Times New Roman',Times,serif; text-align: center;">a.</td>
              <td style="width: auto; vertical-align: top;">
                <div style="font-family: 'Times New Roman', Times, serif;">the terms and conditions of such Debt Securities have been duly established by supplemental indenture or officers&#8217; certificate in accordance with the terms and conditions of the
                  Base Indenture,</div>
              </td>
            </tr>

        </table>
        <div><br>
        </div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z4749d5b40db5485383494c0a3e42dd2f" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt;"><br>
              </td>
              <td style="width: 18pt; vertical-align: top; font-family: 'Times New Roman',Times,serif; text-align: center;">b.</td>
              <td style="width: auto; vertical-align: top;">
                <div style="font-family: 'Times New Roman', Times, serif;">any such supplemental indenture has been duly executed and delivered by the Company and the relevant trustee (together with the Base Indenture, the &#8220;<u>Indenture</u>&#8221;), and</div>
              </td>
            </tr>

        </table>
        <div><br>
        </div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zc3c45e3506f7493e919795fcfc6133ab" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt;"><br>
              </td>
              <td style="width: 18pt; vertical-align: top; font-family: 'Times New Roman',Times,serif; text-align: center;">c.</td>
              <td style="width: auto; vertical-align: top;">
                <div style="font-family: 'Times New Roman', Times, serif;">such Debt Securities have been executed (in the case of certificated Debt Securities), delivered and authenticated in accordance with the terms of the applicable Indenture and
                  issued and sold for the consideration set forth in the applicable definitive purchase, underwriting or similar agreement,</div>
              </td>
            </tr>

        </table>
        <div><br>
        </div>
        <div style="text-indent: 36pt; margin-left: 54pt; font-family: 'Times New Roman', Times, serif;">such Debt Securities will be legal, valid and binding obligations of the Company, enforceable against the Company in accordance with their respective
          terms.</div>
        <div><br>
        </div>
        <div style="text-indent: 72pt;"><font style="font-family: 'Times New Roman', Times, serif;">2.</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-family: 'Times New Roman', Times, serif;">With respect to any shares of Preferred Stock, when:</font></div>
        <div><br>
        </div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z1a3c051ac56a49e7ae8f8e15ac93d6cd" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt;"><br>
              </td>
              <td style="width: 18pt; vertical-align: top; font-family: 'Times New Roman',Times,serif; text-align: center;">a.</td>
              <td style="width: auto; vertical-align: top;">
                <div style="font-family: 'Times New Roman', Times, serif;">the certificate of designations relating to such Preferred Stock (the &#8220;<u>Certificate of Designations</u>&#8221;) has been duly executed and filed with the Office of the Secretary of
                  State of the State of Delaware,</div>
              </td>
            </tr>

        </table>
        <div><br>
        </div>
        <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
          <div id="DSPFPageBreak" style="page-break-after: always;">
            <hr style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;" noshade="noshade"></div>
        </div>
        <div>
          <div style="font-size: 12pt; text-indent: 0px;"> <br>
          </div>
          <div style="text-indent: 0px;">BioCryst Pharmaceuticals, Inc.</div>
          <div style="text-indent: 0px;">April 24, 2020</div>
          <div style="font-size: 12pt; text-indent: 0px;"><font style="font-size: 10pt;">Page 4</font><br>
          </div>
        </div>
        <div> <br>
        </div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zdcb6f7e466844ac98ece42e169a8b0cb" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt;"><br>
              </td>
              <td style="width: 18pt; vertical-align: top; font-family: 'Times New Roman',Times,serif; text-align: center;">b.</td>
              <td style="width: auto; vertical-align: top;">
                <div style="font-family: 'Times New Roman', Times, serif;">such shares have been issued either (i) in accordance with the applicable definitive purchase, underwriting or similar agreement and for the consideration therefor provided for
                  therein or (ii) upon exercise, conversion or exchange of any Convertible Security and for any additional consideration specified in such Convertible Security or the instrument governing such Convertible Security providing for such
                  conversion or exercise, which consideration (including any consideration paid for such Convertible Security), on a per-share basis, shall in either event not be less than the par value of the Preferred Stock, and</div>
              </td>
            </tr>

        </table>
        <div><br>
        </div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z2657c9d5fd64466e883bebde3521a0d9" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt;"><br>
              </td>
              <td style="width: 18pt; vertical-align: top; font-family: 'Times New Roman',Times,serif; text-align: center;">c.</td>
              <td style="width: auto; vertical-align: top;">
                <div style="font-family: 'Times New Roman', Times, serif;">any such Convertible Security was previously validly issued and is fully paid and non-assessable (in the case of an equity Security) or is a legal, valid and binding obligation of
                  the Company, enforceable against the Company in accordance with its terms,</div>
              </td>
            </tr>

        </table>
        <div><br>
        </div>
        <div style="text-indent: 36pt; margin-left: 54pt; font-family: 'Times New Roman', Times, serif;">such shares of Preferred Stock will be validly issued, fully paid and non-assessable.</div>
        <div><br>
        </div>
        <div style="text-indent: 72pt;"><font style="font-family: 'Times New Roman', Times, serif;">3.</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-family: 'Times New Roman', Times, serif;">With respect to Depositary Shares, when:</font></div>
        <div><br>
        </div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z3481b9410bba44e5803a0cf213da28c3" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt;"><br>
              </td>
              <td style="width: 18pt; vertical-align: top; font-family: 'Times New Roman',Times,serif; text-align: center;">a.</td>
              <td style="width: auto; vertical-align: top;">
                <div style="font-family: 'Times New Roman', Times, serif;">a deposit agreement relating to such Depositary Shares (&#8220;<u>Deposit Agreement</u>&#8221;) has been duly executed and delivered by the Company and the depositary appointed by the Company,</div>
              </td>
            </tr>

        </table>
        <div><br>
        </div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z7526cc47ce04419fa15bdc18c102edb0" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt;"><br>
              </td>
              <td style="width: 18pt; vertical-align: top; font-family: 'Times New Roman',Times,serif; text-align: center;">b.</td>
              <td style="width: auto; vertical-align: top;">
                <div style="font-family: 'Times New Roman', Times, serif;">the terms of the Depositary Shares have been established in accordance with the Deposit Agreement, and</div>
              </td>
            </tr>

        </table>
        <div><br>
        </div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z18133877c05d45a783337ebb81f126ef" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt;"><br>
              </td>
              <td style="width: 18pt; vertical-align: top; font-family: 'Times New Roman',Times,serif; text-align: center;">c.</td>
              <td style="width: auto; vertical-align: top;">
                <div style="font-family: 'Times New Roman', Times, serif;">the depositary receipts representing the Depositary Shares have been duly executed and countersigned (in the case of certificated Depositary Shares), registered and delivered in
                  accordance with the related Deposit Agreement and the applicable definitive purchase, underwriting or similar agreement for the consideration provided therein,</div>
              </td>
            </tr>

        </table>
        <div><br>
        </div>
        <div style="text-indent: 36pt; margin-left: 54pt; font-family: 'Times New Roman', Times, serif;">the Depositary Shares will be legally issued and will entitle the holders of such Depositary Shares to the rights specified in the applicable Deposit
          Agreement and the applicable depositary receipts.</div>
        <div><br>
        </div>
        <div style="text-indent: 72pt;"><font style="font-family: 'Times New Roman', Times, serif;">4.</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-family: 'Times New Roman', Times, serif;">With respect to shares of Common Stock, when:</font></div>
        <div><br>
        </div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z449e7b3a7dc44549bf89fc4f7211fdb3" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt;"><br>
              </td>
              <td style="width: 18pt; vertical-align: top; font-family: 'Times New Roman',Times,serif; text-align: center;">a.</td>
              <td style="width: auto; vertical-align: top;">
                <div style="font-family: 'Times New Roman', Times, serif;">such shares of Common Stock have been duly executed (in the case of certificated shares) and delivered either (i) in accordance with the applicable definitive purchase, underwriting
                  or similar agreement for the consideration provided for therein, or (ii) upon conversion or exercise of any Convertible Security, in accordance with the terms of such Convertible Security or the instrument governing such Convertible
                  Security providing for such conversion or exercise, and for any additional consideration specified therein, which consideration (including any consideration paid for such Convertible Security), on a per-share basis, shall in either event
                  not be less than the par value of the Common Stock, and</div>
              </td>
            </tr>

        </table>
        <div><br>
        </div>
        <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
          <div id="DSPFPageBreak" style="page-break-after: always;">
            <hr style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;" noshade="noshade"></div>
        </div>
        <div>
          <div style="font-size: 12pt; text-indent: 0px;"> <br>
          </div>
          <div style="text-indent: 0px;">BioCryst Pharmaceuticals, Inc.</div>
          <div style="text-indent: 0px;">April 24, 2020</div>
          <div style="font-size: 12pt; text-indent: 0px;"><font style="font-size: 10pt;">Page 5</font><br>
          </div>
        </div>
        <div> <br>
        </div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zb2ea1f7d22b84ab7adb688c37eadd5f4" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt;"><br>
              </td>
              <td style="width: 18pt; vertical-align: top; font-family: 'Times New Roman',Times,serif; text-align: center;">b.</td>
              <td style="width: auto; vertical-align: top;">
                <div style="font-family: 'Times New Roman', Times, serif;">any such Convertible Security was previously validly issued and is fully paid and non-assessable (in the case of an equity Security) or is a legal, valid and binding obligation of
                  the Company, enforceable against the Company in accordance with its terms,</div>
              </td>
            </tr>

        </table>
        <div><br>
        </div>
        <div style="text-indent: 36pt; margin-left: 54pt; font-family: 'Times New Roman', Times, serif;">such shares of Common Stock will be validly issued, fully paid and non-assessable.</div>
        <div><br>
        </div>
        <div style="text-indent: 72pt;"><font style="font-family: 'Times New Roman', Times, serif;">5.</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-family: 'Times New Roman', Times, serif;">With respect to any Purchase Contracts, when:</font></div>
        <div><br>
        </div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z49462986c599452bbf3477f16f3d370e" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt;"><br>
              </td>
              <td style="width: 18pt; vertical-align: top; font-family: 'Times New Roman',Times,serif; text-align: center;">a.</td>
              <td style="width: auto; vertical-align: top;">
                <div style="font-family: 'Times New Roman', Times, serif;">the related purchase contract agreement (&#8220;<u>Purchase Contract Agreement</u>&#8221;), if any, has been duly executed by the Company and each other party thereto,</div>
              </td>
            </tr>

        </table>
        <div><br>
        </div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z01d5284c60014329b369ae1cd089805e" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt;"><br>
              </td>
              <td style="width: 18pt; vertical-align: top; font-family: 'Times New Roman',Times,serif; text-align: center;">b.</td>
              <td style="width: auto; vertical-align: top;">
                <div style="font-family: 'Times New Roman', Times, serif;">the terms of the Purchase Contracts have been established in accordance with the Purchase Contract Agreement, if any, or the applicable definitive purchase, underwriting or similar
                  agreement,</div>
              </td>
            </tr>

        </table>
        <div><br>
        </div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z8969862db703414fac88ee45319ee3d0" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt;"><br>
              </td>
              <td style="width: 18pt; vertical-align: top; font-family: 'Times New Roman',Times,serif; text-align: center;">c.</td>
              <td style="width: auto; vertical-align: top;">
                <div style="font-family: 'Times New Roman', Times, serif;">the terms of any collateral or security arrangements relating to such Purchase Contracts have been established and the agreements thereto have been validly executed and delivered by
                  each of the parties thereto and any collateral has been deposited with the collateral agent, if applicable, in accordance with such arrangements, and</div>
              </td>
            </tr>

        </table>
        <div><br>
        </div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zad67cb66f3224f4da4b53b81e19c8c4c" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt;"><br>
              </td>
              <td style="width: 18pt; vertical-align: top; font-family: 'Times New Roman',Times,serif; text-align: center;">d.</td>
              <td style="width: auto; vertical-align: top;">
                <div style="font-family: 'Times New Roman', Times, serif;">such Purchase Contracts have been executed (in the case of certificated Purchase Contracts) and delivered in accordance with the Purchase Contract Agreement, if any, and the
                  applicable definitive purchase, underwriting or similar agreement for the consideration provided for therein,</div>
              </td>
            </tr>

        </table>
        <div><br>
        </div>
        <div style="text-indent: 36pt; margin-left: 54pt; font-family: 'Times New Roman', Times, serif;">such Purchase Contracts will be legal, valid and binding obligations of the Company, enforceable against the Company in accordance with their terms.</div>
        <div><br>
        </div>
        <div style="text-indent: 72pt;"><font style="font-family: 'Times New Roman', Times, serif;">6.</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-family: 'Times New Roman', Times, serif;">With respect to any Warrants, when:</font></div>
        <div><br>
        </div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z6e1b00f289b44f96a4665880a9e871a5" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt;"><br>
              </td>
              <td style="width: 18pt; vertical-align: top; font-family: 'Times New Roman',Times,serif; text-align: center;">a.</td>
              <td style="width: auto; vertical-align: top;">
                <div style="font-family: 'Times New Roman', Times, serif;">the warrant agreement relating to such Warrants (the &#8220;<u>Warrant Agreement</u>&#8221;), if any, has been duly executed and delivered by the Company and each other party thereto,</div>
              </td>
            </tr>

        </table>
        <div><br>
        </div>
        <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
          <div id="DSPFPageBreak" style="page-break-after: always;">
            <hr style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;" noshade="noshade"></div>
        </div>
        <div>
          <div style="font-size: 12pt; text-indent: 0px;"> <br>
          </div>
          <div style="text-indent: 0px;">BioCryst Pharmaceuticals, Inc.</div>
          <div style="text-indent: 0px;">April 24, 2020</div>
          <div style="font-size: 12pt; text-indent: 0px;"><font style="font-size: 10pt;">Page 6</font><br>
          </div>
        </div>
        <div> <br>
        </div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z6fbf111c4c4e4bbab8fb96c893e57689" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt;"><br>
              </td>
              <td style="width: 18pt; vertical-align: top; font-family: 'Times New Roman',Times,serif; text-align: center;">b.</td>
              <td style="width: auto; vertical-align: top;">
                <div style="font-family: 'Times New Roman', Times, serif;">the terms of the Warrants have been established in accordance with the Warrant Agreement, if any, and the applicable definitive purchase, underwriting or similar agreement, and</div>
              </td>
            </tr>

        </table>
        <div><br>
        </div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z3871f928cd3b4185b3961caa7e440042" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt;"><br>
              </td>
              <td style="width: 18pt; vertical-align: top; font-family: 'Times New Roman',Times,serif; text-align: center;">c.</td>
              <td style="width: auto; vertical-align: top;">
                <div style="font-family: 'Times New Roman', Times, serif;">the Warrants have been duly executed (in the case of certificated Warrants) and delivered in accordance with the Warrant Agreement, if any, and the applicable definitive purchase,
                  underwriting or similar agreement for the consideration provided for therein,</div>
              </td>
            </tr>

        </table>
        <div><br>
        </div>
        <div style="text-indent: 36pt; margin-left: 54pt; font-family: 'Times New Roman', Times, serif;">such Warrants will be legal, valid and binding obligations of the Company, enforceable against the Company in accordance with their terms.</div>
        <div><br>
        </div>
        <div style="text-indent: 72pt;"><font style="font-family: 'Times New Roman', Times, serif;">7.</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-family: 'Times New Roman', Times, serif;">With respect to any Units, when:</font></div>
        <div><br>
        </div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zcfd521c2b2e5436bac624fd441991991" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt;"><br>
              </td>
              <td style="width: 18pt; vertical-align: top; font-family: 'Times New Roman',Times,serif; text-align: center;">a.</td>
              <td style="width: auto; vertical-align: top;">
                <div style="font-family: 'Times New Roman', Times, serif;">the unit agreement relating to the Units (the &#8220;<u>Unit Agreement</u>&#8221;), if any, has been duly executed and delivered by the Company and each other party thereto,</div>
              </td>
            </tr>

        </table>
        <div><br>
        </div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zc12307e644df4d2f9aa82b86b644aa29" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt;"><br>
              </td>
              <td style="width: 18pt; vertical-align: top; font-family: 'Times New Roman',Times,serif; text-align: center;">b.</td>
              <td style="width: auto; vertical-align: top;">
                <div style="font-family: 'Times New Roman', Times, serif;">the terms of the Units have been duly established in accordance with the Unit Agreement, if any, and the applicable definitive purchase, underwriting or similar agreement, and</div>
              </td>
            </tr>

        </table>
        <div><br>
        </div>
        <table style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zfe907161335143e3b20f288f03d2bb7e" cellpadding="0" cellspacing="0">

            <tr>
              <td style="width: 72pt;"><br>
              </td>
              <td style="width: 18pt; vertical-align: top; font-family: 'Times New Roman',Times,serif; text-align: center;">c.</td>
              <td style="width: auto; vertical-align: top;">
                <div style="font-family: 'Times New Roman', Times, serif;">the Units have been duly executed (in the case of certificated Units) and delivered in accordance with the Unit Agreement, if any, and the applicable definitive purchase,
                  underwriting or similar agreement for the consideration provided for therein,</div>
              </td>
            </tr>

        </table>
        <div><br>
        </div>
        <div style="text-indent: 36pt; margin-left: 54pt; font-family: 'Times New Roman', Times, serif;">the Units will be legal, valid and binding obligations of the Company, enforceable against the Company in accordance with their terms.</div>
        <div><br>
        </div>
        <div style="font-family: 'Times New Roman', Times, serif;">The opinions expressed above are subject to the following exceptions, qualifications, limitations and assumptions:</div>
        <div><br>
        </div>
        <div style="text-indent: 72pt; font-family: 'Times New Roman', Times, serif;">A.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;We render no opinion herein as to matters involving the laws of any jurisdiction other than the State of New York and, for purposes of paragraphs 2 and 4
          above, the Delaware General Corporation Law.&#160; This opinion is limited to the effect of the current state of the laws of the State of New York, the Delaware General Corporation Law and the facts as they currently exist.&#160; We assume no obligation to
          revise or supplement this opinion in the event of future changes in such laws or the interpretations thereof or such facts.</div>
        <div><br>
        </div>
        <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
          <div id="DSPFPageBreak" style="page-break-after: always;">
            <hr style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;" noshade="noshade"></div>
        </div>
        <div style="font-family: 'Times New Roman', Times, serif; text-indent: 0px;">
          <div style="font-size: 12pt; text-indent: 0px;"> <br>
          </div>
          <div style="text-indent: 0px;">BioCryst Pharmaceuticals, Inc.</div>
          <div style="text-indent: 0px;">April 24, 2020</div>
          <div style="font-size: 12pt; text-indent: 0px;"><font style="font-size: 10pt;">Page 7</font><br>
          </div>
          <div style="font-size: 12pt; text-indent: 0px;"><font id="DSPFPageNumber"> <br>
            </font></div>
          <font id="DSPFPageNumber"></font></div>
        <div style="text-indent: 72pt; font-family: 'Times New Roman', Times, serif;">B.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;The opinions above with respect to the Indenture, the Debt Securities, depositary receipts representing the Depositary Shares, the Deposit Agreement, the
          Purchase Contracts, any Purchase Contract Agreement, the Warrants, the Warrant Agreement, the Units and the Unit Agreement (collectively, the &#8220;<u>Documents</u>&#8221;) are each subject to (i) the effect of any bankruptcy, insolvency, reorganization,
          moratorium, arrangement or similar laws affecting the rights and remedies of creditors generally, including without limitation the effect of statutory or other laws regarding fraudulent transfers or preferential transfers, (ii) general principles
          of equity, including without limitation concepts of materiality, reasonableness, good faith and fair dealing and the possible unavailability of specific performance, injunctive relief or other equitable remedies regardless of whether
          enforceability is considered in a proceeding in equity or at law and (iii) the provisions of the sixth article of the Company&#8217;s Third Restated Certificate of Incorporation, as amended.</div>
        <div><br>
        </div>
        <div style="text-indent: 72pt; font-family: 'Times New Roman', Times, serif;">C.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;We express no opinion regarding the effectiveness of (i) any waiver of stay, extension or usury laws; (ii) provisions relating to indemnification,
          exculpation or contribution, to the extent such provisions may be held unenforceable as contrary to public policy or federal or state securities laws, (iii) any waiver of the right to jury trial or (iv) any provision to the effect that every
          right or remedy is cumulative and may be exercised in addition to any other right or remedy or that the election of some particular remedy does not preclude recourse to one or more others.</div>
        <div><br>
        </div>
        <div style="text-indent: 72pt; font-family: 'Times New Roman', Times, serif;">D.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;To the extent relevant to our opinions in paragraphs 3, 5, 6 and 7 and not covered by our opinions in paragraphs 1, 2 or 4, we have assumed that any
          securities, currencies or commodities underlying, comprising or issuable upon exchange, conversion or exercise of any Depositary Shares, Purchase Contracts, Warrants, or Units are validly issued, fully paid and non-assessable (in the case of an
          equity security) or a legal, valid and binding obligation of the issuer thereof, enforceable against such issuer in accordance with its terms.</div>
        <div><br>
        </div>
        <div style="font-family: 'Times New Roman', Times, serif;">You have informed us that you intend to issue Securities from time to time on a delayed or continuous basis, and we understand that prior to issuing any Securities pursuant to the
          Registration Statement (i) you will advise us in writing of the terms thereof, and (ii) you will afford us an opportunity to (x) review the operative documents pursuant to which such Securities are to be issued or sold (including the applicable
          offering documents), and (y) file such supplement or amendment to this opinion (if any) as we may reasonably consider necessary or appropriate.</div>
        <div><br>
        </div>
        <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
          <div id="DSPFPageBreak" style="page-break-after: always;">
            <hr style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;" noshade="noshade"></div>
        </div>
        <div style="font-family: 'Times New Roman', Times, serif;">
          <div style="font-size: 12pt; text-indent: 0px;"> <br>
          </div>
          <div style="text-indent: 0px;">BioCryst Pharmaceuticals, Inc.</div>
          <div style="text-indent: 0px;">April 24, 2020</div>
          <div style="text-indent: 0px;">Page 8<br>
          </div>
        </div>
        <div style="font-family: 'Times New Roman', Times, serif;"> <br>
        </div>
        <div style="font-family: 'Times New Roman', Times, serif;">We consent to the filing of this opinion as an exhibit to the Registration Statement, and we further consent to the use of our name under the caption &#8220;Legal Matters&#8221; in the Registration
          Statement and the prospectus that forms a part thereof.&#160; In giving these consents, we do not thereby admit that we are within the category of persons whose consent is required under Section 7 of the Securities Act or the rules and regulations of
          the Commission promulgated thereunder.</div>
        <div><br>
        </div>
        <div style="font-family: 'Times New Roman', Times, serif;">Very truly yours,</div>
        <div><br>
        </div>
        <div style="font-family: 'Times New Roman', Times, serif;">/s/ Gibson, Dunn &amp; Crutcher LLP</div>
        <div style="font-family: 'Times New Roman', Times, serif;"> <br>
        </div>
        <div style="font-family: 'Times New Roman', Times, serif;">
          <hr style="height: 2px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;" align="center" noshade="noshade"> </div>
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</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.1
<SEQUENCE>4
<FILENAME>nt10011234x1_ex23-1.htm
<DESCRIPTION>EXHIBIT 23.1
<TEXT>
<html>
  <head>
    <title></title>
    <!-- Licensed to: Broadridge Finanicial Soultions, Inc.
         Document created using EDGARfilings PROfile 7.0.0.0
         Copyright 1995 - 2020 Broadridge -->
  </head>
<body style="font-family: 'Times New Roman'; font-size: 10pt; text-align: left; color: #000000;" bgcolor="#ffffff">
  <div>
    <div style="text-align: right; font-family: 'Times New Roman', Times, serif; font-weight: bold;">
      <hr style="height: 4px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;" align="center" noshade="noshade">Exhibit 23.1</div>
    <div><br>
    </div>
    <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">Consent of Independent Registered Public Accounting Firm</div>
    <div><br>
    </div>
    <div style="text-align: justify; font-family: 'Times New Roman', Times, serif;">We consent to the reference to our firm under the caption "Experts" in this Registration Statement (Form S-3) and related Prospectus of BioCryst
      Pharmaceuticals, Inc. for the registration of common stock and other securities and to the incorporation by reference therein of our reports dated March 13, 2020, with respect to the consolidated financial statements of BioCryst Pharmaceuticals, Inc.
      and the effectiveness of internal control over financial reporting of BioCryst Pharmaceuticals, Inc., included in its Annual Report (Form 10-K) for the year ended December 31, 2019, filed with the Securities and Exchange Commission.</div>
    <div><br>
    </div>
    <div style="font-family: 'Times New Roman', Times, serif;">/s/ Ernst &amp; Young</div>
    <div><br>
    </div>
    <div style="font-family: 'Times New Roman', Times, serif;">Raleigh, North Carolina</div>
    <div style="font-family: 'Times New Roman', Times, serif;">April 23, 2020</div>
    <div>
      <hr style="height: 2px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;" align="center" noshade="noshade"></div>
  </div>
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</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-25.1
<SEQUENCE>5
<FILENAME>nt10011234x1_ex25-1.htm
<DESCRIPTION>EXHIBIT 25.1
<TEXT>
<html>
  <head>
    <title></title>
    <!-- Licensed to: Broadridge Finanicial Soultions, Inc.
         Document created using EDGARfilings PROfile 7.0.0.0
         Copyright 1995 - 2020 Broadridge -->
  </head>
<body bgcolor="#ffffff" style="font-family: 'Times New Roman'; font-size: 10pt; text-align: left; color: #000000;">
  <div>
    <hr noshade="noshade" align="center" style="height: 4px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;"></div>
  <div style="font-weight: bold; text-align: right;">Exhibit 25.1<br>
  </div>
  <div><br>
  </div>
  <div>
    <div style="text-align: center; font-variant: small-caps; font-weight: bold;">securities and exchange commission</div>
    <div style="text-align: center; font-weight: bold;">Washington, D.C. 20549</div>
    <div style="text-align: center;"><br>
    </div>
    <div style="text-align: center;">
      <hr noshade="noshade" align="center" style="background-color: #000000; border-bottom: medium none; border-left: medium none; border-right: medium none; border-top: medium none; margin: 0px auto; height: 2px; width: 20%; color: #000000;"></div>
    <div><br>
    </div>
    <div style="text-align: center; font-weight: bold;">FORM T-1</div>
    <div><br>
    </div>
    <div style="text-align: center; font-weight: bold;">STATEMENT OF ELIGIBILITY UNDER</div>
    <div style="text-align: center; font-weight: bold;">THE TRUST INDENTURE ACT OF 1939 OF A</div>
    <div style="text-align: center; font-weight: bold;">CORPORATION DESIGNATED TO ACT AS TRUSTEE</div>
    <div style="text-align: center;">Check if an Application to Determine Eligibility of</div>
    <div style="text-align: center;">a Trustee Pursuant to Section 305(b)(2) &#9744;</div>
    <div style="text-align: center;"><br>
    </div>
    <div style="text-align: center;">
      <hr noshade="noshade" align="center" style="background-color: #000000; border-bottom: medium none; border-left: medium none; border-right: medium none; border-top: medium none; margin: 0px auto; height: 2px; width: 50%; color: #000000;"></div>
    <div><br>
    </div>
    <div style="text-align: center; font-weight: bold;">U.S. BANK NATIONAL ASSOCIATION</div>
    <div style="text-align: center;">(Exact name of Trustee as specified in its charter)</div>
    <div><br>
    </div>
    <div style="text-align: center; font-weight: bold;">31-0841368</div>
    <div style="text-align: center;">I.R.S. Employer Identification No.</div>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" id="z08e5fa658b384f0e832a6c6098d715a8" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

        <tr>
          <td style="width: 49.94%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">800 Nicollet Mall</div>
            <div style="text-align: center;">Minneapolis, Minnesota</div>
          </td>
          <td style="width: 49.94%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>&#160;</div>
            <div style="text-align: center;">55402</div>
          </td>
        </tr>
        <tr>
          <td style="width: 49.94%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">(Address of principal executive offices)</div>
          </td>
          <td style="width: 49.94%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">(Zip Code)</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div style="text-align: center;">Paul Vaden</div>
    <div style="text-align: center;">U.S. Bank National Association</div>
    <div style="text-align: center; color: rgb(0, 0, 0);">214 North Tryon Street, 27<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">th</sup> Floor</div>
    <div style="text-align: center; color: rgb(0, 0, 0);">Charlotte, NC 28202-1078</div>
    <div style="text-align: center;">(704) 335-4654</div>
    <div style="text-align: center;">(Name, address and telephone number of agent for service)</div>
    <div><br>
    </div>
    <div style="text-align: center; font-weight: bold;">BioCryst Pharmaceuticals, Inc.</div>
    <div style="text-align: center; color: rgb(0, 0, 0);">(Issuer with respect to the Securities)</div>
    <div style="text-align: center; color: rgb(0, 0, 0);"> <br>
    </div>
    <table cellspacing="0" cellpadding="0" id="za12a4790d1ea4d5ab1799aaa4264130a" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

        <tr>
          <td style="width: 48.9%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">Delaware</div>
          </td>
          <td style="width: 50.97%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center; font-weight: bold;">62-1413174</div>
          </td>
        </tr>
        <tr>
          <td style="width: 48.9%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">(State or other jurisdiction of incorporation or organization)</div>
          </td>
          <td style="width: 50.97%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">(I.R.S. Employer Identification No.)</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" id="za50d102feaf944ccbf64734c2725c36a" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

        <tr>
          <td style="width: 49.03%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center; font-weight: bold;">4505 Emperor Blvd., Suite 200</div>
            <div style="text-align: center; font-weight: bold;">Durham, North Carolina</div>
          </td>
          <td style="width: 50.84%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div>&#160;</div>
            <div style="text-align: center; font-weight: bold;">27703</div>
          </td>
        </tr>
        <tr>
          <td style="width: 49.03%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">(Address of Principal Executive Offices)</div>
          </td>
          <td style="width: 50.84%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="text-align: center;">(Zip Code)</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div style="text-align: center; font-weight: bold;">Debt Securities</div>
    <div style="text-align: center; font-weight: bold;">(Title of the Indenture Securities)</div>
    <div><br>
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageBreak" style="page-break-after:always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
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    <!--PROfilePageNumberReset%Num%2%%%-->
    <div style="text-align: center; font-weight: bold;"><u>FORM T-1</u></div>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" id="z08ec4373243e41859791724ef85ba384" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 54pt; vertical-align: top; font-weight: bold;">Item 1.</td>
          <td style="width: auto; vertical-align: top;">
            <div style="font-size: 12pt;"><font style="font-weight: bold; font-size: 10pt;">GENERAL INFORMATION</font><font style="font-weight: bold; font-style: italic; font-size: 10pt;">.</font><font style="font-size: 10pt;">&#160; Furnish the following
                information as to the Trustee.</font></div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" id="zce1a89419876433b80db567e63dae989" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 54pt;"><br>
          </td>
          <td style="width: 18pt; vertical-align: top;">a)</td>
          <td style="width: auto; vertical-align: top;">
            <div style="font-style: italic;">Name and address of each examining or supervising authority to which it is subject.</div>
          </td>
        </tr>

    </table>
    <div style="margin-left: 90pt;">Comptroller of the Currency</div>
    <div style="margin-left: 90pt;">Washington, D.C.</div>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" id="z54b95c04a6fa48dbbf945fafb3182c15" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 54pt;"><br>
          </td>
          <td style="width: 18pt; vertical-align: top;">b)</td>
          <td style="width: auto; vertical-align: top;">
            <div style="font-style: italic;">Whether it is authorized to exercise corporate trust powers.</div>
          </td>
        </tr>

    </table>
    <div style="text-align: justify; margin-left: 90pt;">Yes</div>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" id="zbc338a8f9f674de690a21122b54c364c" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 54pt; vertical-align: top; font-weight: bold;">Item 2.</td>
          <td style="width: auto; vertical-align: top;">
            <div style="font-size: 12pt;"><font style="font-weight: bold; font-size: 10pt;">AFFILIATIONS WITH OBLIGOR. </font><font style="font-weight: bold; font-style: italic; font-size: 10pt;">&#160;</font><font style="font-style: italic; font-size: 10pt;">If

                the obligor is an affiliate of the Trustee, describe each such affiliation.</font></div>
          </td>
        </tr>

    </table>
    <div style="margin-left: 72pt;">None</div>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" id="z2897cae582734922a107c427c9d75456" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 72pt; vertical-align: top; font-weight: bold;">Items 3-15</td>
          <td style="width: auto; vertical-align: top;">
            <div style="font-style: italic;">Items 3-15 are not applicable because to the best of the Trustee's knowledge, the obligor is not in default under any Indenture for which the Trustee acts as Trustee.</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" id="zc15f77a95d4e4feba2418e140fe20e10" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 54pt; vertical-align: top; font-weight: bold;">Item 16.</td>
          <td style="width: auto; vertical-align: top;">
            <div style="font-size: 12pt;"><font style="font-weight: bold; font-size: 10pt;">LIST OF EXHIBITS:</font><font style="font-size: 10pt;">&#160;<font style="font-style: italic;"> List below all exhibits filed as a part of this statement of eligibility
                  and qualification.</font></font></div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" id="z0c359d3a4c534d83b6be0143c7c59a81" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 54pt;"><br>
          </td>
          <td style="width: 18pt; vertical-align: top;">1.</td>
          <td style="width: auto; vertical-align: top;">
            <div>A copy of the Articles of Association of the Trustee.*</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" id="zc0745525453f40479996e083ac9183fe" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 54pt;"><br>
          </td>
          <td style="width: 18pt; vertical-align: top;">2.</td>
          <td style="width: auto; vertical-align: top;">
            <div>A copy of the certificate of authority of the Trustee to commence business, attached as Exhibit 2.</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" id="z39a3ebe209944957a97914ee64adacb5" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 54pt;"><br>
          </td>
          <td style="width: 18pt; vertical-align: top;">3.</td>
          <td style="width: auto; vertical-align: top;">
            <div>A copy of the certificate of authority of the Trustee to exercise corporate trust powers, attached as Exhibit 3.</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" id="z264e7cdaaa474a17b71923abf77ea009" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 54pt;"><br>
          </td>
          <td style="width: 18pt; vertical-align: top;">4.</td>
          <td style="width: auto; vertical-align: top;">
            <div>A copy of the existing bylaws of the Trustee.**</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" id="zdd3c4b7c405d4c2fb461e9bd7b9a81bc" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 54pt;"><br>
          </td>
          <td style="width: 18pt; vertical-align: top;">5.</td>
          <td style="width: auto; vertical-align: top;">
            <div>A copy of each Indenture referred to in Item 4.&#160; Not applicable.</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" id="z9082fa8ce65e4fc5a32bd4e624518506" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 54pt;"><br>
          </td>
          <td style="width: 18pt; vertical-align: top;">6.</td>
          <td style="width: auto; vertical-align: top;">
            <div>The consent of the Trustee required by Section 321(b) of the Trust Indenture Act of 1939, attached as Exhibit 6.</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" id="z2914068bc5a64d46bd4e3ffcecded713" class="DSPFListTable" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

        <tr>
          <td style="width: 54pt;"><br>
          </td>
          <td style="width: 18pt; vertical-align: top;">7.</td>
          <td style="width: auto; vertical-align: top;">
            <div>Report of Condition of the Trustee as of December 31, 2019 published pursuant to law or the requirements of its supervising or examining authority, attached as Exhibit 7.</div>
          </td>
        </tr>

    </table>
    <div><br>
    </div>
    <div style="margin-left: 36pt;">* Incorporated by reference to Exhibit 25.1 to Amendment No. 2 to registration statement on S-4, Registration Number 333-128217 filed on November 15, 2005.</div>
    <div><br>
    </div>
    <div style="margin-left: 36pt;">** Incorporated by reference to Exhibit 25.1 to registration statement on form S-3ASR,&#160; Registration Number 333-199863 filed on November 5, 2014.</div>
    <div><br>
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">2</font></div>
      <div id="DSPFPageBreak" style="page-break-after:always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
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    <div style="text-align: center; font-weight: bold;">SIGNATURE</div>
    <div><br>
    </div>
    <div style="text-indent: 36pt;">Pursuant to the requirements of the Trust Indenture Act of 1939, as amended, the Trustee, U.S. BANK NATIONAL ASSOCIATION, a national banking association organized and existing under the laws of the United States of
      America, has duly caused this statement of eligibility and qualification to be signed on its behalf by the undersigned, thereunto duly authorized, all in the City of Charlotte, State of North Carolina on the 22nd of April, 2020.</div>
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    <table cellspacing="0" cellpadding="0" border="0" id="z938325891b8b4e038cf2f0733e263abf" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

        <tr>
          <td style="width: 50%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
          <td style="width: 5%; vertical-align: top; padding-bottom: 2px;">
            <div>By:</div>
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          <td style="width: 20%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div>/s/ Paul Vaden</div>
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          <td style="width: 24.62%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
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        <tr>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
          <td style="width: 5%; vertical-align: top;">&#160;</td>
          <td style="width: 20%; vertical-align: top;">
            <div>Paul Vaden</div>
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          <td style="width: 24.62%; vertical-align: top;">&#160;</td>
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        <tr>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
          <td style="width: 5%; vertical-align: top;">&#160;</td>
          <td style="width: 20%; vertical-align: top;">
            <div>Vice President</div>
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          <td style="width: 24.62%; vertical-align: top;">&#160;</td>
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    <div><br>
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    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">3</font></div>
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    <div style="text-align: center; font-weight: bold;"><u>Exhibit 2</u></div>
    <div style="font-weight: bold;"><u> <br>
      </u></div>
    <div style="text-align: center;"><img src="nt10011234x1_ex25-1image01.jpg"></div>
    <div><br>
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">4</font></div>
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        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
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    <div style="text-align: center; font-weight: bold;"><u>Exhibit 3</u></div>
    <div><br>
    </div>
    <div style="text-align: center;"><img src="nt10011234x1_ex25-1image02.jpg"></div>
    <div><br>
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">5</font></div>
      <div id="DSPFPageBreak" style="page-break-after:always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <div style="text-align: center; font-weight: bold;"><u>Exhibit 6</u></div>
    <div><br>
    </div>
    <div style="text-align: center; font-weight: bold;">CONSENT</div>
    <div><br>
    </div>
    <div style="text-indent: 36pt;">In accordance with Section 321(b) of the Trust Indenture Act of 1939, the undersigned, U.S. BANK NATIONAL ASSOCIATION hereby consents that reports of examination of the undersigned by Federal, State, Territorial or
      District authorities may be furnished by such authorities to the Securities and Exchange Commission upon its request therefor.</div>
    <div><br>
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    <table cellspacing="0" cellpadding="0" id="zdcbeece02a0b4389bb46e62e39d57713" style="font-family: 'Times New Roman'; font-size: 10pt; width: 100%; border-collapse: collapse; text-align: left; color: #000000;">

        <tr>
          <td style="width: 50%; vertical-align: top;">
            <div>Dated: April 22, 2020</div>
          </td>
          <td style="width: 5%; vertical-align: top;">&#160;</td>
          <td style="width: 20%; vertical-align: top;">&#160;</td>
          <td style="width: 24.62%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
          <td style="width: 5%; vertical-align: top;">&#160;</td>
          <td style="width: 20%; vertical-align: top;">&#160;</td>
          <td style="width: 24.62%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 50%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
          <td style="width: 5%; vertical-align: top; padding-bottom: 2px;">
            <div>By:</div>
          </td>
          <td style="width: 20%; vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);">
            <div>/s/ Paul Vaden</div>
          </td>
          <td style="width: 24.62%; vertical-align: top; padding-bottom: 2px;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
          <td style="width: 5%; vertical-align: top;">&#160;</td>
          <td style="width: 20%; vertical-align: top;">
            <div>Paul Vaden</div>
          </td>
          <td style="width: 24.62%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
          <td style="width: 5%; vertical-align: top;">&#160;</td>
          <td style="width: 20%; vertical-align: top;">
            <div>Vice President</div>
          </td>
          <td style="width: 24.62%; vertical-align: top;">&#160;</td>
        </tr>

    </table>
    <div><br>
    </div>
    <div id="DSPFPageBreakArea" style="clear: both; margin-top: 10pt; margin-bottom: 10pt;">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">6</font></div>
      <div id="DSPFPageBreak" style="page-break-after:always;">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <div style="text-align: center; font-weight: bold;"><u>Exhibit 7</u></div>
    <div style="text-align: center; font-weight: bold;">U.S. Bank National Association</div>
    <div style="text-align: center; font-weight: bold;">Statement of Financial Condition</div>
    <div style="text-align: center; font-weight: bold;">As of 12/31/2019</div>
    <div><br>
    </div>
    <div style="text-align: center; font-weight: bold;">($000&#8217;s)</div>
    <div><br>
    </div>
    <table cellspacing="0" cellpadding="0" border="0" style="width: 70%; color: #000000; font-family: 'Times New Roman'; font-size: 10pt; text-align: left;" id="zf8b5394ac2d64ce48f080a13bdb362f5">

        <tr>
          <td valign="bottom" style="vertical-align: top; padding-bottom: 2px; width: 58%;">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; padding-bottom: 2px; width: 1%;" colspan="1">&#160;</td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: top; border-bottom: 2px solid rgb(0, 0, 0);" colspan="2">
            <div style="font-weight: bold; text-align: right;"> 12/31/2019</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; padding-bottom: 2px; width: 1%;" colspan="1">&#160;</td>
        </tr>
        <tr>
          <td valign="bottom" style="vertical-align: top; width: 58%;">
            <div style="font-weight: bold; text-indent: -9pt; margin-left: 9pt;">Assets</div>
          </td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%;" colspan="1">&#160;</td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: top;" colspan="2">&#160;</td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%;" colspan="1">&#160;</td>
        </tr>
        <tr>
          <td valign="bottom" style="vertical-align: top; width: 58%; background-color: rgb(204, 238, 255);">
            <div style="text-indent: -9pt; margin-left: 18pt;">Cash and Balances Due From Depository Institutions</div>
          </td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: #CCEEFF;" colspan="1">
            <div>$</div>
          </td>
          <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 9%; background-color: #CCEEFF;" colspan="1">
            <div>22,256,667</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" colspan="1">&#160;</td>
        </tr>
        <tr>
          <td valign="bottom" style="vertical-align: top; width: 58%; background-color: rgb(255, 255, 255);">
            <div style="text-indent: -9pt; margin-left: 18pt;">Securities</div>
          </td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255);" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255);" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(255, 255, 255);" colspan="1">
            <div>120,982,766</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255);" colspan="1">&#160;</td>
        </tr>
        <tr>
          <td valign="bottom" style="vertical-align: top; width: 58%; background-color: rgb(204, 238, 255);">
            <div style="text-indent: -9pt; margin-left: 18pt;">Federal Funds</div>
          </td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" colspan="1">
            <div>881,341</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" colspan="1">&#160;</td>
        </tr>
        <tr>
          <td valign="bottom" style="vertical-align: top; width: 58%; background-color: rgb(255, 255, 255);">
            <div style="text-indent: -9pt; margin-left: 18pt;">Loans &amp; Lease Financing Receivables</div>
          </td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255);" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255);" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(255, 255, 255);" colspan="1">
            <div>297,660,359</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255);" colspan="1">&#160;</td>
        </tr>
        <tr>
          <td valign="bottom" style="vertical-align: top; width: 58%; background-color: rgb(204, 238, 255);">
            <div style="text-indent: -9pt; margin-left: 18pt;">Fixed Assets</div>
          </td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" colspan="1">
            <div>5,895,381</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" colspan="1">&#160;</td>
        </tr>
        <tr>
          <td valign="bottom" style="vertical-align: top; width: 58%; background-color: rgb(255, 255, 255);">
            <div style="text-indent: -9pt; margin-left: 18pt;">Intangible Assets</div>
          </td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255);" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255);" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(255, 255, 255);" colspan="1">
            <div>12,915,451</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255);" colspan="1">&#160;</td>
        </tr>
        <tr>
          <td valign="bottom" style="vertical-align: top; width: 58%; background-color: rgb(204, 238, 255); padding-bottom: 2px;">
            <div style="text-indent: -9pt; margin-left: 18pt;">Other Assets</div>
          </td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); padding-bottom: 2px;" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0);" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255); border-bottom: 2px solid rgb(0, 0, 0);" colspan="1">
            <div>25,412,255</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255); padding-bottom: 2px;" colspan="1">&#160;</td>
        </tr>
        <tr>
          <td valign="bottom" style="vertical-align: top; width: 58%; background-color: rgb(255, 255, 255);">
            <div style="font-weight: bold; text-indent: -9pt; margin-left: 18pt;">Total Assets</div>
          </td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255);" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255);" colspan="1">
            <div style="font-weight: bold;">$</div>
          </td>
          <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(255, 255, 255);" colspan="1">
            <div style="font-weight: bold;">486,004,220</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255);" colspan="1">&#160;</td>
        </tr>
        <tr>
          <td valign="bottom" style="vertical-align: top; width: 58%; background-color: rgb(204, 238, 255); text-indent: -9pt; margin-left: 9pt;">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" colspan="1">&#160;</td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" colspan="1">&#160;</td>
        </tr>
        <tr>
          <td valign="bottom" style="vertical-align: top; width: 58%; background-color: rgb(255, 255, 255);">
            <div style="font-weight: bold; text-indent: -9pt; margin-left: 9pt;">Liabilities</div>
          </td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255);" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255);" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(255, 255, 255);" colspan="1">&#160;</td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255);" colspan="1">&#160;</td>
        </tr>
        <tr>
          <td valign="bottom" style="vertical-align: top; width: 58%; background-color: rgb(204, 238, 255);">
            <div style="text-indent: -9pt; margin-left: 18pt;">Deposits</div>
          </td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" colspan="1">
            <div>$</div>
          </td>
          <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" colspan="1">
            <div>374,303,872</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" colspan="1">&#160;</td>
        </tr>
        <tr>
          <td valign="bottom" style="vertical-align: top; width: 58%; background-color: rgb(255, 255, 255);">
            <div style="text-indent: -9pt; margin-left: 18pt;">Fed Funds</div>
          </td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255);" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255);" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(255, 255, 255);" colspan="1">
            <div>1,094,396</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255);" colspan="1">&#160;</td>
        </tr>
        <tr>
          <td valign="bottom" style="vertical-align: top; width: 58%; background-color: rgb(204, 238, 255);">
            <div style="text-indent: -9pt; margin-left: 18pt;">Treasury Demand Notes</div>
          </td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" colspan="1">
            <div>0</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" colspan="1">&#160;</td>
        </tr>
        <tr>
          <td valign="bottom" style="vertical-align: top; width: 58%; background-color: rgb(255, 255, 255);">
            <div style="text-indent: -9pt; margin-left: 18pt;">Trading Liabilities</div>
          </td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255);" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255);" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(255, 255, 255);" colspan="1">
            <div>769,407</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255);" colspan="1">&#160;</td>
        </tr>
        <tr>
          <td valign="bottom" style="vertical-align: top; width: 58%; background-color: rgb(204, 238, 255);">
            <div style="text-indent: -9pt; margin-left: 18pt;">Other Borrowed Money</div>
          </td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" colspan="1">
            <div>41,653,916</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" colspan="1">&#160;</td>
        </tr>
        <tr>
          <td valign="bottom" style="vertical-align: top; width: 58%; background-color: rgb(255, 255, 255);">
            <div style="text-indent: -9pt; margin-left: 18pt;">Acceptances</div>
          </td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255);" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255);" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(255, 255, 255);" colspan="1">
            <div>0</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%; background-color: rgb(255, 255, 255);" colspan="1">&#160;</td>
        </tr>
        <tr>
          <td valign="bottom" style="vertical-align: top; width: 58%; background-color: rgb(204, 238, 255);">
            <div style="text-indent: -9pt; margin-left: 18pt;">Subordinated Notes and Debentures</div>
          </td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" colspan="1">&#160;</td>
          <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(204, 238, 255);" colspan="1">
            <div>3,850,000</div>
          </td>
          <td valign="bottom" nowrap="nowrap" style="vertical-align: bottom; width: 1%; background-color: rgb(204, 238, 255);" colspan="1">&#160;</td>
        </tr>
        <tr>
          <td valign="bottom" style="vertical-align: top; width: 58%; background-color: rgb(255, 255, 255); padding-bottom: 2px;">
            <div style="text-indent: -9pt; margin-left: 18pt;">Other Liabilities</div>
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            <div>14,266,915</div>
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            <div>34,306,761</div>
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            <div>800,627</div>
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            <div style="font-weight: bold;">49,392,503</div>
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            <div style="font-weight: bold;">$</div>
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          <td valign="bottom" style="vertical-align: bottom; text-align: right; width: 9%; background-color: rgb(255, 255, 255);" colspan="1">
            <div style="font-weight: bold;">486,004,220</div>
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<DOCUMENT>
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<SEQUENCE>10
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end
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
