<SEC-DOCUMENT>0001140361-20-011394.txt : 20200612
<SEC-HEADER>0001140361-20-011394.hdr.sgml : 20200612
<ACCEPTANCE-DATETIME>20200512131813
<PRIVATE-TO-PUBLIC>
ACCESSION NUMBER:		0001140361-20-011394
CONFORMED SUBMISSION TYPE:	CORRESP
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20200512

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			BIOCRYST PHARMACEUTICALS INC
		CENTRAL INDEX KEY:			0000882796
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				621413174
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		CORRESP

	BUSINESS ADDRESS:	
		STREET 1:		4505 EMPEROR BOULEVARD
		STREET 2:		SUITE 200
		CITY:			DURHAM
		STATE:			NC
		ZIP:			27703
		BUSINESS PHONE:		919-859-1302

	MAIL ADDRESS:	
		STREET 1:		4505 EMPEROR BOULEVARD
		STREET 2:		SUITE 200
		CITY:			DURHAM
		STATE:			NC
		ZIP:			27703
</SEC-HEADER>
<DOCUMENT>
<TYPE>CORRESP
<SEQUENCE>1
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    <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-size: 12pt;">BioCryst Pharmaceuticals, Inc.</div>
    <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-size: 12pt;">4505 Emperor Blvd., Suite 200</div>
    <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-size: 12pt;">Durham, North Carolina 27703</div>
    <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(919) 859-1302</div>
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    <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-size: 12pt;">May 12, 2020</div>
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    <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;"><u>VIA EDGAR</u></div>
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    <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">Securities and Exchange Commission<br>
      Division of Corporation Finance<br>
      100 F Street, N.E.<br>
      Washington, DC 20549<br>
      Attn:&#160; Courtney Lindsay and Celeste Murphy</div>
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            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt; font-style: italic; font-weight: bold;">BioCryst Pharmaceuticals, Inc.</div>
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    <div style="margin-right: 36pt; margin-left: 72pt; font-family: 'Times New Roman', Times, serif; font-size: 12pt; font-style: italic; font-weight: bold;">Registration Statement on Form S-3 (File No. 333-237820)</div>
    <div style="margin-right: 36pt; margin-left: 72pt; font-family: 'Times New Roman', Times, serif; font-size: 12pt; font-style: italic; font-weight: bold;">Filed April 24, 2020</div>
    <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">&#160; <br>
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    <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">Ladies and Gentlemen:</div>
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    <div style="text-indent: 36pt; font-family: 'Times New Roman', Times, serif; font-size: 12pt;">Pursuant to Rule&#160;461 promulgated under the Securities Act of 1933, as amended, BioCryst Pharmaceuticals, Inc., a Delaware corporation (the
      &#8220;Company&#8221;), hereby respectfully requests that the effective time of the above referenced Registration Statement on Form S-3 filed by the Company (the &#8220;Registration Statement&#8221;) be accelerated to 4:00 p.m., Eastern Daylight Time, on May 14, 2020 or as
      soon thereafter as practicable.</div>
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            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">Very truly yours,</div>
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            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">BioCryst Pharmaceuticals, Inc.</div>
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            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;"><u>/s/ Alane Barnes&#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160;&#160;&#160; <br>
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            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">Alane Barnes</div>
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            <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">Senior Vice President and Chief Legal Officer</div>
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      &#160;</div>
    <div><font style="font-size: 12pt; font-family: 'Times New Roman', Times, serif;">cc:</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;<font style="font-size: 12pt; font-family: 'Times New Roman', Times, serif;">Robyn Zolman, Gibson, Dunn &amp; Crutcher LLP</font></div>
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