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Note 1 - Significant Accounting Policies and Concentrations of Risk (Tables) | 12 Months Ended
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Dec. 31, 2020
Notes Tables |
Debt Securities, Available-for-sale [Table Text Block] |
|  | December 31, 2020 |
|  | Amortized Cost |  |  | Accrued Interest |  |  | Gross Unrealized Gains |  |  | Gross Unrealized Losses |  |  | Estimated Fair Value |
Obligations of U.S. Government and its agencies |  | $ | 24,986 |  |  | $ | 14 |  |  | $ | 3 |  |  | $ | (3 | ) |  | $ | 25,000 |
Certificates of deposit |  |  | 3,225 |  |  |  | 11 |  |  |  | 3 |  |  |  | − |  |  |  | 3,239 |
Total Investments |  | $ | 28,211 |  |  | $ | 25 |  |  | $ | 6 |  |  | $ | (3 | ) |  | $ | 28,239 |
|  | December 31, 2019 |
|  | Amortized Cost |  |  | Accrued Interest |  |  | Gross Unrealized Gains |  |  | Gross Unrealized Losses |  |  | Estimated Fair Value |
Obligations of U.S. Government and its agencies |  | $ | 10,488 |  |  | $ | 50 |  |  | $ | 23 |  |  | $ | − |  |  | $ | 10,561 |
Corporate debt securities |  |  | 9,742 |  |  |  | 59 |  |  |  | 10 |  |  |  | (1 | ) |  |  | 9,810 |
Certificates of deposit |  |  | 1,669 |  |  |  | 7 |  |  |  | 7 |  |  |  | − |  |  |  | 1,683 |
Total Investments |  | $ | 21,899 |  |  | $ | 116 |  |  | $ | 40 |  |  | $ | (1 | ) |  | $ | 22,054 |
Schedule of Receivables from Collaborations [Table Text Block] |
|  | December 31, 20 20 |
|  | Billed |  |  | Unbilled |  |  | Total |
U.S. Department of Health and Human Services |  | $ | − |  |  | $ | 5,402 |  |  | $ | 5,402 |
Shionogi & Co. Ltd. |  |  | 2,037 |  |  |  | 4 |  |  |  | 2,041 |
Green Cross Corporation |  |  | 740 |  |  |  | 21 |  |  |  | 761 |
Mundipharma International Holdings Limited |  |  | 39 |  |  |  | − |  |  |  | 39 |
Total receivables |  | $ | 2,816 |  |  | $ | 5,427 |  |  | $ | 8,243 |
|  | December 31, 2019
|  | Billed |  |  | Unbilled |  |  | Total |
U.S. Department of Health and Human Services |  | $ | 1,353 |  |  | $ | 15,023 |  |  | $ | 16,376 |
Shionogi & Co. Ltd. |  |  | 1,336 |  |  |  | 4 |  |  |  | 1,340 |
Green Cross Corporation |  |  | 2,924 |  |  |  | 8 |  |  |  | 2,932 |
Mundipharma International Holdings Limited |  |  | 56 |  |  |  | - |  |  |  | 56 |
Seqirus UK Limited |  |  | 1,091 |  |  |  | 351 |  |  |  | 1,442 |
Total receivables |  | $ | 6,760 |  |  | $ | 15,386 |  |  | $ | 22,146 |
Schedule of Accrued Liabilities [Table Text Block] |
|  | December 31, |
|  | 20 20 |  |  | 201 9 |
Compensation and benefits |  | $ | 11,030 |  |  | $ | 6,190 |
Development costs |  |  | 15,150 |  |  |  | 11,302 |
Inventory |  |  | 2,453 |  |  |  | 29 |
Professional fees |  |  | 333 |  |  |  | 326 |
Duties and taxes |  |  | 80 |  |  |  | 67 |
Other |  |  | 4,896 |  |  |  | 3,451 |
Total accrued expenses |  | $ | 33,942 |  |  | $ | 21,365 |
Disaggregation of Revenue [Table Text Block] |
|  | 2020 |  |  | 2019 |  |  | 2018 |
Product sales, net |  | $ | 3,301 |  |  | $ | 17,533 |  |  | $ | − |
Royalty revenue |  |  | 3,381 |  |  |  | 6,303 |  |  |  | 6,101 |
Collaborative and other research and development revenues: |  |  |  |  |  |  |  |  |  |  |  |
U.S. Department of Health and Human Services |  |  | 9,231 |  |  |  | 4,898 |  |  |  | 2,552 |
Torii Pharmaceutical Co., Ltd. |  |  | 1,899 |  |  |  | 20,101 |  |  |  | − |
Seqirus UK Limited |  |  | − |  |  |  | − |  |  |  | 12,000 |
Total collaborative and other research and development revenues |  |  | 11,130 |  |  |  | 24,999 |  |  |  | 14,552 |
Total revenues |  | $ | 17,812 |  |  | $ | 48,835 |  |  | $ | 20,653 |

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