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Note 9 - Income Taxes - Components of Deferred Tax Assets and Liabilities (Details) - USD ($) $ in Thousands | Dec. 31, 2020 | Dec. 31, 2019
--- | --- | ---
Net federal and state operating losses | $ 159,939 | $ 155,190
Research and development credits | 66,331 | 63,275
Royalty income | 28,034 | 0
Stock-based compensation | 10,732 | 9,786
Leasing obligations | 1,135 | 1,070
Other | 5,563 | 3,801
Total deferred tax assets | 271,734 | 233,122
Fixed assets | (124) | (114)
Right of use asset | (854) | (803)
Total deferred tax liabilities | (978) | (917)
Valuation allowance | $ (270,756) | $ (232,205)

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