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v3.20.4

Note 1 - Significant Accounting Policies and Concentrations of Risk (Details Textual) - USD ($) | 1 Months Ended | 12 Months Ended
--- | --- | ---
Dec. 31, 2020 | Dec. 31, 2020 | Dec. 31, 2019 | Dec. 31, 2018
Restricted Cash and Cash Equivalents, Current, Total | $ 2,221,000 | $ 2,221,000 | $ 1,551,000 |
Inventory, Raw Materials, Gross, Total | 206,000 | 206,000 |  |
Inventory, Work in Process, Gross | 2,555,000 | 2,555,000 |  |
Inventory, Finished Goods, Gross, Total | 4,548,000 | 4,548,000 | 276,000 |
Inventory Valuation Reserves, Ending Balance | 270,000 | 270,000 | 276,000 |
Reclassification from Accumulated Other Comprehensive Income, Current Period, before Tax |  | 1,000 | 0 |
Advertising Expense |  | 6,567 | 0 | $ 0
Interest Expense, Debt, Total |  | 14,501,000 | 11,892,000 | 9,176,000
Amortization of Debt Financing Costs and Original Issue Discounts |  | $ 1,217,000 | $ 1,278,000 | $ 885,000
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount (in shares) |  | 14,957 | 2,805 | 2,274
Foreign Exchange Contract [Member] | Not Designated as Hedging Instrument [Member] |  |  |  |
Derivative, Loss on Derivative |  | $ 632,000 | $ 347,000 | $ 1,049,000
Derivative, Gain on Derivative |  | $ 662,000 | 863,000 | $ 941,000
Computer Equipment [Member] |  |  |  |
Property, Plant and Equipment, Useful Life (Year) |  | 3 years |  |
Laboratory Equipment, Office Equipment and Software [Member] |  |  |  |
Property, Plant and Equipment, Useful Life (Year) |  | 5 years |  |
Furniture and Fixtures [Member] |  |  |  |
Property, Plant and Equipment, Useful Life (Year) |  | 7 years |  |
Collaboration Receivables [Member] |  |  |  |
Accounts Receivable, Allowance for Credit Loss, Ending Balance | 0 | $ 0 | 0 |
Trade Accounts Receivable [Member] |  |  |  |
Accounts Receivable, Allowance for Credit Loss, Ending Balance | 0 | 0 |  |
Accounts Receivable, after Allowance for Credit Loss, Total |  |  | 0 |
Trade Accounts Receivable [Member] | RAPIVAB [Member] |  |  |  |
Accounts Receivable, after Allowance for Credit Loss, Total | 254,000 | 254,000 |  |
Trade Accounts Receivable [Member] | ORLADEYO [Member] |  |  |  |
Accounts Receivable, after Allowance for Credit Loss, Total | 149,000 | $ 149,000 |  |
Maximum [Member] |  |  |  |
Maturity Period of High Quality Marketable Securities (Year) |  | 3 years |  |
Average Maturity Period of High Quality Marketable Securities (Month) |  | 18 months |  |
Maturity Period of Short Term Investment (Month) |  | 12 months |  |
Average Maturity for Portfolio Investments (Month) |  | 18 months |  |
Minimum [Member] |  |  |  |
Long-term Investment Maturity, Minimum (Month) |  | 12 months |  |
Royalty Receivable [Member] |  |  |  |
Restricted Cash and Cash Equivalents, Current, Total | 796,000 | $ 796,000 | 134,000 |
Collateral for Credit [Member] |  |  |  |
Restricted Cash and Cash Equivalents, Current, Total | 1,425,000 | 1,425,000 | $ 1,417,000 |
Senior Credit Facility [Member] | MidCap Financial Services, LLC [Member] |  |  |  |
Line of Credit Facility, Remaining Borrowing Capacity | 75,000,000 | 75,000,000 |  |
Write off of Deferred Debt Issuance Cost | $ 1,211,000 | $ 1,211,000 |  |

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