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Note 1 - Significant Accounting Policies (Tables) | 3 Months Ended
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Mar. 31, 2021
Notes Tables |
Debt Securities, Available-for-sale [Table Text Block] |
|  | March 31, 2021 |
|  |  |  |  |  |  |  |  |  | Gross |  |  | Gross |  |  |  |  |
|  | Amortized |  |  | Accrued |  |  | Unrealized |  |  | Unrealized |  |  | Estimated |
|  | Cost |  |  | Interest |  |  | Gains |  |  | Losses |  |  | Fair Value |
Obligations of U.S. Government and its agencies |  | $ | 10,675 |  |  | $ | 6 |  |  | $ | 3 |  |  | $ | - |  |  | $ | 10,684 |
Certificates of deposit |  |  | 2,758 |  |  |  | 11 |  |  |  | 1 |  |  |  | - |  |  |  | 2,770 |
Total investments |  | $ | 13,433 |  |  | $ | 17 |  |  | $ | 4 |  |  | $ | - |  |  | $ | 13,454 |
|  | December 31, 2020 |
|  |  |  |  |  |  |  |  |  | Gross |  |  | Gross |  |  |  |  |
|  | Amortized |  |  | Accrued |  |  | Unrealized |  |  | Unrealized |  |  | Estimated |
|  | Cost |  |  | Interest |  |  | Gains |  |  | Losses |  |  | Fair Value |
Obligations of U.S. Government and its agencies |  | $ | 24,986 |  |  | $ | 14 |  |  | $ | 3 |  |  | $ | (3 | ) |  | $ | 25,000 |
Certificates of deposit |  |  | 3,225 |  |  |  | 11 |  |  |  | 3 |  |  |  | - |  |  |  | 3,239 |
Total investments |  | $ | 28,211 |  |  | $ | 25 |  |  | $ | 6 |  |  | $ | (3 | ) |  | $ | 28,239 |
Schedule of Receivables from Collaborations [Table Text Block] |
|  | March 31, 2021 |
|  | Billed |  |  | Unbilled |  |  | Total |
U.S. Department of Health and Human Services |  | $ | 3,966 |  |  | $ | 3,514 |  |  | $ | 7,480 |
Shionogi & Co. Ltd. |  |  | (190 | ) |  |  | 4 |  |  |  | (186 | )
Green Cross Corporation |  |  | 1,157 |  |  |  | 21 |  |  |  | 1,178 |
Mundipharma International Holdings Limited |  |  | 32 |  |  |  | - |  |  |  | 32 |
Total receivables |  | $ | 4,965 |  |  | $ | 3,539 |  |  | $ | 8,504 |
|  | December 31, 2020 |
|  | Billed |  |  | Unbilled |  |  | Total |
U.S. Department of Health and Human Services |  | $ | - |  |  | $ | 5,402 |  |  | $ | 5,402 |
Shionogi & Co. Ltd. |  |  | 2,037 |  |  |  | 4 |  |  |  | 2,041 |
Green Cross Corporation |  |  | 740 |  |  |  | 21 |  |  |  | 761 |
Mundipharma International Holdings Limited |  |  | 39 |  |  |  | - |  |  |  | 39 |
Total receivables |  | $ | 2,816 |  |  | $ | 5,427 |  |  | $ | 8,243 |
Schedule of Inventory, Current [Table Text Block] |
|  | March 31, |  |  | December, 31 |
|  | 2021 |  |  | 2020 |
Raw materials |  | $ | 101 |  |  | $ | 206 |
Work-in-process |  |  | 5,012 |  |  |  | 2,555 |
Finished goods |  |  | 270 |  |  |  | 4,548 |
Total Inventory |  | $ | 5,383 |  |  | $ | 7,309 |
Reserves |  |  | (270 | ) |  |  | (270 | )
Total Inventory, net |  | $ | 5,113 |  |  | $ | 7,039 |
Disaggregation of Revenue [Table Text Block] |
|  | Three Months Ended March 31, |
|  | 2021 |  |  | 2020 |
Product sales, net: |  |  |  |  |  |  |  |
ORLADEYO |  | $ | 10,938 |  |  | $ | - |
Peramivir |  |  | 6,820 |  |  |  | 218 |
RAPIVAB |  |  | 113 |  |  |  | - |
Total product sales, net |  |  | 17,871 |  |  |  | 218 |
Royalty revenue |  |  | (897 | ) |  |  | 1,945 |
Collaborative and other research and development revenues: |  |  |  |  |  |  |  |
U.S. Department of Health and Human Services |  |  | 2,085 |  |  |  | 1,607 |
Torii Pharmaceutical Co., Ltd. |  |  | - |  |  |  | 1,053 |
Total collaborative and other research and development revenues |  |  | 2,085 |  |  |  | 2,660 |
Total revenues |  | $ | 19,059 |  |  | $ | 4,823 |

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