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Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
 6 Months Ended
Jun. 30, 2021
Jun. 30, 2020
Operating activities    
Net loss $ (107,482) $ (76,206)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 377 401
Stock-based compensation expense 13,111 6,034
Non-cash interest expense on royalty financing obligation 15,604 0
Non-cash paid in-kind interest on secured term loan 7,459 0
Amortization of debt issuance costs (399) 681
Amortization of premium/discount on investments 34 104
Change in fair value of foreign currency derivative 0 590
Changes in operating assets and liabilities:    
Receivables (18,976) 18,149
Inventory (2,809) (5,233)
Prepaid expenses and other assets (34) 817
Accounts payable and accrued expenses 2,743 (1,156)
Interest payable 3,547 2,902
Deferred revenue 403 (1,405)
Net cash used in operating activities (86,422) (54,322)
Investing activities    
Acquisitions of property and equipment (912) (187)
Purchases of investments 0 (15,438)
Sales and maturities of investments 20,089 21,417
Net cash provided by investing activities 19,177 5,792
Financing activities    
Sale of common stock, net 0 92,848
Sale of pre-funded warrants 0 14,817
Net proceeds from common stock issued under stock-based compensation plans 7,474 798
Net cash provided by (used in) financing activities 7,474 108,463
Effect of exchange rate on cash and cash equivalents 85 0
(Decrease) increase in cash, cash equivalents and restricted cash (59,686) 59,933
Cash, cash equivalents and restricted cash at beginning of period 274,348 115,723
Cash, cash equivalents and restricted cash at end of period $ 214,662 $ 175,656