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Note 7 - Stock-based Compensation (Details Textual) - USD ($) $ / shares in Units, $ in Thousands |  | 1 Months Ended | 9 Months Ended | 12 Months Ended
--- | --- | --- | --- | ---
Aug. 09, 2021 | Dec. 31, 2019 | Dec. 31, 2014 | Aug. 31, 2013 | Sep. 30, 2021 | Sep. 30, 2020 | Dec. 31, 2020
Share-based Payment Arrangement, Expense |  |  |  |  | $ 26,140 | $ 8,907 |
Share-based Compensation Arrangement by Share-based Payment Award, Accelerated Vesting, Number (in shares) | 582,084 |  |  |  |  |  |
Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount, Total |  |  |  |  | 60,420 |  |
Employee Service Share-based Compensation Nonvested Awards Compensation Cost Expected to be Recognized For Remainder of Fiscal Year |  |  |  |  | 6,324 |  |
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Expected to be Recognized Next Year |  |  |  |  | 21,474 |  |
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Expected to be Recognized Year Two |  |  |  |  | 16,788 |  |
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Expected to be Recognized Year Three |  |  |  |  | 14,020 |  |
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Expected to be Recognized Year Four |  |  |  |  | $ 1,814 |  |
Stock Issued During Period, Shares, Employee Stock Purchase Plans (in shares) |  |  |  |  | 316,000 |  |
Incentive Plan [Member] |  |  |  |  |  |  |
Share-based Payment Arrangement, Expense |  |  |  |  | $ 19,973 | $ 7,492 |
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant (in shares) |  |  |  |  | 10,092,000 |  | 4,592,000
Incentive Plan [Member] | Share-based Payment Arrangement, Option [Member] |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value (in dollars per share) |  |  |  |  | $ 8.11 | $ 3.35 |
Incentive Plan [Member] | Share-based Payment Arrangement, Option [Member] | Maximum [Member] |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term (Year) |  |  |  |  | 10 years |  |
Incentive Plan [Member] | Share-based Payment Arrangement, Option [Member] | Vest 25% Each Year Until Fully Vested [Member] |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Rights, Percentage |  |  |  |  | 25.00% |  |
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period (Year) |  |  |  |  | 4 years |  |
Incentive Plan [Member] | Performance Shares [Member] | August 2013 [Member] |  |  |  |  |  |  |
Share-based Payment Arrangement, Expense |  |  |  |  |  |  | $ 1,768
Incentive Plan [Member] | Performance Shares [Member] | December 2019 [Member] |  |  |  |  |  |  |
Share-based Payment Arrangement, Expense |  |  |  |  |  |  | $ 684
Incentive Plan [Member] | Performance Shares [Member] | Vest Upon Successful Completion of Specific Development Milestones [Member] |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Rights, Percentage |  | 100.00% | 85.00% | 100.00% |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross (in shares) |  | 315,000 | 1,250,000 | 1,032,000 |  |  |
Inducement Plan [Member] |  |  |  |  |  |  |
Share-based Payment Arrangement, Expense |  |  |  |  | $ 5,025 | $ 1,053 |
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period (Year) |  |  |  |  | 4 years |  |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value (in dollars per share) |  |  |  |  | $ 9.74 | $ 2.41 |
Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period (Year) |  |  |  |  | 10 years |  |
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant (in shares) |  |  |  |  | 1,113,000 |  | 229,000
Inducement Plan [Member] | Vest 25% Each Year Until Fully Vested [Member] |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Rights, Percentage |  |  |  |  | 25.00% |  |
Inducement Plan [Member] | Share-based Payment Arrangement, Option [Member] |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Dividend Rate |  |  |  |  | 0.00% |  |
Employee Stock Purchase Plan [Member] |  |  |  |  |  |  |
Share-based Payment Arrangement, Expense |  |  |  |  | $ 1,142 | $ 362 |
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized (in shares) |  |  |  |  | 7,975,000 |  |
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant (in shares) |  |  |  |  | 6,056,000 |  |
Percentage of Salary to Purchase Common Stock, Maximum |  |  |  |  | 15.00% |  |
Percentage of Common Stock Shares, Beginning |  |  |  |  | 85.00% |  |
Percentage of Common Stock Shares, Ending |  |  |  |  | 85.00% |  |
Share-based Compensation Arrangement by Share-based Payment Award, Maximum Number of Shares Per Employee (in shares) |  |  |  |  | 3,000 |  |
Share-based Compensation Arrangement by Share-based Payment Award, Maximum Number of Shares Per Employee, Amount |  |  |  |  | $ 25 |  |

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- Definition The difference between the maximum number of shares (or other type of equity) authorized for issuance under the plan (including the effects of amendments and adjustments), and the sum of: 1) the number of shares (or other type of equity) already issued upon exercise of options or other equity-based awards under the plan; and 2) shares (or other type of equity) reserved for issuance on granting of outstanding awards, net of cancellations and forfeitures, if applicable. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=120381028&loc=d3e5070-113901 + Details
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