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Note 1 - Significant Accounting Policies (Tables) | 9 Months Ended
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Sep. 30, 2021
Notes Tables |
Debt Securities, Available-for-sale [Table Text Block] |
|  | December 31, 2020 |
|  |  |  |  |  |  |  |  |  | Gross |  |  | Gross |  |  |  |  |
|  | Amortized |  |  | Accrued |  |  | Unrealized |  |  | Unrealized |  |  | Estimated |
|  | Cost |  |  | Interest |  |  | Gains |  |  | Losses |  |  | Fair Value |
Obligations of U.S. Government and its agencies |  | $ | 24,986 |  |  | $ | 14 |  |  | $ | 3 |  |  | $ | (3 | ) |  | $ | 25,000 |
Certificates of deposit |  |  | 3,225 |  |  |  | 11 |  |  |  | 3 |  |  |  | - |  |  |  | 3,239 |
Total investments |  | $ | 28,211 |  |  | $ | 25 |  |  | $ | 6 |  |  | $ | (3 | ) |  | $ | 28,239 |
Schedule of Receivables from Collaborations [Table Text Block] |
|  | September 30, 2021 |
|  | Billed |  |  | Unbilled |  |  | Total |
U.S. Department of Health and Human Services |  | $ | - |  |  | $ | 3,086 |  |  | $ | 3,086 |
Royalty receivables from partners |  |  | 200 |  |  |  | - |  |  |  | 200 |
Total receivables |  | $ | 200 |  |  | $ | 3,086 |  |  | $ | 3,286 |
|  | December 31, 2020 |
|  | Billed |  |  | Unbilled |  |  | Total |
U.S. Department of Health and Human Services |  | $ | - |  |  | $ | 5,402 |  |  | $ | 5,402 |
Royalty receivables from partners |  |  | 2,816 |  |  |  | 25 |  |  |  | 2,841 |
Total receivables |  | $ | 2,816 |  |  | $ | 5,427 |  |  | $ | 8,243 |
Schedule of Inventory, Current [Table Text Block] |
|  | September 30, |  |  | December 31, |
|  | 2021 |  |  | 2020 |
Raw materials |  | $ | 6,830 |  |  | $ | 206 |
Work-in-process |  |  | 6,619 |  |  |  | 2,555 |
Finished goods |  |  | 637 |  |  |  | 4,548 |
Total Inventory |  | $ | 14,086 |  |  | $ | 7,309 |
Reserves |  |  | (423 | ) |  |  | (270 | )
Total Inventory, net |  | $ | 13,663 |  |  | $ | 7,039 |
Disaggregation of Revenue [Table Text Block] |
|  | Three Months Ended |  |  | Nine Months Ended |
|  | September 30, |  |  | September 30, |
|  | 2021 |  |  | 2020 |  |  | 2021 |  |  | 2020 |
Product sales, net: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
ORLADEYO |  | $ | 36,711 |  |  | $ | - |  |  | $ | 76,023 |  |  | $ | - |
RAPIVAB |  |  | 2,430 |  |  |  | 11 |  |  |  | 7,165 |  |  |  | 11 |
Peramivir |  |  | - |  |  |  | 2,467 |  |  |  | 7,254 |  |  |  | 2,685 |
Total product sales, net |  |  | 39,141 |  |  |  | 2,478 |  |  |  | 90,442 |  |  |  | 2,696 |
Royalty revenue |  |  | 322 |  |  |  | 254 |  |  |  | (447 | ) |  |  | 2,243 |
Milestone revenue |  |  | - |  |  |  | - |  |  |  | 15,000 |  |  |  | - |
Collaborative and other research and development revenues: |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
U.S. Department of Health and Human Services |  |  | 1,531 |  |  |  | 3,088 |  |  |  | 5,017 |  |  |  | 7,240 |
Torii Pharmaceutical Co., Ltd. |  |  | - |  |  |  | 282 |  |  |  | - |  |  |  | 1,617 |
Total collaborative and other research and development revenues |  |  | 1,531 |  |  |  | 3,370 |  |  |  | 5,017 |  |  |  | 8,857 |
Total revenues |  | $ | 40,994 |  |  | $ | 6,102 |  |  | $ | 110,012 |  |  | $ | 13,796 |

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