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Amount of increase in the fair value of derivatives recognized in the income statement.

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Amount of the cost of borrowed funds accounted for as interest expense for debt.

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Note 1 - Significant Accounting Policies (Details Textual) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2021	Sep. 30, 2020	Sep. 30, 2021	Sep. 30, 2020	Dec. 31, 2020
Restricted Cash and Cash Equivalents, Current, Total	$ 4,296		$ 4,296		$ 2,221
Investments, Total	0		0
Reclassification from Accumulated Other Comprehensive Income, Current Period, before Tax			1	$ 1
Advertising Expense	1,492	$ 0	4,696	0
Interest Expense, Debt, Total	14,115	2,927	40,514	8,892
Amortization of Debt Financing Costs and Original Issue Discounts	$ 158	$ 381	$ 369	$ 1,061
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount (in shares)	28,472	16,544	26,131	14,154
Foreign Exchange Contract [Member] \| Not Designated as Hedging Instrument [Member]
Derivative, Loss on Derivative				$ 630
Derivative, Gain on Derivative				660
Computer Equipment [Member]
Property, Plant and Equipment, Useful Life (Year)			3 years
Laboratory Equipment, Office Equipment and Software [Member]
Property, Plant and Equipment, Useful Life (Year)			5 years
Furniture and Fixtures [Member]
Property, Plant and Equipment, Useful Life (Year)			7 years
Trade Accounts Receivable [Member]
Accounts Receivable, after Allowance for Credit Loss, Total	$ 0		$ 0		0
Collaboration Receivables [Member]
Accounts Receivable, Allowance for Credit Loss, Ending Balance	0		0		0
ORLADEYO [Member] \| Trade Accounts Receivable [Member]
Accounts Receivable, after Allowance for Credit Loss, Total	22,893		22,893		149
RAPIVAB [Member] \| Trade Accounts Receivable [Member]
Accounts Receivable, after Allowance for Credit Loss, Total	33		$ 33		254
Maximum [Member]
Maturity Period of High Quality Marketable Securities (Year)			3 years
Average Maturity Period of High Quality Marketable Securities (Month)			18 months
Maturity Period of Short Term Investment (Month)			12 months
Average Maturity for Portfolio Investments (Month)			18 months
Minimum [Member]
Long-term Investment Maturity, Minimum (Month)			12 months
Royalty Receivable [Member]
Restricted Cash and Cash Equivalents, Current, Total	2,872		$ 2,872		796
Collateral for Credit [Member]
Restricted Cash and Cash Equivalents, Current, Total	1,424,000		1,424,000		$ 1,425
Senior Credit Facility [Member] \| MidCap Financial Services, LLC [Member]
Line of Credit Facility, Remaining Borrowing Capacity	$ 75,000		$ 75,000
Interest Expense, Debt, Total				$ 4,064