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Consolidated Statements of Cash Flows (Unaudited) - USD ($)
$ in Thousands
9 Months Ended
Sep. 30, 2021
Sep. 30, 2020
Cash flows from operating activities    
Net loss $ (166,283) $ (122,321)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 606 568
Stock-based compensation expense 26,140 8,907
Non-cash interest expense on royalty financing obligation 24,125 0
Non-cash paid in-kind interest on secured term loan 12,871 0
Amortization of debt issuance costs (556) 1,061
Amortization of premium/discount on investments 35 106
Change in fair value of foreign currency derivative 0 630
Changes in operating assets and liabilities:    
Receivables (17,579) 16,724
Inventory (6,630) (6,241)
Prepaid expenses and other assets (3,460) (1,448)
Accounts payable and accrued expenses 16,692 6,725
Interest payable 3,884 4,400
Deferred revenue 457 (1,688)
Net cash used in operating activities (109,698) (92,577)
Cash flows from investing activities    
Acquisitions of property and equipment (1,277) (359)
Purchases of investments 0 (49,818)
Sales and maturities of investments 28,201 21,907
Net cash provided by (used in) investing activities 26,924 (28,270)
Cash flows from financing activities    
Sale of common stock, net 0 92,848
Sale of pre-funded warrants 0 14,817
Payment of senior credit facility 0 (5,000)
Net proceeds from common stock issued under stock-based compensation plans 12,250 1,164
Net cash provided by financing activities 12,250 103,829
Effect of exchange rate on cash and cash equivalents 69 0
Decrease in cash, cash equivalents and restricted cash (70,455) (17,018)
Cash, cash equivalents and restricted cash at beginning of period 274,348 115,723
Cash, cash equivalents and restricted cash at end of period $ 203,893 $ 98,705