<SEC-DOCUMENT>0000899140-21-000082.txt : 20210125
<SEC-HEADER>0000899140-21-000082.hdr.sgml : 20210125
<ACCEPTANCE-DATETIME>20210125164309
ACCESSION NUMBER:		0000899140-21-000082
CONFORMED SUBMISSION TYPE:	SC 13G
PUBLIC DOCUMENT COUNT:		2
FILED AS OF DATE:		20210125
DATE AS OF CHANGE:		20210125
GROUP MEMBERS:		ALEXANDER J. DENNER, PH.D.

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			BIOCRYST PHARMACEUTICALS INC
		CENTRAL INDEX KEY:			0000882796
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				621413174
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-44055
		FILM NUMBER:		21550107

	BUSINESS ADDRESS:	
		STREET 1:		4505 EMPEROR BOULEVARD
		STREET 2:		SUITE 200
		CITY:			DURHAM
		STATE:			NC
		ZIP:			27703
		BUSINESS PHONE:		919-859-1302

	MAIL ADDRESS:	
		STREET 1:		4505 EMPEROR BOULEVARD
		STREET 2:		SUITE 200
		CITY:			DURHAM
		STATE:			NC
		ZIP:			27703

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Sarissa Capital Management LP
		CENTRAL INDEX KEY:			0001577524
		IRS NUMBER:				900924432
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G

	BUSINESS ADDRESS:	
		STREET 1:		660 STEAMBOAT ROAD
		CITY:			GREENWICH
		STATE:			CT
		ZIP:			06830
		BUSINESS PHONE:		203-302-2330

	MAIL ADDRESS:	
		STREET 1:		660 STEAMBOAT ROAD
		CITY:			GREENWICH
		STATE:			CT
		ZIP:			06830
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G
<SEQUENCE>1
<FILENAME>s13ga.htm
<DESCRIPTION>SCHEDULE 13G
<TEXT>
<html>
  <head>
    <title></title>
    <!-- Licensed to: asdf
         Document created using EDGARfilings PROfile 7.2.0.0
         Copyright 1995 - 2021 Broadridge -->
  </head>
<body bgcolor="#ffffff" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left; color: #000000;">
  <!--PROfilePageNumberReset%Num%1%%%-->
  <div>
    <div>
      <div style="margin-bottom: 2pt;"><br>
      </div>
      <div>
        <hr noshade="noshade" align="center" style="height: 2px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;"></div>
    </div>
    <div style="text-align: center; margin-top: 12pt; margin-bottom: 8pt; font-size: 18pt; font-weight: bold;">SECURITIES AND EXCHANGE COMMISSION</div>
    <div style="text-align: center; margin-bottom: 2pt;">Washington, D.C. 20549 <br>
      <hr noshade="noshade" align="center" style="height: 2px; color: #000000; background-color: #000000; margin-left: auto; margin-right: auto; border: none;"></div>
    <div style="text-align: center; margin-top: 12pt; margin-bottom: 12pt; font-size: 18pt; font-weight: bold;">SCHEDULE 13G</div>
    <div style="text-align: center; margin-bottom: 12pt; font-weight: bold;">Under the Securities Exchange Act of 1934</div>
    <div style="text-align: center; margin-bottom: 2pt;">(Amendment No. &#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;)* <br>
    </div>
    <div>
      <div>
        <hr noshade="noshade" align="center" style="height: 2px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;"></div>
    </div>
    <div style="text-align: center; margin-top: 12pt; margin-bottom: 8pt; font-size: 18pt; font-weight: bold;">BioCryst Pharmaceuticals, Inc.</div>
    <div style="text-align: center; margin-bottom: 8pt; font-weight: bold;">(Name of Issuer)</div>
    <div style="text-align: center; margin-top: 12pt; margin-bottom: 8pt; font-weight: bold;">Common Stock, par value $0.01 per share</div>
    <div style="text-align: center; margin-bottom: 8pt; font-size: 8pt; font-weight: bold;">(Title of Class of Securities)</div>
    <div style="text-align: center; margin-top: 12pt; margin-bottom: 8pt; font-weight: bold;">09058V103</div>
    <div style="text-align: center; margin-bottom: 8pt; font-size: 8pt; font-weight: bold;">(CUSIP Number)</div>
    <div style="text-align: center; margin-top: 12pt; margin-bottom: 8pt; font-weight: bold;">January 15, 2021</div>
    <div style="text-align: center; margin-bottom: 8pt; font-size: 8pt; font-weight: bold;">(Date of Event Which Requires Filing of this Statement)</div>
    <div>
      <div style="margin-top: 12pt; margin-bottom: 8pt;">
        <hr noshade="noshade" align="center" style="height: 2px; color: #000000; background-color: #000000; text-align: center; margin-left: auto; margin-right: auto; border: none;">Check the appropriate box to designate the rule pursuant to which this
        Schedule is filed:</div>
    </div>
    <div style="margin-top: 12pt; margin-bottom: 8pt;">&#9744; Rule 13d-1(b)</div>
    <div style="margin-top: 12pt; margin-bottom: 8pt;">&#9746; Rule 13d-1(c)</div>
    <div style="margin-top: 12pt; margin-bottom: 12pt;">&#9744; Rule 13d-1(d)</div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" id="zae4016e84bec48b7a4845ca7fd275c7c">

        <tr>
          <td style="width: 4%; vertical-align: top;">
            <div>*</div>
          </td>
          <td style="width: 96%; vertical-align: top;">
            <div>The remainder of this cover page shall be filled out for a reporting person&#8217;s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the
              disclosures provided in a prior cover page.</div>
          </td>
        </tr>

    </table>
    <div style="margin-top: 12pt; margin-bottom: 8pt;">The information required in the remainder of this cover page shall not be deemed to be &#8220;filed&#8221; for the purpose of Section&#160;18 of the Securities Exchange Act of 1934 or otherwise subject to the
      liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, <font style="font-style: italic;">see</font> the <font style="font-style: italic;">Notes</font>).</div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">1</font></div>
      <div style="page-break-after:always;" id="DSPFPageBreak">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <div style="margin-top: 12pt; margin-bottom: 8pt;"><br>
    </div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" id="zed3644aabc914ed7bdc44655ee441a83">

        <tr>
          <td style="border-bottom: 2px solid #000000; border-left: 2px solid #000000; border-right: 2px solid #000000; border-top: 2px solid #000000; vertical-align: top; width: 47.85%;">
            <div>CUSIP&#160;No. 09058V103</div>
          </td>
          <td style="width: 1.34%; vertical-align: bottom;">
            <div>&#160;</div>
          </td>
          <td style="width: 0.14%; vertical-align: top;">&#160;</td>
          <td style="width: 1.13%; vertical-align: bottom;">
            <div>&#160;</div>
          </td>
          <td style="width: 8.11%; vertical-align: top;">
            <div style="text-align: center;">13G</div>
          </td>
          <td style="width: 1.13%; vertical-align: bottom;">
            <div>&#160;</div>
          </td>
          <td style="width: 0.34%; vertical-align: top;">&#160;</td>
          <td style="border-bottom: 2px solid #000000; border-left: 2px solid #000000; border-right: 2px solid #000000; border-top: 2px solid #000000; vertical-align: bottom; width: 39.95%;">
            <div style="text-align: right;">Page 2 of 8 Pages</div>
          </td>
        </tr>

    </table>
    <div style="margin-bottom: 8pt;"><br>
    </div>
    <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman',Times,serif; font-size: 10pt; width: 100%; text-align: left; color: rgb(0, 0, 0);" id="z4c962d3475ba41da8111dc189c19c548">

        <tr>
          <td style="width: 14.61%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">1.</div>
          </td>
          <td colspan="2" style="width: 85.39%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif;">NAMES OF REPORTING PERSONS</div>
            <div style="font-family: 'Times New Roman', Times, serif;"> <br>
            </div>
            <div style="font-family: 'Times New Roman', Times, serif;">Sarissa Capital Management LP</div>
          </td>
        </tr>
        <tr>
          <td style="width: 14.61%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">2.</div>
          </td>
          <td colspan="2" style="width: 85.39%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif;">CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)</div>
            <div style="font-family: 'Times New Roman', Times, serif;">(a)&#160;&#160;&#9723;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;(b)&#160;&#160;&#9723;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 14.61%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">3.</div>
          </td>
          <td colspan="2" style="width: 85.39%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif;">SEC USE ONLY</div>
            <div style="font-family: 'Times New Roman', Times, serif;"> <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 14.61%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">4.</div>
          </td>
          <td colspan="2" style="width: 85.39%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif;">CITIZENSHIP OR PLACE OF ORGANIZATION</div>
            <div style="font-family: 'Times New Roman', Times, serif;"> <br>
            </div>
            <div style="font-family: 'Times New Roman', Times, serif;">Delaware</div>
          </td>
        </tr>
        <tr>
          <td rowspan="4" style="width: 14.61%; vertical-align: middle; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">NUMBER&#160;OF</div>
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">SHARES</div>
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">&#160;BENEFICIALLY</div>
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">OWNED&#160;BY</div>
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">EACH</div>
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">REPORTING</div>
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">PERSON</div>
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">WITH&#160;</div>
          </td>
          <td style="width: 5.72%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">5.</div>
          </td>
          <td style="width: 79.67%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif;">SOLE VOTING POWER</div>
            <div style="font-family: 'Times New Roman', Times, serif;"> <br>
            </div>
            <div style="font-family: 'Times New Roman', Times, serif;">8,844,000</div>
          </td>
        </tr>
        <tr>
          <td style="width: 5.72%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">6.</div>
          </td>
          <td style="width: 79.67%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif;">SHARED VOTING POWER</div>
            <div style="font-family: 'Times New Roman', Times, serif;"> <br>
            </div>
            <div style="font-family: 'Times New Roman', Times, serif;">0</div>
          </td>
        </tr>
        <tr>
          <td style="width: 5.72%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">7.</div>
          </td>
          <td style="width: 79.67%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif;">SOLE DISPOSITIVE POWER</div>
            <div style="font-family: 'Times New Roman', Times, serif;"> <br>
            </div>
            <div style="font-family: 'Times New Roman', Times, serif;">8,844,000</div>
          </td>
        </tr>
        <tr>
          <td style="width: 5.72%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">8.</div>
          </td>
          <td style="width: 79.67%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif;">SHARED DISPOSITIVE POWER</div>
            <div style="font-family: 'Times New Roman', Times, serif;"> <br>
            </div>
            <div style="font-family: 'Times New Roman', Times, serif;">0</div>
          </td>
        </tr>
        <tr>
          <td style="width: 14.61%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">9.</div>
          </td>
          <td colspan="2" style="width: 85.39%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif;">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</div>
            <div style="font-family: 'Times New Roman', Times, serif;"> <br>
            </div>
            <div style="font-family: 'Times New Roman', Times, serif;">8,844,000</div>
          </td>
        </tr>
        <tr>
          <td style="width: 14.61%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">10.</div>
          </td>
          <td colspan="2" style="width: 85.39%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif;">CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)&#160;&#160;&#9723;</div>
            <div style="font-family: 'Times New Roman', Times, serif;">&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 14.61%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">11.</div>
          </td>
          <td colspan="2" style="width: 85.39%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif;">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9<br>
              <br>
            </div>
            <div style="font-family: 'Times New Roman', Times, serif;">5.0%(1)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 14.61%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">12.</div>
          </td>
          <td colspan="2" style="width: 85.39%; vertical-align: bottom; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif;">TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)</div>
            <div style="font-family: 'Times New Roman', Times, serif;"> <br>
            </div>
            <div style="font-family: 'Times New Roman', Times, serif;">PN</div>
          </td>
        </tr>

    </table>
    <div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z874e6ea0c38c43dfa826ac946003b735">

          <tr>
            <td style="width: 36pt; vertical-align: top; align: right;">
              <div style="margin-left: 18pt;"> <br>
              </div>
              <div style="margin-left: 18pt;">(1)</div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div> <br>
              </div>
              <div>Calculations are based upon&#160;176,565,622 Shares outstanding as of October 31, 2020, as set forth in the Form 10-Q of the Issuer filed with the U.S. Securities and Exchange Commission on November 6, 2020.</div>
            </td>
          </tr>

      </table>
    </div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">2</font></div>
      <div style="page-break-after:always;" id="DSPFPageBreak">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <div style="margin-bottom: 8pt;"><br>
    </div>
    <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman',Times,serif; font-size: 10pt; width: 100%; text-align: left; color: rgb(0, 0, 0);" id="z26c8c222950f4893afa928a0f4fc7a79">

        <tr>
          <td style="border-bottom: 2px solid #000000; border-left: 2px solid #000000; border-right: 2px solid #000000; border-top: 2px solid #000000; vertical-align: top; width: 47.85%;">
            <div style="font-family: 'Times New Roman', Times, serif;">CUSIP&#160;No. 09058V103</div>
          </td>
          <td style="width: 1.34%; vertical-align: bottom;">
            <div style="font-family: 'Times New Roman', Times, serif;">&#160;</div>
          </td>
          <td style="width: 0.14%; vertical-align: top;">&#160;</td>
          <td style="width: 1.13%; vertical-align: bottom;">
            <div style="font-family: 'Times New Roman', Times, serif;">&#160;</div>
          </td>
          <td style="width: 8.11%; vertical-align: top;">
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">13G</div>
          </td>
          <td style="width: 1.13%; vertical-align: bottom;">
            <div style="font-family: 'Times New Roman', Times, serif;">&#160;</div>
          </td>
          <td style="width: 0.34%; vertical-align: top;">&#160;</td>
          <td style="border-bottom: 2px solid #000000; border-left: 2px solid #000000; border-right: 2px solid #000000; border-top: 2px solid; vertical-align: bottom; width: 39.95%;">
            <div style="text-align: right; font-family: 'Times New Roman', Times, serif;">Page 3 of 8 Pages</div>
          </td>
        </tr>

    </table>
    <div style="margin-bottom: 8pt;"><br>
    </div>
    <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman',Times,serif; font-size: 10pt; width: 100%; text-align: left; color: rgb(0, 0, 0);" id="zc0a88f80c61d4ccdb824f538e0679c11">

        <tr>
          <td style="width: 14.61%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">1.</div>
          </td>
          <td colspan="2" style="width: 85.39%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif;">NAMES OF REPORTING PERSONS</div>
            <div style="font-family: 'Times New Roman', Times, serif;"> <br>
            </div>
            <div style="font-family: 'Times New Roman', Times, serif;">Alexander J. Denner, Ph.D.</div>
          </td>
        </tr>
        <tr>
          <td style="width: 14.61%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">2.</div>
          </td>
          <td colspan="2" style="width: 85.39%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif;">CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS)</div>
            <div style="font-family: 'Times New Roman', Times, serif;"> <br>
            </div>
            <div style="font-family: 'Times New Roman', Times, serif;">(a)&#160;&#160;&#9723;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;(b)&#160;&#160;&#9723;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 14.61%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">3.</div>
          </td>
          <td colspan="2" style="width: 85.39%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif;">SEC USE ONLY</div>
            <div style="font-family: 'Times New Roman', Times, serif;"> <br>
            </div>
          </td>
        </tr>
        <tr>
          <td style="width: 14.61%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">4.</div>
          </td>
          <td colspan="2" style="width: 85.39%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif;">CITIZENSHIP OR PLACE OF ORGANIZATION</div>
            <div style="font-family: 'Times New Roman', Times, serif;"> <br>
            </div>
            <div style="font-family: 'Times New Roman', Times, serif;">United States</div>
          </td>
        </tr>
        <tr>
          <td rowspan="4" style="width: 14.61%; vertical-align: middle; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">NUMBER&#160;OF</div>
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">SHARES</div>
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">&#160;BENEFICIALLY</div>
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">OWNED&#160;BY</div>
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">EACH</div>
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">REPORTING</div>
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">PERSON</div>
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">WITH</div>
          </td>
          <td style="width: 5.72%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">5.</div>
          </td>
          <td style="width: 79.67%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif;">SOLE VOTING POWER</div>
            <div style="font-family: 'Times New Roman', Times, serif;"> <br>
            </div>
            <div style="font-family: 'Times New Roman', Times, serif;">0</div>
          </td>
        </tr>
        <tr>
          <td style="width: 5.72%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">6.</div>
          </td>
          <td style="width: 79.67%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif;">SHARED VOTING POWER</div>
            <div style="font-family: 'Times New Roman', Times, serif;"> <br>
            </div>
            <div style="font-family: 'Times New Roman', Times, serif;">8,844,000</div>
          </td>
        </tr>
        <tr>
          <td style="width: 5.72%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">7.</div>
          </td>
          <td style="width: 79.67%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif;">SOLE DISPOSITIVE POWER</div>
            <div style="font-family: 'Times New Roman', Times, serif;"> <br>
            </div>
            <div style="font-family: 'Times New Roman', Times, serif;">0</div>
          </td>
        </tr>
        <tr>
          <td style="width: 5.72%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">8.</div>
          </td>
          <td style="width: 79.67%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif;">SHARED DISPOSITIVE POWER</div>
            <div style="font-family: 'Times New Roman', Times, serif;"> <br>
            </div>
            <div style="font-family: 'Times New Roman', Times, serif;">8,844,000</div>
          </td>
        </tr>
        <tr>
          <td style="width: 14.61%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">9.</div>
          </td>
          <td colspan="2" style="width: 85.39%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif;">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</div>
            <div style="font-family: 'Times New Roman', Times, serif;"> <br>
            </div>
            <div style="font-family: 'Times New Roman', Times, serif;">8,844,000</div>
          </td>
        </tr>
        <tr>
          <td style="width: 14.61%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">10.</div>
          </td>
          <td colspan="2" style="width: 85.39%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif;">CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)&#160;&#160;&#9723;</div>
            <div style="font-family: 'Times New Roman', Times, serif;">&#160;</div>
          </td>
        </tr>
        <tr>
          <td style="width: 14.61%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">11.</div>
          </td>
          <td colspan="2" style="width: 85.39%; vertical-align: bottom; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif;">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9</div>
            <div style="font-family: 'Times New Roman', Times, serif;"> <br>
            </div>
            <div style="font-family: 'Times New Roman', Times, serif;">5.0%(1)</div>
          </td>
        </tr>
        <tr>
          <td style="width: 14.61%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
            <div style="text-align: center; font-family: 'Times New Roman', Times, serif;">12.</div>
          </td>
          <td colspan="2" style="width: 85.39%; vertical-align: bottom; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">
            <div style="font-family: 'Times New Roman', Times, serif;">TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)</div>
            <div style="font-family: 'Times New Roman', Times, serif;"> <br>
            </div>
            <div style="font-family: 'Times New Roman', Times, serif;">IN</div>
          </td>
        </tr>

    </table>
    <div>
      <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z7b7be6aa7cf64590b4efb087827e22eb">

          <tr>
            <td style="width: 36pt; vertical-align: top; align: right;">
              <div style="margin-left: 18pt;"> <br>
              </div>
              <div style="margin-left: 18pt;">(1)</div>
            </td>
            <td style="width: auto; vertical-align: top;">
              <div> <br>
              </div>
              <div>Calculations are based upon&#160;176,565,622 Shares outstanding as of October 31, 2020, as set forth in the Form 10-Q of the Issuer filed with the U.S. Securities and Exchange Commission on November 6, 2020.</div>
            </td>
          </tr>

      </table>
    </div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">3</font></div>
      <div style="page-break-after:always;" id="DSPFPageBreak">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" id="za4adb2de9dbf470bb7c49daaa2bc8457">

        <tr>
          <td style="width: 10%; vertical-align: top;">
            <div style="font-weight: bold;">Item&#160;1(a).</div>
          </td>
          <td style="width: 90%; vertical-align: top;">
            <div style="font-weight: bold;">Name of Issuer:</div>
          </td>
        </tr>

    </table>
    <div style="margin-top: 6pt; margin-bottom: 6pt;">BioCryst Pharmaceuticals, Inc. (the &#8220;Issuer&#8221;)</div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" id="za117437aea46404e81bdcff4d45af943">

        <tr>
          <td style="width: 10%; vertical-align: top;">
            <div style="font-weight: bold;">Item&#160;1(b).</div>
          </td>
          <td style="width: 90%; vertical-align: top;">
            <div style="font-weight: bold;">Address of Issuer&#8217;s Principal Executive Offices:</div>
          </td>
        </tr>

    </table>
    <div style="margin-top: 6pt; margin-bottom: 6pt;">4505 Emperor Blvd., Suite 200, Durham, North Carolina 27703</div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" id="z717f685434e948c987cf4d0e48586b96">

        <tr>
          <td style="width: 10%; vertical-align: top;">
            <div style="font-weight: bold;">Item&#160;2(a).</div>
          </td>
          <td style="width: 90%; vertical-align: top;">
            <div style="font-weight: bold;">Name of Person Filing:</div>
          </td>
        </tr>

    </table>
    <div style="margin-top: 6pt; margin-bottom: 6pt;">The persons filing this statement are Sarissa Capital Management LP, a Delaware limited partnership (&#8220;Sarissa Capital&#8221;) and Alexander J. Denner, Ph.D., a citizen of the United States of America
      (collectively, the &#8220;Reporting Persons&#8221;).</div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" id="z3d97d2804ab947ebb26fedbd50f523c1">

        <tr>
          <td style="width: 10%; vertical-align: top;">
            <div style="font-weight: bold;">Item&#160;2(b).</div>
          </td>
          <td style="width: 90%; vertical-align: top;">
            <div style="font-weight: bold;">Address of Principal Business Office or, if None, Residence:</div>
          </td>
        </tr>

    </table>
    <div style="margin-top: 6pt; margin-bottom: 6pt;">The principal business address of (i) each of Sarissa Capital and Dr. Denner is c/o Sarissa Capital Management LP, 660 Steamboat Road, Greenwich, CT 06830.</div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" id="zd504de335fec40d8a2292306ecaaa0c5">

        <tr>
          <td style="width: 10%; vertical-align: top;">
            <div style="font-weight: bold;">Item&#160;2(c).</div>
          </td>
          <td style="width: 90%; vertical-align: top;">
            <div style="font-weight: bold;">Citizenship:</div>
          </td>
        </tr>

    </table>
    <div style="margin-top: 6pt; margin-bottom: 6pt;">See Item 2(a).</div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" id="zdbbe7eb7831e4a5484b82119a77f0902">

        <tr>
          <td style="width: 10%; vertical-align: top;">
            <div style="font-weight: bold;">Item&#160;2(d).</div>
          </td>
          <td style="width: 90%; vertical-align: top;">
            <div style="font-weight: bold;">Title of Class of Securities:</div>
          </td>
        </tr>

    </table>
    <div style="margin-top: 6pt; margin-bottom: 6pt;">Common Stock, $0.01 par value per share (&#8220;Shares&#8221;).</div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" id="z409275aedf304989ac8e187ff2ad767e">

        <tr>
          <td style="width: 10%; vertical-align: top;">
            <div style="font-weight: bold;">Item&#160;2(e).</div>
          </td>
          <td style="width: 90%; vertical-align: top;">
            <div style="font-weight: bold;">CUSIP Number:</div>
          </td>
        </tr>

    </table>
    <div style="margin-top: 6pt; margin-bottom: 6pt;">09058V103</div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" id="z937a6c21c329458086526c5dfadf22bb">

        <tr>
          <td style="width: 10%; vertical-align: top;">
            <div style="font-weight: bold;">Item&#160;3.</div>
          </td>
          <td style="width: 90%; vertical-align: top;">
            <div style="font-weight: bold;">If this statement is filed pursuant to Rule 13d-1(b) or Rule 13d-2(b) or (c), check whether the person filing is a:</div>
          </td>
        </tr>

    </table>
    <div style="margin-top: 6pt; margin-bottom: 6pt;">Not applicable.</div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" id="zbb145b43f0164315adce571bbdf67e89">

        <tr>
          <td style="width: 10%; vertical-align: top;">
            <div style="font-weight: bold;">Item&#160;4.</div>
          </td>
          <td style="width: 90%; vertical-align: top;">
            <div style="font-weight: bold;">Ownership.</div>
          </td>
        </tr>

    </table>
    <div style="margin-top: 6pt; margin-bottom: 6pt;">The information required by Items 4(a)-(c)&#160;is set forth in Rows 5-11 of the cover pages&#160;hereto for each Reporting Person and is incorporated herein by reference for each such Reporting Person.</div>
    <div style="margin-bottom: 12pt;">Sarissa Capital has sole voting power and sole dispositive power with regard to 8,844,000 Shares.&#160; By virtue of his position as the Chief Investment Officer of Sarissa Capital, Dr. Denner may be deemed to have the
      shared power to vote or direct the vote of (and the shared power to dispose or direct the disposition of) the 8,844,000 Shares over which Sarissa Capital has sole voting power and sole dispositive power.</div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" id="z3f6a0fab0d614a4cbbb38d40b5320ff5">

        <tr>
          <td style="width: 10%; vertical-align: top;">
            <div style="font-weight: bold;">Item&#160;5.</div>
          </td>
          <td style="width: 90%; vertical-align: top;">
            <div style="font-weight: bold;">Ownership of Five Percent or Less of a Class.</div>
          </td>
        </tr>

    </table>
    <div style="margin-top: 6pt; margin-bottom: 6pt;">Not applicable.</div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">4</font></div>
      <div style="page-break-after:always;" id="DSPFPageBreak">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" id="zb46103398e2d4c2789a56fcb0402bf0a">

        <tr>
          <td style="width: 10%; vertical-align: top;">
            <div style="font-weight: bold;">Item&#160;6.</div>
          </td>
          <td style="width: 90%; vertical-align: top;">
            <div style="font-weight: bold;">Ownership of More than Five Percent on Behalf of Another Person.</div>
          </td>
        </tr>

    </table>
    <div style="margin-top: 6pt; margin-bottom: 6pt;">Not applicable.</div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" id="z96b46ad33079497f9895151af645ff7e">

        <tr>
          <td style="width: 10%; vertical-align: top;">
            <div style="font-weight: bold;">Item&#160;7.</div>
          </td>
          <td style="width: 90%; vertical-align: top;">
            <div style="font-weight: bold;">Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company.</div>
          </td>
        </tr>

    </table>
    <div style="margin-top: 6pt; margin-bottom: 6pt;">Not applicable.</div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" id="z99f479fbcb6c4a1aa90221e2816bc839">

        <tr>
          <td style="width: 10%; vertical-align: top;">
            <div style="font-weight: bold;">Item&#160;8.</div>
          </td>
          <td style="width: 90%; vertical-align: top;">
            <div style="font-weight: bold;">Identification and Classification of Members of the Group.</div>
          </td>
        </tr>

    </table>
    <div style="margin-top: 6pt; margin-bottom: 12pt;">The Reporting Persons are making this single, joint filing because they may be deemed to constitute a &#8220;group&#8221; within the meaning of Section&#160;13(d)(3) of the Securities Exchange Act of 1934, as amended
      (the &#8220;Exchange Act&#8221;).&#160;The agreement among the Reporting Persons to file jointly in accordance with Rule 13d-1(k) of the Exchange Act is attached hereto as Exhibit 99.1.&#160;The Reporting Persons disclaim membership in a group and this report shall not be
      deemed an admission by any of the Reporting Persons that they are or may be members of a &#8220;group&#8221; for purposes of Rule 13d-5 or for any other purpose.</div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" id="z9b3c884f77014c8b9eedd5ce02cff471">

        <tr>
          <td style="width: 10%; vertical-align: top;">
            <div style="font-weight: bold;">Item&#160;9.</div>
          </td>
          <td style="width: 90%; vertical-align: top;">
            <div style="font-weight: bold;">Notice of Dissolution of Group.</div>
          </td>
        </tr>

    </table>
    <div style="margin-top: 6pt; margin-bottom: 6pt;">Not applicable.</div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" id="zd0f3b30abbc94b2f930e04b3f58153b0">

        <tr>
          <td style="width: 10%; vertical-align: top;">
            <div style="font-weight: bold;">Item&#160;10.</div>
          </td>
          <td style="width: 90%; vertical-align: top;">
            <div style="font-weight: bold;">Certification.</div>
          </td>
        </tr>

    </table>
    <div style="margin-top: 6pt; margin-bottom: 8pt;">By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or
      influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under
      &#167; 240.14a-11.</div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">5</font></div>
      <div style="page-break-after:always;" id="DSPFPageBreak">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <div><br>
    </div>
    <div style="text-align: center; margin-top: 6pt; margin-bottom: 8pt;">SIGNATURE</div>
    <div style="margin-top: 6pt; margin-bottom: 12pt;">After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.</div>
    <div style="margin-bottom: 8pt;">Dated:&#160; January 25, 2021</div>
    <div style="margin-bottom: 8pt;"><br>
    </div>
    <div style="margin-bottom: 8pt;">SARISSA CAPITAL MANAGEMENT LP</div>
    <div style="margin-bottom: 8pt;"><br>
    </div>
    <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman',Times,serif; font-size: 10pt; width: 100%; text-align: left; color: rgb(0, 0, 0);" id="z21dec229c91643ed9f1dbd459f1edd0f">

        <tr>
          <td style="width: 6.51%; vertical-align: top;">
            <div style="font-family: 'Times New Roman', Times, serif;">By:</div>
          </td>
          <td style="width: 53.85%; vertical-align: top;">
            <div style="font-family: 'Times New Roman', Times, serif;"><u>/s/ Mark DiPaolo&#160;</u><u>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </u><br>
            </div>
          </td>
          <td style="width: 39.64%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 6.51%; vertical-align: top;">&#160;</td>
          <td style="width: 53.85%; vertical-align: top;">
            <div style="font-family: 'Times New Roman', Times, serif;">Name: Mark DiPaolo</div>
          </td>
          <td style="width: 39.64%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 6.51%; vertical-align: top;">&#160;</td>
          <td style="width: 53.85%; vertical-align: top;">
            <div style="font-family: 'Times New Roman', Times, serif;">Title: Senior Partner and General Counsel</div>
          </td>
          <td style="width: 39.64%; vertical-align: top;">&#160;</td>
        </tr>

    </table>
    <div style="margin-bottom: 8pt;"><br>
    </div>
    <div style="margin-bottom: 8pt;"><u>/s/Alexander J. Denner</u>________________________<br>
      Alexander J. Denner</div>
    <div style="margin-bottom: 8pt;"><br>
    </div>
    <div style="margin-bottom: 8pt;"><br>
    </div>
    <div style="margin-bottom: 8pt;"><br>
    </div>
    <div style="margin-bottom: 8pt;"><br>
    </div>
    <div style="text-align: center; margin-bottom: 8pt;"><br>
    </div>
    <div style="margin-bottom: 8pt;"><br>
    </div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">6</font></div>
      <div style="page-break-after:always;" id="DSPFPageBreak">
        <hr noshade="noshade" style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;"></div>
    </div>
    <div style="text-align: center; margin-bottom: 8pt;">EXHIBIT INDEX</div>
    <div style="margin-bottom: 8pt;">&#160;</div>
    <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" id="zd4bfe0d3f0994966ad5e29aaaa0b8960">

        <tr>
          <td nowrap="nowrap" style="width: 10.19%; vertical-align: top;">
            <div>Exhibit&#160;99.1</div>
          </td>
          <td style="width: 0.97%; vertical-align: bottom;">
            <div>&#160;&#160;</div>
          </td>
          <td style="width: 88.84%; vertical-align: top;">
            <div>Joint Filing Agreement, as required by Rule 13d-1(k) under the Securities Exchange Act of 1934, as amended</div>
          </td>
        </tr>

    </table>
  </div>
  <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;"> <br>
    </font></div>
  <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;"> <br>
    </font></div>
  <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;"> <br>
    </font></div>
  <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;"> <br>
    </font></div>
  <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;"> <br>
    </font></div>
  <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;"> <br>
    </font></div>
  <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;"> <br>
    </font></div>
  <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;"> <br>
    </font></div>
  <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;"> <br>
    </font></div>
  <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;"> <br>
    </font></div>
  <div id="DSPFPageNumberArea" style="text-align: center;"><font id="DSPFPageNumber" style="font-size: 8pt; font-weight: normal; font-style: normal;">7</font></div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99.1
<SEQUENCE>2
<FILENAME>s13gb.htm
<DESCRIPTION>JOINT FILING AGREEMENT
<TEXT>
<html>
  <head>
    <title></title>
    <!-- Licensed to: asdf
         Document created using EDGARfilings PROfile 7.2.0.0
         Copyright 1995 - 2021 Broadridge -->
  </head>
<body bgcolor="#ffffff" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left; color: #000000;">
  <div>
    <div style="text-align: right; font-weight: bold;">Exhibit 99.1</div>
    <div style="margin-bottom: 8pt;"><br>
    </div>
    <div style="text-align: center; margin-bottom: 8pt;">JOINT FILING AGREEMENT</div>
    <div style="margin-bottom: 8pt;">In accordance with Rule 13d&#8722;1(k)(1) under the Securities Exchange Act of 1934, as amended, the persons named below agree to the joint filing on behalf of each of them of a statement on Schedule 13G (including amendments
      thereto) with respect to the Common Stock of BioCryst Pharmaceuticals, Inc. and further agree that this Joint Filing Agreement be included as an Exhibit to such joint filings. In evidence thereof, the undersigned, being duly authorized, have executed
      this Joint Filing Agreement this 25<sup style="vertical-align: text-top; line-height: 1; font-size: smaller;">th</sup> day of January, 2021.</div>
    <div style="margin-bottom: 8pt;"><br>
    </div>
    <div style="margin-bottom: 8pt;">SARISSA CAPITAL MANAGEMENT LP</div>
    <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman',Times,serif; font-size: 10pt; width: 100%; text-align: left; color: rgb(0, 0, 0);" id="zb8615f466a824a1581e8e4aaff5f7757">

        <tr>
          <td style="width: 6.11%; vertical-align: top;">
            <div style="font-family: 'Times New Roman', Times, serif;">By:</div>
          </td>
          <td style="width: 54.09%; vertical-align: top;">
            <div style="font-family: 'Times New Roman', Times, serif;"><u>/s/ Mark DiPaolo&#160;</u><u>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </u><br>
            </div>
          </td>
          <td style="width: 39.81%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 6.11%; vertical-align: top;">&#160;</td>
          <td style="width: 54.09%; vertical-align: top;">
            <div style="font-family: 'Times New Roman', Times, serif;">Name: Mark DiPaolo</div>
          </td>
          <td style="width: 39.81%; vertical-align: top;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 6.11%; vertical-align: top;">&#160;</td>
          <td style="width: 54.09%; vertical-align: top;">
            <div style="font-family: 'Times New Roman', Times, serif;">Title: Senior Partner and General Counsel</div>
          </td>
          <td style="width: 39.81%; vertical-align: top;">&#160;</td>
        </tr>

    </table>
    <div style="margin-bottom: 8pt;"><br>
    </div>
    <div style="margin-bottom: 8pt;"><u>/s/Alexander J. Denner&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160; </u><br>
      Alexander J. Denner</div>
    <div style="margin-top: 12pt;"><br>
    </div>
    <div style="margin-bottom: 8pt;"><br>
    </div>
  </div>
</body>
</html>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
