<SEC-DOCUMENT>0000899140-21-000289.txt : 20210216
<SEC-HEADER>0000899140-21-000289.hdr.sgml : 20210216
<ACCEPTANCE-DATETIME>20210216151621
ACCESSION NUMBER:		0000899140-21-000289
CONFORMED SUBMISSION TYPE:	SC 13G/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20210216
DATE AS OF CHANGE:		20210216
GROUP MEMBERS:		CUBIST SYSTEMATIC STRATEGIES, LLC
GROUP MEMBERS:		POINT72 CAPITAL ADVISORS, INC.
GROUP MEMBERS:		POINT72 HONG KONG LTD
GROUP MEMBERS:		STEVEN A. COHEN

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			BIOCRYST PHARMACEUTICALS INC
		CENTRAL INDEX KEY:			0000882796
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				621413174
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-44055
		FILM NUMBER:		21636940

	BUSINESS ADDRESS:	
		STREET 1:		4505 EMPEROR BOULEVARD
		STREET 2:		SUITE 200
		CITY:			DURHAM
		STATE:			NC
		ZIP:			27703
		BUSINESS PHONE:		919-859-1302

	MAIL ADDRESS:	
		STREET 1:		4505 EMPEROR BOULEVARD
		STREET 2:		SUITE 200
		CITY:			DURHAM
		STATE:			NC
		ZIP:			27703

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Point72 Asset Management, L.P.
		CENTRAL INDEX KEY:			0001603466
		IRS NUMBER:				465064661
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		72 CUMMINGS POINT ROAD
		CITY:			STAMFORD
		STATE:			CT
		ZIP:			06902
		BUSINESS PHONE:		203-890-2000

	MAIL ADDRESS:	
		STREET 1:		72 CUMMINGS POINT ROAD
		CITY:			STAMFORD
		STATE:			CT
		ZIP:			06902
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G/A
<SEQUENCE>1
<FILENAME>b021221a.htm
<DESCRIPTION>SCHEDULE 13G (AMENDMENT #1)
<TEXT>
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  <div style="font-size: 12pt; font-weight: bold;">240.13d-102 Schedule 13G - Information to be included in statements filed</div>
  <div style="font-size: 12pt; font-weight: bold;">pursuant to 240.13d-1(b), (c), and (d) and amendments thereto</div>
  <div style="font-size: 12pt; font-weight: bold;">filed pursuant to 240.13d-2.</div>
  <div>
    <div style="text-indent: -24pt; margin-left: 24pt; margin-top: 10pt; margin-bottom: 5pt; font-size: 12pt;">Securities and Exchange Commission, Washington, D.C. 20549</div>
  </div>
  <div>
    <div style="margin-top: 10pt; margin-bottom: 12pt; font-size: 12pt;">Schedule 13G</div>
    <div style="margin-top: 10pt; margin-bottom: 12pt; font-size: 12pt;">Under the Securities Exchange Act of 1934</div>
    <div style="margin-top: 10pt; margin-bottom: 12pt; font-size: 12pt;">(Amendment No. 2)*</div>
    <div style="margin-top: 10pt; margin-bottom: 12pt; font-size: 12pt;">(Name of Issuer)</div>
    <div style="margin-top: 10pt; margin-bottom: 12pt; font-size: 12pt;">BIOCRYST PHARMACEUTICALS, INC.</div>
    <div style="margin-top: 10pt; margin-bottom: 12pt; font-size: 12pt;">(Title of Class of Securities)</div>
  </div>
  <div>
    <div style="font-size: 12pt;">Common Stock, Par Value $0.01 Per Share</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">(CUSIP Number)</div>
    <div><br>
    </div>
    <div style="font-size: 12pt;">09058V103</div>
  </div>
  <div>
    <div style="margin-top: 10pt; margin-bottom: 12pt; font-size: 12pt;">(Date of Event Which Requires Filing of this Statement)</div>
  </div>
  <div style="font-size: 12pt;">December 31, 2020</div>
  <div><br>
  </div>
  <div style="font-size: 12pt;">Check the appropriate box to designate the rule pursuant to which this</div>
  <div style="font-size: 12pt;">Schedule is filed:</div>
  <div>
    <div style="text-indent: -24pt; margin-left: 24pt; margin-top: 10pt; margin-bottom: 5pt; font-size: 12pt;">[&#160; ] Rule 13d-1(b)</div>
    <div style="text-indent: -24pt; margin-left: 24pt; margin-top: 10pt; margin-bottom: 5pt; font-size: 12pt;">[ x ] Rule 13d-1(c)</div>
    <div style="text-indent: -24pt; margin-left: 24pt; margin-top: 10pt; margin-bottom: 5pt; font-size: 12pt;">[&#160; ] Rule 13d-1(d)</div>
  </div>
  <div>
    <div style="margin-top: 10pt; margin-bottom: 5pt;"><font style="font-size: 12pt;">*The remainder of this cover page shall be filled out for a reporting person's<br>
        initial filing on this form with respect to the subject class of securities, and<br>
        for any subsequent amendment containing information which would alter the<br>
        disclosures provided in a prior cover page.<br>
        <br>
        The information required in the remainder of this cover page shall not be<br>
        deemed to be &#8220;filed&#8221; for the purpose of Section 18 of the Securities Exchange<br>
        Act of 1934 (&#8220;Act&#8221;) or otherwise subject to the liabilities of that section of the<br>
        Act but shall be subject to all other provisions of the Act (however, see<br>
        the Notes).<br>
        </font><br>
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        <td style="width: 100%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);" colspan="2">
          <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-size: 12pt;">CUSIP No. 09058V103</div>
        </td>
      </tr>
      <tr>
        <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(1) Names of reporting persons&#160; &#160; Point72 Asset Management, L.P.</div>
        </td>
        <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
      </tr>
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        <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(2) Check the appropriate box if a member of a group</div>
        </td>
        <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(a)</div>
        </td>
      </tr>
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        <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
          <div style="text-indent: 176.2pt; font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(see instructions)</div>
        </td>
        <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(b)X</div>
        </td>
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        <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(3) SEC use only</div>
        </td>
        <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
      </tr>
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        <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(4) Citizenship or place of organization Delaware</div>
        </td>
        <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
      </tr>
      <tr>
        <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">Number of shares beneficially owned by each reporting person with:</div>
        </td>
        <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
      </tr>
      <tr>
        <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(5) Sole voting power&#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; 0</div>
        </td>
        <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
      </tr>
      <tr>
        <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(6) Shared voting power&#160; &#160; &#160; &#160; &#160; &#160; &#160; 3,230,800 (see Item 4)</div>
        </td>
        <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
      </tr>
      <tr>
        <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(7) Sole dispositive power&#160; &#160; &#160; &#160; &#160;&#160; 0</div>
        </td>
        <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
      </tr>
      <tr>
        <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(8) Shared dispositive power&#160; &#160; &#160;&#160; 3,230,800 (see Item 4)</div>
        </td>
        <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
      </tr>
      <tr>
        <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(9) Aggregate amount beneficially owned by each reporting person</div>
          <div style="margin-left: 21.6pt; font-family: 'Times New Roman', Times, serif; font-size: 12pt;">3,230,800 (see Item 4)</div>
        </td>
        <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
      </tr>
      <tr>
        <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(10) Check if the aggregate amount in Row (9) excludes certain shares</div>
          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(see instructions)</div>
        </td>
        <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
      </tr>
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        <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(11) Percent of class represented by amount in Row (9) 1.8% (see Item 4)</div>
        </td>
        <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
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          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(12) Type of reporting person (see instructions)&#160; &#160;&#160; PN</div>
        </td>
        <td style="width: 6.38%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">&#160;</td>
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        <td style="width: 100%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);" colspan="2">
          <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-size: 12pt;">CUSIP No. 09058V103</div>
        </td>
      </tr>
      <tr>
        <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(1) Names of reporting persons&#160; &#160; Point72 Capital Advisors, Inc.</div>
        </td>
        <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
      </tr>
      <tr>
        <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(2) Check the appropriate box if a member of a group</div>
        </td>
        <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(a)</div>
        </td>
      </tr>
      <tr>
        <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
          <div style="text-indent: 176.2pt; font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(see instructions)</div>
        </td>
        <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(b)X</div>
        </td>
      </tr>
      <tr>
        <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(3) SEC use only</div>
        </td>
        <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
      </tr>
      <tr>
        <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(4) Citizenship or place of organization Delaware</div>
        </td>
        <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
      </tr>
      <tr>
        <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">Number of shares beneficially owned by each reporting person with:</div>
        </td>
        <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
      </tr>
      <tr>
        <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(5) Sole voting power&#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; 0</div>
        </td>
        <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
      </tr>
      <tr>
        <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(6) Shared voting power&#160; &#160; &#160; &#160; &#160; &#160; &#160; 3,230,800 (see Item 4)</div>
        </td>
        <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
      </tr>
      <tr>
        <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(7) Sole dispositive power&#160; &#160; &#160; &#160; &#160;&#160; 0</div>
        </td>
        <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
      </tr>
      <tr>
        <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(8) Shared dispositive power&#160; &#160; &#160;&#160; 3,230,800 (see Item 4)</div>
        </td>
        <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
      </tr>
      <tr>
        <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(9) Aggregate amount beneficially owned by each reporting person</div>
          <div style="margin-left: 21.6pt; font-family: 'Times New Roman', Times, serif; font-size: 12pt;">3,230,800 (see Item 4)</div>
        </td>
        <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
      </tr>
      <tr>
        <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(10) Check if the aggregate amount in Row (9) excludes certain shares</div>
          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(see instructions)</div>
        </td>
        <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
      </tr>
      <tr>
        <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(11) Percent of class represented by amount in Row (9) 1.8% (see Item 4)</div>
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          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(12) Type of reporting person (see instructions)&#160; &#160;&#160; CO</div>
        </td>
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          <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-size: 12pt;">CUSIP No. 09058V103</div>
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          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(1) Names of reporting persons&#160; &#160; Cubist Systematic Strategies, LLC</div>
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        <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
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        <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(2) Check the appropriate box if a member of a group</div>
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          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(a)</div>
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          <div style="text-indent: 176.2pt; font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(see instructions)</div>
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        <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(b)X</div>
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          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(3) SEC use only</div>
        </td>
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          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(4) Citizenship or place of organization Delaware</div>
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          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">Number of shares beneficially owned by each reporting person with:</div>
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        <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
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          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(5) Sole voting power&#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; 0</div>
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        <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
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          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(6) Shared voting power&#160; &#160; &#160; &#160; &#160; &#160; &#160; 456,564 (see Item 4)</div>
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          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(7) Sole dispositive power&#160; &#160; &#160; &#160; &#160;&#160; 0</div>
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          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(8) Shared dispositive power&#160; &#160; &#160;&#160; 456,564 (see Item 4)</div>
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        <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
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          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(9) Aggregate amount beneficially owned by each reporting person</div>
          <div style="margin-left: 21.6pt; font-family: 'Times New Roman', Times, serif; font-size: 12pt;">456,564 (see Item 4)</div>
        </td>
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          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(10) Check if the aggregate amount in Row (9) excludes certain shares</div>
          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(see instructions)</div>
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        <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
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          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(11) Percent of class represented by amount in Row (9) 0.3% (see Item 4)</div>
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          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(12) Type of reporting person (see instructions)&#160; &#160;&#160; OO</div>
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          <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-size: 12pt;">CUSIP No. 09058V103</div>
        </td>
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        <td style="width: 93.74%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(1) Names of reporting persons&#160; &#160; Point72 Hong Kong Limited</div>
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        <td style="width: 6.26%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
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          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(2) Check the appropriate box if a member of a group</div>
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        <td style="width: 6.26%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(a)</div>
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          <div style="text-indent: 176.2pt; font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(see instructions)</div>
        </td>
        <td style="width: 6.26%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(b)X</div>
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          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(3) SEC use only</div>
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          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(4) Citizenship or place of organization Hong Kong</div>
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          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">Number of shares beneficially owned by each reporting person with:</div>
        </td>
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          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(5) Sole voting power&#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; 0</div>
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        <td style="width: 6.26%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
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        <td style="width: 93.74%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(6) Shared voting power&#160; &#160; &#160; &#160; &#160; &#160; &#160; 4,268 (see Item 4)</div>
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        <td style="width: 6.26%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
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          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(7) Sole dispositive power&#160; &#160; &#160; &#160; &#160;&#160; 0</div>
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        <td style="width: 6.26%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
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          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(8) Shared dispositive power&#160; &#160; &#160;&#160; 4,268 (see Item 4)</div>
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        <td style="width: 6.26%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
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          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(9) Aggregate amount beneficially owned by each reporting person</div>
          <div style="margin-left: 21.6pt; font-family: 'Times New Roman', Times, serif; font-size: 12pt;">0 (see Item 4)</div>
        </td>
        <td style="width: 6.26%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
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          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(10) Check if the aggregate amount in Row (9) excludes certain shares</div>
          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(see instructions)</div>
        </td>
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          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(11) Percent of class represented by amount in Row (9) &lt;0.1% (see Item 4)</div>
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          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(12) Type of reporting person (see instructions)&#160; &#160;&#160; OO</div>
        </td>
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          <div style="text-align: center; font-family: 'Times New Roman', Times, serif; font-size: 12pt;">CUSIP No. 09058V103</div>
        </td>
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        <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(1) Names of reporting persons&#160; &#160; Steven A. Cohen</div>
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        <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
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          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(2) Check the appropriate box if a member of a group</div>
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          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(a)</div>
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          <div style="text-indent: 176.2pt; font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(see instructions)</div>
        </td>
        <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">
          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(b)X</div>
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          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(3) SEC use only</div>
        </td>
        <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
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          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(4) Citizenship or place of organization United States</div>
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          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">Number of shares beneficially owned by each reporting person with:</div>
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      <tr>
        <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(5) Sole voting power&#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; &#160; 0</div>
        </td>
        <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
      </tr>
      <tr>
        <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(6) Shared voting power&#160; &#160; &#160; &#160; &#160; &#160; &#160; 3,691,632 (see Item 4)</div>
        </td>
        <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
      </tr>
      <tr>
        <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(7) Sole dispositive power&#160; &#160; &#160; &#160; &#160;&#160; 0</div>
        </td>
        <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
      </tr>
      <tr>
        <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(8) Shared dispositive power&#160; &#160; &#160;&#160; 3,691,632 (see Item 4)</div>
        </td>
        <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
      </tr>
      <tr>
        <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(9) Aggregate amount beneficially owned by each reporting person</div>
          <div style="margin-left: 21.6pt; font-family: 'Times New Roman', Times, serif; font-size: 12pt;">3,691,632 (see Item 4)</div>
        </td>
        <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
      </tr>
      <tr>
        <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(10) Check if the aggregate amount in Row (9) excludes certain shares</div>
          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(see instructions)</div>
        </td>
        <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
      </tr>
      <tr>
        <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0);">
          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(11) Percent of class represented by amount in Row (9) 2.1% (see Item 4)</div>
        </td>
        <td style="width: 6.38%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-right: 2px solid rgb(0, 0, 0);">&#160;</td>
      </tr>
      <tr>
        <td style="width: 93.62%; vertical-align: top; border-top: 2px solid rgb(0, 0, 0); border-left: 2px solid rgb(0, 0, 0); border-bottom: 2px solid rgb(0, 0, 0);">
          <div style="font-family: 'Times New Roman', Times, serif; font-size: 12pt;">(12) Type of reporting person (see instructions)&#160; &#160; IN</div>
        </td>
        <td style="width: 6.38%; vertical-align: top; border-width: 2px; border-style: solid; border-color: rgb(0, 0, 0);">&#160;</td>
      </tr>

  </table>
  <div>
    <div><br>
    </div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="page-break-after: always;" id="DSPFPageBreak">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div style="margin-top: 12pt; margin-bottom: 12pt; font-size: 12pt;">Item 1(a) Name of issuer:</div>
  </div>
  <div>
    <div style="margin-top: 10pt; margin-bottom: 12pt; font-size: 12pt;">BIOCRYST PHARMACEUTICALS, INC.</div>
  </div>
  <div>
    <div style="margin-top: 12pt; margin-bottom: 12pt; font-size: 12pt;">Item 1(b) Address of issuer's principal executive offices:</div>
    <div style="margin-top: 12pt; margin-bottom: 12pt; font-size: 12pt;">4505 Emperor Blvd., Suite&#160;200, Durham, North Carolina 27703</div>
    <div style="margin-top: 12pt; margin-bottom: 12pt; font-size: 12pt;">2(a) Name of person filing:</div>
    <div style="margin-top: 12pt; margin-bottom: 12pt; font-size: 12pt;">This statement is filed by: (i) Point72 Asset Management, L.P. (&#8220;Point72 Asset<br>
      Management&#8221;) with respect to shares of common stock, par value $0.01 per share (&#8220;Shares&#8221;), of<br>
      the Issuer held by certain investment funds it manages; (ii) Point72 Capital Advisors, Inc.<br>
      (&#8220;Point72 Capital Advisors Inc.&#8221;) with respect to Shares held by certain investment funds<br>
      managed by Point72 Asset Management; (iii) Cubist Systematic Strategies, LLC (&#8220;Cubist<br>
      Systematic Strategies&#8221;) with respect to Shares held by certain investment funds it<br>
      manages; (iv) Point72 Hong Kong Limited (&#8220;Point72 Hong Kong&#8221;) with respect to<br>
      Shares held by certain investment funds it manages; and (v) Steven A. Cohen<br>
      (&#8220;Mr. Cohen&#8221;) with respect to Shares beneficially owned by Point72 Asset<br>
      Management, Point72 Capital Advisors Inc., Cubist Systematic Strategies, and<br>
      Point72 Hong Kong.</div>
    <div style="margin-top: 12pt; margin-bottom: 12pt; font-size: 12pt;">2(b) Address or principal business office or, if none, residence:</div>
    <div style="margin-top: 12pt; margin-bottom: 12pt; font-size: 12pt;">The address of the principal business office of (i) Point72 Asset Management,<br>
      Point72 Capital Advisors Inc., and Mr. Cohen is 72 Cummings Point Road,<br>
      Stamford, CT 06902; (ii) Cubist Systematic Strategies is 55 Hudson Yards, New York, NY<br>
      10001; and (iii) Point72 Hong Kong is 12th Floor, Chater House, 8 Connaught Road Central,<br>
      Hong Kong.</div>
    <div style="margin-top: 12pt; margin-bottom: 12pt; font-size: 12pt;">2(c) Citizenship:</div>
    <div style="margin-top: 12pt; margin-bottom: 12pt; font-size: 12pt;">Point72 Asset Management is a Delaware limited partnership. Point72 Capital Advisors Inc. is a<br>
      Delaware corporation. Cubist Systematic Strategies is a Delaware limited liability company.<br>
      Point72 Hong Kong is a Hong Kong limited liability company. Mr. Cohen is a United States<br>
      citizen.</div>
    <div style="margin-top: 12pt; margin-bottom: 12pt; font-size: 12pt;">2(d) Title of class of securities:</div>
  </div>
  <div>
    <div style="font-size: 12pt;">Common Stock, Par Value $0.01 Per Share</div>
  </div>
  <div>
    <div style="margin-top: 12pt; margin-bottom: 12pt; font-size: 12pt;">2(e) CUSIP Number:</div>
  </div>
  <div>
    <div style="font-size: 12pt;">09058V103</div>
    <div style="font-size: 12pt;"> <br>
    </div>
  </div>
  <div style="font-size: 12pt; font-style: italic;">Item 3.</div>
  <div><br>
  </div>
  <div style="font-size: 12pt;">Not applicable</div>
  <div><br>
  </div>
  <div style="font-size: 12pt;"><font style="font-style: italic;">Item 4. </font>Ownership</div>
  <div><br>
  </div>
  <div style="font-size: 12pt;">As of the close of business on December 31, 2020:</div>
  <div><br>
  </div>
  <div style="font-size: 12pt;">1. Point72 Asset Management, L.P.</div>
  <div style="font-size: 12pt;">(a) Amount beneficially owned: 3,230,800</div>
  <div><font style="font-size: 12pt;">(b) Percent of class: 1.8%</font><font id="TRGRRTFtoHTMLTab" style="display: inline-block; text-indent: 0px; font-size: 1px; width: 144pt">&#160;</font></div>
  <div style="font-size: 12pt;">(c) Number of shares as to which the person has:</div>
  <div style="font-size: 12pt;">(i) Sole power to vote or to direct the vote: 0</div>
  <div><font style="font-size: 12pt;">(ii) Shared power to vote or to direct the vote: 3,230,800</font><font id="TRGRRTFtoHTMLTab" style="display: inline-block; text-indent: 0px; font-size: 1px; width: 324pt">&#160;</font></div>
  <div style="font-size: 12pt;">(iii) Sole power to dispose or to direct the disposition of: 0</div>
  <div style="font-size: 12pt;">(iv) Shared power to dispose or to direct the disposition of: 3,230,800</div>
  <div><br>
  </div>
  <div style="font-size: 12pt;">2. Point72 Capital Advisors, Inc.</div>
  <div style="font-size: 12pt;">(a) Amount beneficially owned: 3,230,800</div>
  <div><font style="font-size: 12pt;">(b) Percent of class: 1.8%</font><font id="TRGRRTFtoHTMLTab" style="display: inline-block; text-indent: 0px; font-size: 1px; width: 144pt">&#160;</font></div>
  <div style="font-size: 12pt;">(c) Number of shares as to which the person has:</div>
  <div style="font-size: 12pt;">(i) Sole power to vote or to direct the vote: 0</div>
  <div><font style="font-size: 12pt;">(ii) Shared power to vote or to direct the vote: 3,230,800</font><font id="TRGRRTFtoHTMLTab" style="display: inline-block; text-indent: 0px; font-size: 1px; width: 324pt">&#160;</font></div>
  <div style="font-size: 12pt;">(iii) Sole power to dispose or to direct the disposition of: 0</div>
  <div style="font-size: 12pt;">(iv) Shared power to dispose or to direct the disposition of: 3,230,800</div>
  <div><br>
  </div>
  <div style="font-size: 12pt;">3. Cubist Systematic Strategies, LLC</div>
  <div style="font-size: 12pt;">(a) Amount beneficially owned: 456,564</div>
  <div><font style="font-size: 12pt;">(b) Percent of class: 0.3%</font><font id="TRGRRTFtoHTMLTab" style="display: inline-block; text-indent: 0px; font-size: 1px; width: 144pt">&#160;</font></div>
  <div style="font-size: 12pt;">(c) Number of shares as to which the person has:</div>
  <div style="font-size: 12pt;">(i) Sole power to vote or to direct the vote: 0</div>
  <div><font style="font-size: 12pt;">(ii) Shared power to vote or to direct the vote: 456,564</font><font id="TRGRRTFtoHTMLTab" style="display: inline-block; text-indent: 0px; font-size: 1px; width: 324pt">&#160;</font></div>
  <div style="font-size: 12pt;">(iii) Sole power to dispose or to direct the disposition of: 0</div>
  <div style="font-size: 12pt;">(iv) Shared power to dispose or to direct the disposition of: 456,564</div>
  <div><br>
  </div>
  <div style="font-size: 12pt;">4. Point72 Hong Kong Limited</div>
  <div style="font-size: 12pt;">(a) Amount beneficially owned: 4,268</div>
  <div><font style="font-size: 12pt;">(b) Percent of class: &lt;0.1%</font><font id="TRGRRTFtoHTMLTab" style="display: inline-block; text-indent: 0px; font-size: 1px; width: 180pt">&#160;</font></div>
  <div style="font-size: 12pt;">(c) Number of shares as to which the person has:</div>
  <div style="font-size: 12pt;">(i) Sole power to vote or to direct the vote: 0</div>
  <div><font style="font-size: 12pt;">(ii) Shared power to vote or to direct the vote: </font><font style="font-size: 12pt;">4,268</font><font id="TRGRRTFtoHTMLTab" style="display: inline-block; text-indent: 0px; font-size: 1px; width: 288pt">&#160;</font></div>
  <div style="font-size: 12pt;">(iii) Sole power to dispose or to direct the disposition of: 0</div>
  <div style="font-size: 12pt;">(iv) Shared power to dispose or to direct the disposition of: 4,268</div>
  <div><br>
  </div>
  <div style="font-size: 12pt;">5. Steven A. Cohen</div>
  <div style="font-size: 12pt;">(a) Amount beneficially owned: 3,691,632</div>
  <div><font style="font-size: 12pt;">(b) Percent of class: 2.1%</font><font id="TRGRRTFtoHTMLTab" style="display: inline-block; text-indent: 0px; font-size: 1px; width: 144pt">&#160;</font></div>
  <div style="font-size: 12pt;">(c) Number of shares as to which the person has:</div>
  <div style="font-size: 12pt;">(i) Sole power to vote or to direct the vote: 0</div>
  <div><font style="font-size: 12pt;">(ii) Shared power to vote or to direct the vote: 3,691,632</font><font id="TRGRRTFtoHTMLTab" style="display: inline-block; text-indent: 0px; font-size: 1px; width: 324pt">&#160;</font></div>
  <div style="font-size: 12pt;">(iii) Sole power to dispose or to direct the disposition of: 0</div>
  <div style="font-size: 12pt;">(iv) Shared power to dispose or to direct the disposition of: 3,691,632</div>
  <div>
    <div style="margin-top: 12pt; margin-bottom: 12pt; font-size: 12pt;">Point72 Asset Management, Point72 Capital Advisors Inc., Cubist Systematic<br>
      Strategies, Point72 Hong Kong, and Mr. Cohen own directly no Shares. Pursuant to an<br>
      investment management agreement, Point72 Asset Management maintains investment and voting<br>
      power with respect to the securities held by certain investment funds it manages. Point72 Capital<br>
      Advisors Inc. is the general partner of Point72 Asset Management. Pursuant to an investment<br>
      management agreement, Cubist Systematic Strategies maintains investment and voting power<br>
      with respect to the securities held by certain investment funds it manages. Pursuant to an<br>
      investment management agreement, Point72 Hong Kong maintains investment and voting power<br>
      with respect to the securities held by certain investment funds it manages. Mr. Cohen controls<br>
      each of Point72 Asset Management, Point72 Capital Advisors Inc., Cubist Systematic Strategies,<br>
      and Point72 Hong Kong. As of December 31, 2020, by reason of the provisions of Rule 13d-3 of<br>
      the Securities Exchange Act of 1934, as amended, each of (i) Point72 Asset Management,<br>
      Point72 Capital Advisors Inc., and Mr. Cohen may be deemed to beneficially own<br>
      3,230,800 Shares (constituting approximately 1.8% of the Shares outstanding); (ii) Cubist<br>
      Systematic Strategies and Mr. Cohen may be deemed to beneficially own 456,564 Shares<br>
      (constituting approximately 0.3% of the Shares outstanding) and (iii) Point72 Hong Kong and<br>
      Mr. Cohen may be deemed to beneficially own 4,268 Shares (constituting &lt;0.1% of the Shares<br>
      outstanding).&#160; Each of Point72 Asset Management, Point72 Capital Advisors Inc., Cubist<br>
      Systematic Strategies, Point72 Hong Kong, and Mr. Cohen disclaims beneficial ownership of<br>
      any of the securities covered by this statement.</div>
  </div>
  <div style="font-size: 12pt;"><font style="font-style: italic;">Item 5. </font>Ownership of 5 Percent or Less of a Class.</div>
  <div><br>
  </div>
  <div style="font-size: 12pt;">If this statement is being filed to report the fact that as of the date hereof</div>
  <div style="font-size: 12pt;">the reporting person has ceased to be the beneficial owner of more than</div>
  <div style="font-size: 12pt;">5 percent of the class of securities, check the following [X].</div>
  <div><br>
  </div>
  <div style="font-size: 12pt;"><font style="font-style: italic;">Item 6.</font>&#160; Ownership of More than 5 Percent on Behalf of
    Another Person.</div>
  <div><br>
  </div>
  <div style="font-size: 12pt;">Not applicable</div>
  <div><br>
  </div>
  <div style="font-size: 12pt;"><font style="font-style: italic;">Item 7.</font>&#160; Identification and Classification of the
    Subsidiary Which Acquired</div>
  <div style="font-size: 12pt;">the Security Being Reporting on by the Parent Holding Company or Control</div>
  <div style="font-size: 12pt;">Person.</div>
  <div>
    <div style="margin-top: 10pt; margin-bottom: 5pt; font-size: 12pt;">Not applicable</div>
    <div style="margin-top: 10pt; margin-bottom: 5pt; font-size: 12pt;"><font style="font-style: italic;">Item 8. </font>Identification
      and Classification of Members of the Group</div>
    <div><br>
    </div>
  </div>
  <div style="font-size: 12pt;">Not applicable</div>
  <div><br>
  </div>
  <div style="font-size: 12pt;"><font style="font-style: italic;">Item 9.</font>&#160; Notice of Dissolution of Group.</div>
  <div><br>
  </div>
  <div style="font-size: 12pt;">Not applicable</div>
  <div><br>
  </div>
  <div style="font-size: 12pt;"><font style="font-style: italic;">Item 10. </font>Certifications</div>
  <div><br>
  </div>
  <div style="font-size: 12pt;">By signing below I certify that, to the best of my knowledge and belief,</div>
  <div style="font-size: 12pt;">the securities referred to above were not acquired and are not held for the purpose</div>
  <div style="font-size: 12pt;">of or with the effect of changing or influencing the control of the issuer of</div>
  <div style="font-size: 12pt;">the securities and were not acquired and are not held in connection with or</div>
  <div style="font-size: 12pt;">as a participant in any transaction having that purpose or effect, and other than</div>
  <div style="font-size: 12pt;">activities solely in connection with a nomination under &#167; 240.14a-11.</div>
  <div><br>
  </div>
  <div style="font-size: 12pt;"><font style="font-style: italic;">Signature.</font>&#160; After reasonable inquiry and to the best of
    my knowledge and belief,</div>
  <div style="font-size: 12pt;">I certify that the information set forth in this statement is true, complete</div>
  <div style="font-size: 12pt;">and correct.</div>
  <div>
    <div><br>
    </div>
    <div style="margin-top: 12pt; margin-bottom: 12pt; font-size: 12pt;">Dated: <u>February 16, 2021</u></div>
    <div><br>
    </div>
  </div>
  <div style="margin-bottom: 10pt; font-size: 12pt;">POINT72 ASSET MANAGEMENT, L.P.</div>
  <div style="margin-bottom: 10pt; font-size: 12pt;">By: <u>/s/ Jason M. Colombo</u></div>
  <div style="font-size: 12pt;">Name: Jason M. Colombo</div>
  <div style="font-size: 12pt;">Title: Authorized Person</div>
  <div><br>
  </div>
  <div style="margin-bottom: 10pt; font-size: 12pt;">POINT72 CAPITAL ADVISORS, INC.</div>
  <div style="margin-bottom: 10pt; font-size: 12pt;">By: <u>/s/ Jason M. Colombo</u></div>
  <div style="font-size: 12pt;">Name: Jason M. Colombo</div>
  <div style="font-size: 12pt;">Title: Authorized Person</div>
  <div><br>
  </div>
  <div style="margin-bottom: 10pt; font-size: 12pt;">CUBIST SYSTEMATIC STRATEGIES, LLC</div>
  <div style="margin-bottom: 10pt; font-size: 12pt;">By: <u>/s/ Jason M. Colombo</u></div>
  <div style="font-size: 12pt;">Name: Jason M. Colombo</div>
  <div style="font-size: 12pt;">Title: Authorized Person</div>
  <div style="margin-bottom: 10pt;"><br>
  </div>
  <div style="margin-bottom: 10pt; font-size: 12pt;">POINT72 HONG KONG LIMITED</div>
  <div style="margin-bottom: 10pt; font-size: 12pt;">By: <u>/s/ Jason M. Colombo</u></div>
  <div style="font-size: 12pt;">Name: Jason M. Colombo</div>
  <div style="font-size: 12pt;">Title: Authorized Person</div>
  <div><br>
  </div>
  <div style="margin-bottom: 10pt; font-size: 12pt;">STEVEN A. COHEN</div>
  <div style="margin-bottom: 10pt; font-size: 12pt;">By: <u>/s/ Jason M. Colombo</u></div>
  <div style="font-size: 12pt;">Name: Jason M. Colombo</div>
  <div style="font-size: 12pt;">Title: Authorized Person</div>
  <div><br>
  </div>
  <div style="margin-bottom: 10pt;"><br>
  </div>
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</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
