<SEC-DOCUMENT>0001104659-21-024117-index.html : 20210216
<SEC-HEADER>0001104659-21-024117.hdr.sgml : 20210216
<ACCEPTANCE-DATETIME>20210216163039
ACCESSION NUMBER:		0001104659-21-024117
CONFORMED SUBMISSION TYPE:	SC 13G/A
PUBLIC DOCUMENT COUNT:		2
FILED AS OF DATE:		20210216
DATE AS OF CHANGE:		20210216
GROUP MEMBERS:		CALC IV LP
GROUP MEMBERS:		CITADEL ADVISORS HOLDINGS LP
GROUP MEMBERS:		CITADEL GP LLC
GROUP MEMBERS:		CITADEL SECURITIES GP LLC
GROUP MEMBERS:		CITADEL SECURITIES LLC
GROUP MEMBERS:		KENNETH GRIFFIN

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			BIOCRYST PHARMACEUTICALS INC
		CENTRAL INDEX KEY:			0000882796
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				621413174
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-44055
		FILM NUMBER:		21639263

	BUSINESS ADDRESS:	
		STREET 1:		4505 EMPEROR BOULEVARD
		STREET 2:		SUITE 200
		CITY:			DURHAM
		STATE:			NC
		ZIP:			27703
		BUSINESS PHONE:		919-859-1302

	MAIL ADDRESS:	
		STREET 1:		4505 EMPEROR BOULEVARD
		STREET 2:		SUITE 200
		CITY:			DURHAM
		STATE:			NC
		ZIP:			27703

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			CITADEL ADVISORS LLC
		CENTRAL INDEX KEY:			0001423053
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		131 S. DEARBORN ST., 32ND FLOOR
		CITY:			CHICAGO
		STATE:			IL
		ZIP:			60603
		BUSINESS PHONE:		312-395-2100

	MAIL ADDRESS:	
		STREET 1:		131 S. DEARBORN ST., 32ND FLOOR
		CITY:			CHICAGO
		STATE:			IL
		ZIP:			60603
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G/A
<SEQUENCE>1
<FILENAME>tm214737d2_sc13ga.htm
<DESCRIPTION>SCHEDULE 13G/A
<TEXT>
Document 1 - file: tm214737d2_sc13ga.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99.1
<SEQUENCE>2
<FILENAME>tm214737d2_ex99-1.htm
<DESCRIPTION>EXHIBIT 99.1
<TEXT>
Document 2 - file: tm214737d2_ex99-1.htm

</DOCUMENT>
</SEC-DOCUMENT>