<SEC-DOCUMENT>0001104659-21-024306.txt : 20210216
<SEC-HEADER>0001104659-21-024306.hdr.sgml : 20210216
<ACCEPTANCE-DATETIME>20210216165305
ACCESSION NUMBER:		0001104659-21-024306
CONFORMED SUBMISSION TYPE:	SC 13G/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20210216
DATE AS OF CHANGE:		20210216
GROUP MEMBERS:		BAKER BROS. ADVISORS (GP) LLC
GROUP MEMBERS:		FELIX J. BAKER
GROUP MEMBERS:		JULIAN C. BAKER

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			BIOCRYST PHARMACEUTICALS INC
		CENTRAL INDEX KEY:			0000882796
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				621413174
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-44055
		FILM NUMBER:		21640165

	BUSINESS ADDRESS:	
		STREET 1:		4505 EMPEROR BOULEVARD
		STREET 2:		SUITE 200
		CITY:			DURHAM
		STATE:			NC
		ZIP:			27703
		BUSINESS PHONE:		919-859-1302

	MAIL ADDRESS:	
		STREET 1:		4505 EMPEROR BOULEVARD
		STREET 2:		SUITE 200
		CITY:			DURHAM
		STATE:			NC
		ZIP:			27703

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			BAKER BROS. ADVISORS LP
		CENTRAL INDEX KEY:			0001263508
		IRS NUMBER:				134093645
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		860 WASHINGTON STREET
		STREET 2:		3RD FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10014
		BUSINESS PHONE:		2123395600

	MAIL ADDRESS:	
		STREET 1:		860 WASHINGTON STREET
		STREET 2:		3RD FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10014

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	BAKER BROS ADVISORS LLC
		DATE OF NAME CHANGE:	20030911
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G/A
<SEQUENCE>1
<FILENAME>tm216730d1_sc13ga.htm
<DESCRIPTION>SC 13G/A
<TEXT>
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<P STYLE="margin: 0">&nbsp;</P>

<P STYLE="margin: 0"></P>

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<P STYLE="margin: 0">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">SCHEDULE 13G</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">SECURITIES AND EXCHANGE COMMISSION<BR>
WASHINGTON, DC 20549</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><FONT STYLE="font-weight: normal">Under the Securities Exchange Act of 1934</FONT><BR>
<FONT STYLE="font-weight: normal">(Amendment No. 4)*</FONT></P>

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<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%">
<TR STYLE="vertical-align: bottom">
    <TD COLSPAN="1" STYLE="font: bold 14pt Times New Roman, Times, Serif; border-bottom: Black 1pt solid; text-align: center">BioCryst Pharmaceuticals, Inc.</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD COLSPAN="1" STYLE="font: normal 10pt Times New Roman, Times, Serif; text-align: center">(Name of Issuer) &nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD COLSPAN="1" STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD COLSPAN="1" STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: center; border-bottom: Black 1pt solid">Common Stock, par value $0.01 per share</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD COLSPAN="1" STYLE="font: normal 10pt Times New Roman, Times, Serif; text-align: center">(Title of Class of Securities) &nbsp;</TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><B>&nbsp;</B></P>

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<TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 25%; font: bold 10pt Times New Roman, Times, Serif; text-align: center">&nbsp;</TD>
    <TD STYLE="width: 50%; font: bold 10pt Times New Roman, Times, Serif; text-align: center; border-bottom: Black 1pt solid">09058V103</TD>
    <TD STYLE="width: 25%; font: bold 10pt Times New Roman, Times, Serif; text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center">(CUSIP Number)</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: center">&nbsp;</TD>
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: center; border-bottom: Black 1pt solid">December 31, 2020</TD>
    <TD STYLE="font: bold 10pt Times New Roman, Times, Serif; text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center">&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center">(Date of Event which Requires Filing of this Statement) &nbsp; &nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center"> &nbsp;</TD></TR>
</TABLE>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: left; text-indent: 0.5in"><B>Check
the appropriate box to designate the rule pursuant to which this Schedule is filed:</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; text-indent: 0.5in; margin-bottom: 0pt; text-align: left"><FONT STYLE="font-family: Wingdings">&#120;</FONT> <B>Rule
13d-1(b)</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in; text-align: left">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; text-indent: 0.5in; margin-bottom: 0pt; text-align: left"><FONT STYLE="font-family: Wingdings">&#168;</FONT> <B>Rule
13d-1(c)</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; text-indent: 0.5in; margin-bottom: 0pt; text-align: left"><FONT STYLE="font-family: Wingdings">&#168;</FONT> <B>Rule
13d-1(d)</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; text-indent: 0.5in; margin-bottom: 0pt; text-align: left"><B>*The remainder
of this cover page shall be filled out for a reporting person&rsquo;s initial filing on this form with respect to the subject class
of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover
page.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-align: left; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; text-indent: 0.5in; margin-bottom: 0pt; text-align: left"><B>The information
required on the remainder of this cover page shall not be deemed to be &ldquo;filed&rdquo; for the purpose of Section&nbsp;18 of
the Securities Exchange Act of 1934 (the &ldquo;Act&rdquo;) or otherwise subject to the liabilities of that section of the Act,
but shall be subject to all other provisions of the Act (however, see the Notes).</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: left"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: left"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: left"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: left"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><B>CUSIP
No. &nbsp;<U><U>09058V103</U></U></B></P>

<P STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><FONT STYLE="font-size: 10pt"></FONT></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top; font-size: 10pt">
    <TD STYLE="border: Black 1pt solid; font-size: 10pt; text-align: center; vertical-align: top; padding-top: 5pt; padding-bottom: 5pt"><B>1</B> </TD>
    <TD COLSPAN="2" STYLE="border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; font-size: 10pt; padding-top: 5pt; padding-left: 5pt; padding-bottom: 5pt"><P STYLE="margin-top: 0; margin-bottom: 0"><B>NAMES OF REPORTING PERSONS</B></P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0"><B>&nbsp;<BR> </B> Baker Bros. Advisors LP &nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top; font-size: 10pt">
    <TD STYLE="border-right: Black 1pt solid; width: 5%; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding-top: 5pt; padding-bottom: 5pt; font-size: 10pt; text-align: center; vertical-align: top"><B></B> <B>2</B> </TD>
    <TD STYLE="width: 87%; border-bottom: Black 1pt solid; padding: 5pt; font-size: 10pt"><B>CHECK
THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions) </B></TD>
    <TD STYLE="width: 8%; border-bottom: Black 1pt solid; padding: 5pt; border-right: Black 1pt solid; font-size: 10pt; text-align: right"><P STYLE="margin-top: 0; margin-bottom: 0"><B>&nbsp;(a)
                                         <FONT STYLE="font-family: Wingdings">&#168;</FONT></B></P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0"><B>(b)
                                         <FONT STYLE="font-family: Wingdings">&#168;</FONT></B></P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0"><B>&nbsp;</B></P></TD></TR>
<TR STYLE="vertical-align: top; font-size: 10pt">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding-bottom: 5pt; font-size: 10pt; text-align: center; vertical-align: top; padding-top: 5pt"><B>3</B></TD>
    <TD COLSPAN="2" STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-bottom: 5pt; padding-left: 5pt; font-size: 10pt; padding-top: 5pt"><P STYLE="margin-top: 0; margin-bottom: 0"><B>SEC
USE ONLY</B></P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top; font-size: 10pt">
    <TD STYLE="border-right: Black 1pt solid; border-left: Black 1pt solid; padding-bottom: 5pt; font-size: 10pt; text-align: center; vertical-align: top; padding-top: 5pt"><B>4</B></TD>
    <TD COLSPAN="2" STYLE="border-right: Black 1pt solid; padding-bottom: 5pt; padding-left: 5pt; font-size: 10pt; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>CITIZENSHIP
OR PLACE OF ORGANIZATION<BR> <BR> </B></FONT> Delaware &nbsp;</TD></TR>
</TABLE>



<P STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR>
    <TD ROWSPAN="4" STYLE="width: 15%; border: Black 1pt solid; padding-bottom: 5pt; padding-left: 5pt; text-align: center; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>NUMBER
OF<BR> SHARES<BR> BENEFICIALLY<BR> OWNED BY<BR> EACH<BR> REPORTING<BR> PERSON<BR> WITH</B> &nbsp;</FONT></TD>
    <TD STYLE="border-top: Black 1pt solid; vertical-align: top; width: 5%; border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-bottom: 5pt; text-align: center; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>5</B></FONT></TD>
    <TD STYLE="vertical-align: top; width: 80%; border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-bottom: 5pt; padding-left: 5pt; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>SOLE
VOTING POWER<BR> <BR> </B> 18,100,968 (1) &nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-bottom: 5pt; text-align: center; vertical-align: top; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>6</B></FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-bottom: 5pt; padding-left: 5pt; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>SHARED
VOTING POWER<BR> <BR> </B> -0- &nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-bottom: 5pt; text-align: center; vertical-align: top; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>7</B></FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-bottom: 5pt; padding-left: 5pt; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>SOLE
DISPOSITIVE POWER<BR> <BR> </B> 18,100,968 (1) &nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-bottom: 5pt; text-align: center; vertical-align: top; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>8</B></FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-bottom: 5pt; padding-left: 5pt; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>SHARED
DISPOSITIVE POWER<BR> <BR> </B> -0- &nbsp;</FONT></TD></TR>
</TABLE>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: left"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: left"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding-bottom: 5pt; text-align: center; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>9</B></FONT></TD>
    <TD COLSPAN="2" STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-bottom: 5pt; padding-left: 5pt; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>AGGREGATE
AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON<BR> <BR> </B>18,100,968 (1) &nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding-top: 5pt; padding-bottom: 5pt; text-align: center; width: 5%"><FONT STYLE="font-size: 10pt"><B>10</B></FONT></TD>
    <TD STYLE="border-bottom: Black 1pt solid; padding: 5pt; width: 87%"><P STYLE="margin-top: 0; margin-bottom: 0"><FONT STYLE="font-size: 10pt"><B>CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES</B></FONT></P>
                                                                                                                                     <P STYLE="margin-top: 0; margin-bottom: 0"><FONT STYLE="font-size: 10pt"><B><B>(See Instructions)</B></B></FONT></P>
                                                                                                                                     <P STYLE="margin-top: 0; margin-bottom: 0"><FONT STYLE="font-size: 10pt"><B><B>&nbsp;</B> </B></FONT></P></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 5pt; width: 8%; text-align: right"><FONT STYLE="font-family: Wingdings"><B>&#168;</B></FONT><P STYLE="margin-top: 0; margin-bottom: 0"></P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0"></P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding-bottom: 5pt; text-align: center; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>11</B></FONT></TD>
    <TD COLSPAN="2" STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-bottom: 5pt; padding-left: 5pt; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>PERCENT
OF CLASS REPRESENTED BY AMOUNT IN ROW 9<BR> <BR> </B> 9.95% (1)(2) &nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding-bottom: 5pt; text-align: center; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>12</B></FONT></TD>
    <TD COLSPAN="2" STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-bottom: 5pt; padding-left: 5pt; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>TYPE
OF REPORTING PERSON (See Instructions)<BR> </B> IA, PN </FONT></TD></TR>
</TABLE>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: left"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: left">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">(1)</TD><TD STYLE="text-align: justify">Includes 15,000 shares of the common stock (&ldquo;Common
Stock&rdquo;) of BioCryst Pharmaceuticals, Inc. (the &ldquo;Issuer&rdquo;) underlying options (&ldquo;Stock Options&rdquo;) and
5,390,150 shares of Common Stock issuable upon exercise of the Pre-Funded Warrants (as defined in Item 4 below and subject to
the limitations as described therein) directly held by the Funds (as defined in Item 4 below).</TD>
</TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">(2)</TD><TD STYLE="text-align: justify">Based on 176,565,622 shares of Common Stock outstanding
as of October 31, 2020, as reported in the Issuer&rsquo;s Form 10-Q filed with the Securities and Exchange Commission (&ldquo;SEC&rdquo;)
on November 6, 2020, plus 15,000 shares of Common Stock underlying Stock Options and 5,390,150 shares of Common Stock issuable
upon the exercise of the Pre-Funded Warrants (as defined in Item 4 below and subject to the limitations as described therein).</TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: -0.25in"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><B>CUSIP
No. &nbsp;<U><U>09058V103</U></U></B></P>

<P STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><FONT STYLE="font-size: 10pt"></FONT></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top; font-size: 10pt">
    <TD STYLE="border: Black 1pt solid; font-size: 10pt; text-align: center; vertical-align: top; padding-top: 5pt; padding-bottom: 5pt"><B>1</B> </TD>
    <TD COLSPAN="2" STYLE="border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; font-size: 10pt; padding-top: 5pt; padding-left: 5pt; padding-bottom: 5pt"><P STYLE="margin-top: 0; margin-bottom: 0"><B>NAMES OF REPORTING PERSONS</B></P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0"><B>&nbsp;<BR> </B> Baker Bros. Advisors (GP) LLC&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top; font-size: 10pt">
    <TD STYLE="border-right: Black 1pt solid; width: 5%; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding-top: 5pt; padding-bottom: 5pt; font-size: 10pt; text-align: center; vertical-align: top"><B></B> <B>2</B> </TD>
    <TD STYLE="width: 87%; border-bottom: Black 1pt solid; padding: 5pt; font-size: 10pt"><B>CHECK
THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions) </B></TD>
    <TD STYLE="width: 8%; border-bottom: Black 1pt solid; padding: 5pt; border-right: Black 1pt solid; font-size: 10pt; text-align: right"><P STYLE="margin-top: 0; margin-bottom: 0"><B>&nbsp;(a)
                                         <FONT STYLE="font-family: Wingdings">&#168;</FONT></B></P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0"><B>(b)
                                         <FONT STYLE="font-family: Wingdings">&#168;</FONT></B></P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0"><B>&nbsp;</B></P></TD></TR>
<TR STYLE="vertical-align: top; font-size: 10pt">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding-bottom: 5pt; font-size: 10pt; text-align: center; vertical-align: top; padding-top: 5pt"><B>3</B></TD>
    <TD COLSPAN="2" STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-bottom: 5pt; padding-left: 5pt; font-size: 10pt; padding-top: 5pt"><P STYLE="margin-top: 0; margin-bottom: 0"><B>SEC
USE ONLY</B></P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top; font-size: 10pt">
    <TD STYLE="border-right: Black 1pt solid; border-left: Black 1pt solid; padding-bottom: 5pt; font-size: 10pt; text-align: center; vertical-align: top; padding-top: 5pt"><B>4</B></TD>
    <TD COLSPAN="2" STYLE="border-right: Black 1pt solid; padding-bottom: 5pt; padding-left: 5pt; font-size: 10pt; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>CITIZENSHIP
OR PLACE OF ORGANIZATION<BR> <BR> </B></FONT> Delaware &nbsp;</TD></TR>
</TABLE>



<P STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR>
    <TD ROWSPAN="4" STYLE="width: 15%; border: Black 1pt solid; padding-bottom: 5pt; padding-left: 5pt; text-align: center; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>NUMBER
OF<BR> SHARES<BR> BENEFICIALLY<BR> OWNED BY<BR> EACH<BR> REPORTING<BR> PERSON<BR> WITH</B> &nbsp;</FONT></TD>
    <TD STYLE="border-top: Black 1pt solid; vertical-align: top; width: 5%; border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-bottom: 5pt; text-align: center; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>5</B></FONT></TD>
    <TD STYLE="vertical-align: top; width: 80%; border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-bottom: 5pt; padding-left: 5pt; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>SOLE
VOTING POWER<BR> <BR> </B> 18,100,968 (1) &nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-bottom: 5pt; text-align: center; vertical-align: top; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>6</B></FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-bottom: 5pt; padding-left: 5pt; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>SHARED
VOTING POWER<BR> <BR> </B> -0- &nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-bottom: 5pt; text-align: center; vertical-align: top; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>7</B></FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-bottom: 5pt; padding-left: 5pt; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>SOLE
DISPOSITIVE POWER<BR> <BR> </B> 18,100,968 (1) &nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-bottom: 5pt; text-align: center; vertical-align: top; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>8</B></FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-bottom: 5pt; padding-left: 5pt; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>SHARED
DISPOSITIVE POWER<BR> <BR> </B> -0- &nbsp;</FONT></TD></TR>
</TABLE>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: left"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: left"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding-bottom: 5pt; text-align: center; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>9</B></FONT></TD>
    <TD COLSPAN="2" STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-bottom: 5pt; padding-left: 5pt; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>AGGREGATE
AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON<BR> <BR> </B>18,100,968 (1) &nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding-top: 5pt; padding-bottom: 5pt; text-align: center; width: 5%"><FONT STYLE="font-size: 10pt"><B>10</B></FONT></TD>
    <TD STYLE="border-bottom: Black 1pt solid; padding: 5pt; width: 87%"><P STYLE="margin-top: 0; margin-bottom: 0"><FONT STYLE="font-size: 10pt"><B>CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES</B></FONT></P>
                                                                                                                                     <P STYLE="margin-top: 0; margin-bottom: 0"><FONT STYLE="font-size: 10pt"><B><B>(See Instructions)</B></B></FONT></P>
                                                                                                                                     <P STYLE="margin-top: 0; margin-bottom: 0"><FONT STYLE="font-size: 10pt"><B><B>&nbsp;</B> </B></FONT></P></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 5pt; width: 8%; text-align: right"><FONT STYLE="font-family: Wingdings"><B>&#168;</B></FONT><P STYLE="margin-top: 0; margin-bottom: 0"></P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0"></P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding-bottom: 5pt; text-align: center; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>11</B></FONT></TD>
    <TD COLSPAN="2" STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-bottom: 5pt; padding-left: 5pt; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>PERCENT
OF CLASS REPRESENTED BY AMOUNT IN ROW 9<BR> <BR> </B> 9.95% (1)(2) &nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding-bottom: 5pt; text-align: center; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>12</B></FONT></TD>
    <TD COLSPAN="2" STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-bottom: 5pt; padding-left: 5pt; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>TYPE
OF REPORTING PERSON (See Instructions)<BR> </B> HC,OO </FONT></TD></TR>
</TABLE>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: left"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: left">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">(1)</TD><TD STYLE="text-align: justify">Includes 15,000 shares of Common Stock underlying Stock
Options and 5,390,150 shares of Common Stock issuable upon exercise of the Pre-Funded Warrants (as defined in Item 4 below and
subject to the limitations as described therein) directly held by the Funds (as defined in Item 4 below).</TD>
</TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">(2)</TD><TD STYLE="text-align: justify">Based on 176,565,622 shares of Common Stock outstanding
as of October 31, 2020, as reported in the Issuer&rsquo;s Form 10-Q filed with the SEC on November 6, 2020, plus 15,000 shares
of Common Stock underlying Stock Options and 5,390,150 shares of Common Stock issuable upon the exercise of the Pre-Funded Warrants
(as defined in Item 4 below and subject to the limitations as described therein).</TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;&nbsp;</P>

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    <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: left"></P>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: -0.25in"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: left"><FONT STYLE="font-size: 10pt"></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: left"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><B>CUSIP
No. &nbsp;<U><U>09058V103</U></U></B></P>

<P STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><FONT STYLE="font-size: 10pt"></FONT></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top; font-size: 10pt">
    <TD STYLE="border: Black 1pt solid; font-size: 10pt; text-align: center; vertical-align: top; padding-top: 5pt; padding-bottom: 5pt"><B>1</B> </TD>
    <TD COLSPAN="2" STYLE="border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; font-size: 10pt; padding-top: 5pt; padding-left: 5pt; padding-bottom: 5pt"><P STYLE="margin-top: 0; margin-bottom: 0"><B>NAMES OF REPORTING PERSONS</B></P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0"><B>&nbsp;<BR> </B> Felix J. Baker &nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top; font-size: 10pt">
    <TD STYLE="border-right: Black 1pt solid; width: 5%; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding-top: 5pt; padding-bottom: 5pt; font-size: 10pt; text-align: center; vertical-align: top"><B></B> <B>2</B> </TD>
    <TD STYLE="width: 87%; border-bottom: Black 1pt solid; padding: 5pt; font-size: 10pt"><B>CHECK
THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions) </B></TD>
    <TD STYLE="width: 8%; border-bottom: Black 1pt solid; padding: 5pt; border-right: Black 1pt solid; font-size: 10pt; text-align: right"><P STYLE="margin-top: 0; margin-bottom: 0"><B>&nbsp;(a)
                                         <FONT STYLE="font-family: Wingdings">&#168;</FONT></B></P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0"><B>(b)
                                         <FONT STYLE="font-family: Wingdings">&#168;</FONT></B></P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0"><B>&nbsp;</B></P></TD></TR>
<TR STYLE="vertical-align: top; font-size: 10pt">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding-bottom: 5pt; font-size: 10pt; text-align: center; vertical-align: top; padding-top: 5pt"><B>3</B></TD>
    <TD COLSPAN="2" STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-bottom: 5pt; padding-left: 5pt; font-size: 10pt; padding-top: 5pt"><P STYLE="margin-top: 0; margin-bottom: 0"><B>SEC
USE ONLY</B></P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top; font-size: 10pt">
    <TD STYLE="border-right: Black 1pt solid; border-left: Black 1pt solid; padding-bottom: 5pt; font-size: 10pt; text-align: center; vertical-align: top; padding-top: 5pt"><B>4</B></TD>
    <TD COLSPAN="2" STYLE="border-right: Black 1pt solid; padding-bottom: 5pt; padding-left: 5pt; font-size: 10pt; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>CITIZENSHIP
OR PLACE OF ORGANIZATION<BR> <BR> </B></FONT> United States &nbsp;</TD></TR>
</TABLE>



<P STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR>
    <TD ROWSPAN="4" STYLE="width: 15%; border: Black 1pt solid; padding-bottom: 5pt; padding-left: 5pt; text-align: center; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>NUMBER
OF<BR> SHARES<BR> BENEFICIALLY<BR> OWNED BY<BR> EACH<BR> REPORTING<BR> PERSON<BR> WITH</B> &nbsp;</FONT></TD>
    <TD STYLE="border-top: Black 1pt solid; vertical-align: top; width: 5%; border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-bottom: 5pt; text-align: center; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>5</B></FONT></TD>
    <TD STYLE="vertical-align: top; width: 80%; border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-bottom: 5pt; padding-left: 5pt; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>SOLE
VOTING POWER<BR> <BR> </B> 18,178,881 (1) &nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-bottom: 5pt; text-align: center; vertical-align: top; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>6</B></FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-bottom: 5pt; padding-left: 5pt; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>SHARED
VOTING POWER<BR> <BR> </B> -0- &nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-bottom: 5pt; text-align: center; vertical-align: top; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>7</B></FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-bottom: 5pt; padding-left: 5pt; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>SOLE
DISPOSITIVE POWER<BR> <BR> </B> 18,178,881 (1) &nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-bottom: 5pt; text-align: center; vertical-align: top; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>8</B></FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-bottom: 5pt; padding-left: 5pt; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>SHARED
DISPOSITIVE POWER<BR> <BR> </B> -0- &nbsp;</FONT></TD></TR>
</TABLE>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: left"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: left"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding-bottom: 5pt; text-align: center; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>9</B></FONT></TD>
    <TD COLSPAN="2" STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-bottom: 5pt; padding-left: 5pt; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>AGGREGATE
AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON<BR> <BR> </B>18,178,881 (1) &nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding-top: 5pt; padding-bottom: 5pt; text-align: center; width: 5%"><FONT STYLE="font-size: 10pt"><B>10</B></FONT></TD>
    <TD STYLE="border-bottom: Black 1pt solid; padding: 5pt; width: 87%"><P STYLE="margin-top: 0; margin-bottom: 0"><FONT STYLE="font-size: 10pt"><B>CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES</B></FONT></P>
                                                                                                                                     <P STYLE="margin-top: 0; margin-bottom: 0"><FONT STYLE="font-size: 10pt"><B><B>(See Instructions)</B></B></FONT></P>
                                                                                                                                     <P STYLE="margin-top: 0; margin-bottom: 0"><FONT STYLE="font-size: 10pt"><B><B>&nbsp;</B> </B></FONT></P></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 5pt; width: 8%; text-align: right"><FONT STYLE="font-family: Wingdings"><B>&#168;</B></FONT><P STYLE="margin-top: 0; margin-bottom: 0"></P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0"></P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding-bottom: 5pt; text-align: center; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>11</B></FONT></TD>
    <TD COLSPAN="2" STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-bottom: 5pt; padding-left: 5pt; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>PERCENT
OF CLASS REPRESENTED BY AMOUNT IN ROW 9<BR> <BR> </B> 9.99% (1)(2) &nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding-bottom: 5pt; text-align: center; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>12</B></FONT></TD>
    <TD COLSPAN="2" STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-bottom: 5pt; padding-left: 5pt; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>TYPE
OF REPORTING PERSON (See Instructions)<BR> </B> IN, HC</FONT></TD></TR>
</TABLE>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: left"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: left">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">(1)</TD><TD STYLE="text-align: justify">Includes 15,000 shares of Common Stock underlying Stock
Options and 5,390,150 shares of Common Stock issuable upon exercise of the Pre-Funded Warrants (as defined in Item 4 below and
subject to the limitations as described therein) directly held by the Funds (as defined in Item 4 below).</TD>
</TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">(2)</TD><TD STYLE="text-align: justify">Based on 176,565,622 shares of Common Stock outstanding
as of October 31, 2020, as reported in the Issuer&rsquo;s Form 10-Q filed with the SEC on November 6, 2020, plus 15,000 shares
of Common Stock underlying Stock Options and 5,390,150 shares of Common Stock issuable upon the exercise of the Pre-Funded Warrants
(as defined in Item 4 below and subject to the limitations as described therein).</TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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    <DIV STYLE="margin-top: 12pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: left">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: left"><FONT STYLE="font-size: 10pt"></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: left"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><B>CUSIP
No. &nbsp;<U><U>09058V103</U></U></B></P>

<P STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="text-align: left; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><FONT STYLE="font-size: 10pt"></FONT></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top; font-size: 10pt">
    <TD STYLE="border: Black 1pt solid; font-size: 10pt; text-align: center; vertical-align: top; padding-top: 5pt; padding-bottom: 5pt"><B>1</B> </TD>
    <TD COLSPAN="2" STYLE="border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; font-size: 10pt; padding-top: 5pt; padding-left: 5pt; padding-bottom: 5pt"><P STYLE="margin-top: 0; margin-bottom: 0"><B>NAMES OF REPORTING PERSONS</B></P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0"><B>&nbsp;<BR> </B> Julian C. Baker &nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top; font-size: 10pt">
    <TD STYLE="border-right: Black 1pt solid; width: 5%; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding-top: 5pt; padding-bottom: 5pt; font-size: 10pt; text-align: center; vertical-align: top"><B></B> <B>2</B> </TD>
    <TD STYLE="width: 87%; border-bottom: Black 1pt solid; padding: 5pt; font-size: 10pt"><B>CHECK
THE APPROPRIATE BOX IF A MEMBER OF A GROUP (See Instructions) </B></TD>
    <TD STYLE="width: 8%; border-bottom: Black 1pt solid; padding: 5pt; border-right: Black 1pt solid; font-size: 10pt; text-align: right"><P STYLE="margin-top: 0; margin-bottom: 0"><B>&nbsp;(a)
                                         <FONT STYLE="font-family: Wingdings">&#168;</FONT></B></P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0"><B>(b)
                                         <FONT STYLE="font-family: Wingdings">&#168;</FONT></B></P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0"><B>&nbsp;</B></P></TD></TR>
<TR STYLE="vertical-align: top; font-size: 10pt">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding-bottom: 5pt; font-size: 10pt; text-align: center; vertical-align: top; padding-top: 5pt"><B>3</B></TD>
    <TD COLSPAN="2" STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-bottom: 5pt; padding-left: 5pt; font-size: 10pt; padding-top: 5pt"><P STYLE="margin-top: 0; margin-bottom: 0"><B>SEC
USE ONLY</B></P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top; font-size: 10pt">
    <TD STYLE="border-right: Black 1pt solid; border-left: Black 1pt solid; padding-bottom: 5pt; font-size: 10pt; text-align: center; vertical-align: top; padding-top: 5pt"><B>4</B></TD>
    <TD COLSPAN="2" STYLE="border-right: Black 1pt solid; padding-bottom: 5pt; padding-left: 5pt; font-size: 10pt; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>CITIZENSHIP
OR PLACE OF ORGANIZATION<BR> <BR> </B></FONT> United States &nbsp;</TD></TR>
</TABLE>



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<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR>
    <TD ROWSPAN="4" STYLE="width: 15%; border: Black 1pt solid; padding-bottom: 5pt; padding-left: 5pt; text-align: center; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>NUMBER
OF<BR> SHARES<BR> BENEFICIALLY<BR> OWNED BY<BR> EACH<BR> REPORTING<BR> PERSON<BR> WITH</B> &nbsp;</FONT></TD>
    <TD STYLE="border-top: Black 1pt solid; vertical-align: top; width: 5%; border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-bottom: 5pt; text-align: center; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>5</B></FONT></TD>
    <TD STYLE="vertical-align: top; width: 80%; border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-bottom: 5pt; padding-left: 5pt; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>SOLE
VOTING POWER<BR> <BR> </B> 18,178,881 (1) &nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-bottom: 5pt; text-align: center; vertical-align: top; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>6</B></FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-bottom: 5pt; padding-left: 5pt; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>SHARED
VOTING POWER<BR> <BR> </B> -0- &nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-bottom: 5pt; text-align: center; vertical-align: top; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>7</B></FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-bottom: 5pt; padding-left: 5pt; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>SOLE
DISPOSITIVE POWER<BR> <BR> </B> 18,178,881 (1) &nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-bottom: 5pt; text-align: center; vertical-align: top; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>8</B></FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-bottom: 5pt; padding-left: 5pt; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>SHARED
DISPOSITIVE POWER<BR> <BR> </B> -0- &nbsp;</FONT></TD></TR>
</TABLE>



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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: left"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding-bottom: 5pt; text-align: center; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>9</B></FONT></TD>
    <TD COLSPAN="2" STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-bottom: 5pt; padding-left: 5pt; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>AGGREGATE
AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON<BR> <BR> </B>18,178,881 (1) &nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding-top: 5pt; padding-bottom: 5pt; text-align: center; width: 5%"><FONT STYLE="font-size: 10pt"><B>10</B></FONT></TD>
    <TD STYLE="border-bottom: Black 1pt solid; padding: 5pt; width: 87%"><P STYLE="margin-top: 0; margin-bottom: 0"><FONT STYLE="font-size: 10pt"><B>CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES</B></FONT></P>
                                                                                                                                     <P STYLE="margin-top: 0; margin-bottom: 0"><FONT STYLE="font-size: 10pt"><B><B>(See Instructions)</B></B></FONT></P>
                                                                                                                                     <P STYLE="margin-top: 0; margin-bottom: 0"><FONT STYLE="font-size: 10pt"><B><B>&nbsp;</B> </B></FONT></P></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding: 5pt; width: 8%; text-align: right"><FONT STYLE="font-family: Wingdings"><B>&#168;</B></FONT><P STYLE="margin-top: 0; margin-bottom: 0"></P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0"></P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding-bottom: 5pt; text-align: center; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>11</B></FONT></TD>
    <TD COLSPAN="2" STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-bottom: 5pt; padding-left: 5pt; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>PERCENT
OF CLASS REPRESENTED BY AMOUNT IN ROW 9<BR> <BR> </B> 9.99% (1)(2) &nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; padding-bottom: 5pt; text-align: center; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>12</B></FONT></TD>
    <TD COLSPAN="2" STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; padding-bottom: 5pt; padding-left: 5pt; padding-top: 5pt"><FONT STYLE="font-size: 10pt"><B>TYPE
OF REPORTING PERSON (See Instructions)<BR> </B> IN, HC </FONT></TD></TR>
</TABLE>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: left"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: left">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">(1)</TD><TD STYLE="text-align: justify">Includes 15,000 shares of Common Stock underlying Stock
Options and 5,390,150 shares of Common Stock issuable upon exercise of the Pre-Funded Warrants (as defined in Item 4 below and
subject to the limitations as described therein) directly held by the Funds (as defined in Item 4 below).</TD>
</TR></TABLE>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 0in"></TD><TD STYLE="width: 0.25in; text-align: left">(2)</TD><TD STYLE="text-align: justify">Based on 176,565,622 shares of Common Stock outstanding
as of October 31, 2020, as reported in the Issuer&rsquo;s Form 10-Q filed with the SEC on November 6, 2020, plus 15,000 shares
of Common Stock underlying Stock Options and 5,390,150 shares of Common Stock issuable upon the exercise of the Pre-Funded Warrants
(as defined in Item 4 below and subject to the limitations as described therein).</TD>
</TR></TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: left">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><FONT STYLE="font-size: 10pt"><B>Amendment
No. 4 to Schedule 13G</B></FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 10pt">This Amendment No. 4 to Schedule
13G amends the previously filed Schedule 13G filed by Baker Bros. Advisors LP (the &ldquo;Adviser&rdquo;), Baker Bros. Advisors
(GP) LLC (the &ldquo;Adviser GP&rdquo;), Julian C. Baker and Felix J. Baker (collectively, the &ldquo;Reporting Persons&rdquo;).
Except as supplemented herein, such statements, as heretofore amended and supplemented, remain in full force and effect.</FONT></P>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

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<TR STYLE="vertical-align: top">
    <TD STYLE="width: 1in"><FONT STYLE="font-size: 10pt"><B>Item 1(a)</B></FONT></TD>
    <TD><FONT STYLE="font-size: 10pt"><B>Name of Issuer:</B></FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in"><FONT STYLE="font-size: 10pt">BioCryst
Pharmaceuticals, Inc.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

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<TR STYLE="vertical-align: top">
    <TD STYLE="width: 1in"><FONT STYLE="font-size: 10pt"><B>Item 1(b)</B></FONT></TD>
    <TD><FONT STYLE="font-size: 10pt"><B>Address of Issuer&#8217;s Principal Executive Offices:</B></FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in"><FONT STYLE="font-size: 10pt">4505 Emperor Blvd., Ste.
200</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in"><FONT STYLE="font-size: 10pt">&nbsp;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in"><FONT STYLE="font-size: 10pt">Durham, North Carolina
27703</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 1in"><B>Item 2(a)</B></TD>
    <TD><B>Name of Person Filing:</B></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">This Amendment No. 4 is
being filed jointly by the Reporting Persons.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 1in"><B>Item 2(b)</B></TD>
    <TD><B>Address of Principal Business Office or, if None, Residence:</B></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">The business address of each of
the Reporting Persons is:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">c/o Baker Bros. Advisors LP</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">860 Washington Street, 3<SUP>rd</SUP>
Floor</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">New York, NY 10014</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 0.5in; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 1in">(212) 339-5690</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 1in">&nbsp;</P>



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<TR STYLE="vertical-align: top">
    <TD STYLE="width: 1in"><B>Item 2(c)</B></TD>
    <TD><B>Citizenship:</B></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in">The Adviser is a limited partnership organized under
the laws of the State of Delaware. The Adviser GP is a limited liability company organized under the laws of the State of Delaware.
The citizenship of each of Julian C. Baker and Felix J. Baker is the United States of America.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in"></P>

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<TR STYLE="vertical-align: top">
    <TD STYLE="width: 1in"><B>Item 2(d)</B></TD>
    <TD STYLE="text-align: left"><B>Title of Class of Securities</B></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in">Common Stock, par value $0.01 per share (&ldquo;Common
Stock&rdquo;)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0.5in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 1in"><B>Item 2(e)</B></TD>
    <TD><B>CUSIP Number</B></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in">09058V103</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 1in"><B>Item 3.</B></TD>
    <TD><B>If this statement is filed pursuant to &sect;&sect;240.13d-1(b) or (c), check whether the person filing is a: </B></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>(a) <FONT STYLE="font-family: Wingdings">&#168;</FONT> Broker or dealer registered under Section 15 of the Exchange Act.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>(b) <FONT STYLE="font-family: Wingdings">&#168;</FONT> Bank as defined in section 3(a)(6) of the Exchange Act.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>(c) <FONT STYLE="font-family: Wingdings">&#168;</FONT> Insurance company as defined in section 3(a)(19) of the Exchange Act.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>(d) <FONT STYLE="font-family: Wingdings">&#168;</FONT> Investment company registered under section 8 of the Investment Company Act of 1940.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>(e) <FONT STYLE="font-family: Wingdings">&#120;</FONT> An investment adviser in accordance with Rule 13d-1(b)(1)(ii)(E).</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>(f) <FONT STYLE="font-family: Wingdings">&#168;</FONT> An employee benefit plan or endowment fund in accordance with Rule 13d-1(b)(1)(ii)(F).</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>(g) <FONT STYLE="font-family: Wingdings">&#120;</FONT> A parent holding company or control person in accordance with Rule 13d-1(b)(1)(ii)(G).</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>(h) <FONT STYLE="font-family: Wingdings">&#168;</FONT> A savings association as defined in Section 3(b) of the Federal Deposit Insurance Act.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="text-indent: -0.25in; padding-left: 0.25in">(i) <FONT STYLE="font-family: Wingdings">&#168;</FONT> A church plan that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>(j) <FONT STYLE="font-family: Wingdings">&#168;</FONT> Group, in accordance with Rule 13d-1(b)(1)(ii)(J).</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; margin-top: 0pt; margin-bottom: 0pt">
<TR STYLE="vertical-align: top; text-align: justify">
    <TD STYLE="width: 0"></TD>
    <TD STYLE="width: 1in; text-align: left"><B>Item 4.</B></TD>
    <TD STYLE="text-align: justify"><B>Ownership.</B></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 1in">Items 5 through 9 and 11 of each of the cover pages to this
Amendment No. 4 are incorporated herein by reference. Set forth below is the aggregate number of shares of Common Stock of the
Issuer directly held by each of 667, L.P. (&ldquo;667&rdquo;) and Baker Brothers Life Sciences, L.P. (&ldquo;Life Sciences&rdquo;,
and together with 667, the &ldquo;Funds&rdquo;), including 5,390,150 shares of Common Stock issuable upon the exercise of the Pre-Funded
Warrants (as defined below), which may be deemed to be indirectly beneficially owned by the Reporting Persons. The information
set forth below is based upon 176,565,622 shares of Common Stock outstanding as of October 31, 2020, as reported on the Issuer&rsquo;s
Form 10-Q filed with the Securities and Exchange Commission on November 6, 2020, plus 5,390,150 shares of Common Stock issuable
upon the exercise of Pre-Funded Warrants (as defined below). Such percentage figures were calculated in accordance with Rule 13d-3
under the Securities Exchange Act of 1934, as amended (the &ldquo;Exchange Act&rdquo;).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 55%; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt; border-bottom: Black 1pt solid">Holder</TD><TD STYLE="font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="white-space: nowrap; font-size: 10pt; text-align: center; border-bottom: Black 1pt solid">Number of Shares of<BR>
 Common Stock we<BR>
 own or have the right<BR>
 to acquire within 60<BR>
 days</TD><TD STYLE="white-space: nowrap; padding-bottom: 1pt; font-size: 10pt">&nbsp;</TD><TD STYLE="white-space: nowrap; font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="white-space: nowrap; font-size: 10pt; text-align: center; border-bottom: Black 1pt solid">Percent of Class<BR>
 Outstanding</TD><TD STYLE="padding-bottom: 1pt; font-size: 10pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="width: 72%; font-size: 10pt; text-align: left">667, L.P.</TD><TD STYLE="width: 2%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 10%; font-size: 10pt; text-align: right">1,505,548</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 2%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 10%; font-size: 10pt; text-align: right">0.8</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">%</TD></TR>
<TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left">Baker Brothers Life Sciences, L.P.</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">16,544,587</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">9.1</TD><TD STYLE="font-size: 10pt; text-align: left">%</TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 1in">The warrants have an exercise price of $0.01 per share and have
no expiration date (the &ldquo;Pre-Funded Warrants&rdquo;). The Pre-Funded Warrants are only exercisable to the extent that after
giving effect to such exercise the holders thereof and their affiliates and any persons who are members of a Section 13(d) group
with the holders or their affiliates would beneficially own in the aggregate, for purposes of Rule 13d-3 under the Exchange Act,
no more than 9.99% of the outstanding Common Stock (the &ldquo;Maximum Percentage&rdquo;). By written notice to the Issuer, the
Funds may from time to time increase or decrease the Maximum Percentage applicable to that Fund to any other percentage not in
excess of 19.99%. Any such increase will not be effective until the 61st&nbsp;day after such notice is delivered to the Issuer.&nbsp;As
a result of this restriction, the number of shares of Common Stock that may be issued upon exercise of the Pre-Funded Warrants
by the above holders may change depending upon changes in the outstanding Common Stock.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 1in">The Adviser GP, Felix J. Baker and Julian C. Baker as managing
members of the Adviser GP, and the Adviser may be deemed to be beneficial owners of securities of the Issuer directly held by the
Funds.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 1in">The Adviser GP is the sole general partner of the Adviser. Pursuant
to the management agreements, as amended, among the Adviser, Life Sciences and 667 and their respective general partners, the Funds&rsquo;
respective general partners relinquished to the Adviser all discretion and authority with respect to the investment and voting
power of the securities held by the Funds, and thus the Adviser has complete and unlimited discretion and authority with respect
to the Funds&rsquo; investments and voting power over investments.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 1in">Julian C. Baker and Felix J. Baker each directly hold and beneficially
own 77,913 shares of Common Stock of the Issuer received from pro-rata distributions without consideration.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 1in">Dr. Stephen R. Biggar, an employee of the Adviser, is a former
Director of the Issuer. In connection with his previous service on the Board of Directors of the Issuer (the &ldquo;Board&rdquo;),
Dr. Biggar holds 15,000 non-qualified options to purchase Common Stock of Issuer (&ldquo;Stock Options&rdquo;) and 35,833 shares
of Common Stock received from the exercise of options to purchase Common Stock of the Issuer. Dr. Biggar previously served on the
Board as a representative of the Funds. The policy of the Funds and the Adviser does not permit employees of the Adviser to receive
compensation for serving as a Director of the Issuer. Therefore, Dr. Biggar has no pecuniary interest in any Stock Options or shares
of Common Stock directly held by him. The Funds are instead entitled to the pecuniary interest in any Stock Options and shares
of Common Stock received as director compensation.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 1in">The Adviser has voting and investment power over the Common
Stock, Stock Options, Common Stock underlying such Stock Options and Common Stock received from the exercise of Stock Options by
Dr. Biggar as directors&rsquo; compensation received for past service. The Adviser GP, Felix J. Baker and Julian C. Baker as managing
members of the Adviser GP, may be deemed to have the power to vote or direct the vote of and the power to dispose or direct the
disposition of the Common Stock, Stock Options, Common Stock received from the exercise of Stock Options and Common Stock underlying
such Stock Options received by Dr. Biggar as director&rsquo;s compensation.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>


<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; margin-top: 0pt; margin-bottom: 0pt">
<TR STYLE="vertical-align: top; text-align: justify">
    <TD STYLE="width: 1in; text-align: left"><B>Item 5.</B></TD>
    <TD STYLE="text-align: justify"><B>Ownership of Five Percent or Less of a Class.</B></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 1in">If this statement is being
filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five
percent of the class of securities, check the following <FONT STYLE="font-family: Wingdings">&#168;</FONT>. N/A</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 0.5in">&nbsp;&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; margin-top: 0pt; margin-bottom: 0pt">
<TR STYLE="vertical-align: top; text-align: justify">
    <TD STYLE="width: 1in; text-align: left"><B>Item 6.</B></TD>
    <TD STYLE="text-align: justify"><B>Ownership of More than Five Percent on Behalf of Another Person.</B></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in">N/A</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; margin-top: 0pt; margin-bottom: 0pt">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 1in"><B>Item 7.</B></TD>
    <TD><B>Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person.</B></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left; text-indent: 1in">The information in Item
4 is incorporated herein by reference.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 1in"><B>Item 8.</B></TD>
    <TD><B>Identification and Classification of Members of the Group.</B></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">N/A</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 1in"><B>Item 9.</B></TD>
    <TD><B>Notice of Dissolution of Group.</B></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">N/A</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 1in"><B>Item 10.</B></TD>
    <TD><B>Certification.</B></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; text-align: left; margin-top: 0pt; margin-right: 0; margin-bottom: 0pt">By
signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held
in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or
influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant
in any transaction having that purpose or effect.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 1in">&nbsp;</P>

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    <!-- Field: /Page --><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 1in">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 2.25pt; text-align: center">SIGNATURE</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 2.25pt; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">After reasonable inquiry and to the best of my knowledge and
belief, I certify that the information set forth in this statement is true, complete and correct.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3in; text-indent: -3in">February 16, 2021</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3in; text-indent: -3in">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>BAKER BROS. ADVISORS LP</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">By: Baker Bros. Advisors (GP) LLC, its general partner</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 50%">&nbsp;</TD>
    <TD STYLE="width: 3%; font-size: 10pt">By:&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; width: 47%; font-size: 10pt">/s/ Scott L. Lessing</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="font-size: 10pt">Name: Scott L. Lessing<BR>
Title: President</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3in">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2" STYLE="font-size: 10pt"><B>BAKER BROS. ADVISORS (GP) LLC</B></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 50%">&nbsp;</TD>
    <TD STYLE="width: 3%; font-size: 10pt">By:&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; width: 47%; font-size: 10pt">/s/ Scott L. Lessing</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="font-size: 10pt">Name: Scott L. Lessing<BR>
Title: President</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 3in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="border-collapse: collapse; width: 100%; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt; width: 50%; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt; width: 50%">/s/ Julian C. Baker</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt">Julian C. Baker</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt; padding-bottom: 1pt">&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1pt solid; font-size: 10pt">/s/ Felix J. Baker</TD></TR>
<TR STYLE="vertical-align: bottom">
    <TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt">Felix J. Baker</TD></TR>
</TABLE>
<P STYLE="font-size: 10pt; margin: 0pt 0">&nbsp;</P>

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