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Note 8 - Royalty Monetizations (Details Textual) - USD ($) $ in Thousands |  |  |  | 12 Months Ended |  |
--- | --- | --- | --- | --- | --- | ---
Nov. 19, 2021 | Dec. 07, 2020 | Mar. 09, 2011 | Dec. 31, 2021 | Dec. 31, 2020 | Jun. 30, 2021 | Dec. 01, 2020
Proceeds from Issuance of Secured Debt |  |  |  |  | $ 119,867 |  |
Gain (Loss) on Extinguishment of Debt, Total |  |  |  | $ 55,838 | $ (2,011) |  |
RPI 2019 Intermediate Finance Trust [Member] |  |  |  |  |  |  |
Shares Issued, Common Stock, Premium |  |  |  | 4,269 |  |  |
RPI 2019 Intermediate Finance Trust [Member] | ORLADEYO [Member] |  |  |  |  |  |  |
Royalty Purchase Agreement, Royalties, Percentage of Sublicense Revenue in Other Markets |  | 20.00% |  |  |  |  |
RPI 2019 Intermediate Finance Trust [Member] | ORLADEYO [Member] | Annual Net Sales Under $350,000 [Member] |  |  |  |  |  |  |
Royalty Purchase Agreement, Royalties, Percentage of Annual Net Sales in Key Territories |  | 8.75% |  |  |  |  |
RPI 2019 Intermediate Finance Trust [Member] | ORLADEYO [Member] | Annual Net Sales Between $350,000 and $550,000 [Member] |  |  |  |  |  |  |
Royalty Purchase Agreement, Royalties, Percentage of Annual Net Sales in Key Territories |  | 2.75% |  |  |  |  |
RPI 2019 Intermediate Finance Trust [Member] | ORLADEYO [Member] | Annual Net Sales Over $550,000 [Member] |  |  |  |  |  |  |
Royalty Purchase Agreement, Royalties, Percentage of Annual Net Sales in Key Territories |  | 0.00% |  |  |  |  |
RPI 2019 Intermediate Finance Trust [Member] | ORLADEYO [Member] | Annual Net Sales Under $150,000 [Member] |  |  |  |  |  |  |
Royalty Purchase Agreement, Royalties, Percentage of Annual Net Sales in Other Markets |  | 20.00% |  |  |  |  |
RPI 2019 Intermediate Finance Trust [Member] | ORLADEYO [Member] | Annual Net Sales Between $150,000 and $230,000 [Member] |  |  |  |  |  |  |
Royalty Purchase Agreement, Royalties, Percentage of Annual Net Sales in Other Markets |  | 10.00% |  |  |  |  |
RPI 2019 Intermediate Finance Trust [Member] | ORLADEYO [Member] | Annual Net Sales Over $230,000 [Member] |  |  |  |  |  |  |
Royalty Purchase Agreement, Royalties, Percentage of Annual Net Sales in Other Markets |  | 0.00% |  |  |  |  |
RPI 2019 Intermediate Finance Trust [Member] | BCX9930 [Member] |  |  |  |  |  |  |
Royalty Purchase Agreement, Royalties, Percentage of Global Annual Net Sales |  | 1.00% |  |  |  |  |
Royalty Purchase Agreement, Royalties, Maximum Tiered Profit Share Percentage on Permitted Sales in Other Markets | 3.00% |  |  |  |  |  |
RPI 2019 Intermediate Finance Trust [Member] | BCX9930 [Member] | Annual Net Sales Over $3 Billions [Member] |  |  |  |  |  |  |
Royalty Purchase Agreement, Royalties, Annual Net Sales Payment Threshold | $ 3,000,000 |  |  |  |  |  |
RPI 2019 Intermediate Finance Trust [Member] | Future Royalties Payable [Member] |  |  |  |  |  |  |
Proceeds from Issuance of Debt |  | $ 125,000 |  |  |  |  |
Debt Issuance Costs, Net, Total |  |  |  | 2,370 |  |  |
RPI 2021 and 2020 Intermediate Finance Trust [Member] | Future Royalties Payable [Member] |  |  |  |  |  |  |
Proceeds from Issuance of Debt | $ 150,000 |  |  |  |  |  |
The 2021 RPI Royalty Purchase Agreement [Member] | Annual Net Sales Under $350,000 [Member] |  |  |  |  |  |  |
Royalty Purchase Agreement, Royalties, Percentage of Annual Net Sales in Key Territories | 0.75% |  |  |  |  |  |
The 2021 RPI Royalty Purchase Agreement [Member] | Annual Net Sales Between $350,000 and $550,000 [Member] |  |  |  |  |  |  |
Royalty Purchase Agreement, Royalties, Percentage of Annual Net Sales in Key Territories | 1.75% |  |  |  |  |  |
Royalty Purchase Agreement, Royalties, Percentage of Annual Net Sales in Other Markets | 0.00% |  |  |  |  |  |
The 2021 RPI Royalty Purchase Agreement [Member] | Annual Net Sales Under $150,000 [Member] |  |  |  |  |  |  |
Royalty Purchase Agreement, Royalties, Percentage of Sublicense Revenue in Other Markets | 3.00% |  |  |  |  |  |
The 2021 RPI Royalty Purchase Agreement [Member] | Annual Net Sales Between $150,000 and $230,000 [Member] |  |  |  |  |  |  |
Royalty Purchase Agreement, Royalties, Percentage of Sublicense Revenue in Other Markets | 2.00% |  |  |  |  |  |
The 2021 RPI Royalty Purchase Agreement [Member] | BCX9930 [Member] | Annual Net Sales Under $1.5 Billion [Member] |  |  |  |  |  |  |
Royalty Purchase Agreement, Royalties, Percentage of Annual Net Sales in Key Territories | 3.00% |  |  |  |  |  |
The 2021 RPI Royalty Purchase Agreement [Member] | BCX9930 [Member] | Annual Net Sales Between $1.5 and $3 Billions [Member] |  |  |  |  |  |  |
Royalty Purchase Agreement, Royalties, Percentage of Annual Net Sales in Key Territories | 2.00% |  |  |  |  |  |
The 2021 RPI Royalty Purchase Agreement [Member] | BCX9930 [Member] | Annual Net Sales Over $3 Billions [Member] |  |  |  |  |  |  |
Royalty Purchase Agreement, Royalties, Percentage of Annual Net Sales in Other Markets | 0.00% |  |  |  |  |  |
OMERS Capital Markets [Member] | ORLADEYO [Member] |  |  |  |  |  |  |
Royalty Purchase Agreement, Royalties, Percentage of Sublicense Revenue in Other Markets | 20.00% |  |  |  |  |  |
Royalty Purchase Agreement, Royalties, Percentage of Annual Net Sales in Other Markets | 10.00% |  |  |  |  |  |
Royalty Purchase Agreement, Royalties, Purchase Price, Amount | $ 150,000 |  |  |  |  |  |
OMERS Capital Markets [Member] | ORLADEYO [Member] | Minimum [Member] |  |  |  |  |  |  |
Royalty Purchase Agreement, Royalties, Percentage of Purchase Price | 142.50% |  |  |  |  |  |
OMERS Capital Markets [Member] | ORLADEYO [Member] | Maximum [Member] |  |  |  |  |  |  |
Royalty Purchase Agreement, Royalties, Percentage of Purchase Price | 155.00% |  |  |  |  |  |
OMERS Capital Markets [Member] | ORLADEYO [Member] | Annual Net Sales Under $350,000 [Member] |  |  |  |  |  |  |
Royalty Purchase Agreement, Royalties, Percentage of Annual Net Sales | 7.50% |  |  |  |  |  |
Royalty Purchase Agreement, Royalties, Percentage of Annual Net Sales, Based on Reduction in Sales | 10.00% |  |  |  |  |  |
OMERS Capital Markets [Member] | ORLADEYO [Member] | Annual Net Sales Between $350,000 and $550,000 [Member] |  |  |  |  |  |  |
Royalty Purchase Agreement, Royalties, Percentage of Annual Net Sales | 6.00% |  |  |  |  |  |
Royalty Purchase Agreement, Royalties, Percentage of Annual Net Sales, Based on Reduction in Sales | 3.00% |  |  |  |  |  |
OMERS Capital Markets [Member] | ORLADEYO [Member] | Annual Net Sales Over $550,000 [Member] |  |  |  |  |  |  |
Royalty Purchase Agreement, Royalties, Percentage of Annual Net Sales | 0.00% |  |  |  |  |  |
Royalty Purchase Agreement, Royalties, Percentage of Annual Net Sales, Based on Reduction in Sales | 0.00% |  |  |  |  |  |
OMERS Capital Markets [Member] | ORLADEYO [Member] | Annual Net Sales Under $150,000 [Member] |  |  |  |  |  |  |
Royalty Purchase Agreement, Royalties, Percentage of Sublicense Revenue in Other Markets | 20.00% |  |  |  |  |  |
OMERS Capital Markets [Member] | ORLADEYO [Member] | Annual Net Sales Between $150,000 and $230,000 [Member] |  |  |  |  |  |  |
Royalty Purchase Agreement, Royalties, Percentage of Sublicense Revenue in Other Markets | 10.00% |  |  |  |  |  |
OMERS Capital Markets [Member] | ORLADEYO [Member] | Annual Net Sales Over $230,000 [Member] |  |  |  |  |  |  |
Royalty Purchase Agreement, Royalties, Percentage of Sublicense Revenue in Other Markets | 0.00% |  |  |  |  |  |
JPR Royalty Sub LLC [Member] | PhaRMA Notes Member] |  |  |  |  |  |  |
Private Placement of Senior Secured Notes |  |  | $ 30,000 |  |  |  |
Debt Instrument, Interest Rate, Stated Percentage |  |  | 14.00% |  |  |  |
Secured Debt, Total |  |  |  |  |  |  | $ 30,000
Interest Payable |  |  |  |  |  |  | $ 20,614
Gain (Loss) on Extinguishment of Debt, Total |  |  |  | $ 25,838 |  |  |
JPR Royalty Sub LLC [Member] | PhaRMA Notes Member] | Fair Value, Inputs, Level 2 [Member] |  |  |  |  |  |  |
Notes Payable, Fair Value Disclosure |  |  |  |  |  | $ 30,000 |
JPR Royalty Sub LLC [Member] | Royalty Monetization [Member] |  |  |  |  |  |  |
Debt Instrument, Face Amount |  |  | $ 30,000 |  |  |  |
Proceeds from Issuance of Secured Debt |  |  | 22,691 |  |  |  |
Transaction Costs |  |  | 4,309 |  |  |  |
Interest Reserve |  |  | $ 3,000 |  |  |  |

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