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Note 13 - Income Taxes - Components of Deferred Tax Assets and Liabilities (Details) - USD ($) $ in Thousands | Dec. 31, 2021 | Dec. 31, 2020
--- | --- | ---
Net federal and state operating losses | $ 113,649 | $ 159,939
Research and development credits | 71,197 | 66,331
Royalty income | 106,007 | 28,034
Stock-based compensation | 14,512 | 10,732
Capitalized R&D | 8,997 |
Leasing obligations | 1,836 | 1,135
Other | 4,809 | 5,563
Total deferred tax assets | 321,007 | 271,734
Fixed assets | (607) | (124)
Right of use asset | (1,527) | (854)
Total deferred tax liabilities | (2,134) | (978)
Valuation allowance | (318,714) | $ (270,756)
Net deferred tax assets | $ 159 |

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