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Note 1 - Significant Accounting Policies and Concentrations of Risk (Details Textual) - USD ($) $ in Thousands | 1 Months Ended | 12 Months Ended
--- | --- | ---
Dec. 31, 2020 | Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
Net Cash Provided by (Used in) Operating Activities, Total |  | $ (142,157) | $ (135,108) | $ (89,584)
Net Cash Provided by (Used in) Financing Activities, Total |  | 359,668 | 300,589 | 99,098
Restricted Cash and Cash Equivalents, Current, Total | $ 2,221 | 3,345 | 2,221 |
Advertising Expense |  | 5,705 | 6,567 | 0
Interest Expense, Debt, Total |  | 59,294 | 14,501 | 11,892
Amortization of Debt Financing Costs and Original Issue Discounts |  | $ 531 | $ 1,217 | $ 1,278
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount (in shares) |  | 26,034 | 14,957 | 2,805
Reclassification from Accumulated Other Comprehensive Income, Current Period, before Tax |  | $ 1 | $ 1 |
Foreign Exchange Contract [Member] | Not Designated as Hedging Instrument [Member] |  |  |  |
Derivative, Loss on Derivative |  |  | 632 | $ 347
Derivative, Gain on Derivative |  |  | 662 | $ 863
Computer Equipment [Member] |  |  |  |
Property, Plant and Equipment, Useful Life (Year) |  | 3 years |  |
Laboratory Equipment, Office Equipment and Software [Member] |  |  |  |
Property, Plant and Equipment, Useful Life (Year) |  | 5 years |  |
Furniture and Fixtures [Member] |  |  |  |
Property, Plant and Equipment, Useful Life (Year) |  | 7 years |  |
Royalty Receivable [Member] |  |  |  |
Restricted Cash and Cash Equivalents, Current, Total | 796 | $ 1,924 | 796 |
Collateral for Credit [Member] |  |  |  |
Restricted Cash and Cash Equivalents, Current, Total | 1,425 | $ 1,421 | 1,425 |
Maximum [Member] |  |  |  |
Maturity Period of High Quality Marketable Securities (Year) |  | 3 years |  |
Average Maturity Period of High Quality Marketable Securities (Month) |  | 12 months |  |
Maturity Period of Short Term Investment (Month) |  | 12 months |  |
Minimum [Member] |  |  |  |
Long-term Investment Maturity, Minimum (Year) |  | 12 years |  |
Previously Reported [Member] |  |  |  |
Net Cash Provided by (Used in) Operating Activities, Total |  |  | (137,216) |
Net Cash Provided by (Used in) Financing Activities, Total |  |  | 302,697 |
Senior Credit Facility [Member] | MidCap Financial Services, LLC [Member] |  |  |  |
Line of Credit Facility, Remaining Borrowing Capacity |  | $ 75,000 |  |
Write off of Deferred Debt Issuance Cost | $ 1,211 |  | $ 1,211 |

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