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Note 13 - Income Taxes (Tables) | 12 Months Ended
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Dec. 31, 2021
Notes Tables |
Schedule of Income before Income Tax, Domestic and Foreign [Table Text Block] |
|  | Years Ended December 31, |
|  | 2021 |  |  | 2020 |
Domestic |  | $ | (159,632 | ) |  | $ | (176,613 | )
Foreign |  |  | (22,177 | ) |  |  | (6,201 | )
Loss before provision for income taxes |  | $ | (181,809 | ) |  | $ | (182,814 | )
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block] |
|  | 2021 |  |  | 2020 |  |  | 2019 |
Income tax benefit at federal statutory rate (21% for 2021, 2020 and 2019) |  | $ | (38,175 | ) |  | $ | (38,391 | ) |  | $ | (22,868 | )
State and local income taxes net of federal tax benefit |  |  | (2,288 | ) |  |  | (2,544 | ) |  |  | (1,591 | )
Permanent items |  |  | (1,343 | ) |  |  | 774 |  |  |  | 691 |
Rate change |  |  | − |  |  |  | (82 | ) |  |  | 625 |
Expiration of attribute carryforwards |  |  | (1,057 | ) |  |  | 3,774 |  |  |  | 3,976 |
Research and development tax credits |  |  | (5,994 | ) |  |  | (4,080 | ) |  |  | (4,938 | )
Foreign rate differential |  |  | 1,940 |  |  |  | 542 |  |  |  | - |
Other |  |  | 1,216 |  |  |  | 1,456 |  |  |  | 281 |
Change in valuation allowance |  |  | 47,954 |  |  |  | 38,551 |  |  |  | 23,824 |
Income tax expense |  | $ | 2,253 |  |  | $ | − |  |  | $ | − |
Schedule of Unrecognized Tax Benefits Roll Forward [Table Text Block] |
|  | 2021 |  |  | 2020 |
Balance at January 1, |  | $ | 8,230 |  |  | $ | 7,210 |
Additions to current period tax positions |  |  | 1,499 |  |  |  | 1,020 |
Balance at December 31, |  | $ | 9,729 |  |  | $ | 8,230 |
Schedule of Deferred Tax Assets and Liabilities [Table Text Block] |
|  | 2021 |  |  | 2020 |
Deferred tax assets: |  |  |  |  |  |  |  |
Net federal and state operating losses |  | $ | 113,649 |  |  | $ | 159,939 |
Research and development credits |  |  | 71,197 |  |  |  | 66,331 |
Royalty income |  |  | 106,007 |  |  |  | 28,034 |
Stock-based compensation |  |  | 14,512 |  |  |  | 10,732 |
Capitalized R&D |  |  | 8,997 |  |  |  | − |
Leasing obligations |  |  | 1,836 |  |  |  | 1,135 |
Other |  |  | 4,809 |  |  |  | 5,563 |
Total deferred tax assets |  |  | 321,007 |  |  |  | 271,734 |
Deferred tax liabilities: |  |  |  |  |  |  |  |
Fixed assets |  |  | (607 | ) |  |  | (124 | )
Right of use asset |  |  | (1,527 | ) |  |  | (854 | )
Total deferred tax liabilities |  |  | (2,134 | ) |  |  | (978 | )
Valuation allowance |  |  | (318,714 | ) |  |  | (270,756 | )
Net deferred tax assets |  | $ | 159 |  |  | $ | − |

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