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Note 9 - Debt (Details Textual) - USD ($) $ in Thousands |  |  | 1 Months Ended | 12 Months Ended |  |
--- | --- | --- | --- | --- | --- | ---
Dec. 07, 2020 | Feb. 05, 2019 | Dec. 31, 2020 | Dec. 31, 2021 | Dec. 31, 2020 | Sep. 30, 2021 | Jan. 01, 2020
Repayments of Lines of Credit |  |  |  |  | $ 52,420 |  |
Long-term Debt, Total |  |  | $ 122,609 | $ 298,142 | 122,609 |  |
MidCap Financial Services, LLC [Member] | Senior Credit Facility [Member] |  |  |  |  |  |  |
Debt Instrument, Face Amount |  | $ 100,000 |  |  |  |  |
Repayments of Lines of Credit | $ 43,298 |  |  |  |  |  |
Debt Instrument, Basis Spread on Variable Rate |  | 8.00% |  |  |  |  |
Debt Instrument, Minimum LIBOR |  | 0.50% |  |  |  |  |
Debt Instrument, Term (Month) |  | 30 months |  |  |  |  |
Extinguishment of Debt, Amount |  |  | 40,000 |  |  |  |
Payment for Debt Extinguishment or Debt Prepayment Cost |  |  | 3,298 |  |  |  |
Write off of Deferred Debt Issuance Cost |  |  | $ 1,211 |  | 1,211 |  |
Credit Agreement [Member] | Athyrium [Member] |  |  |  |  |  |  |
Debt Instrument, Face Amount | $ 200,000 |  |  |  |  |  |
Debt Instrument, LIBOR Floor | 1.75% |  |  |  |  |  |
Debt Instrument, LIBOR Cap | 3.50% |  |  |  |  |  |
Debt Instrument, Exit Fee, Percentage of Principal | 2.00% |  |  |  |  |  |
Debt Instrument, Commitment Fee Percentage | 1.00% |  |  |  |  |  |
Long-term Debt, Gross |  |  |  | 125,000 |  |  |
Paid-in-Kind Interest |  |  |  | 16,009 | 1,056 |  |
Long-term Debt, Total |  |  |  | 142,065 |  |  |
Debt Instrument, Interest Rate, Effective Percentage |  |  |  |  |  | 12.17% |
Credit Agreement [Member] | Athyrium [Member] | Prior to the Second Anniversary [Member] |  |  |  |  |  |  |
Debt Instrument, Prepayment Fee, Percentage of Principal Voluntary Payments | 102.00% |  |  |  |  |  |
Debt Instrument, Prepayment Fee, Percentage of Accrued Interest | 0.50% |  |  |  |  |  |
Credit Agreement [Member] | Athyrium [Member] | Between the Second and Third Anniversaries [Member] |  |  |  |  |  |  |
Debt Instrument, Prepayment Fee, Percentage of Principal Voluntary Payments | 2.00% |  |  |  |  |  |
Credit Agreement [Member] | Athyrium [Member] | Between the Third and Fourth Anniversaries [Member] |  |  |  |  |  |  |
Debt Instrument, Prepayment Fee, Percentage of Principal Voluntary Payments | 1.00% |  |  |  |  |  |
Credit Agreement [Member] | Athyrium [Member] | After Fourth Anniversary [Member] |  |  |  |  |  |  |
Debt Instrument, Prepayment Fee, Percentage of Principal Voluntary Payments | 0.00% |  |  |  |  |  |
Credit Agreement [Member] | Athyrium [Member] | Term Loan A Drawn [Member] |  |  |  |  |  |  |
Debt Instrument, Covenant, Minimum Unrestricted Cash and Cash Equivalents | $ 15,000 |  |  |  |  |  |
Credit Agreement [Member] | Athyrium [Member] | Term Loan A and B Drawn [Member] |  |  |  |  |  |  |
Debt Instrument, Covenant, Minimum Unrestricted Cash and Cash Equivalents | 20,000 |  |  |  |  |  |
Credit Agreement [Member] | Athyrium [Member] | Term Loans A, B and C Drawn [Member] |  |  |  |  |  |  |
Debt Instrument, Covenant, Minimum Unrestricted Cash and Cash Equivalents | 15,000 |  |  |  |  |  |
Credit Agreement [Member] | Athyrium [Member] | Term Loans A, B and C Drawn and Cure Right Exercised [Member] |  |  |  |  |  |  |
Debt Instrument, Covenant, Minimum Unrestricted Cash and Cash Equivalents | $ 20,000 |  |  |  |  |  |
Credit Agreement [Member] | Athyrium [Member] | London Interbank Offered Rate (LIBOR) [Member] |  |  |  |  |  |  |
Debt Instrument, Basis Spread on Variable Rate | 8.25% |  |  |  |  |  |
Credit Agreement [Member] | Athyrium [Member] | London Interbank Offered Rate (LIBOR) [Member] | PIK Interest Payment is Made [Member] |  |  |  |  |  |  |
Debt Instrument, Basis Spread on Variable Rate | 10.25% |  |  |  |  |  |
Credit Agreement [Member] | Athyrium [Member] | Term A Loan [Member] |  |  |  |  |  |  |
Proceeds from Issuance of Long-term Debt, Total | $ 125,000 |  |  |  |  |  |
Debt Instrument, Unamortized Discount (Premium) and Debt Issuance Costs, Net, Total |  |  |  | 8,483 |  |  | $ 7,764
Amortization of Debt Issuance Costs |  |  |  | $ 531 | $ 131 |  |
Credit Agreement [Member] | Athyrium [Member] | Term B Loan [Member] |  |  |  |  |  |  |
Debt Instrument, Face Amount | 25,000 |  |  |  |  |  |
Credit Agreement [Member] | Athyrium [Member] | Term C Loan [Member] |  |  |  |  |  |  |
Debt Instrument, Face Amount | $ 50,000 |  |  |  |  |  |
Secured Credit Facility, First Tranche [Member] | MidCap Financial Services, LLC [Member] | Senior Credit Facility [Member] |  |  |  |  |  |  |
Debt Instrument, Face Amount |  | $ 50,000 |  |  |  |  |
Repayments of Long-term Debt, Total |  | 30,000 |  |  |  |  |
Secured Credit Facility, Second Tranche [Member] | MidCap Financial Services, LLC [Member] | Senior Credit Facility [Member] |  |  |  |  |  |  |
Debt Instrument, Face Amount |  | 30,000 |  |  |  |  |
Secured Credit Facility, Third Tranche [Member] | MidCap Financial Services, LLC [Member] | Senior Credit Facility [Member] |  |  |  |  |  |  |
Debt Instrument, Face Amount |  | $ 20,000 |  |  |  |  |

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