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Note 12 - Stock-based Compensation (Tables)

12 Months Ended

Dec. 31, 2021

Notes Tables

Share-based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]

		Years Ended December 31,
		2021				2020				2019
Research and development		$	20,179			$	10,222			$	13,977
Selling, general and administrative			14,461				4,572				3,742
Total stock-based compensation expense		$	34,640			$	14,794			$	17,719

Share-based Payment Arrangement, Activity [Table Text Block]

										Weighted
										Average
		Awards				Options				Exercise
		Available				Outstanding				Price
Balance at December 31, 2018			805				17,491			$	6.49
Plan amendment			4,000				−				−
Restricted stock awards granted			(27	)			−				−
Stock option awards granted			(4,511	)			4,511				3.91
Stock option awards exercised			−				(251	)			3.75
Stock option awards cancelled			701				(701	)			6.82
Balance at December 31, 2019			968				21,050			$	5.96
Plan amendment			8,000				−				−
Restricted stock awards granted			(31	)			−				−
Stock option awards granted			(7,469	)			7,469				8.06
Stock option awards exercised			−				(510	)			3.56
Stock option awards cancelled			3,124				(3,124	)			6.93
Balance at December 31, 2020			4,592				24,885			$	6.52
Plan amendment			7,500				−				−
Restricted stock units granted			(1,936	)			−				−
Stock option awards granted			(6,753	)			6,753
Stock option awards exercised			−				(2,705	)			4.36
Stock option awards cancelled			248				(248	)			7.62
Balance at December 31, 2021			3,651				28,685			$	7.90

										Weighted
										Average
		Awards				Options				Exercise
		Available				Outstanding				Price
Balance at December 31, 2020			229				4,171			$	3.88
Plan amendment			1,500				−				−
Stock option awards granted			(1,003	)			1,003				13.91
Stock option awards exercised			−				(592	)			3.63
Stock option awards cancelled			174				(174	)			3.67
Balance at December 31, 2021			900				4,408			$	6.20

Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]

		2021				2020				2019
Expected Life			5.5				5.5				5.5
Expected Volatility			84	%			84	%			81	%
Expected Dividend Yield			0.0	%			0.0	%			0.0	%
Risk-Free Interest Rate			1.1	%			0.4	%			1.8	%

Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding and Exercisable [Table Text Block]

							Outstanding											Exercisable
										Weighted				Weighted								Weighted
										Average				Average								Average
										Remaining				Exercise								Exercise
Range						Number				Life				Price				Number				Price
$	0	to	3				1,874				5.9			$	2.30				1,158			$	2.12
	3	to	6				10,190				6.5				4.22				7,317				4.41
	6	to	9				10,599				8.2				7.89				4,317				7.56
	9	to	12				8,228				8.1				11.14				2,120				10.86
	12	to	15				1,291				6.8				13.10				535				12.31
	15	to	18				911				9.0				15.95				114				15.56
$	0	to	18				33,093				7.5			$	7.68				15,561			$	6.34

Share-based Payment Arrangement, Option, Activity [Table Text Block]

		Non-Vested Stock Option Awards				Weighted Average Grant-Date Fair Value
Balance December 31, 2020			16,020			$	4.25
Stock option awards granted			7,756				3.31
Stock option awards vested			(5,837	)			3.97
Stock option awards forfeited			(407	)			4.14
Balance December 31, 2021			17,532			$	3.86

X

- Definition

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