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Note 1 - Significant Accounting Policies and Concentrations of Risk (Details Textual) - USD ($)
shares in Thousands, $ in Thousands
 3 Months Ended
Mar. 31, 2022
Mar. 31, 2021
Dec. 31, 2021
Restricted Cash and Cash Equivalents, Current, Total $ 3,354   $ 3,345
Advertising Expense 3,984 $ 1,404  
Interest Expense, Debt, Total 23,837 12,904  
Amortization of Debt Financing Costs and Original Issue Discounts $ 167 $ 58  
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount (in shares) 28,699 23,741  
Reclassification from Accumulated Other Comprehensive Income, Current Period, before Tax $ 0 $ (1)  
Computer Equipment [Member]      
Property, Plant and Equipment, Useful Life (Year) 3 years    
Laboratory Equipment, Office Equipment and Software [Member]      
Property, Plant and Equipment, Useful Life (Year) 5 years    
Furniture and Fixtures [Member]      
Property, Plant and Equipment, Useful Life (Year) 7 years    
Maximum [Member]      
Maturity Period of High Quality Marketable Securities (Year) 3 years    
Average Maturity Period of High Quality Marketable Securities (Month) 12 months    
Maturity Period of Short Term Investment (Month) 12 months    
Minimum [Member]      
Long-term Investment Maturity, Minimum (Year) 12 years    
Royalty Receivable [Member]      
Restricted Cash and Cash Equivalents, Current, Total $ 1,924   1,924
Collateral for Credit [Member]      
Restricted Cash and Cash Equivalents, Current, Total 1,430   $ 1,421
Senior Credit Facility [Member] | MidCap Financial Services, LLC [Member]      
Line of Credit Facility, Remaining Borrowing Capacity $ 75,000