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Note 6 - Royalty Monetizations (Details Textual) - USD ($) $ in Thousands				12 Months Ended
	Nov. 19, 2021	Dec. 07, 2020	Mar. 09, 2011	Dec. 31, 2021	Mar. 31, 2022	Jun. 30, 2021	Dec. 01, 2020
Debt Issuance Costs, Net, Total					$ 34
RPI 2019 Intermediate Finance Trust [Member]
Shares Issued, Common Stock, Premium					4,269
RPI 2019 Intermediate Finance Trust [Member] \| ORLADEYO [Member]
Royalty Purchase Agreement, Royalties, Percentage of Sublicense Revenue in Other Markets		20.00%
RPI 2019 Intermediate Finance Trust [Member] \| ORLADEYO [Member] \| Annual Net Sales Under $350,000 [Member]
Royalty Purchase Agreement, Royalties, Percentage of Annual Net Sales in Key Territories		8.75%
RPI 2019 Intermediate Finance Trust [Member] \| ORLADEYO [Member] \| Annual Net Sales Between $350,000 and $550,000 [Member]
Royalty Purchase Agreement, Royalties, Percentage of Annual Net Sales in Key Territories		2.75%
RPI 2019 Intermediate Finance Trust [Member] \| ORLADEYO [Member] \| Annual Net Sales Over $550,000 [Member]
Royalty Purchase Agreement, Royalties, Percentage of Annual Net Sales in Key Territories		0.00%
RPI 2019 Intermediate Finance Trust [Member] \| ORLADEYO [Member] \| Annual Net Sales Under $150,000 [Member]
Royalty Purchase Agreement, Royalties, Percentage of Annual Net Sales in Other Markets		20.00%
RPI 2019 Intermediate Finance Trust [Member] \| ORLADEYO [Member] \| Annual Net Sales Between $150,000 and $230,000 [Member]
Royalty Purchase Agreement, Royalties, Percentage of Annual Net Sales in Other Markets		10.00%
RPI 2019 Intermediate Finance Trust [Member] \| ORLADEYO [Member] \| Annual Net Sales Over $230,000 [Member]
Royalty Purchase Agreement, Royalties, Percentage of Annual Net Sales in Other Markets		0.00%
RPI 2019 Intermediate Finance Trust [Member] \| BCX9930 [Member]
Royalty Purchase Agreement, Royalties, Percentage of Global Annual Net Sales		1.00%
Royalty Purchase Agreement, Royalties, Maximum Tiered Profit Share Percentage on Permitted Sales in Other Markets	3.00%
RPI 2019 Intermediate Finance Trust [Member] \| BCX9930 [Member] \| Annual Net Sales Over $3 Billions [Member]
Royalty Purchase Agreement, Royalties, Annual Net Sales Payment Threshold	$ 3,000,000
RPI 2019 Intermediate Finance Trust [Member] \| Future Royalties Payable [Member]
Proceeds from Issuance of Debt		$ 125,000
Debt Issuance Costs, Net, Total					$ 8,531
RPI 2021 and 2020 Intermediate Finance Trust [Member] \| Future Royalties Payable [Member]
Proceeds from Issuance of Debt	$ 150,000
The 2021 RPI Royalty Purchase Agreement [Member] \| Annual Net Sales Under $350,000 [Member]
Royalty Purchase Agreement, Royalties, Percentage of Annual Net Sales in Key Territories	0.75%
The 2021 RPI Royalty Purchase Agreement [Member] \| Annual Net Sales Between $350,000 and $550,000 [Member]
Royalty Purchase Agreement, Royalties, Percentage of Annual Net Sales in Key Territories	1.75%
Royalty Purchase Agreement, Royalties, Percentage of Annual Net Sales in Other Markets	0.00%
The 2021 RPI Royalty Purchase Agreement [Member] \| Annual Net Sales Under $150,000 [Member]
Royalty Purchase Agreement, Royalties, Percentage of Sublicense Revenue in Other Markets	3.00%
The 2021 RPI Royalty Purchase Agreement [Member] \| Annual Net Sales Between $150,000 and $230,000 [Member]
Royalty Purchase Agreement, Royalties, Percentage of Sublicense Revenue in Other Markets	2.00%
The 2021 RPI Royalty Purchase Agreement [Member] \| BCX9930 [Member] \| Annual Net Sales Under $1.5 Billion [Member]
Royalty Purchase Agreement, Royalties, Percentage of Annual Net Sales in Key Territories	3.00%
The 2021 RPI Royalty Purchase Agreement [Member] \| BCX9930 [Member] \| Annual Net Sales Between $1.5 and $3 Billions [Member]
Royalty Purchase Agreement, Royalties, Percentage of Annual Net Sales in Key Territories	2.00%
The 2021 RPI Royalty Purchase Agreement [Member] \| BCX9930 [Member] \| Annual Net Sales Over $3 Billions [Member]
Royalty Purchase Agreement, Royalties, Percentage of Annual Net Sales in Other Markets	0.00%
OMERS Capital Markets [Member] \| ORLADEYO [Member]
Royalty Purchase Agreement, Royalties, Percentage of Sublicense Revenue in Other Markets	20.00%
Royalty Purchase Agreement, Royalties, Percentage of Annual Net Sales in Other Markets	10.00%
Royalty Purchase Agreement, Royalties, Purchase Price, Amount	$ 150,000
OMERS Capital Markets [Member] \| ORLADEYO [Member] \| Minimum [Member]
Royalty Purchase Agreement, Royalties, Percentage of Purchase Price	142.50%
OMERS Capital Markets [Member] \| ORLADEYO [Member] \| Maximum [Member]
Royalty Purchase Agreement, Royalties, Percentage of Purchase Price	155.00%
OMERS Capital Markets [Member] \| ORLADEYO [Member] \| Annual Net Sales Under $350,000 [Member]
Royalty Purchase Agreement, Royalties, Percentage of Annual Net Sales	7.50%
Royalty Purchase Agreement, Royalties, Percentage of Annual Net Sales, Based on Reduction in Sales	10.00%
OMERS Capital Markets [Member] \| ORLADEYO [Member] \| Annual Net Sales Between $350,000 and $550,000 [Member]
Royalty Purchase Agreement, Royalties, Percentage of Annual Net Sales	6.00%
Royalty Purchase Agreement, Royalties, Percentage of Annual Net Sales, Based on Reduction in Sales	3.00%
OMERS Capital Markets [Member] \| ORLADEYO [Member] \| Annual Net Sales Over $550,000 [Member]
Royalty Purchase Agreement, Royalties, Percentage of Annual Net Sales	0.00%
Royalty Purchase Agreement, Royalties, Percentage of Annual Net Sales, Based on Reduction in Sales	0.00%
OMERS Capital Markets [Member] \| ORLADEYO [Member] \| Annual Net Sales Under $150,000 [Member]
Royalty Purchase Agreement, Royalties, Percentage of Sublicense Revenue in Other Markets	20.00%
OMERS Capital Markets [Member] \| ORLADEYO [Member] \| Annual Net Sales Between $150,000 and $230,000 [Member]
Royalty Purchase Agreement, Royalties, Percentage of Sublicense Revenue in Other Markets	10.00%
OMERS Capital Markets [Member] \| ORLADEYO [Member] \| Annual Net Sales Over $230,000 [Member]
Royalty Purchase Agreement, Royalties, Percentage of Sublicense Revenue in Other Markets	0.00%
JPR Royalty Sub LLC [Member] \| PhaRMA Notes Member]
Private Placement of Senior Secured Notes			$ 30,000
Debt Instrument, Interest Rate, Stated Percentage			14.00%
Secured Debt, Total							$ 30,000
Interest Payable							$ 20,614
Gain (Loss) on Extinguishment of Debt, Total				$ 25,838
JPR Royalty Sub LLC [Member] \| PhaRMA Notes Member] \| Fair Value, Inputs, Level 2 [Member]
Notes Payable, Fair Value Disclosure						$ 30,000
JPR Royalty Sub LLC [Member] \| Royalty Monetization [Member]
Debt Instrument, Face Amount			$ 30,000
Proceeds from Issuance of Secured Debt			22,691
Transaction Costs			4,309
Interest Reserve			$ 3,000