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Consolidated Statements of Comprehensive Loss (Unaudited) - USD ($)
shares in Thousands, $ in Thousands
 3 Months Ended
Mar. 31, 2022
Mar. 31, 2021
Revenues:    
Revenues $ 49,923 $ 19,059
Expenses    
Cost of product sales 236 5,923
Research and development 65,360 42,435
Selling, general and administrative 34,282 22,114
Royalty 2 (36)
Total operating expenses 99,880 70,436
Loss from operations (49,957) (51,377)
Interest and other income 54 26
Interest expense (23,837) (12,904)
Foreign currency losses, net (177) (29)
Loss before income taxes (73,917) (64,284)
Income tax expense 279 0
Net loss (74,196) (64,284)
Foreign currency translation adjustment 78 178
Unrealized (loss) gain on available for sale investments (69) 1
Comprehensive loss $ (74,187) $ (64,105)
Basic and diluted net loss per common share (in dollars per share) $ (0.40) $ (0.36)
Weighted average shares outstanding (in shares) 184,898 177,343
Product [Member]    
Revenues:    
Revenues $ 49,546 $ 17,871
Royalty [Member]    
Revenues:    
Revenues 347 (897)
Collaborative and Other Research and Development [Member]    
Revenues:    
Revenues $ 30 $ 2,085