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v3.22.2.2

Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 9 Months Ended
--- | ---
Sep. 30, 2022 | Sep. 30, 2021
Cash flows from operating activities: |  |
Net loss | $ (175,575) | $ (166,283)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation and amortization | 1,041 | 606
Stock-based compensation expense | 29,419 | 26,140
Non-cash interest expense on royalty financing obligations and secured term loan and amortization of debt issuance costs | 55,119 | 36,440
Amortization of premium/discount on investments | (818) | 35
Changes in operating assets and liabilities: |  |
Receivables | (13,827) | (17,579)
Inventory | (11,263) | (6,630)
Prepaid expenses and other assets | (1,132) | (3,460)
Accounts payable and accrued expenses | (27,639) | 16,692
Interest payable | 6,345 | 3,884
Deferred revenue | 329 | 457
Net cash used in operating activities | (138,001) | (109,698)
Cash flows from investing activities: |  |
Acquisitions of property and equipment | (825) | (1,277)
Purchase of investments | (244,283) | 0
Sales and maturities of investments | 39,655 | 28,201
Net cash (used in) provided by investing activities | (205,453) | 26,924
Cash flows from financing activities: |  |
Net proceeds from common stock issued under stock-based compensation plans | 10,756 | 12,250
Net proceeds from secured term loans | 73,072 | 0
Net cash provided by financing activities | 83,828 | 12,250
Effect of exchange rate on cash, cash equivalents, and restricted cash | 235 | 69
Decrease in cash, cash equivalents and restricted cash | (259,391) | (70,455)
Cash, cash equivalents and restricted cash at beginning of period | 507,734 | 274,348
Cash, cash equivalents and restricted cash at end of period | $ 248,343 | $ 203,893

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- Definition The cash outflow for purchases of and capital improvements on property, plant and equipment (capital expenditures), software, and other intangible assets. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (c) -URI https://asc.fasb.org/extlink&oid=126954810&loc=d3e3213-108585 Reference 2: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 805 -SubTopic 50 -Section 30 -Paragraph 1 -URI https://asc.fasb.org/extlink&oid=126928898&loc=d3e9212-128498 Reference 3: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 805 -SubTopic 50 -Section 30 -Paragraph 2 -URI https://asc.fasb.org/extlink&oid=126928898&loc=d3e9215-128498 Reference 4: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 805 -SubTopic 50 -Section 25 -Paragraph 1 -URI https://asc.fasb.org/extlink&oid=127000608&loc=d3e9135-128495 + Details
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- Definition Amount of cash inflow from contractual arrangement with the lender, including but not limited to, letter of credit, standby letter of credit and revolving credit arrangements. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (b) -URI https://asc.fasb.org/extlink&oid=126954810&loc=d3e3255-108585 Reference 2: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 235 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.4-08(f)) -URI https://asc.fasb.org/extlink&oid=120395691&loc=d3e23780-122690 + Details
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