    <SEC-DOCUMENT>0001140361-22-015743-index.html : 20220425
    <SEC-HEADER>0001140361-22-015743.hdr.sgml : 20220425
    <ACCEPTANCE-DATETIME>20220425163026
    ACCESSION NUMBER:		0001140361-22-015743
    CONFORMED SUBMISSION TYPE:	DEF 14A
    PUBLIC DOCUMENT COUNT:		4
    CONFORMED PERIOD OF REPORT:	20220607
    FILED AS OF DATE:		20220425
    DATE AS OF CHANGE:		20220425

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			BIOCRYST PHARMACEUTICALS INC
    		CENTRAL INDEX KEY:			0000882796
    		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
    		IRS NUMBER:				621413174
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		DEF 14A
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	000-23186
    		FILM NUMBER:		22850051

    	BUSINESS ADDRESS:
    		STREET 1:		4505 EMPEROR BOULEVARD
    		STREET 2:		SUITE 200
    		CITY:			DURHAM
    		STATE:			NC
    		ZIP:			27703
    		BUSINESS PHONE:		919-859-1302

    	MAIL ADDRESS:
    		STREET 1:		4505 EMPEROR BOULEVARD
    		STREET 2:		SUITE 200
    		CITY:			DURHAM
    		STATE:			NC
    		ZIP:			27703
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>DEF 14A
    <SEQUENCE>1
    <FILENAME>ny20002713x1_def14a.htm
    <DESCRIPTION>DEF14A
    <TEXT>
    Document 1 - file: ny20002713x1_def14a.htm

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    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>2
    <FILENAME>logo_biocryst2a.jpg
    <TEXT>
    Document 2 - file: logo_biocryst2a.jpg

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    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>3
    <FILENAME>ny20002713x1_pc01.jpg
    <TEXT>
    Document 3 - file: ny20002713x1_pc01.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>4
    <FILENAME>ny20002713x1_pc02.jpg
    <TEXT>
    Document 4 - file: ny20002713x1_pc02.jpg

    </DOCUMENT>
    </SEC-DOCUMENT>