    <SEC-DOCUMENT>0001140361-23-020956-index.html : 20230427
    <SEC-HEADER>0001140361-23-020956.hdr.sgml : 20230427
    <ACCEPTANCE-DATETIME>20230427161944
    ACCESSION NUMBER:		0001140361-23-020956
    CONFORMED SUBMISSION TYPE:	ARS
    PUBLIC DOCUMENT COUNT:		1
    CONFORMED PERIOD OF REPORT:	20221231
    FILED AS OF DATE:		20230427
    DATE AS OF CHANGE:		20230427
    EFFECTIVENESS DATE:		20230427

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			BIOCRYST PHARMACEUTICALS INC
    		CENTRAL INDEX KEY:			0000882796
    		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
    		IRS NUMBER:				621413174
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		ARS
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	000-23186
    		FILM NUMBER:		23857272

    	BUSINESS ADDRESS:
    		STREET 1:		4505 EMPEROR BOULEVARD
    		STREET 2:		SUITE 200
    		CITY:			DURHAM
    		STATE:			NC
    		ZIP:			27703
    		BUSINESS PHONE:		919-859-1302

    	MAIL ADDRESS:
    		STREET 1:		4505 EMPEROR BOULEVARD
    		STREET 2:		SUITE 200
    		CITY:			DURHAM
    		STATE:			NC
    		ZIP:			27703
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>ARS
    <SEQUENCE>1
    <FILENAME>ny20007126x4_ars.pdf
    <DESCRIPTION>FORM ARS
    <TEXT>
    Document 1 - file: ny20007126x4_ars.pdf

    </DOCUMENT>
    </SEC-DOCUMENT>