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Stock-based Compensation (Details Textual)
$ / shares in Units, $ in Thousands
1 Months Ended 3 Months Ended 6 Months Ended 12 Months Ended
Jan. 31, 2022
shares
Dec. 31, 2014
shares
Mar. 31, 2023
shares
Mar. 31, 2022
shares
Jun. 30, 2023
USD ($)
plan
$ / shares
shares
Jun. 30, 2022
$ / shares
shares
Dec. 31, 2022
shares
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]              
Number of plans | plan         3    
Total unrecognized compensation expense related to non-vested stock options and RSU awards | $         $ 126,812    
Compensation cost expected to be recognized for remainder of fiscal year | $         25,967    
Compensation cost expected to be recognized next year | $         47,207    
Compensation cost expected to be recognized year two | $         34,593    
Compensation cost expected to be recognized year three | $         18,582    
Compensation cost expected to be recognized year four | $         $ 463    
Employee stock purchase plan sales, net (in shares)     176,000 115,000 176,000 115,000  
Share-Based Payment Arrangement, Option | Non-employee Directors              
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]              
Award vesting period (in years)         1 year    
Incentive Plan              
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]              
Number of common stock shares available for purchase (in shares)         11,501,000   4,206,000
Incentive Plan | Share-Based Payment Arrangement, Option              
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]              
Weighted average grant date fair value stock option awards (in dollars per share) | $ / shares         $ 6.40 $ 7.78  
Incentive Plan | Share-Based Payment Arrangement, Option | Maximum              
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]              
Stock option awards remaining contractual term (in years)         10 years    
Incentive Plan | Share-Based Payment Arrangement, Option | Vest 25% Each Year Until Fully Vested              
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]              
Award vesting rights, percentage         25.00%    
Award vesting period (in years)         4 years    
Incentive Plan | Share-Based Payment Arrangement, Option | Thirty-six Equal Monthly Installments | Non-employee Directors              
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]              
Award vesting period (in years)         3 years    
Incentive Plan | Performance Shares | Vest Upon Successful Completion of Specific Development Milestones              
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]              
Award vesting rights, percentage   85.00%          
Performance-based stock options issued in period (in shares)   1,250,000          
Incentive Plan | Performance-based Restricted Stock Units              
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]              
Award vesting period (in years) 3 years            
Incentive Plan | Performance-based Restricted Stock Units | Vest 25% Each Year Until Fully Vested              
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]              
Award vesting rights, percentage 25.00%            
Incentive Plan | Performance-based Restricted Stock Units | Vest Upon Successful Completion of Specific Development Milestones              
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]              
Performance-based restricted stock unit awards issued (in shares) 221,000           21
Incentive Plan | Performance-based Restricted Stock Units | Share-Based Payment Arrangement, Tranche One              
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]              
Award vesting rights, percentage 50.00%            
Incentive Plan | Restricted Stock Units (RSUs)              
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]              
Weighted average grant date fair value (in dollars per share) | $ / shares         $ 9.18 13.25  
Inducement Plan              
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]              
Award vesting period (in years)         4 years    
Expiration period (in years)         10 years    
Weighted average grant date fair value stock option awards (in dollars per share) | $ / shares         $ 6.38 10.28  
Number of common stock shares available for purchase (in shares)         342,000   947,000
Inducement Plan | Vest 25% Each Year Until Fully Vested              
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]              
Award vesting rights, percentage         25.00%    
Inducement Plan | Share-Based Payment Arrangement, Option              
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]              
Expected Dividend Yield         0.00%    
Inducement Plan | Restricted Stock Units (RSUs)              
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]              
Weighted average grant date fair value (in dollars per share) | $ / shares         $ 8.84 $ 13.88  
Employee Stock Purchase Plan              
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]              
Number of shares of common stock authorized to be purchased (in shares)         7,975,000    
Number of common stock shares available for purchase (in shares)         5,617,000    
Percentage of salary to purchase common stock, maximum         15.00%    
Percentage of common stock shares, beginning         85.00%    
Percentage of common stock shares, ending         85.00%    
Maximum number of shares per employee (in shares)         3,000    
Maximum number of shares per employee, amount | $         $ 25