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Stock-based Compensation (Details Textual) $ / shares in Units, $ in Thousands | 1 Months Ended | 3 Months Ended | 9 Months Ended | 12 Months Ended
--- | --- | --- | --- | ---
Jan. 31, 2022 shares | Dec. 31, 2014 shares | Sep. 30, 2023 USD ($) plan shares | Mar. 31, 2023 shares | Sep. 30, 2022 shares | Mar. 31, 2022 shares | Sep. 30, 2023 USD ($) plan $ / shares shares | Sep. 30, 2022 $ / shares shares | Dec. 31, 2022 shares
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items] |  |  |  |  |  |  |  |  |
Number of plans | plan |  |  | 3 |  |  |  | 3 |  |
Total unrecognized compensation expense related to non-vested stock options and RSU awards | $ |  |  | $ 111,804 |  |  |  | $ 111,804 |  |
Weighted-average term to recognize non-vested stock options and RSU awards |  |  |  |  |  |  | 1 year 3 months 18 days |  |
Employee stock purchase plan sales, net (in shares) |  |  | 162,000 | 176,000 | 145,000 | 115,000 | 338,000 | 260,000 |
Outstanding stock options | Non-employee Directors |  |  |  |  |  |  |  |  |
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items] |  |  |  |  |  |  |  |  |
Award vesting period (in years) |  |  |  |  |  |  | 1 year |  |
Incentive Plan |  |  |  |  |  |  |  |  |
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items] |  |  |  |  |  |  |  |  |
Number of common stock shares available for purchase (in shares) |  |  | 11,934,000 |  |  |  | 11,934,000 |  | 4,206,000
Incentive Plan | Outstanding stock options |  |  |  |  |  |  |  |  |
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items] |  |  |  |  |  |  |  |  |
Weighted average grant date fair value stock option awards (in dollars per share) | $ / shares |  |  |  |  |  |  | $ 6.40 | $ 7.78 |
Incentive Plan | Outstanding stock options | Maximum |  |  |  |  |  |  |  |  |
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items] |  |  |  |  |  |  |  |  |
Stock option awards remaining contractual term (in years) |  |  |  |  |  |  | 10 years |  |
Incentive Plan | Outstanding stock options | Vest 25% Each Year Until Fully Vested |  |  |  |  |  |  |  |  |
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items] |  |  |  |  |  |  |  |  |
Award vesting rights, percentage |  |  |  |  |  |  | 25.00% |  |
Award vesting period (in years) |  |  |  |  |  |  | 4 years |  |
Incentive Plan | Outstanding stock options | Thirty-six Equal Monthly Installments | Non-employee Directors |  |  |  |  |  |  |  |  |
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items] |  |  |  |  |  |  |  |  |
Award vesting period (in years) |  |  |  |  |  |  | 3 years |  |
Incentive Plan | Performance Shares | Vest Upon Successful Completion of Specific Development Milestones |  |  |  |  |  |  |  |  |
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items] |  |  |  |  |  |  |  |  |
Award vesting rights, percentage |  | 85.00% |  |  |  |  |  |  |
Performance-based stock options issued in period (in shares) |  | 1,250,000 |  |  |  |  |  |  |
Incentive Plan | Performance-based Restricted Stock Units |  |  |  |  |  |  |  |  |
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items] |  |  |  |  |  |  |  |  |
Award vesting period (in years) | 3 years |  |  |  |  |  |  |  |
Incentive Plan | Performance-based Restricted Stock Units | Vest 25% Each Year Until Fully Vested |  |  |  |  |  |  |  |  |
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items] |  |  |  |  |  |  |  |  |
Award vesting rights, percentage | 25.00% |  |  |  |  |  |  |  |
Incentive Plan | Performance-based Restricted Stock Units | Vest Upon Successful Completion of Specific Development Milestones |  |  |  |  |  |  |  |  |
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items] |  |  |  |  |  |  |  |  |
Performance-based restricted stock unit awards issued (in shares) | 221,000 |  |  |  |  |  |  |  | 21,000
Incentive Plan | Performance-based Restricted Stock Units | Share-Based Payment Arrangement, Tranche One |  |  |  |  |  |  |  |  |
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items] |  |  |  |  |  |  |  |  |
Award vesting rights, percentage | 50.00% |  |  |  |  |  |  |  |
Incentive Plan | Restricted Stock Units (RSUs) |  |  |  |  |  |  |  |  |
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items] |  |  |  |  |  |  |  |  |
Weighted average grant date fair value (in dollars per share) | $ / shares |  |  |  |  |  |  | $ 9.18 | 13.18 |
Inducement Plan |  |  |  |  |  |  |  |  |
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items] |  |  |  |  |  |  |  |  |
Award vesting period (in years) |  |  |  |  |  |  | 4 years |  |
Expiration period (in years) |  |  |  |  |  |  | 10 years |  |
Weighted average grant date fair value stock option awards (in dollars per share) | $ / shares |  |  |  |  |  |  | $ 6.14 | 9.72 |
Number of common stock shares available for purchase (in shares) |  |  | 200,000 |  |  |  | 200,000 |  | 947,000
Inducement Plan | Vest 25% Each Year Until Fully Vested |  |  |  |  |  |  |  |  |
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items] |  |  |  |  |  |  |  |  |
Award vesting rights, percentage |  |  |  |  |  |  | 25.00% |  |
Inducement Plan | Outstanding stock options |  |  |  |  |  |  |  |  |
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items] |  |  |  |  |  |  |  |  |
Expected Dividend Yield |  |  |  |  |  |  | 0.00% |  |
Inducement Plan | Restricted Stock Units (RSUs) |  |  |  |  |  |  |  |  |
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items] |  |  |  |  |  |  |  |  |
Weighted average grant date fair value (in dollars per share) | $ / shares |  |  |  |  |  |  | $ 8.35 | $ 13.38 |
Employee Stock Purchase Plan |  |  |  |  |  |  |  |  |
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items] |  |  |  |  |  |  |  |  |
Number of shares of common stock authorized to be purchased (in shares) |  |  | 7,975,000 |  |  |  | 7,975,000 |  |
Number of common stock shares available for purchase (in shares) |  |  | 5,454,000 |  |  |  | 5,454,000 |  |
Percentage of salary to purchase common stock, maximum |  |  |  |  |  |  | 15.00% |  |
Percentage of common stock shares, beginning |  |  |  |  |  |  | 85.00% |  |
Percentage of common stock shares, ending |  |  |  |  |  |  | 85.00% |  |
Maximum number of shares per employee (in shares) |  |  |  |  |  |  | 3,000 |  |
Maximum number of shares per employee, amount | $ |  |  | $ 25 |  |  |  | $ 25 |  |

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