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Represents share-based compensation arrangement by share-based payment award maximum value per employee amount.

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Amount of cost not yet recognized for nonvested award under share-based payment arrangement.

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Weighted-average period over which cost not yet recognized is expected to be recognized for award under share-based payment arrangement, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days.

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Period over which grantee's right to exercise award under share-based payment arrangement is no longer contingent on satisfaction of service or performance condition, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents reported fact of one year, five months, and thirteen days. Includes, but is not limited to, combination of market, performance or service condition.

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The weighted average fair value at grant date for nonvested equity-based awards issued during the period on other than stock (or unit) option plans (for example, phantom stock or unit plan, stock or unit appreciation rights plan, performance target plan).

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The estimated dividend rate (a percentage of the share price) to be paid (expected dividends) to holders of the underlying shares over the option's term.

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Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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The highest quantity of shares an employee can purchase under the plan per period.

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Net number of non-option equity instruments granted to participants.

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Number of shares authorized for issuance under share-based payment arrangement.

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The difference between the maximum number of shares (or other type of equity) authorized for issuance under the plan (including the effects of amendments and adjustments), and the sum of: 1) the number of shares (or other type of equity) already issued upon exercise of options or other equity-based awards under the plan; and 2) shares (or other type of equity) reserved for issuance on granting of outstanding awards, net of cancellations and forfeitures, if applicable.

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Gross number of share options (or share units) granted during the period.

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The weighted average grant-date fair value of options granted during the reporting period as calculated by applying the disclosed option pricing methodology.

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Percentage of vesting of award under share-based payment arrangement.

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Period from grant date that an equity-based award expires, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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Weighted average remaining contractual term for vested portions of options outstanding and currently exercisable or convertible, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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Number of shares issued during the period as a result of an employee stock purchase plan.

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Stock-based Compensation (Details Textual) $ / shares in Units, $ in Thousands	1 Months Ended		3 Months Ended				9 Months Ended		12 Months Ended
	Jan. 31, 2022 shares	Dec. 31, 2014 shares	Sep. 30, 2023 USD ($) plan shares	Mar. 31, 2023 shares	Sep. 30, 2022 shares	Mar. 31, 2022 shares	Sep. 30, 2023 USD ($) plan $ / shares shares	Sep. 30, 2022 $ / shares shares	Dec. 31, 2022 shares
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Number of plans \| plan			3				3
Total unrecognized compensation expense related to non-vested stock options and RSU awards \| $			$ 111,804				$ 111,804
Weighted-average term to recognize non-vested stock options and RSU awards							1 year 3 months 18 days
Employee stock purchase plan sales, net (in shares)			162,000	176,000	145,000	115,000	338,000	260,000
Outstanding stock options \| Non-employee Directors
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Award vesting period (in years)							1 year
Incentive Plan
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Number of common stock shares available for purchase (in shares)			11,934,000				11,934,000		4,206,000
Incentive Plan \| Outstanding stock options
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Weighted average grant date fair value stock option awards (in dollars per share) \| $ / shares							$ 6.40	$ 7.78
Incentive Plan \| Outstanding stock options \| Maximum
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Stock option awards remaining contractual term (in years)							10 years
Incentive Plan \| Outstanding stock options \| Vest 25% Each Year Until Fully Vested
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Award vesting rights, percentage							25.00%
Award vesting period (in years)							4 years
Incentive Plan \| Outstanding stock options \| Thirty-six Equal Monthly Installments \| Non-employee Directors
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Award vesting period (in years)							3 years
Incentive Plan \| Performance Shares \| Vest Upon Successful Completion of Specific Development Milestones
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Award vesting rights, percentage		85.00%
Performance-based stock options issued in period (in shares)		1,250,000
Incentive Plan \| Performance-based Restricted Stock Units
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Award vesting period (in years)	3 years
Incentive Plan \| Performance-based Restricted Stock Units \| Vest 25% Each Year Until Fully Vested
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Award vesting rights, percentage	25.00%
Incentive Plan \| Performance-based Restricted Stock Units \| Vest Upon Successful Completion of Specific Development Milestones
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Performance-based restricted stock unit awards issued (in shares)	221,000								21,000
Incentive Plan \| Performance-based Restricted Stock Units \| Share-Based Payment Arrangement, Tranche One
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Award vesting rights, percentage	50.00%
Incentive Plan \| Restricted Stock Units (RSUs)
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Weighted average grant date fair value (in dollars per share) \| $ / shares							$ 9.18	13.18
Inducement Plan
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Award vesting period (in years)							4 years
Expiration period (in years)							10 years
Weighted average grant date fair value stock option awards (in dollars per share) \| $ / shares							$ 6.14	9.72
Number of common stock shares available for purchase (in shares)			200,000				200,000		947,000
Inducement Plan \| Vest 25% Each Year Until Fully Vested
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Award vesting rights, percentage							25.00%
Inducement Plan \| Outstanding stock options
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Expected Dividend Yield							0.00%
Inducement Plan \| Restricted Stock Units (RSUs)
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Weighted average grant date fair value (in dollars per share) \| $ / shares							$ 8.35	$ 13.38
Employee Stock Purchase Plan
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Number of shares of common stock authorized to be purchased (in shares)			7,975,000				7,975,000
Number of common stock shares available for purchase (in shares)			5,454,000				5,454,000
Percentage of salary to purchase common stock, maximum							15.00%
Percentage of common stock shares, beginning							85.00%
Percentage of common stock shares, ending							85.00%
Maximum number of shares per employee (in shares)							3,000
Maximum number of shares per employee, amount \| $			$ 25				$ 25