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Income Taxes - Deferred Tax Assets and Liabilities (Details) - USD ($) $ in Thousands | Dec. 31, 2023 | Dec. 31, 2022
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Deferred tax assets: |  |
Net federal and state operating losses | $ 108,753 | $ 101,600
Research and development credits | 88,390 | 86,321
Royalty income | 122,391 | 115,554
Stock-based compensation | 26,113 | 19,374
Capitalized R&D | 75,081 | 62,794
Leasing obligations | 3,076 | 1,842
Other | 17,515 | 4,354
Total deferred tax assets | 441,319 | 391,839
Deferred tax liabilities: |  |
Fixed assets | (678) | (717)
Right of use asset | (2,872) | (1,525)
Total deferred tax liabilities | (3,550) | (2,242)
Valuation allowance | (437,098) | (389,608)
Net deferred tax assets (liabilities) | $ 671 |
Net deferred tax assets (liabilities) |  | $ (11)

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