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Income Taxes (Tables) | 12 Months Ended
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Dec. 31, 2023
Income Tax Disclosure [Abstract] |
Schedule Of Loss Before Provision For Income Taxes | The components of loss before provision for income taxes were as follows (in thousands):
| Years Ended December 31,
| 2023 |  | 2022 |  | 2021
Domestic | $ | (206,674) |  |  | $ | (225,127) |  |  | $ | (159,632) |
Foreign | (19,555) |  |  | (19,256) |  |  | (22,177) |
Loss before provision for income taxes | $ | (226,229) |  |  | $ | (244,383) |  |  | $ | (181,809) |
Schedule of Components of Income Tax (Benefit) Expense | The components of the (benefit) expense for income taxes were as follows (in thousands):
| Years Ended December 31,
| 2023 |  | 2022 |  | 2021
Current expense (benefit) provision: |  |  |  |  |
U.S. Federal and state | $ | (45) |  |  | $ | 2,430 |  |  | $ | 2,179 |
Foreign | 1,037 |  |  | 292 |  |  | 233 |
Total current expense provision | 992 |  |  | 2,722 |  |  | 2,412 |
Deferred expense (benefit) provision: |  |  |  |  |
U.S. Federal and state | (120) |  |  | 11 |  |  | (159) |
Foreign | (562) |  |  | — |  |  | — |
Total deferred expense provision | (682) |  |  | 11 |  |  | (159) |
Total expense provision | $ | 310 |  |  | $ | 2,733 |  |  | $ | 2,253 |
Summary Of The Differences Between The Company's Effective Tax Rate And Statutory Tax Rate | The differences between the Company’s effective tax rate and the statutory tax rate in 2023, 2022, and 2021 were as follows (in thousands):
| Years Ended December 31,
| 2023 |  | 2022 |  | 2021
Income tax benefit at federal statutory rate (21% for 2023, 2022 and 2021) | $ | (47,328) |  |  | $ | (51,321) |  |  | $ | (38,175) |
State and local income taxes net of federal tax benefit | (3,477) |  |  | (1,816) |  |  | (2,288) |
Permanent items | 3,015 |  |  | (1,608) |  |  | (1,343) |
Expiration of attribute carryforwards | — |  |  | — |  |  | (1,057) |
Research and development tax credits | (3,301) |  |  | (9,793) |  |  | (5,994) |
Foreign rate differential | 2,255 |  |  | 1,862 |  |  | 1,940 |
Other | 1,656 |  |  | (5,485) |  |  | 1,216 |
Change in valuation allowance | 47,490 |  |  | 70,894 |  |  | 47,954 |
Income tax expense | $ | 310 |  |  | $ | 2,733 |  |  | $ | 2,253 |
Schedule Of Unrecognized Tax Benefits | A reconciliation of the beginning and ending amount of unrecognized tax benefits is as follows (in thousands):
| 2023 |  | 2022
Balance at January 1, | $ | 13,844 |  |  | $ | 9,729 |
Additions to current period tax positions | 825 |  |  | 4,115 |
Reductions to prior period tax provisions | (307) |  |  | — |
Balance at December 31, | $ | 14,362 |  |  | $ | 13,844 |
Schedule Of Deferred Tax Assets And Liabilities | Significant components of the Company’s deferred tax assets and liabilities are as follows (in thousands):
| December 31,
| 2023 |  | 2022
Deferred tax assets: |  |  |
Net federal and state operating losses | $ | 108,753 |  |  | $ | 101,600 |
Research and development credits | 88,390 |  |  | 86,321 |
Royalty income | 122,391 |  |  | 115,554 |
Stock-based compensation | 26,113 |  |  | 19,374 |
Capitalized R&D | 75,081 |  |  | 62,794 |
Leasing obligations | 3,076 |  |  | 1,842 |
Other | 17,515 |  |  | 4,354 |
Total deferred tax assets | 441,319 |  |  | 391,839 |
Deferred tax liabilities: |  |  |
Fixed assets | (678) |  |  | (717) |
Right of use asset | (2,872) |  |  | (1,525) |
Total deferred tax liabilities | (3,550) |  |  | (2,242) |
Valuation allowance | (437,098) |  |  | (389,608) |
Net deferred tax assets (liabilities) | $ | 671 |  |  | $ | (11) |

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