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Insider Trading Arrangements
 3 Months Ended 12 Months Ended
Dec. 31, 2023
Dec. 31, 2023
Trading Arrangements, by Individual    
Rule 10b5-1 Arrangement Adopted false  
Non-Rule 10b5-1 Arrangement Adopted false  
Rule 10b5-1 Arrangement Terminated true  
Non-Rule 10b5-1 Arrangement Terminated false  
Officer Trading Arrangement [Member]    
Trading Arrangements, by Individual    
Material Terms of Trading Arrangement  
During the three months ended December 31, 2023, the directors and officers of the Company adopted or terminated the “Rule 10b5-1 trading arrangements” or “non-Rule 10b5-1 trading arrangements” (as each term is defined in Item 408(a) of Regulation S-K) set forth in the table below.

Name (Title)
Action
Termination Date
Type of Trading Arrangement
Duration of Trading Arrangement
Aggregate Number of Securities
Jon P. Stonehouse, President and Chief Executive Officer
TerminationNovember 7, 2023Rule 10b5-1 trading arrangement(1)(1)
Anthony J. Doyle, Chief Financial Officer and Treasurer
TerminationNovember 7, 2023Rule 10b5-1 trading arrangement(1)(1)
Helen M. Thackray, M.D., Chief Research & Development Officer
TerminationNovember 8, 2023Rule 10b5-1 trading arrangement(2)(2)
Alane P. Barnes, Chief Legal Officer and Secretary
TerminationNovember 7, 2023Rule 10b5-1 trading arrangement(1)(1)
Charles K. Gayer, Chief Commercial Officer
TerminationNovember 7, 2023Rule 10b5-1 trading arrangement(2)(2)
(1) This trading plan was originally adopted on March 11, 2022, to cover tax withholding obligations, commissions and any fees related to the vesting of restricted stock units, with a scheduled expiration date of December 31, 2025. The aggregate number of securities that would have been sold under this plan is indeterminable because the number of shares that would have been sold to satisfy applicable tax withholding obligations upon vesting is unknown, as the number would vary based on the extent to which vesting conditions were satisfied and the market price of the Company’s common stock at the time of settlement.
(2) This trading plan was originally adopted on March 14, 2022, to cover tax withholding obligations, commissions and any fees related to the vesting of restricted stock units, with a scheduled expiration date of December 31, 2025. The aggregate number of securities that would have been sold under this plan is indeterminable because the number of shares that would have been sold to satisfy applicable tax withholding obligations upon vesting is unknown, as the number would vary based on the extent to which vesting conditions were satisfied and the market price of the Company’s common stock at the time of settlement.
Officer Trading Arrangement [Member] | Jon P. Stonehouse [Member]    
Trading Arrangements, by Individual    
Name Jon P. Stonehouse  
Title President and Chief Executive Officer  
Rule 10b5-1 Arrangement Terminated true  
Termination Date November 7, 2023  
Officer Trading Arrangement [Member] | Anthony J. Doyle [Member]    
Trading Arrangements, by Individual    
Name Anthony J. Doyle  
Title Chief Financial Officer and Treasurer  
Rule 10b5-1 Arrangement Terminated true  
Termination Date November 7, 2023  
Officer Trading Arrangement [Member] | Helen M. Thackray [Member]    
Trading Arrangements, by Individual    
Name Helen M. Thackray, M.D.  
Title Chief Research & Development Officer  
Rule 10b5-1 Arrangement Terminated true  
Termination Date November 8, 2023  
Officer Trading Arrangement [Member] | Alane P. Barnes [Member]    
Trading Arrangements, by Individual    
Name Alane P. Barnes  
Title Chief Legal Officer and Secretary  
Rule 10b5-1 Arrangement Terminated true  
Termination Date November 7, 2023  
Officer Trading Arrangement [Member] | Charles K. Gayer [Member]    
Trading Arrangements, by Individual    
Name Charles K. Gayer  
Title Chief Commercial Officer  
Rule 10b5-1 Arrangement Terminated true  
Termination Date November 7, 2023