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Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 3 Months Ended
--- | ---
Mar. 31, 2024 | Mar. 31, 2023
Cash flows from operating activities: |  |
Net loss | $ (35,379) | $ (53,333)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation and amortization | 306 | 405
Inventory obsolescence | 0 | 236
Stock-based compensation expense | 13,652 | 14,007
Non-cash interest expense on royalty financing obligations and secured term loan and amortization of debt issuance costs | 19,440 | 20,216
Amortization of premium/discount on investments | (3,181) | (1,385)
Changes in operating assets and liabilities: |  |
Receivables | (3,839) | 2,019
Inventory | (1,220) | 131
Prepaid expenses and other assets | 1,106 | (2,547)
Accounts payable and accrued expenses | (44,569) | (27,226)
Deferred revenue | 0 | (35)
Net cash used in operating activities | (53,684) | (47,512)
Cash flows from investing activities: |  |
Acquisitions of property and equipment | (235) | (160)
Purchase of investments | (88,009) | (148,637)
Sales and maturities of investments | 117,000 | 41,688
Net cash provided by (used in) investing activities | 28,756 | (107,109)
Cash flows from financing activities: |  |
Net proceeds from common stock issued under stock-based compensation plans | 1,681 | 5,077
Net proceeds from common stock issued to directors in lieu of cash retainer | 11 | 0
Withholding taxes paid on stock-based awards | (2,350) | 0
Principal payments on finance lease liabilities | (390) | 0
Net cash (used in) provided by financing activities | (1,048) | 5,077
Effect of exchange rate on cash, cash equivalents, and restricted cash | (340) | (96)
Decrease in cash, cash equivalents and restricted cash | (26,316) | (149,640)
Cash, cash equivalents and restricted cash at beginning of period | 112,447 | 306,239
Cash, cash equivalents and restricted cash at end of period | 86,131 | 156,599
Supplemental Cash Flow Information [Abstract] |  |
Cash paid for interest | 4,987 | 7,142
Cash paid for taxes | 186 | 142
Taxes withheld on stock-based awards included in accrued expenses | $ 1,846 | $ 2,128

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