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Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 6 Months Ended
--- | ---
Jun. 30, 2024 | Jun. 30, 2023
Cash flows from operating activities: |  |
Net loss | $ (48,053) | $ (128,659)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation and amortization | 626 | 812
Inventory obsolescence | 1 | 238
Stock-based compensation expense | 26,825 | 26,848
Non-cash interest expense on royalty financing obligations and secured term loan and amortization of debt issuance costs | 39,041 | 43,935
Amortization of premium/discount on investments | (6,674) | (4,217)
Loss on extinguishment of debt | 0 | 29,019
Changes in operating assets and liabilities: |  |
Receivables | (12,085) | (6,968)
Inventory | (481) | 1,029
Prepaid expenses and other assets | 2,851 | (1,484)
Accounts payable and accrued expenses | (57,103) | (27,414)
Deferred revenue | 0 | 535
Net cash used in operating activities | (55,052) | (66,326)
Cash flows from investing activities: |  |
Acquisitions of property and equipment | (390) | (627)
Purchase of investments | (200,303) | (233,530)
Sales and maturities of investments | 227,000 | 108,013
Net cash provided by (used in) investing activities | 26,307 | (126,144)
Cash flows from financing activities: |  |
Net proceeds from common stock issued under stock-based compensation plans | 1,945 | 6,825
Common stock issued to directors in lieu of cash retainer | 23 | 206
Withholding taxes paid on stock-based awards | (4,190) | 0
Net proceeds from Pharmakon Tranche A term loan | 0 | 300,000
Repayment of Athyrium secured term loans principal | 0 | (240,452)
Prepayment and repayment fees on Athyrium secured term loans | 0 | (21,261)
Payment of debt issuance costs on Pharmakon Tranche A term loan | 0 | (10,885)
Principal payments on finance lease liabilities | (792) | 0
Net cash (used in) provided by financing activities | (3,014) | 34,433
Effect of exchange rate on cash, cash equivalents, and restricted cash | (483) | (413)
Decrease in cash, cash equivalents and restricted cash | (32,242) | (158,450)
Cash, cash equivalents and restricted cash at beginning of period | 112,447 | 306,239
Cash, cash equivalents and restricted cash at end of period | 80,205 | 147,789
Supplemental Cash Flow Information [Abstract] |  |
Cash paid for interest | 10,041 | 12,300
Cash paid for taxes | 865 | 1,126
Taxes withheld on stock-based awards included in accrued expenses | $ 189 | $ 2,188

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