<SEC-DOCUMENT>0001971857-24-000841.txt : 20241213
<SEC-HEADER>0001971857-24-000841.hdr.sgml : 20241213
<ACCEPTANCE-DATETIME>20241213162329
ACCESSION NUMBER:		0001971857-24-000841
CONFORMED SUBMISSION TYPE:	144
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20241213
DATE AS OF CHANGE:		20241213

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			BIOCRYST PHARMACEUTICALS INC
		CENTRAL INDEX KEY:			0000882796
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		ORGANIZATION NAME:           	03 Life Sciences
		IRS NUMBER:				621413174
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		144
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	000-23186
		FILM NUMBER:		241548701

	BUSINESS ADDRESS:	
		STREET 1:		4505 EMPEROR BOULEVARD
		STREET 2:		SUITE 200
		CITY:			DURHAM
		STATE:			NC
		ZIP:			27703
		BUSINESS PHONE:		919-859-1302

	MAIL ADDRESS:	
		STREET 1:		4505 EMPEROR BOULEVARD
		STREET 2:		SUITE 200
		CITY:			DURHAM
		STATE:			NC
		ZIP:			27703

REPORTING-OWNER:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Hutson Nancy J
		CENTRAL INDEX KEY:			0001379222
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		144

	MAIL ADDRESS:	
		STREET 1:		64 MONTAUK AVENUE
		CITY:			STONINGTON
		STATE:			CT
		ZIP:			06378
</SEC-HEADER>
<DOCUMENT>
<TYPE>144
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001379222</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0000882796</issuerCik>
      <issuerName>BIOCRYST PHARMACEUTICALS INC</issuerName>
      <secFileNumber>000-23186</secFileNumber>
      <issuerAddress>
        <com:street1>4505 EMPEROR BOULEVARD</com:street1>
        <com:street2>SUITE 200</com:street2>
        <com:city>DURHAM</com:city>
        <com:stateOrCountry>NC</com:stateOrCountry>
        <com:zipCode>27703</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>919-859-1302</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Hutson Nancy J</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Director</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Merrill Lynch</name>
        <address>
          <com:street1>1800 K ST NW</com:street1>
          <com:street2>Suite 800</com:street2>
          <com:city>Washington</com:city>
          <com:stateOrCountry>DC</com:stateOrCountry>
          <com:zipCode>20006</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>7000</noOfUnitsSold>
      <aggregateMarketValue>52584.00</aggregateMarketValue>
      <noOfUnitsOutstanding>207132571</noOfUnitsOutstanding>
      <approxSaleDate>12/13/2024</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common</securitiesClassTitle>
      <acquiredDate>06/13/2024</acquiredDate>
      <natureOfAcquisitionTransaction>RSU Vesting under Stock Plan</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>16745</amountOfSecuritiesAcquired>
      <paymentDate>06/13/2024</paymentDate>
      <natureOfPayment>n/a</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <remarks>The sale reported on this Form 144 was made pursuant to a Rule 10b5-1 trading plan previously entered into by the reporting person for the sole purpose of generating sufficient proceeds to cover the tax liability incurred in connection with the vesting of previously granted restricted stock units.</remarks>
    <noticeSignature>
      <noticeDate>12/13/2024</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>06/18/2024</planAdoptionDate>
      </planAdoptionDates>
      <signature>Nancy J Hutson</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
