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Significant Accounting Policies and Concentrations of Risk (Tables) | 12 Months Ended
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Dec. 31, 2024
Accounting Policies [Abstract] |
Summary of Revenues | The Company recorded the following revenues for the years ended December 31, 2024, 2023, and 2022 (in thousands):
| Years Ended December 31,
| 2024 |  | 2023 |  | 2022
Product sales, net | $ | 442,668 |  |  | $ | 324,696 |  |  | $ | 267,710 |
Collaborative and other revenues | 8,044 |  |  | 6,716 |  |  | 3,117 |
Total revenues | $ | 450,712 |  |  | $ | 331,412 |  |  | $ | 270,827 |
The Company recorded the following revenues for the years ended December 31, 2024, 2023, and 2022 (in thousands):
| Years Ended December 31,
| 2024 |  | 2023 |  | 2022
ORLADEYO: |  |  |  |  |
U.S. | $ | 385,961 |  |  | $ | 288,361 |  |  | $ | 226,358 |
Outside of U.S. | 51,699 |  |  | 37,629 |  |  | 25,275 |
Total ORLADEYO | 437,660 |  |  | 325,990 |  |  | 251,633 |
Other revenues | 13,052 |  |  | 5,422 |  |  | 19,194 |
Total revenues | $ | 450,712 |  |  | $ | 331,412 |  |  | $ | 270,827 |
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share | The Company excluded the following potential common shares, presented based on amounts outstanding as of December 31, 2024 and 2023, from the computation of diluted net loss per share attributable to common stockholders for the years ended December 31, 2024 and 2023 because including them would have had an anti-dilutive effect:
| December 31,
| 2024 |  | 2023
Outstanding stock options | 44,240 |  |  | 41,032 |
Unvested restricted stock unit awards | 10,112 |  |  | 6,507 |
Total | 54,352 |  |  | 47,539 |

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- Definition Tabular disclosure of disaggregation of revenue into categories depicting how nature, amount, timing, and uncertainty of revenue and cash flows are affected by economic factor. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 606 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 5 -Publisher FASB -URI https://asc.fasb.org/1943274/2147479806/606-10-50-5 + Details
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- Definition Tabular disclosure of securities (including those issuable pursuant to contingent stock agreements) that could potentially dilute basic earnings per share (EPS) in the future that were not included in the computation of diluted EPS because to do so would increase EPS amounts or decrease loss per share amounts for the period presented, by antidilutive securities. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Topic 260 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (c) -Publisher FASB -URI https://asc.fasb.org/1943274/2147482662/260-10-50-1 + Details
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