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Segment Information | 12 Months Ended
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Dec. 31, 2024
Segment Reporting [Abstract] |
Segment Information | Segment Information The Company operates as one operating and reportable segment, centered around its commercialized product, ORLADEYO, and its pipeline with the goal of developing first-in-class or best-in-class oral small-molecule and injectable protein therapeutics to target difficult-to-treat rare diseases. The determination of a single segment is consistent with the consolidated financial information regularly provided to the Company’s chief operating decision maker (“CODM”). The Chief Executive Officer, as the CODM, uses consolidated, single-segment financial information for purposes of evaluating performance, making operating decisions, allocating resources, and planning and forecasting for future periods. The CODM assesses performance and decides how to allocate resources based on consolidated net loss. This measure is used to monitor budget versus actual results to evaluate the performance of the segment. The CODM uses consolidated cash, cash equivalents and investments as the measure of segment assets. As of December 31, 2024 and 2023, the Company’s cash, cash equivalents, and investments were $341,173 and $388,987, respectively. The following table illustrates information about segment revenues, significant segment expenses, and segment net loss for the years ended December 31, 2024, 2023, and 2022 (in thousands):
| Years Ended December 31,
| 2024 |  | 2023 |  | 2022
Revenues | $ | 450,712 |  |  | $ | 331,412 |  |  | $ | 270,827 |
Less 1: |  |  |  |  |
Cost of product sales | 12,269 |  |  | 4,481 |  |  | 6,408 |
Research and development |  |  |  |  |
Berotralstat | 45,033 |  |  | 42,835 |  |  | 32,637 |
Factor D Program | 24,072 |  |  | 94,517 |  |  | 174,234 |
BCX17725 | 32,417 |  |  | 19,133 |  |  | — |
Other research, preclinical and development costs | 73,116 |  |  | 60,081 |  |  | 46,426 |
Selling, general and administrative | 266,132 |  |  | 213,894 |  |  | 159,371 |
Royalty | 216 |  |  | 180 |  |  | 186 |
Other segment items 2 | 641 |  |  | 30,058 |  |  | 1,983 |
Interest income | (14,746) |  |  | (15,777) |  |  | (5,127) |
Interest expense | 98,516 |  |  | 108,239 |  |  | 99,092 |
Income tax expense | 1,927 |  |  | 310 |  |  | 2,733 |
Segment net loss | (88,881) |  |  | (226,539) |  |  | (247,116) |
Reconciliation of segment profit or loss: |  |  |  |  |
Adjustments and reconciling items | — |  |  | — |  |  | — |
Consolidated net loss | $ | (88,881) |  |  | $ | (226,539) |  |  | $ | (247,116) |
1 The significant expense categories and amounts align with the segment-level information that is regularly provided to the CODM.
2 Other segment items included in Segment net loss include loss on extinguishment of debt and foreign currency losses, net.
All material long-lived assets of the Company reside in the U.S. For geographic information about the Company’s product revenues, see “Note 2—Revenue”.

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- Definition The entire disclosure for reporting segments including data and tables. Reportable segments include those that meet any of the following quantitative thresholds a) it's reported revenue, including sales to external customers and intersegment sales or transfers is 10 percent or more of the combined revenue, internal and external, of all operating segments b) the absolute amount of its reported profit or loss is 10 percent or more of the greater, in absolute amount of 1) the combined reported profit of all operating segments that did not report a loss or 2) the combined reported loss of all operating segments that did report a loss c) its assets are 10 percent or more of the combined assets of all operating segments. + References Reference 1: http://www.xbrl.org/2003/role/exampleRef -Topic 280 -SubTopic 10 -Name Accounting Standards Codification -Section 55 -Paragraph 48 -Publisher FASB -URI https://asc.fasb.org/1943274/2147482785/280-10-55-48 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Topic 280 -SubTopic 10 -Name Accounting Standards 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