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v3.25.0.1

Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2022
Cash flows from operating activities: |  |  |
Net loss | $ (88,881) | $ (226,539) | $ (247,116)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Depreciation and amortization | 1,246 | 1,655 | 1,437
Inventory obsolescence | 1,350 | 422 | 932
Stock-based compensation expense | 65,413 | 55,615 | 44,701
Non-cash interest expense on royalty financing obligations and secured term loan and amortization of debt issuance costs | 67,607 | 85,803 | 98,918
Amortization of premium (discount) on investments, net | (11,473) | (10,263) | (1,777)
Loss on extinguishment of debt | 0 | 29,019 | 0
Loss on impairment | 0 | 1,548 | 0
Changes in operating assets and liabilities: |  |  |
Receivables | (22,698) | (6,095) | (21,470)
Inventory | (4,164) | (1,450) | (12,423)
Prepaid expenses and other assets | 1,959 | (6,820) | (2,583)
Accounts payable and accrued expenses | (62,379) | (16,806) | (22,360)
Deferred revenue | 0 | (1,230) | (109)
Net cash used in operating activities | (52,020) | (95,141) | (161,850)
Cash flows from investing activities: |  |  |
Acquisitions of property and equipment | (1,124) | (2,168) | (1,351)
Purchases of investments | (266,763) | (514,407) | (244,283)
Maturities of investments | 320,480 | 385,077 | 117,396
Net cash provided by (used in) investing activities | 52,593 | (131,498) | (128,238)
Cash flows from financing activities: |  |  |
Net proceeds from common stock issued under stock-based compensation plans | 3,444 | 8,340 | 14,765
Common stock issued to directors in lieu of cash retainer | 34 | 342 | 190
Withholding taxes paid on stock-based awards | (7,535) | (2,172) | 0
Net proceeds from secured term loans | 0 | 300,000 | 73,072
Repayment of Athyrium secured term loans principal | 0 | (240,452) | 0
Prepayment and repayment fees on Athyrium secured term loans | 0 | (21,261) | 0
Payment of debt issuance costs on Pharmakon Tranche A term loan | 0 | (11,147) | 0
Principal payments on finance lease liabilities | (1,704) | (1,165) | 0
Net cash (used in) provided by financing activities | (5,761) | 32,485 | 88,027
Effect of exchange rates on cash, cash equivalents and restricted cash | (936) | 362 | 566
Decrease in cash, cash equivalents and restricted cash | (6,124) | (193,792) | (201,495)
Cash, cash equivalents and restricted cash at beginning of year | 112,447 | 306,239 | 507,734
Cash, cash equivalents and restricted cash at end of year | 106,323 | 112,447 | 306,239
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents [Abstract] |  |  |
Cash and cash equivalents | 104,713 | 110,643 | 304,767
Restricted cash | 210 | 1,804 | 1,472
Restricted cash in other assets | 1,400 | 0 | 0
Total cash, cash equivalents and restricted cash | 106,323 | 112,447 | 306,239
Supplemental cash flow disclosure: |  |  |
Cash paid for interest | 30,383 | 22,139 | 0
Cash paid for taxes | 1,603 | 1,434 | 3,542
Taxes withheld on stock-based awards included in accrued expenses | $ 758 | $ 4,199 | $ 1,990

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