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Income Taxes - Deferred Tax Assets and Liabilities (Details) - USD ($) $ in Thousands | Dec. 31, 2024 | Dec. 31, 2023
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Deferred tax assets: |  |
Net federal and state operating losses | $ 105,865 | $ 108,753
Research and development credits | 87,287 | 88,390
Royalty income | 117,570 | 122,391
Stock-based compensation | 34,486 | 26,113
Capitalized R&D | 82,476 | 75,081
Leasing obligations | 2,806 | 3,076
Other | 22,693 | 17,515
Total deferred tax assets | 453,183 | 441,319
Deferred tax liabilities: |  |
Fixed assets | (797) | (678)
Right of use asset | (2,620) | (2,872)
Total deferred tax liabilities | (3,417) | (3,550)
Valuation allowance | (448,740) | (437,098)
Net deferred tax assets | $ 1,026 | $ 671

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