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Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 12 Months Ended
Sep. 30, 2021
Sep. 30, 2020
Sep. 30, 2019
Cash flows from operating activities      
Net loss $ (152,098) $ (139,931) $ (107,669)
Adjustments to reconcile net loss to net cash used in operating activities      
Depreciation and amortization 9,750 6,677 6,111
Non-cash lease expense 2,243 (1,043)  
Loss on disposal of property and equipment 2   189
Stock-based compensation 36,998 17,096 11,170
Discount (premium) accretion on investment securities 593 (214) (1,249)
Realized gain on investments (5)    
Allowance for doubtful accounts 40    
Change in fair value of contingent consideration and indemnity holdback (534)    
Non-cash interest expense 67 152 233
Amortization of debt discount 81 184 282
Changes in assets and liabilities:      
Accounts receivable, net (2,202) (14,272) (6,685)
Inventories (19,489) (4,956) (1,302)
Prepaid expenses and other current assets (2,058) (3,683) 746
Other non-current assets (4,653) (554) (2,064)
Accounts payable 8,542 (5,506) 3,278
Accrued expenses 3,115 (2,648) 4,210
Accrued compensation 7,392 4,465 5,060
Other liabilities (28) 1,978 (247)
Net cash used in operating activities (112,244) (142,255) (87,937)
Cash flows from investing activities      
Purchases of property and equipment (27,061) (9,868) (14,757)
Proceeds from sale of property and equipment     21
Business acquisition, net of cash acquired (483)    
Purchases of investments (58,795) (202,882) (177,574)
Proceeds from maturity of investments 242,494 98,100 87,500
Net cash provided by (used in) investing activities 156,155 (114,650) (104,810)
Cash flows from financing activities      
Proceeds from exercise of stock options 14,559 10,495 2,170
Proceeds from public offerings, net of underwriting discounts, commissions and offering expenses 323,861 295,563 156,208
Proceeds from issuance under employee stock purchase plan 4,944 3,428 2,700
Repayments of long-term debt (3,333) (3,333) (2,500)
Repurchases of common stock for income tax withholding (10,849) (2,421)  
Net cash provided by financing activities 329,182 303,732 158,578
Effect of exchange rates on cash, cash equivalents and restricted cash 20 21 30
Net increase (decrease) in cash, cash equivalents and restricted cash 373,113 46,848 (34,139)
Cash, cash equivalents, and restricted cash at beginning of year 94,246 47,398 81,537
Cash, cash equivalents, and restricted cash at end of year 467,359 94,246 47,398
Supplemental disclosure of cash flow information      
Interest paid 167 438 779
Income taxes paid, net of refunds 101 172 291
Non-cash investing and financing activities      
Property and equipment additions included in accrued expenses and accounts payable 2,011 1,333 170
Operating lease right-of-use assets obtained in exchange for operating lease liabilities 33,617 $ 3,718  
Conversion of redeemable convertible preferred stock warrant liability to equity     631
Conversion of redeemable convertible preferred stock to common stock     $ 290,462
Issuance of common stock in connection with the iGenomX acquisition $ 26,773