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Commitments and Contingencies - Narrative (Details) |  | 1 Months Ended | 3 Months Ended | 6 Months Ended |
--- | --- | --- | --- | --- | ---
Jan. 01, 2021 USD ($) shares | Aug. 31, 2023 USD ($) | Jun. 30, 2024 USD ($) | Jun. 30, 2023 USD ($) | Jun. 30, 2024 USD ($) | Jun. 30, 2023 USD ($) | Mar. 31, 2024 term
Liability For Sale of Future Royalties [Line Items] |  |  |  |  |  |  |
Research and development |  |  | $ 314,819,000 | $ 79,490,000 | $ 470,791,000 | $ 142,951,000 |
Pittsburgh Centre Avenue Lease Agreement |  |  |  |  |  |  |
Liability For Sale of Future Royalties [Line Items] |  |  |  |  |  |  |
Lease agreement, term (in months) |  |  |  |  |  |  | 122 months
Option to extend, term | term |  |  |  |  |  |  | 1
Extension term (in months) |  |  |  |  |  |  | 60 months
Pittsburgh Centre Avenue Lease Agreement | Minimum |  |  |  |  |  |  |
Liability For Sale of Future Royalties [Line Items] |  |  |  |  |  |  |
Annual commitments |  |  | 1,859,000 |  | 1,859,000 |  |
Pittsburgh Centre Avenue Lease Agreement | Maximum |  |  |  |  |  |  |
Liability For Sale of Future Royalties [Line Items] |  |  |  |  |  |  |
Annual commitments |  |  | $ 2,373,000 |  | 2,373,000 |  |
Moda Agreement |  |  |  |  |  |  |
Liability For Sale of Future Royalties [Line Items] |  |  |  |  |  |  |
Eligible commercial milestone payments |  | $ 23,000,000 |  |  |  |  |
Eligible develoment and regulatory milestone payments |  | $ 25,200,000 |  |  |  |  |
Moda Pharmaceuticals LLC |  |  |  |  |  |  |
Liability For Sale of Future Royalties [Line Items] |  |  |  |  |  |  |
Research and development |  |  |  | $ 0 | 850,000 | $ 0 |
Moda Pharmaceuticals LLC | Moda Agreement |  |  |  |  |  |  |
Liability For Sale of Future Royalties [Line Items] |  |  |  |  |  |  |
Eligible development milestone payments | $ 81,612,000 |  |  |  |  |  |
Eligible commercial milestone payments | $ 30,171,000 |  |  |  |  |  |
Initial term of agreement (in years) | 4 years |  |  |  |  |  |
Moda Pharmaceuticals LLC | License agreement | Moda Agreement |  |  |  |  |  |  |
Liability For Sale of Future Royalties [Line Items] |  |  |  |  |  |  |
Payment for license agreement | $ 2,700,000 |  |  |  |  |  |
Issuance of common shares as payment for assets (in shares) | shares | 37,836 |  |  |  |  |  |
Issuance of common shares as payment for assets | $ 3,243,000 |  |  |  |  |  |
Research and Development Arrangement |  |  |  |  |  |  |
Liability For Sale of Future Royalties [Line Items] |  |  |  |  |  |  |
Research commitments |  |  |  |  | $ 0 |  |

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