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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 6 Months Ended
--- | ---
Jun. 30, 2024 | Jun. 30, 2023
Cash flows from operating activities: |  |
Net loss | $ (499,275) | $ (160,838)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation and amortization | 3,400 | 3,480
Non-cash share-based compensation | 47,109 | 8,460
Issuance of common shares as payment for acquisition of IPR&D asset | 10,793 | 0
Issuance of common shares as payment under license and other agreements | 71,618 | 0
Fair value of forward contract and derivative liabilities under license agreement | 102,529 | 0
Change in fair value of forward contract and derivative liabilities | (9,129) | 0
Issuance of warrant under license agreement | 3,340 | 0
Other non-cash items, net | (3,129) | (3,682)
Changes in operating assets and liabilities, net of effects of acquisition: |  |
Prepaid expenses and other current and non-current assets | (13,491) | 39,283
Accounts payable | (60) | 1,336
Accrued expenses and other current and non-current liabilities | 15,860 | (10,070)
Net cash used in operating activities | (270,435) | (122,031)
Cash flows from investing activities: |  |
Proceeds from maturities of marketable securities | 182,364 | 124,977
Proceeds from sales of marketable securities | 0 | 4,920
Purchases of marketable securities | (243,266) | (53,372)
Purchases of property and equipment | (3,389) | (1,330)
Cash acquired from acquisition of IPR&D asset | 391 | 0
Net cash (used in) provided by investing activities | (63,900) | 75,195
Cash flows from financing activities: |  |
Proceeds from issuance of common shares | 318,520 | 0
Payment of issuance costs | (800) | 0
Change in restricted cash due to Former Parent | 0 | 5,203
Proceeds from equity incentive plan and employee share purchase plan | 4,568 | 1,126
Other financing activities, net | 2,258 | 0
Net cash provided by financing activities | 324,546 | 6,329
Effects of exchange rates on cash, cash equivalents, and restricted cash | (13) | (147)
Net decrease in cash, cash equivalents, and restricted cash | (9,802) | (40,654)
Cash, cash equivalents, and restricted cash at beginning of period | 252,120 | 242,604
Cash, cash equivalents, and restricted cash at end of period | $ 242,318 | $ 201,950

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