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Shareholders' Equity - Changes in Shareholders' Deficit (Details) - USD ($)
$ in Thousands
3 Months Ended 6 Months Ended
Jun. 30, 2024
Mar. 31, 2024
Jun. 30, 2023
Mar. 31, 2023
Jun. 30, 2024
Jun. 30, 2023
Increase (Decrease) in Stockholders' Equity [Roll Forward]            
Net loss $ (319,771)   $ (90,346)   $ (499,275) $ (160,838)
Other comprehensive (loss) income 28   (146)   (13) (264)
Total Shareholders' Equity            
Increase (Decrease) in Stockholders' Equity [Roll Forward]            
Beginning balance 301,447 $ 427,975 472,258 $ 538,771 427,975 538,771
Net loss (319,771) (179,504) (90,346) (70,492)    
Issuance of common shares, net of offering costs 317,720          
Issuance of common shares as payment for assets 446 10,347        
Issuance of common shares as payment under license and other agreements 65,981 5,637        
Issuance of common shares under 2022 Equity Incentive Plan   2,156   332    
Issuance of common shares under 2022 Equity Incentive Plan and 2022 Employee Share Purchase Plan 2,317   794      
Issuance of warrant as payment under license agreement 3,340          
Non-cash share-based compensation expense 12,232 34,877 4,695 3,765    
Other comprehensive (loss) income 28 (41) (146) (118)    
Ending balance $ 383,740 $ 301,447 $ 387,255 $ 472,258 $ 383,740 $ 387,255
Common Shares            
Increase (Decrease) in Stockholders' Equity [Roll Forward]            
Beginning balance (in shares) 81,807,221 81,115,723 68,212,479 68,190,479 81,115,723 68,190,479
Beginning balance $ 910,964 $ 887,528 $ 616,246 $ 615,742 $ 887,528 $ 615,742
Issuance of common shares, net of offering costs(in shares) 8,544,951          
Issuance of common shares, net of offering costs $ 317,720          
Issuance of common shares as payment for assets (in shares) 10,452 242,958        
Issuance of common shares as payment for assets $ 446 $ 10,347        
Issuance of common shares as payment under license and other agreements (in shares) 1,872,874 97,233        
Issuance of common shares as payment under license and other agreements $ 65,981 $ 5,637        
Issuance of common shares under equity incentive plan (shares)   351,307   22,000    
Issuance of common shares under 2022 Equity Incentive Plan   $ 7,452   $ 504    
Issuance of common shares under equity incentive plan and employee share purchase plan (in shares) 110,834   104,474      
Issuance of common shares under 2022 Equity Incentive Plan and 2022 Employee Share Purchase Plan $ 3,442   $ 1,264      
Ending balance (in shares) 92,346,332 81,807,221 68,316,953 68,212,479 92,346,332 68,316,953
Ending balance $ 1,298,553 $ 910,964 $ 617,510 $ 616,246 $ 1,298,553 $ 617,510
Additional Paid-in Capital            
Increase (Decrease) in Stockholders' Equity [Roll Forward]            
Beginning balance 69,385 39,804 17,462 13,869 39,804 13,869
Issuance of common shares under 2022 Equity Incentive Plan   (5,296)   (172)    
Issuance of common shares under 2022 Equity Incentive Plan and 2022 Employee Share Purchase Plan (1,125)   (470)      
Issuance of warrant as payment under license agreement 3,340          
Non-cash share-based compensation expense 12,232 34,877 4,695 3,765    
Ending balance 83,832 69,385 21,687 17,462 83,832 21,687
Accumulated Deficit            
Increase (Decrease) in Stockholders' Equity [Roll Forward]            
Beginning balance (678,796) (499,292) (161,616) (91,124) (499,292) (91,124)
Net loss (319,771) (179,504) (90,346) (70,492)    
Ending balance (998,567) (678,796) (251,962) (161,616) (998,567) (251,962)
Accumulated Other Comprehensive Loss            
Increase (Decrease) in Stockholders' Equity [Roll Forward]            
Beginning balance (106) (65) 166 284 (65) 284
Other comprehensive (loss) income 28 (41) (146) (118)    
Ending balance $ (78) $ (106) $ 20 $ 166 $ (78) $ 20