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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) | 9 Months Ended
--- | ---
Sep. 30, 2024 | Sep. 30, 2023
Cash flows from operating activities: |  |
Net loss | $ (659,579,000) | $ (263,412,000)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation and amortization | 5,394,000 | 5,018,000
Non-cash share-based compensation | 59,269,000 | 12,916,000
Issuance of common shares as payment for acquisition of IPR&D asset | 10,811,000 | 0
Issuance of common shares as payment under license and other agreements | 71,627,000 | 0
Fair value of forward contract and derivative liabilities under license agreement | 102,529,000 | 0
Change in fair value of forward contract and derivative liabilities | (21,179,000) | 0
Issuance of warrant under license agreement | 3,340,000 | 0
Other non-cash items, net | (6,749,000) | (4,696,000)
Changes in operating assets and liabilities, net of effects of acquisition: |  |
Prepaid expenses and other current and non-current assets | (290,000) | 28,428,000
Accounts payable | 2,425,000 | (1,188,000)
Accrued expenses and other current and non-current liabilities | 20,691,000 | 6,090,000
Net cash used in operating activities | (411,711,000) | (216,844,000)
Cash flows from investing activities: |  |
Proceeds from maturities of marketable securities | 312,364,000 | 214,224,000
Proceeds from sales of marketable securities | 0 | 4,920,000
Purchases of marketable securities | (466,053,000) | (82,822,000)
Purchases of property and equipment | (4,000,000) | (2,578,000)
Cash acquired from acquisition of IPR&D asset | 391,000 | 0
Net cash (used in) provided by investing activities | (157,298,000) | 133,744,000
Cash flows from financing activities: |  |
Proceeds from issuance of common shares | 394,881,000 | 0
Payment of issuance costs | (800,000) | 0
Change in restricted cash due to Former Parent | 0 | (35,184,000)
Proceeds from equity incentive plan and employee share purchase plan | 8,582,000 | 0
Other financing activities, net | 2,258,000 | 1,857,000
Net cash provided by (used in) financing activities | 404,921,000 | (33,327,000)
Effects of exchange rates on cash, cash equivalents, and restricted cash | (13,000) | (187,000)
Net decrease in cash, cash equivalents, and restricted cash | (164,101,000) | (116,614,000)
Cash, cash equivalents, and restricted cash at beginning of period | 252,120,000 | 242,604,000
Cash, cash equivalents, and restricted cash at end of period | $ 88,019,000 | $ 125,990,000

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