Shareholders' Equity (Tables)

9 Months Ended

Sep. 30, 2024

Stockholders' Equity Note [Abstract]

Schedule of changes in shareholders' equity (deficit)

Changes in shareholders’ equity for the three and nine months ended September 30, 2024 and September 30, 2023 were as follows:


	Common Shares
	Shares	Amount		Additional Paid-in Capital		Accumulated Deficit		Accumulated Other Comprehensive Loss		Total Shareholders' Equity
Balances as of December 31, 2023	81,115,723	$	887,528	$	39,804	$	(499,292)	$	(65)	$	427,975






Net loss	—	—		—		(179,504)		—		(179,504)
Issuance of common shares as payment for acquisition of IPR&D asset	242,958	10,347		—		—		—		10,347
Issuance of common shares as payment under license and other agreements	97,233	5,637		—		—		—		5,637
Issuance of common shares under 2022 Equity Incentive Plan	351,307	7,452		(5,296)		—		—		2,156
Non-cash share-based compensation expense	—	—		34,877		—		—		34,877
Other comprehensive loss	—	—		—		—		(41)		(41)
Balances as of March 31, 2024	81,807,221	910,964		69,385		(678,796)		(106)		301,447
Net loss	—	—		—		(319,771)		—		(319,771)
Issuance of common shares, net of offering costs	8,544,951	317,720		—		—		—		317,720
Issuance of common shares as payment for acquisition of IPR&D asset	10,452	446		—		—		—		446
Issuance of common shares as payment under license and other agreements	1,872,874	65,981		—		—		—		65,981
Issuance of common shares under 2022 Equity Incentive Plan and 2022 Employee Share Purchase Plan	110,834	3,442		(1,125)		—		—		2,317
Issuance of warrant as payment under license agreement	—	—		3,340		—		—		3,340
Non-cash share-based compensation expense	—	—		12,232		—		—		12,232
Other comprehensive income	—	—		—		—		28		28
Balances as of June 30, 2024	92,346,332	1,298,553		83,832		(998,567)		(78)		383,740
Net loss	—	—		—		(160,304)		—		(160,304)
Issuance of common shares, net of offering costs	2,154,857	76,361		—		—		—		76,361
Issuance of common shares as payment for acquisition of IPR&D asset	428	18		—		—		—		18
Issuance of common shares under 2022 Equity Incentive Plan	397,422	6,758		(2,954)		—		—		3,804
Issuance of common shares as payment under license and other agreements	154	9		—		—		—		9
Non-cash share-based compensation expense	—	—		12,160		—		—		12,160

Other comprehensive income	—	—		—		—		218		218
Balance as of September 30, 2024	94,899,193	$	1,381,699	$	93,038	$	(1,158,871)	$	140	$	316,006


	Common Shares
	Shares	Amount		Additional Paid-in Capital		Accumulated Deficit		Accumulated Other Comprehensive Income		Total Shareholders' Equity
Balances as of December 31, 2022	68,190,479	$	615,742	$	13,869	$	(91,124)	$	284	$	538,771
Net loss	—	—		—		(70,492)		—		(70,492)
Issuance of common shares under 2022 Equity Incentive Plan	22,000	504		(172)		—		—		332
Non-cash share-based compensation expense	—	—		3,765		—		—		3,765
Other comprehensive loss	—	—		—		—		(118)		(118)





Balances as of March 31, 2023	68,212,479	616,246		17,462		(161,616)		166		472,258
Net loss	—	—		—		(90,346)		—		(90,346)
Issuance of common shares under 2022 Equity Incentive Plan and 2022 Employee Share Purchase Plan	104,474	1,264		(470)		—		—		794
Non-cash share-based compensation expense	—	—		4,695		—		—		4,695
Other comprehensive loss	—	—		—		—		(146)		(146)
Balance as of June 30, 2023	68,316,953	617,510		21,687		(251,962)		20		387,255
Net loss	—	—		—		(102,574)		—		(102,574)
Issuance of common shares under 2022 Equity Incentive Plan	47,190	1,251		(520)		—		—		731
Non-cash share-based compensation expense	—	—		4,456		—		—		4,456
Other comprehensive income	—	—		—		—		138		138
Balance as of September 30, 2023	68,364,143	$	618,761	$	25,623	$	(354,536)	$	158	$	290,006