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Non-Cash Share-Based Compensation (Tables) | 6 Months Ended
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Jun. 30, 2026
Share-Based Payment Arrangement [Abstract] |
Schedule of non-cash share-based compensation expense | Non-cash share-based compensation expense, consisting of expense for share options, restricted share units ("RSUs"), performance share options, and the Employee Share Purchase Plan, was classified in the condensed consolidated statements of operations and comprehensive loss as follows:
|  | Three Months Ended June 30, |  | Six Months Ended June 30,
|  | 2026 |  | 2025 |  | 2026 |  | 2025
Research and development expenses |  | $ | 11,983 |  |  | $ | 13,110 |  |  | $ | 30,458 |  |  | $ | 48,344 |
General and administrative expenses |  | 7,181 |  |  | 7,702 |  |  | 16,992 |  |  | 25,530 |
Total non-cash share-based compensation expense |  | $ | 19,164 |  |  | $ | 20,812 |  |  | $ | 47,450 |  |  | $ | 73,874 |
Schedule of stock option activity | The following table is a summary of the Company's share option activity for the six months ended June 30, 2026:
|  | Number of Shares |  | Weighted Average Exercise Price |  | Weighted Average Remaining Contractual Term |  | Aggregate Intrinsic Value
|  |  |  |  |  | (in years) |  |
Outstanding as of December 31, 2025 |  | 15,649,514 |  | $ | 21.06 |  |  |  |  |
Granted |  | 5,213,525 |  |  | $ | 11.34 |  |  |  |  |
Exercised |  | (306,185) |  |  | $ | 7.04 |  |  |  |  |
Forfeited |  | (181,320) |  |  | $ | 27.75 |  |  |  |  |
Outstanding as of June 30, 2026 |  | 20,375,534 |  | $ | 18.72 |  |  | 7.66 |  | $ | 75,673 |
Options exercisable as of June 30, 2026 |  | 13,947,512 |  | $ | 17.79 |  |  | 7.00 |  | $ | 61,344 |
Vested and expected to vest as of June 30, 2026 |  | 20,375,534 |  | $ | 18.72 |  |  | 7.66 |  | $ | 75,673 |
Schedule of RSU activity | The following table is a summary of the RSU activity for the six months ended June 30, 2026:
|  | Number of shares |  | Weighted Average Grant Date Fair Value
Unvested as of December 31, 2025 |  | 1,402,696 |  |  | $ | 38.48 |
Granted |  | 15,850 |  |  | $ | 11.02 |
Vested |  | (482,437) |  |  | $ | 39.01 |
Forfeited |  | (36,530) |  |  | $ | 38.97 |
Unvested as of June 30, 2026 |  | 899,579 |  |  | $ | 37.70 |

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- Definition Tabular disclosure of allocation of amount expensed and capitalized for award under share-based payment arrangement to statement of income or comprehensive income and statement of financial position. Includes, but is not limited to, corresponding line item in financial statement. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1) -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 + Details
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- Definition Tabular disclosure of the number and weighted-average grant date fair value for restricted stock units that were outstanding at the beginning and end of the year, and the number of restricted stock units that were granted, vested, or forfeited during the year. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 718 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (c)(1) -Publisher FASB -URI https://asc.fasb.org/1943274/2147480429/718-10-50-2 + Details
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