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v3.26.1

Segment Information (Details) $ in Thousands | 3 Months Ended | 6 Months Ended
--- | --- | ---
Jun. 30, 2026 USD ($) | Jun. 30, 2025 USD ($) | Jun. 30, 2026 USD ($) segment | Jun. 30, 2025 USD ($)
Segment Reporting [Line Items] |  |  |  |
Number of operating segments | segment |  |  | 1 |
Number of reportable segments | segment |  |  | 1 |
Provision for income taxes | $ 391 | $ 261 | $ 663 | $ 870
Net loss | 137,311 | 198,147 | 267,843 | 419,824
Operating Segments | Reportable Segment |  |  |  |
Segment Reporting [Line Items] |  |  |  |
Preclinical research programs R&D Expense | 7,730 | 16,398 | 16,279 | 41,933
R&D personnel expense (excluding share-based compensation) | 19,421 | 20,490 | 40,433 | 41,627
R&D Share-based compensation expense | 11,983 | 13,110 | 30,458 | 48,344
G&A personnel expense (excluding share-based compensation) | 5,765 | 6,004 | 11,220 | 12,478
G&A Share-based compensation expense | 7,181 | 7,702 | 16,992 | 25,530
Other segment items | 15,736 | 20,706 | 30,191 | 37,660
Non-operating expense (income) | 12,021 | (13,815) | 11,853 | (14,308)
Provision for income taxes | 391 | 261 | 663 | 870
Net loss | 137,311 | 198,147 | 267,843 | 419,824
Operating Segments | BHV-4157 (Troriluzole) | Reportable Segment |  |  |  |
Segment Reporting [Line Items] |  |  |  |
Direct R&D program expense | 7,704 | 14,245 | 14,626 | 28,033
Operating Segments | BHV-2000 (Taldefgrobep Alfa) | Reportable Segment |  |  |  |
Segment Reporting [Line Items] |  |  |  |
Direct R&D program expense | 5,730 | 8,045 | 15,062 | 14,229
Operating Segments | BHV-7000 & BHV-7010 (Kv7) | Reportable Segment |  |  |  |
Segment Reporting [Line Items] |  |  |  |
Direct R&D program expense | 13,845 | 31,172 | 33,578 | 62,744
Operating Segments | BHV-2100 & BHV-2110 (TRPM3 Antagonist) | Reportable Segment |  |  |  |
Segment Reporting [Line Items] |  |  |  |
Direct R&D program expense | (325) | 6,845 | (530) | 23,594
Operating Segments | BHV-8000 (TYK2/JAK1) | Reportable Segment |  |  |  |
Segment Reporting [Line Items] |  |  |  |
Direct R&D program expense | 4,142 | 21,216 | 9,312 | 25,589
Operating Segments | BHV-1300 (IgG Degrader) | Reportable Segment |  |  |  |
Segment Reporting [Line Items] |  |  |  |
Direct R&D program expense | 9,861 | 11,732 | 11,003 | 20,352
Operating Segments | BHV-1310 (IgG Degrader) | Reportable Segment |  |  |  |
Segment Reporting [Line Items] |  |  |  |
Direct R&D program expense | 15 | 3,612 | (19) | 4,686
Operating Segments | BHV-1400 (IgA Degrader) | Reportable Segment |  |  |  |
Segment Reporting [Line Items] |  |  |  |
Direct R&D program expense | 11,709 | 6,737 | 16,846 | 11,597
Operating Segments | BHV-1600 (β1-AR AAB Degrader) | Reportable Segment |  |  |  |
Segment Reporting [Line Items] |  |  |  |
Direct R&D program expense | (288) | 1,806 | (99) | 4,809
Operating Segments | BHV-1510 (TROP-2) | Reportable Segment |  |  |  |
Segment Reporting [Line Items] |  |  |  |
Direct R&D program expense | 2,465 | 5,384 | 6,502 | 9,873
Operating Segments | BHV-1530 (FGFR3) | Reportable Segment |  |  |  |
Segment Reporting [Line Items] |  |  |  |
Direct R&D program expense | 2,211 | 15,393 | 3,410 | 18,569
Operating Segments | Other R&D program expense | Reportable Segment |  |  |  |
Segment Reporting [Line Items] |  |  |  |
Direct R&D program expense | 14 | 1,104 | 63 | 1,615
Segment Reporting, Reconciling Item, Excluding Corporate Nonsegment |  |  |  |
Segment Reporting [Line Items] |  |  |  |
Net loss | $ 0 | $ 0 | $ 0 | $ 0

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