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Shareholders' Equity (Tables) | 6 Months Ended
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Jun. 30, 2026
Stockholders' Equity Note [Abstract] |
Schedule of changes in shareholders' equity (deficit) | Changes in shareholders’ equity for the three and six months ended June 30, 2026 and 2025 were as follows:
|  | Common Shares |  |  |  |  |  |  |  |
|  | Shares |  | Amount |  | Additional Paid-in Capital |  | Accumulated Deficit |  | Accumulated Other Comprehensive Income (Loss) |  | Total Shareholders' Equity (Deficit)
Balances as of December 31, 2025 |  | 132,775,113 |  |  | $ | 1,934,276 |  |  | $ | 193,984 |  |  | $ | (2,084,536) |  |  | $ | 8,348 |  |  | $ | 52,072 |
Net loss |  | — |  |  | — |  |  | — |  |  | (130,532) |  |  | — |  |  | (130,532) |
Issuance of common shares, net of offering costs |  | 17,164,940 |  |  | 178,884 |  |  | — |  |  | — |  |  | — |  |  | 178,884 |
Issuance of common shares as payment under license and other agreements |  | 76,383 |  |  | 858 |  |  | — |  |  | — |  |  | — |  |  | 858 |
Issuance of common shares under 2022 Equity Incentive Plan |  | 490,054 |  |  | 18,890 |  |  | (18,912) |  |  | — |  |  | — |  |  | (22) |
Non-cash share-based compensation expense |  | — |  |  | — |  |  | 28,286 |  |  | — |  |  | — |  |  | 28,286 |
Other comprehensive loss |  | — |  |  | — |  |  | — |  |  | — |  |  | (46) |  |  | (46) |
Balances as of March 31, 2026 |  | 150,506,490 |  |  | $ | 2,132,908 |  |  | $ | 203,358 |  |  | $ | (2,215,068) |  |  | $ | 8,302 |  |  | $ | 129,500 |
Net loss |  | — |  |  | — |  |  | — |  |  | (137,311) |  |  | — |  |  | (137,311) |
Issuance of common shares under 2022 Equity Incentive Plan and 2022 Employee Share Purchase Plan |  | 511,041 |  |  | 5,953 |  |  | (2,157) |  |  | — |  |  | — |  |  | 3,796 |
Non-cash share-based compensation expense |  | — |  |  | — |  |  | 19,164 |  |  | — |  |  | — |  |  | 19,164 |
Other comprehensive loss |  | — |  |  | — |  |  | — |  |  | — |  |  | (2,927) |  |  | (2,927) |
Balances as of June 30, 2026 |  | 151,017,531 |  |  | $ | 2,138,861 |  |  | $ | 220,365 |  |  | $ | (2,352,379) |  |  | $ | 5,375 |  |  | $ | 12,222 |
|  | Common Shares |  |  |  |  |  |  |  |
|  | Shares |  | Amount |  | Additional Paid-in Capital |  | Accumulated Deficit |  | Accumulated Other Comprehensive Income (Loss) |  | Total Shareholders' Equity
Balances as of December 31, 2024 |  | 101,221,989 |  |  | $ | 1,656,702 |  |  | $ | 112,369 |  |  | $ | (1,345,714) |  |  | $ | 79 |  |  | $ | 423,436 |
Net loss |  | — |  |  | — |  |  | — |  |  | (221,677) |  |  | — |  |  | (221,677) |
Issuance of common shares as payment under license and other agreements |  | 354,819 |  |  | 13,398 |  |  | (8,554) |  |  | — |  |  | — |  |  | 4,844 |
Issuance of common shares under 2022 Equity Incentive Plan |  | 527,216 |  |  | 19,246 |  |  | (19,410) |  |  | — |  |  | — |  |  | (164) |
Non-cash share-based compensation expense |  | — |  |  | — |  |  | 53,062 |  |  | — |  |  | — |  |  | 53,062 |
Other comprehensive loss |  | — |  |  | — |  |  | — |  |  | — |  |  | (6) |  |  | (6) |
Balances as of March 31, 2025 |  | 102,104,024 |  |  | $ | 1,689,346 |  |  | $ | 137,467 |  |  | $ | (1,567,391) |  |  | $ | 73 |  |  | $ | 259,495 |
Net loss |  | — |  |  | — |  |  | — |  |  | (198,147) |  |  | — |  |  | (198,147) |
Issuance of common shares as payment under license and other agreements |  | 3,588,688 |  |  | 51,426 |  |  | — |  |  | — |  |  | — |  |  | 51,426 |
Issuance of common shares under 2022 Equity Incentive Plan and 2022 Employee Share Purchase Plan |  | 89,735 |  |  | 2,337 |  |  | (1,260) |  |  | — |  |  | — |  |  | 1,077 |
Non-cash share-based compensation expense |  | — |  |  | — |  |  | 20,812 |  |  | — |  |  | — |  |  | 20,812 |
Other comprehensive loss |  | — |  |  | — |  |  | — |  |  | — |  |  | (76) |  |  | (76) |
Balances as of June 30, 2025 |  | 105,782,447 |  |  | $ | 1,743,109 |  |  | $ | 157,019 |  |  | $ | (1,765,538) |  |  | $ | (3) |  |  | $ | 134,587 |

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- Definition Tabular disclosure of changes in the separate accounts comprising stockholders' equity (in addition to retained earnings) and of the changes in the number of shares of equity securities during at least the most recent annual fiscal period and any subsequent interim period presented is required to make the financial statements sufficiently informative if both financial position and results of operations are presented. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 505 -SubTopic 10 -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Publisher FASB -URI https://asc.fasb.org/1943274/2147481112/505-10-50-2 Reference 2: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 505 -SubTopic 10 -Name Accounting Standards Codification -Section S99 -Paragraph 1 -Subparagraph (SX 210.3-04) -Publisher FASB -URI https://asc.fasb.org/1943274/2147480008/505-10-S99-1 Reference 3: http://www.xbrl.org/2009/role/commonPracticeRef -Topic 505 -SubTopic 10 -Name Accounting Standards Codification -Section S50 -Paragraph 1 -Publisher FASB -URI https://asc.fasb.org/1943274/2147480070/505-10-S50-1 + Details
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