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Unaudited Consolidated Statements of Operations and Comprehensive Loss - USD ($)
 3 Months Ended 9 Months Ended
Sep. 30, 2018
Sep. 30, 2017
Sep. 30, 2018
Sep. 30, 2017
Income Statement [Abstract]        
Revenue $ 4,493,000 $ 1,315,000 $ 10,794,000 $ 2,795,000
Operating expenses:        
Research and development 32,876,000 20,097,000 94,619,000 53,940,000
General and administrative 9,849,000 7,571,000 26,755,000 20,088,000
Total operating expenses 42,725,000 27,668,000 121,374,000 74,028,000
Loss from operations (38,232,000) (26,353,000) (110,580,000) (71,233,000)
Other income (expense), net:        
Dividend income 1,064,000 515,000 2,354,000 1,287,000
Interest income (expense), net 5,000 1,000 16,000 5,000
Other income (expense), net (468,000) (75,000) (384,000) (211,000)
Total other income (expense), net 601,000 441,000 1,986,000 1,081,000
Loss before income taxes (37,631,000) (25,912,000) (108,594,000) (70,152,000)
Income tax benefit (provision) 0 418,000 (172,000) (1,035,000)
Net loss $ (37,631,000) $ (25,494,000) $ (108,766,000) $ (71,187,000)
Net loss per share attributable to ordinary shareholders—basic and diluted $ (1.28) $ (0.92) $ (3.78) $ (2.73)
Weighted-average ordinary shares used in computing net loss per share attributable to ordinary shareholders—basic and diluted 29,333,994 27,758,792 28,804,357 26,078,696
Other comprehensive income (loss):        
Net loss $ (37,631,000) $ (25,494,000) $ (108,766,000) $ (71,187,000)
Foreign currency translation (20,000) 1,000 65,000 19,000
Comprehensive loss $ (37,651,000) $ (25,493,000) $ (108,701,000) $ (71,168,000)