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v3.10.0.1

Consolidated Statements of Series A Preferred Shares and Shareholders' Equity - USD ($) $ in Thousands | Total | Series A Preferred Shares [Member] | Ordinary Shares [Member] | Additional Paid-In-Capital [Member] | Accumulated Other Comprehensive Income (Loss) [Member] | Accumulated Deficit [Member]
--- | --- | --- | --- | --- | --- | ---
Beginning balance at Dec. 31, 2015 | $ 153,491 |  | $ 185,344 | $ 3,182 | $ 41 | $ (35,076)
Beginning balance, shares at Dec. 31, 2015 |  |  | 21,551,423 |  |  |
Temporary equity, Beginning balance at Dec. 31, 2015 |  | $ 7,874 |  |  |  |
Temporary equity, Beginning balance, shares at Dec. 31, 2015 |  | 3,901,348 |  |  |  |
Issuance of ordinary shares, net of offering costs | 30,000 |  | $ 30,000 |  |  |
Issuance of ordinary shares, net of offering costs, shares |  |  | 1,875,000 |  |  |
Share-based compensation | 6,847 |  |  | 6,847 |  |
Option exercises | 258 |  | $ 258 |  |  |
Option exercises, shares |  |  | 75,746 |  |  |
Other comprehensive income (loss) | (332) |  |  |  | (332) |
Net loss | (55,660) |  |  |  |  | (55,660)
Ending balance at Dec. 31, 2016 | 134,604 |  | $ 215,602 | 10,029 | (291) | (90,736)
Ending balance, shares at Dec. 31, 2016 |  |  | 23,502,169 |  |  |
Temporary equity, Ending balance at Dec. 31, 2016 |  | $ 7,874 |  |  |  |
Temporary equity, Ending balance, shares at Dec. 31, 2016 |  | 3,901,348 |  |  |  |
Issuance of ordinary shares, net of offering costs | 93,509 |  | $ 93,509 |  |  |
Issuance of ordinary shares, net of offering costs, shares |  |  | 4,166,667 |  |  |
Share-based compensation | 12,143 |  |  | 12,143 |  |
Vesting of RSUs, shares |  |  | 22,750 |  |  |
Option exercises | 927 |  | $ 927 |  |  |
Option exercises, shares |  |  | 137,493 |  |  |
Other comprehensive income (loss) | 407 |  |  |  | 407 |
Net loss | (101,980) |  |  |  |  | (101,980)
Ending balance at Dec. 31, 2017 | 139,610 |  | $ 310,038 | 22,172 | 116 | (192,716)
Ending balance, shares at Dec. 31, 2017 |  |  | 27,829,079 |  |  |
Temporary equity, Ending balance at Dec. 31, 2017 | $ 7,874 | $ 7,874 |  |  |  |
Temporary equity, Ending balance, shares at Dec. 31, 2017 | 3,901,348 | 3,901,348 |  |  |  |
Issuance of ordinary shares, net of offering costs | $ 60,000 |  | $ 60,000 |  |  |
Issuance of ordinary shares, net of offering costs, shares |  |  | 1,096,892 |  |  |
Share-based compensation | 15,596 |  |  | 15,596 |  |
Vesting of RSUs, shares |  |  | 38,594 |  |  |
Option exercises | 5,110 |  | $ 5,110 |  |  |
Option exercises, shares |  |  | 507,632 |  |  |
Impact of adoption of ASU 2016-16 | (352) |  |  |  |  | (352)
Other comprehensive income (loss) | 37 |  |  |  | 37 |
Net loss | (146,653) |  |  |  |  | (146,653)
Ending balance at Dec. 31, 2018 | 73,348 |  | $ 375,148 | $ 37,768 | $ 153 | $ (339,721)
Ending balance, shares at Dec. 31, 2018 |  |  | 29,472,197 |  |  |
Temporary equity, Ending balance at Dec. 31, 2018 | $ 7,874 | $ 7,874 |  |  |  |
Temporary equity, Ending balance, shares at Dec. 31, 2018 | 3,901,348 | 3,901,348 |  |  |  |

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