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Income Taxes - Additional Information (Detail) - USD ($) | 12 Months Ended |
--- | --- | ---
Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
Income Taxes [Line Items] |  |  |  |
Income tax benefit (provision) | $ (69,000) | $ (842,000) | $ (482,000) |
U.S. federal corporate tax rate | 21.00% | 35.00% |  |
Benefit related to remeasurement of deferred tax assets and liabilities as result of filing tax return | $ 200,000 |  |  |
Net operating loss carryovers | 58,661,000 | $ 28,913,000 |  |
Increase in valuation allowance | 63,300,000 | 20,100,000 | 8,500,000 |
Gross unrecognized tax benefit | 10,219,000 | 6,207,000 | 2,343,000 | $ 1,280,000
Unrecognized tax benefit that could affect annual effective tax rate if recognized | 5,800,000 |  |  |
Subsidiaries Outside of Singapore [Member] |  |  |  |
Income Taxes [Line Items] |  |  |  |
Cash held by subsidiaries | 53,000,000 | 48,800,000 |  |
Maximum [Member] |  |  |  |
Income Taxes [Line Items] |  |  |  |
Interest and penalties related to uncertain tax positions | 100,000 | 100,000 |  |
Federal [Member] |  |  |  |
Income Taxes [Line Items] |  |  |  |
Net operating loss carryforwards | 82,600,000 |  |  |
Net operating loss carryforwards available to offset future income tax liabilities indefinitely | $ 80,600,000 |  |  |
Net operating loss carryforwards available to offset future income tax liabilities |  | 2,000,000 |  |
Operating Loss Carry forward expiration year | 2037 |  |  |
Research and development tax credit carryforward | 2031 |  |  |
Federal [Member] | Research and development |  |  |  |
Income Taxes [Line Items] |  |  |  |
Research and development tax credit carryforward | $ 6,200,000 | 2,800,000 |  |
Federal [Member] | Orphan Drug Credits [Member] |  |  |  |
Income Taxes [Line Items] |  |  |  |
Research and development tax credit carryforward | $ 5,000,000 |  |  |
U.S.Orphan drug credit carryforward expiration year | 2037 |  |  |
State [Member] |  |  |  |
Income Taxes [Line Items] |  |  |  |
Research and development tax credit carryforward | 2031 |  |  |
State [Member] | Research and development |  |  |  |
Income Taxes [Line Items] |  |  |  |
Research and development tax credit carryforward | $ 1,800,000 | 1,100,000 |  |
Singapore [Member] |  |  |  |
Income Taxes [Line Items] |  |  |  |
Income tax benefit (provision) | $ 0 | $ 0 | $ 0 |
U.S. federal corporate tax rate | 17.00% | 17.00% | 17.00% |
Net operating loss carryovers | $ 161,300,000 | $ 149,200,000 |  |
Tax years open to examination | 2012 |  |  |
United States [Member] |  |  |  |
Income Taxes [Line Items] |  |  |  |
Income tax benefit (provision) | $ 0 |  |  |
Tax years open to examination | 2012 |  |  |
Japan [Member] |  |  |  |
Income Taxes [Line Items] |  |  |  |
Income tax benefit (provision) | $ 0 |  | $ 0 |
Net operating loss carryovers | $ 2,900,000 | 4,100,000 |  |
Operating loss carryforwards expiration year | 2023 |  |  |
Tax years open to examination | 2008 |  |  |
UK [Member] |  |  |  |
Income Taxes [Line Items] |  |  |  |
Income tax benefit (provision) | $ 0 | 0 |  |
Net operating loss carryovers | $ 46,400,000 | 10,500,000 |  |
Tax years open to examination | 2017 |  |  |
Ireland [Member] |  |  |  |
Income Taxes [Line Items] |  |  |  |
Income tax benefit (provision) | $ 0 | $ 0 | $ 0 |

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- Definition Amount of currency on hand as well as demand deposits with banks or financial institutions. Includes other kinds of accounts that have the general characteristics of demand deposits. Excludes cash and cash equivalents within disposal group and discontinued operation. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02.1) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 + Details
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