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Income Taxes - Components of Deferred Tax Assets and Liabilities (Detail) - USD ($) $ in Thousands | Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016
--- | --- | --- | ---
Deferred tax assets: |  |  |
Net operating loss carryforwards | $ 58,661 | $ 28,913 |
Federal and state tax credits | 13,783 | 4,522 |
Accrued expenses | 4,276 | 1,903 |
Share-based compensation | 3,811 | 1,921 |
Accumulated amortization | 18,829 |  |
Other | 1,267 | 176 |
Total deferred tax assets | 100,627 | 37,435 |
Valuation allowance | (99,438) | (36,069) | $ (15,999)
Net deferred tax assets | 1,189 | 1,366 |
Deferred tax liabilities: |  |  |
Accumulated depreciation | (1,155) | (1,366) |
Other | (34) |  |
Total deferred tax liabilities | $ (1,189) | $ (1,366) |

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