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Share Capital - Additional Information (Detail) $ / shares in Units, $ in Thousands |  | 1 Months Ended | 12 Months Ended
--- | --- | --- | ---
May 05, 2016 USD ($) $ / shares shares | Apr. 30, 2018 USD ($) $ / shares shares | Apr. 30, 2017 USD ($) $ / shares shares | May 31, 2016 USD ($) $ / shares shares | Dec. 31, 2018 USD ($) Vote $ / shares shares | Dec. 31, 2017 USD ($) $ / shares | Dec. 31, 2016 USD ($)
Class of Stock [Line Items] |  |  |  |  |  |  |
Equity investment aggregate purchase price | $ |  |  |  |  | $ 60,000 | $ 93,509 | $ 30,000
Net proceeds from sale of ordinary shares | $ |  |  |  |  | $ 60,000 | $ 93,509 | $ 30,000
Common stock, par value | $ / shares |  |  |  |  | $ 0 | $ 0 |
Ordinary share holder, voting right |  |  |  |  | One vote for each ordinary share |  |
Voting rights, votes per share | Vote |  |  |  |  | 1 |  |
Preferred stock liquidation preference, per share | $ / shares |  |  |  |  | $ 10 |  |
Singapore [Member] |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |
Common stock, par value | $ / shares |  |  |  |  |  |  |
Common stock, authorized | shares |  |  |  |  | 0 |  |
Series A Preferred Shares [Member] | Singapore [Member] |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |
Preferred stock, par value | $ / shares |  |  |  |  |  |  |
Preferred stock, shares authorized | shares |  |  |  |  | 0 |  |
Follow-On Underwritten Public Offering [Member] |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |
Shares issued under equity agreement | shares |  |  | 4,166,667 |  |  |  |
Purchase price per share | $ / shares |  |  | $ 24.00 |  |  |  |
Gross proceeds from sale of ordinary shares | $ |  |  | $ 100,000 |  |  |  |
Net proceeds from sale of ordinary shares | $ |  |  | $ 93,500 |  |  |  |
Research, License and Option Agreement [Member] | Pfizer Inc. [Member] |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |
Shares issued under equity agreement | shares | 1,875,000 |  |  | 1,875,000 |  |  |
Purchase price per share | $ / shares | $ 16.00 |  |  | $ 16.00 |  |  |
Equity investment aggregate purchase price | $ | $ 30,000 |  |  | $ 30,000 |  |  |
Collaboration and Share Purchase Agreements [Member] | Takeda [Member] |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |
Shares issued under equity agreement | shares |  | 1,096,892 |  |  |  |  |
Equity investment aggregate purchase price | $ |  | $ 60,000 |  |  |  |  |
Net proceeds from sale of ordinary shares | $ |  | $ 60,000 |  |  |  |  |
Purchase price per share | $ / shares |  | $ 54.70 |  |  |  |  |

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