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Related Parties - Additional Information (Detail) - USD ($) $ in Thousands | 9 Months Ended | 12 Months Ended
--- | --- | ---
Sep. 30, 2018 | Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016
Third-Party Investor [Member] |  |  |  |
Related Party Transaction [Line Items] |  |  |  |
Related party transaction amount |  |  | $ 100 |
Shin Nippon Biomedical Laboratories Ltd. (SNBL) [Member] |  |  |  |
Related Party Transaction [Line Items] |  |  |  |
Payment for contract research services | $ 1,300 |  | $ 500 | $ 400
Scientific Advisor [Member] | Consulting Agreement [Member] |  |  |  |
Related Party Transaction [Line Items] |  |  |  |
Consulting agreement termination notice period |  | 14 days |  |
Consulting service expenses |  | $ 13 |  |

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