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Significant Accounting Policies - Summary of Result of Adopting ASC 606 on Financial Statement - Consolidated Statements of Operations and Comprehensive Loss (Detail) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended								12 Months Ended
	Dec. 31, 2018	Sep. 30, 2018	Jun. 30, 2018	Mar. 31, 2018	Dec. 31, 2017	Sep. 30, 2017	Jun. 30, 2017	Mar. 31, 2017	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016
Condensed Income Statements Captions [Line Items]
Revenue	$ 3,620	$ 4,493	$ 4,879	$ 1,422	$ 1,098	$ 1,315	$ 1,097	$ 383	$ 14,414	$ 3,893	$ 1,092
Loss from operations	(48,943)	(38,232)	(36,573)	(35,775)	(31,158)	(26,353)	(24,673)	(20,207)	(159,523)	(102,391)	(55,720)
Income tax benefit (provision)									(69)	(842)	(482)
Net loss	$ (37,887)	$ (37,631)	$ (35,894)	$ (35,241)	$ (30,793)	$ (25,494)	$ (24,597)	$ (21,096)	$ (146,653)	$ (101,980)	$ (55,660)
Net loss per share attributable to ordinary shareholders—basic and diluted	$ (1.29)	$ (1.28)	$ (1.23)	$ (1.26)	$ (1.11)	$ (0.92)	$ (0.91)	$ (0.90)	$ (5.06)	$ (3.85)	$ (2.44)
As Originally Reported Under ASC 605 [Member] | ASC 606 [Member]
Condensed Income Statements Captions [Line Items]
Revenue										$ 3,704	$ 1,485
Loss from operations										(102,580)	(55,327)
Income tax benefit (provision)										(708)	(616)
Net loss										(102,035)	$ (55,401)
Net loss per share attributable to ordinary shareholders—basic and diluted											$ (2.43)
Effect of Change [Member] | ASC 606 [Member]
Condensed Income Statements Captions [Line Items]
Revenue										189	$ (393)
Loss from operations										189	(393)
Income tax benefit (provision)										(134)	134
Net loss										$ 55	$ (259)
Net loss per share attributable to ordinary shareholders—basic and diluted											$ (0.01)

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