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Consolidated Statements of Series A Preferred Shares and Shareholders' Equity - USD ($)
$ in Thousands
Total
Series A Preferred Shares [Member]
Ordinary Shares [Member]
Additional Paid-In-Capital [Member]
Accumulated Other Comprehensive Income (Loss) [Member]
Accumulated Deficit [Member]
Beginning balance at Dec. 31, 2015 $ 153,491   $ 185,344 $ 3,182 $ 41 $ (35,076)
Beginning balance, shares at Dec. 31, 2015     21,551,423      
Temporary equity, Beginning balance at Dec. 31, 2015   $ 7,874        
Temporary equity, Beginning balance, shares at Dec. 31, 2015   3,901,348        
Issuance of ordinary shares, net of offering costs 30,000   $ 30,000      
Issuance of ordinary shares, net of offering costs, shares     1,875,000      
Share-based compensation 6,847     6,847    
Option exercises 258   $ 258      
Option exercises, shares     75,746      
Other comprehensive income (loss) (332)       (332)  
Net loss (55,660)         (55,660)
Ending balance at Dec. 31, 2016 134,604   $ 215,602 10,029 (291) (90,736)
Ending balance, shares at Dec. 31, 2016     23,502,169      
Temporary equity, Ending balance at Dec. 31, 2016   $ 7,874        
Temporary equity, Ending balance, shares at Dec. 31, 2016   3,901,348        
Issuance of ordinary shares, net of offering costs 93,509   $ 93,509      
Issuance of ordinary shares, net of offering costs, shares     4,166,667      
Share-based compensation 12,143     12,143    
Vesting of RSUs, shares     22,750      
Option exercises 927   $ 927      
Option exercises, shares     137,493      
Other comprehensive income (loss) 407       407  
Net loss (101,980)         (101,980)
Ending balance at Dec. 31, 2017 139,610   $ 310,038 22,172 116 (192,716)
Ending balance, shares at Dec. 31, 2017     27,829,079      
Temporary equity, Ending balance at Dec. 31, 2017 $ 7,874 $ 7,874        
Temporary equity, Ending balance, shares at Dec. 31, 2017 3,901,348 3,901,348        
Issuance of ordinary shares, net of offering costs $ 60,000   $ 60,000      
Issuance of ordinary shares, net of offering costs, shares     1,096,892      
Share-based compensation 15,596     15,596    
Vesting of RSUs, shares     38,594      
Option exercises 5,110   $ 5,110      
Option exercises, shares     507,632      
Impact of adoption of ASU 2016-16 (352)         (352)
Other comprehensive income (loss) 37       37  
Net loss (146,653)         (146,653)
Ending balance at Dec. 31, 2018 73,348   $ 375,148 $ 37,768 $ 153 $ (339,721)
Ending balance, shares at Dec. 31, 2018     29,472,197      
Temporary equity, Ending balance at Dec. 31, 2018 $ 7,874 $ 7,874        
Temporary equity, Ending balance, shares at Dec. 31, 2018 3,901,348 3,901,348