<SEC-DOCUMENT>0001193125-19-014851-index.html : 20190123
<SEC-HEADER>0001193125-19-014851.hdr.sgml : 20190123
<ACCEPTANCE-DATETIME>20190123163153
ACCESSION NUMBER:		0001193125-19-014851
CONFORMED SUBMISSION TYPE:	424B5
PUBLIC DOCUMENT COUNT:		4
FILED AS OF DATE:		20190123
DATE AS OF CHANGE:		20190123

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Wave Life Sciences Ltd.
		CENTRAL INDEX KEY:			0001631574
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			U0
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		424B5
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-215428
		FILM NUMBER:		19537751

	BUSINESS ADDRESS:	
		STREET 1:		7 STRAITS VIEW
		STREET 2:		#12-00, MARINA ONE EAST TOWER
		CITY:			SINGAPORE
		STATE:			U0
		ZIP:			018936
		BUSINESS PHONE:		617-949-2900

	MAIL ADDRESS:	
		STREET 1:		733 CONCORD AVENUE
		CITY:			CAMBRIDGE
		STATE:			MA
		ZIP:			02138

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	WAVE Life Sciences Ltd.
		DATE OF NAME CHANGE:	20170516

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Wave Life Sciences Ltd.
		DATE OF NAME CHANGE:	20151106

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Wave Life Sciences LTD.
		DATE OF NAME CHANGE:	20151106
</SEC-HEADER>
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<TYPE>424B5
<SEQUENCE>1
<FILENAME>d686950d424b5.htm
<DESCRIPTION>424B5
<TEXT>
Document 1 - file: d686950d424b5.htm

</DOCUMENT>
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<TYPE>GRAPHIC
<SEQUENCE>2
<FILENAME>g686950g19h60.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 2 - file: g686950g19h60.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>3
<FILENAME>g686950g21o08.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 3 - file: g686950g21o08.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>4
<FILENAME>g686950g82f00.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 4 - file: g686950g82f00.jpg

</DOCUMENT>
</SEC-DOCUMENT>