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Unaudited Consolidated Statements of Operations and Comprehensive Loss - USD ($)
 3 Months Ended
Mar. 31, 2021
Mar. 31, 2020
Income Statement [Abstract]    
Revenue   $ 4,161,000
Operating expenses:    
Research and development $ 33,393,000 41,158,000
General and administrative 10,078,000 12,996,000
Total operating expenses 43,471,000 54,154,000
Loss from operations (43,471,000) (49,993,000)
Other income, net:    
Dividend income and interest income, net 11,000 388,000
Other income, net 996,000 2,112,000
Total other income, net 1,007,000 2,500,000
Loss before income taxes (42,464,000) (47,493,000)
Income tax provision 0 0
Net loss $ (42,464,000) $ (47,493,000)
Net loss per share attributable to ordinary shareholders—basic and diluted $ (0.86) $ (1.38)
Weighted-average ordinary shares used in computing net loss per share attributable to ordinary shareholders—basic and diluted 49,101,606 34,461,505
Other comprehensive income (loss):    
Net loss $ (42,464,000) $ (47,493,000)
Foreign currency translation (120,000) 6,000
Comprehensive loss $ (42,584,000) $ (47,487,000)