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Unaudited Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2021
Mar. 31, 2020
Cash flows from operating activities    
Net loss $ (42,464) $ (47,493)
Adjustments to reconcile net loss to net cash used in operating activities:    
Amortization of right-of-use assets 512 442
Depreciation of property and equipment 1,948 2,039
Share-based compensation expense 4,063 3,999
Changes in operating assets and liabilities:    
Accounts receivable   20,000
Prepaid expenses 4 (373)
Other assets (1,715) (1,983)
Accounts payable (466) 7,336
Accrued expenses and other current liabilities (5,310) (5,191)
Deferred revenue   (4,161)
Operating lease liabilities (880) (765)
Other non-current liabilities (67) (100)
Net cash used in operating activities (44,375) (26,250)
Cash flows from investing activities    
Purchases of property and equipment (108) (580)
Net cash used in investing activities (108) (580)
Cash flows from financing activities    
Proceeds from the exercise of share options 200 10
Proceeds from the employee share purchase plan 336  
Net cash provided by financing activities 8,641 614
Effect of foreign exchange rates on cash, cash equivalents and restricted cash (120) 6
Net decrease in cash, cash equivalents and restricted cash (35,962) (26,210)
Cash, cash equivalents and restricted cash, beginning of period 188,148 150,808
Cash, cash equivalents and restricted cash, end of period 152,186 124,598
Supplemental disclosure of cash flow information:    
At-the-market offering costs in accounts payable at period end 77  
At-The-Market Equity Program [Member]    
Cash flows from financing activities    
Proceeds from issuance of ordinary shares, net of offering costs $ 8,105 $ 604