-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
 MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen
 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 VAj2wkcgsS6RqUZEvQ1DX9sy4qYLyIs0wSaFkQdUtdWqFbSBNNrBkAx/1pldaPTJ
 DePnrwvxHRMoUypcGZnO7A==

<SEC-DOCUMENT>0000899140-08-000456.txt : 20080213
<SEC-HEADER>0000899140-08-000456.hdr.sgml : 20080213
<ACCEPTANCE-DATETIME>20080213162049
ACCESSION NUMBER:		0000899140-08-000456
CONFORMED SUBMISSION TYPE:	SC 13G/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20080213
DATE AS OF CHANGE:		20080213
GROUP MEMBERS:		DANIEL S. LOEB
GROUP MEMBERS:		THIRD POINT OFFSHORE FUND, LTD.

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			FLAMEL TECHNOLOGIES SA
		CENTRAL INDEX KEY:			0001012477
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-50223
		FILM NUMBER:		08605078

	BUSINESS ADDRESS:	
		STREET 1:		PARC CLUB DU MOULIN A VENT
		STREET 2:		33 AVE DU DOCTEUR GEORGES LEVY
		CITY:			VENISSIEUX CED
		STATE:			I0
		ZIP:			69693
		BUSINESS PHONE:		2126641666

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Third Point LLC
		CENTRAL INDEX KEY:			0001040273
		IRS NUMBER:				133922602
		STATE OF INCORPORATION:			NY
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		390 PARK AVENUE
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022
		BUSINESS PHONE:		2122247400

	MAIL ADDRESS:	
		STREET 1:		390 PARK AVENUE
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	THIRD POINT MANAGEMENT CO LLC
		DATE OF NAME CHANGE:	19970602
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G/A
<SEQUENCE>1
<FILENAME>f4107366b.txt
<DESCRIPTION>FIRST AMENDMENT
<TEXT>


                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549



                                  SCHEDULE 13G

                                (Amendment No. 1)

                   Under the Securities Exchange Act of 1934*

                            Flamel Technologies S.A.
                            ------------------------
                                (Name of Issuer)

              Ordinary Shares, nominal value 0.122 Euros per share
              ----------------------------------------------------
                         (Title of Class of Securities)

                                    338488109
                                    ---------
                                 (CUSIP Number)

                                December 31, 2007
                                -----------------
             (Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

                                [ ] Rule 13d-1(b)
                                [X] Rule 13d-1(c)
                                [ ] Rule 13d-1(d)

  *The remainder of this cover page shall be filled out for a reporting person's
  initial filing on this form with respect to the subject class of securities,
  and for any subsequent amendment containing information which would alter the
  disclosures provided in a prior cover page.

  The information required on the remainder of this cover page shall not be
  deemed to be "filed" for the purpose of Section 18 of the Securities Exchange
  Act of 1934 (the "Act") or otherwise subject to the liabilities of that
  section of the Act but shall be subject to all other provisions of the Act
  (however, see the Notes).



<PAGE>




- ---------------------------------                        -----------------------
CUSIP No.  338488109                        13G          Page 2 of 7 Pages
- ---------------------------------                        -----------------------

- ---------- ---------------------------------------------------------------------
1          NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Third Point LLC
- ---------- ---------------------------------------------------------------------
2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                    (a) [ ]
                                                                    (b) [X]
- ---------- ---------------------------------------------------------------------
3          SEC USE ONLY
- ---------- ---------------------------------------------------------------------
4          CITIZENSHIP OR PLACE OF ORGANIZATION

           Delaware
- -------------------- ------ ----------------------------------------------------
                     5      SOLE VOTING POWER

                            0
                     ------ ----------------------------------------------------
     NUMBER OF       6      SHARED VOTING POWER
      SHARES
   BENEFICIALLY             0
     OWNED BY
       EACH          ------ ----------------------------------------------------
     REPORTING       7      SOLE DISPOSITIVE POWER
      PERSON
       WITH                 0
                     ------ ----------------------------------------------------
                     8      SHARED DISPOSITIVE POWER

                            0
- ---------- ---------------------------------------------------------------------
9          AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           0
- ---------- ---------------------------------------------------------------------
10         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

           N/A
- ---------- ---------------------------------------------------------------------
11         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

           0.0%
- ---------- ---------------------------------------------------------------------
12         TYPE OF REPORTING PERSON

           OO
- ---------- ---------------------------------------------------------------------


<PAGE>


- ---------------------------------                        -----------------------
CUSIP No.  338488109                        13G          Page 3 of 7 Pages
- ---------------------------------                        -----------------------

- ---------- ---------------------------------------------------------------------
1          NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Daniel S. Loeb
- ---------- ---------------------------------------------------------------------
2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                    (a) [ ]
                                                                    (b) [X]
- ---------- ---------------------------------------------------------------------
3          SEC USE ONLY
- ---------- ---------------------------------------------------------------------
4          CITIZENSHIP OR PLACE OF ORGANIZATION

           United States
- -------------------- ------ ----------------------------------------------------
                     5      SOLE VOTING POWER

                            0
                     ------ ----------------------------------------------------
     NUMBER OF       6      SHARED VOTING POWER
      SHARES
   BENEFICIALLY             0
     OWNED BY
       EACH          ------ ----------------------------------------------------
     REPORTING       7      SOLE DISPOSITIVE POWER
      PERSON
       WITH                 0
                     ------ ----------------------------------------------------
                     8      SHARED DISPOSITIVE POWER

                            0
- ---------- ---------------------------------------------------------------------
9          AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           0
- ---------- ---------------------------------------------------------------------
10         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

           N/A
- ---------- ---------------------------------------------------------------------
11         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

           0.0%
- ---------- ---------------------------------------------------------------------
12         TYPE OF REPORTING PERSON

           IN
- ---------- ---------------------------------------------------------------------


<PAGE>



- ---------------------------------                        -----------------------
CUSIP No.  338488109                        13G          Page 4 of 7 Pages
- ---------------------------------                        -----------------------

- ---------- ---------------------------------------------------------------------
1          NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

           Third Point Offshore Fund, Ltd.
- ---------- ---------------------------------------------------------------------
2          CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                    (a) [ ]
                                                                    (b) [X]
- ---------- ---------------------------------------------------------------------
3          SEC USE ONLY
- ---------- ---------------------------------------------------------------------
4          CITIZENSHIP OR PLACE OF ORGANIZATION

           Cayman Islands
- -------------------- ------ ----------------------------------------------------
                     5      SOLE VOTING POWER

                            0
                     ------ ----------------------------------------------------
     NUMBER OF       6      SHARED VOTING POWER
      SHARES
   BENEFICIALLY             0
     OWNED BY
       EACH          ------ ----------------------------------------------------
     REPORTING       7      SOLE DISPOSITIVE POWER
      PERSON
       WITH                 0
                     ------ ----------------------------------------------------
                     8      SHARED DISPOSITIVE POWER

                            0
- ---------- ---------------------------------------------------------------------
9          AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           0
- ---------- ---------------------------------------------------------------------
10         CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

           N/A
- ---------- ---------------------------------------------------------------------
11         PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

           0.0%
- ---------- ---------------------------------------------------------------------
12         TYPE OF REPORTING PERSON

           OO
- ---------- ---------------------------------------------------------------------


<PAGE>


     This Amendment No. 1 to Schedule 13G (this "Amendment No. 1") is being
filed with respect to the Common Stock of Flamel Technologies S.A., a societe
anonyme formed under the laws of the Republic of France (the "Company"), to
amend the Schedule 13G filed on July 16, 2007 (the "Schedule 13G"). Capitalized
terms used herein and not otherwise defined have the meanings ascribed thereto
in the Schedule 13G.

Item 4:   Ownership:
- ------    ---------

Item 4 is hereby amended and restated as follows:

The beneficial ownership of Ordinary Shares by the Reporting Persons, as of
December 31, 2007, is as follows:

  A. Third Point LLC
     ---------------
     (a) Amount beneficially owned: 0
     (b) Percent of class: 0.0%.
     (c) Number of shares as to which such person has:
          (i) Sole power to vote or direct the vote: -0-
          (ii) Shared power to vote or direct the vote: 0
          (iii) Sole power to dispose or direct the disposition: -0-
          (iv) Shared power to dispose or direct the disposition: 0

  B. Daniel S. Loeb
     --------------
     (a) Amount beneficially owned: 0
     (b) Percent of class: 0.0%.
     (c) Number of shares as to which such person has:
          (i) Sole power to vote or direct the vote: -0-
          (ii) Shared power to vote or direct the vote: 0
          (iii) Sole power to dispose or direct the disposition: -0-
          (iv) Shared power to dispose or direct the disposition: 0

  C. Third Point Offshore Fund, Ltd.
     -------------------------------
     (a) Amount beneficially owned: 0
     (b) Percent of class: 0.0%.
     (c) Number of shares as to which such person has:
          (i) Sole power to vote or direct the vote: -0-
          (ii) Shared power to vote or direct the vote: 0
          (iii) Sole power to dispose or direct the disposition: -0-
          (iv) Shared power to dispose or direct the disposition: 0

Item 5:   Ownership of Five Percent or Less of a Class:
- ------    --------------------------------------------

     If this statement is being filed to report the fact that as of the date
hereof the reporting person has ceased to be the beneficial owner of more than
five percent of the class of securities, check the following: [X]

                                      -5-
<PAGE>

Item 10:  Certification:
- -------   -------------

Each of the Reporting Persons hereby makes the following certification:

     By signing below I certify that, to the best of my knowledge and belief,
the securities referred to above were not acquired and are not held for the
purpose of or with the effect of changing or influencing the control of the
issuer of the securities and were not acquired and are not held in connection
with or as a participant in any transaction having that purpose or effect.



                         [Signatures on following page]

                                      -6-

<PAGE>




                                    SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify
that the information set forth in this statement is true, complete and correct.


Dated: February 13, 2008



                                 THIRD POINT LLC

                                 By: Daniel S. Loeb, Chief Executive Officer


                                 By:  /s/ Keith Waller
                                      ------------------------------------------
                                      Name:   Keith Waller
                                      Title:  Attorney-in-Fact




                                 THIRD POINT OFFSHORE FUND, LTD.

                                 By: Daniel S. Loeb, Director


                                 By:  /s/ Keith Waller
                                      ------------------------------------------
                                      Name:   Keith Waller
                                      Title:  Attorney-in-Fact




                                 DANIEL S. LOEB


                                 By:  /s/ Keith Waller
                                      ------------------------------------------
                                      Name:   Keith Waller
                                      Title:  Attorney-in-Fact



       [SIGNATURE PAGE TO AMENDMENT NO. 1 TO SCHEDULE 13G WITH RESPECT TO
                            FLAMEL TECHNOLOGIES S.A.]


</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----
