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Long-Term Debt - Narrative (Details) $ / shares in Units, $ in Thousands |  | 3 Months Ended |  |
--- | --- | --- | --- | ---
Feb. 16, 2018 USD ($) day $ / shares Rate | Mar. 31, 2021 USD ($) | Mar. 31, 2020 USD ($) | Dec. 31, 2020 USD ($) | Dec. 31, 2019 USD ($)
Schedule of Capitalization, Long-term Debt [Line Items] |  |  |  |  |
Interest expense, debt |  | $ 1,929 | $ 3,190 |  |
Amortization of debt discount and debt issuance costs |  | 312 | 1,573 |  |
Stockholders' equity |  | 136,504 | 32,067 | $ 162,266 | $ (29,199)
ADSs, conversion ratio | Rate | 9269.56% |  |  |  |
Additional paid-in capital |  |  |  |  |
Schedule of Capitalization, Long-term Debt [Line Items] |  |  |  |  |
Stockholders' equity |  | 542,093 | 497,249 | 566,916 | 434,391
Accumulated deficit |  |  |  |  |
Schedule of Capitalization, Long-term Debt [Line Items] |  |  |  |  |
Stockholders' equity |  | (383,872) | (392,080) | (384,187) | $ (391,215)
Cumulative Effect, Period of Adoption, Adjustment |  |  |  |  |
Schedule of Capitalization, Long-term Debt [Line Items] |  |  |  |  |
Book value of long-term debt |  |  |  | 12,939 |
Stockholders' equity |  |  |  | (12,939) |
Cumulative Effect, Period of Adoption, Adjustment | Additional paid-in capital |  |  |  |  |
Schedule of Capitalization, Long-term Debt [Line Items] |  |  |  |  |
Stockholders' equity |  |  |  | (26,699) |
Cumulative Effect, Period of Adoption, Adjustment | Accumulated deficit |  |  |  |  |
Schedule of Capitalization, Long-term Debt [Line Items] |  |  |  |  |
Stockholders' equity |  |  |  | 13,760 |
Senior Notes |  |  |  |  |
Schedule of Capitalization, Long-term Debt [Line Items] |  |  |  |  |
Book value of long-term debt |  | 141,461 |  | $ 128,210 |
4.50% Exchangeable Senior Notes Due 2023 | Convertible Debt |  |  |  |  |
Schedule of Capitalization, Long-term Debt [Line Items] |  |  |  |  |
Debt instrument, face amount | $ 125,000 |  |  |  |
Debt instrument, interest rate, stated percentage | 4.50% |  |  |  |
Option to purchase aggregate principal amount, term | 30 days |  |  |  |
Option to increase aggregate principal amount | $ 18,750 |  |  |  |
Payments of debt issuance costs | 6,190 |  |  |  |
Proceeds from loans or conditional grants | $ 137,560 |  |  |  |
ADS, option price per share (in dollars per share) | $ / shares | $ 10.79 |  |  |  |
ADS premium percentage | 20.00% |  |  |  |
ADS purchased, price per share (in dollars per share) | $ / shares | $ 8.99 |  |  |  |
4.50% Exchangeable Senior Notes Due 2023 | Senior Notes |  |  |  |  |
Schedule of Capitalization, Long-term Debt [Line Items] |  |  |  |  |
Interest expense, debt |  | 1,929 | 3,190 |  |
Coupon interest expense |  | 1,617 | 1,617 |  |
Amortization of debt discount and debt issuance costs |  | $ 312 | $ 1,573 |  |
Debt instrument, interest rate, stated percentage |  | 4.50% |  | 4.50% |
Debt Instrument, Redemption, Period One | 4.50% Exchangeable Senior Notes Due 2023 | Convertible Debt |  |  |  |  |
Schedule of Capitalization, Long-term Debt [Line Items] |  |  |  |  |
Number of business days | 5 days |  |  |  |
Consecutive business days | 5 days |  |  |  |
Percentage of product of the last reported sale price of the American Depositary Shares and the exchange rate on each such trading day | 98.00% |  |  |  |
Debt Instrument, Redemption, Period Two | 4.50% Exchangeable Senior Notes Due 2023 | Convertible Debt |  |  |  |  |
Schedule of Capitalization, Long-term Debt [Line Items] |  |  |  |  |
Scheduled threshold trading days | 35 days |  |  |  |
Threshold trading days | day | 95 |  |  |  |
Debt Instrument, Redemption, Period Three | 4.50% Exchangeable Senior Notes Due 2023 | Convertible Debt |  |  |  |  |
Schedule of Capitalization, Long-term Debt [Line Items] |  |  |  |  |
Threshold trading days | day | 20 |  |  |  |
Consecutive trading days | day | 30 |  |  |  |
Threshold percentage of stock price trigger | 130.00% |  |  |  |

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