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Equity Instruments and Transactions (Details) - USD ($) |  |  | 1 Months Ended | 12 Months Ended
--- | --- | --- | --- | ---
Apr. 28, 2020 | Feb. 21, 2020 | Aug. 31, 2020 | Feb. 29, 2020 | Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
Class of Stock [Line Items] |  |  |  |  |  |  |
Ordinary shares, shares authorized (in shares) |  |  |  |  | 500,000,000 | 500,000,000 |
Ordinary shares, nominal value (in usd per share) |  |  |  | $ 0.01 | $ 0.01 | $ 0.01 |
Ordinary shares, shares issued (in shares) |  |  |  |  | 58,620,000 | 58,396,000 |
Ordinary shares, shares outstanding (in shares) |  |  |  |  | 58,620,000 | 58,396,000 |
Preferred shares, shares authorized (in shares) |  |  |  |  | 50,000,000 | 50,000,000 |
Preferred shares, nominal value (in usd per share) |  |  |  | $ 0.01 | $ 0.01 | $ 0.01 |
Preferred shares, shares issued (in shares) |  |  |  |  | 488,000 | 488,000 |
Preferred shares, shares outstanding (in shares) |  |  |  |  | 488,000 | 488,000 |
Maximum aggregate offering price of securities under shelf registration |  |  |  | $ 250,000 |  |  |
Maximum aggregate offering price of ADSs under shelf registration |  |  |  | 50,000 |  |  |
Transaction costs |  |  |  | $ 428,000 |  |  |
Prepaid expenses and other current assets |  |  |  |  | $ 32,826,000 | $ 38,726,000 |
February 2020 private placement |  |  |  |  |  | 60,570,000 |
Proceeds from the February 2020 private placement |  |  |  |  | 0 | 60,570,000 | $ 0
Maximum threshold percentage for trigger of convertible preferred stock |  | 9.99% |  |  |  |  |
Retirement of treasury shares (in shares) |  |  | 5,407,000 |  |  |  |
Retirement of treasury shares |  |  |  |  |  | 0 |
Securities Purchase Agreement |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |
February 2020 private placement |  | $ 65,000,000 |  |  |  |  |
Proceeds from the February 2020 private placement |  | $ 60,570,000 |  |  |  |  |
Securities Purchase Agreement | American Depositary Receipts |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |
Stock issued during period, new issues (in shares) |  | 8,680,000 |  |  |  |  |
Securities Purchase Agreement | Series A Preferred Stock |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |
Stock issued during period, new issues (in shares) |  | 488,000 |  |  |  |  |
Shares issued, price per share (in dollars per share) |  | $ 7.09 |  |  |  |  |
Public Offering | American Depositary Shares |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |
Public offering, shares issued | 11,630,000 |  |  |  |  |  |
Public offering, price per share (in dollars per share) | $ 10.75 |  |  |  |  |  |
Public offering, proceeds | $ 125,000,000 |  |  |  |  |  |
Net proceeds from public offering | $ 116,924,000 |  |  |  |  |  |
Additional paid-in capital |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |
Charges against additional paid-in capital |  |  |  |  |  | 214,000 |
Prepaid expenses and other current assets |  |  |  |  | $ 214,000 |  |
February 2020 private placement |  |  |  |  |  | 60,478,000 |
Issuance costs recorded as a reduction to additional paid-in capital |  | $ 4,430,000 |  |  |  |  |
Retirement of treasury shares |  |  | $ 49,944,000 |  |  | $ 49,944,000 |
Treasury Shares |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |
Retirement of treasury shares (in shares) |  |  |  |  |  | 5,407,000 |
Retirement of treasury shares |  |  | 49,998,000 |  |  | $ 49,998,000 |
Ordinary shares |  |  |  |  |  |  |
Class of Stock [Line Items] |  |  |  |  |  |  |
February 2020 private placement |  |  |  |  |  | $ 87,000 |
Stock issued during period, new issues (in shares) |  |  |  |  |  | 8,680,000 |
Retirement of treasury shares (in shares) |  |  |  |  |  | 5,407,000 |
Retirement of treasury shares |  |  | $ 54,000 |  |  | $ 54,000 |

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