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Income Taxes - Deferred Taxes (Details) - USD ($) $ in Thousands | Dec. 31, 2021 | Dec. 31, 2020
--- | --- | ---
Deferred tax assets: |  |
Net operating loss carryforwards | $ 35,990 | $ 31,302
Orphan drug and R&D tax credit | 4,964 | 2,793
Share-based compensation | 4,108 | 2,626
Amortization | 3,429 | 3,701
Other | 662 | 423
Gross deferred tax assets | 49,153 | 40,845
Deferred tax liabilities: |  |
Other | (925) | (890)
Prepaid expenses | (75) | (75)
Gross deferred tax liabilities | (1,000) | (965)
Less: valuation allowances | (24,025) | (21,624)
Net deferred tax assets | $ 24,128 | $ 18,256

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