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Equity Instruments and Transactions (Details) - USD ($)
 1 Months Ended 12 Months Ended
Apr. 28, 2020
Feb. 21, 2020
Aug. 31, 2020
Feb. 29, 2020
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Class of Stock [Line Items]              
Ordinary shares, shares authorized (in shares)         500,000,000 500,000,000  
Ordinary shares, nominal value (in usd per share)       $ 0.01 $ 0.01 $ 0.01  
Ordinary shares, shares issued (in shares)         58,620,000 58,396,000  
Ordinary shares, shares outstanding (in shares)         58,620,000 58,396,000  
Preferred shares, shares authorized (in shares)         50,000,000 50,000,000  
Preferred shares, nominal value (in usd per share)       $ 0.01 $ 0.01 $ 0.01  
Preferred shares, shares issued (in shares)         488,000 488,000  
Preferred shares, shares outstanding (in shares)         488,000 488,000  
Maximum aggregate offering price of securities under shelf registration       $ 250,000      
Maximum aggregate offering price of ADSs under shelf registration       50,000      
Transaction costs       $ 428,000      
Prepaid expenses and other current assets         $ 32,826,000 $ 38,726,000  
February 2020 private placement           60,570,000  
Proceeds from the February 2020 private placement         0 60,570,000 $ 0
Maximum threshold percentage for trigger of convertible preferred stock   9.99%          
Retirement of treasury shares (in shares)     5,407,000        
Retirement of treasury shares           0  
Securities Purchase Agreement              
Class of Stock [Line Items]              
February 2020 private placement   $ 65,000,000          
Proceeds from the February 2020 private placement   $ 60,570,000          
Securities Purchase Agreement | American Depositary Receipts              
Class of Stock [Line Items]              
Stock issued during period, new issues (in shares)   8,680,000          
Securities Purchase Agreement | Series A Preferred Stock              
Class of Stock [Line Items]              
Stock issued during period, new issues (in shares)   488,000          
Shares issued, price per share (in dollars per share)   $ 7.09          
Public Offering | American Depositary Shares              
Class of Stock [Line Items]              
Public offering, shares issued 11,630,000            
Public offering, price per share (in dollars per share) $ 10.75            
Public offering, proceeds $ 125,000,000            
Net proceeds from public offering $ 116,924,000            
Additional paid-in capital              
Class of Stock [Line Items]              
Charges against additional paid-in capital           214,000  
Prepaid expenses and other current assets         $ 214,000    
February 2020 private placement           60,478,000  
Issuance costs recorded as a reduction to additional paid-in capital   $ 4,430,000          
Retirement of treasury shares     $ 49,944,000     $ 49,944,000  
Treasury Shares              
Class of Stock [Line Items]              
Retirement of treasury shares (in shares)           5,407,000  
Retirement of treasury shares     49,998,000     $ 49,998,000  
Ordinary shares              
Class of Stock [Line Items]              
February 2020 private placement           $ 87,000  
Stock issued during period, new issues (in shares)           8,680,000  
Retirement of treasury shares (in shares)           5,407,000  
Retirement of treasury shares     $ 54,000     $ 54,000